{"id":"https://openalex.org/W142449926","doi":null,"title":"Hormonal, experiential and neural regulation of ventromedial hypothalamic glutamate in the female rat","display_name":"Hormonal, experiential and neural regulation of ventromedial hypothalamic glutamate in the female rat","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W142449926","mag":"142449926"},"language":"en","primary_location":{"id":"pmh:oai:https://spectrum.library.concordia.ca:979344","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/979344/1/NR67326.pdf","pdf_url":"https://spectrum.library.concordia.ca/979344/1/NR67326.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006268612","display_name":"Michaela Georgescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michaela Georgescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006268612"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventromedial-hypothalamic-nucleus","display_name":"ventromedial hypothalamus","score":0.9290000200271606},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.9480000138282776},{"id":"https://openalex.org/keywords/female-sexual-behavior","display_name":"female sexual behavior","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lordosis","display_name":"lordosis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/estradiol-benzoate","display_name":"estradiol benzoate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.6420000195503235},{"id":"https://openalex.org/keywords/dnqx","display_name":"DNQX","score":0.7450000047683716},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.5820000171661377},{"id":"https://openalex.org/keywords/medial-preoptic-area","display_name":"medial preoptic area","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anterior-hypothalamic-area","display_name":"anterior hypothalamic area","score":0.9330000281333923},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vaginocervical-stimulation","display_name":"vaginocervical stimulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/copulation","display_name":"copulation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2777075645","wikidata":"https://www.wikidata.org/wiki/Q4386525","display_name":"DNQX","level":5,"score":0.8720742464065552},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.7231147289276123},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7049143314361572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6792252063751221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6746504902839661},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6588452458381653},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6230429410934448},{"id":"https://openalex.org/C2778506572","wikidata":"https://www.wikidata.org/wiki/Q11450699","display_name":"Estradiol benzoate","level":4,"score":0.5850605964660645},{"id":"https://openalex.org/C2776046087","wikidata":"https://www.wikidata.org/wiki/Q7920337","display_name":"Ventromedial nucleus of the hypothalamus","level":3,"score":0.497651606798172},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.4888305068016052},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4833909571170807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45375820994377136},{"id":"https://openalex.org/C2780626132","wikidata":"https://www.wikidata.org/wiki/Q1249903","display_name":"Lordosis behavior","level":5,"score":0.4206804633140564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3447510302066803},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.3162863850593567},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2687729001045227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16001486778259277},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:https://spectrum.library.concordia.ca:979344","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/979344/1/NR67326.pdf","pdf_url":"https://spectrum.library.concordia.ca/979344/1/NR67326.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:142449926","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/979344/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":201,"referenced_works":["https://openalex.org/W35768850","https://openalex.org/W99351306","https://openalex.org/W103657461","https://openalex.org/W111713383","https://openalex.org/W205197550","https://openalex.org/W1492219502","https://openalex.org/W1504779493","https://openalex.org/W1509103176","https://openalex.org/W1516501072","https://openalex.org/W1522531331","https://openalex.org/W1582986153","https://openalex.org/W1889524175","https://openalex.org/W1965165964","https://openalex.org/W1966037701","https://openalex.org/W1966732699","https://openalex.org/W1967112378","https://openalex.org/W1967166048","https://openalex.org/W1967521171","https://openalex.org/W1968508017","https://openalex.org/W1969402381","https://openalex.org/W1972853292","https://openalex.org/W1974649820","https://openalex.org/W1975258598","https://openalex.org/W1976475887","https://openalex.org/W1977741133","https://openalex.org/W1978504722","https://openalex.org/W1979122167","https://openalex.org/W1979248120","https://openalex.org/W1980692877","https://openalex.org/W1981558160","https://openalex.org/W1981847532","https://openalex.org/W1984890670","https://openalex.org/W1985955646","https://openalex.org/W1987528584","https://openalex.org/W1992319656","https://openalex.org/W1992433373","https://openalex.org/W1993540908","https://openalex.org/W1993777732","https://openalex.org/W1994167399","https://openalex.org/W1994450708","https://openalex.org/W1995998852","https://openalex.org/W1996019116","https://openalex.org/W1999051600","https://openalex.org/W1999959617","https://openalex.org/W2000668515","https://openalex.org/W2004019918","https://openalex.org/W2004071077","https://openalex.org/W2005096312","https://openalex.org/W2006930232","https://openalex.org/W2007284096","https://openalex.org/W2007671041","https://openalex.org/W2011445819","https://openalex.org/W2011543299","https://openalex.org/W2011936972","https://openalex.org/W2012463256","https://openalex.org/W2012585963","https://openalex.org/W2013824766","https://openalex.org/W2013915687","https://openalex.org/W2014081495","https://openalex.org/W2015300991","https://openalex.org/W2018948493","https://openalex.org/W2019223615","https://openalex.org/W2019483700","https://openalex.org/W2020338570","https://openalex.org/W2020609528","https://openalex.org/W2023064923","https://openalex.org/W2024969705","https://openalex.org/W2026207218","https://openalex.org/W2026400826","https://openalex.org/W2027061276","https://openalex.org/W2027171515","https://openalex.org/W2027248555","https://openalex.org/W2028474222","https://openalex.org/W2030225162","https://openalex.org/W2030862291","https://openalex.org/W2032336982","https://openalex.org/W2032784081","https://openalex.org/W2035155058","https://openalex.org/W2035261481","https://openalex.org/W2036378350","https://openalex.org/W2036673176","https://openalex.org/W2036731427","https://openalex.org/W2037320198","https://openalex.org/W2038405319","https://openalex.org/W2038551032","https://openalex.org/W2038819616","https://openalex.org/W2038890115","https://openalex.org/W2039677804","https://openalex.org/W2039813168","https://openalex.org/W2039832006","https://openalex.org/W2042459618","https://openalex.org/W2043061219","https://openalex.org/W2044655438","https://openalex.org/W2045784601","https://openalex.org/W2046732597","https://openalex.org/W2047009822","https://openalex.org/W2047763782","https://openalex.org/W2049335979","https://openalex.org/W2050213435","https://openalex.org/W2050912412","https://openalex.org/W2051679547","https://openalex.org/W2051906934","https://openalex.org/W2052780399","https://openalex.org/W2053417960","https://openalex.org/W2054185351","https://openalex.org/W2054888976","https://openalex.org/W2055445652","https://openalex.org/W2055634968","https://openalex.org/W2057020248","https://openalex.org/W2057313063","https://openalex.org/W2057478065","https://openalex.org/W2058697648","https://openalex.org/W2058724491","https://openalex.org/W2058729089","https://openalex.org/W2060738571","https://openalex.org/W2061334468","https://openalex.org/W2061365435","https://openalex.org/W2062524946","https://openalex.org/W2063861860","https://openalex.org/W2065293959","https://openalex.org/W2065295152","https://openalex.org/W2068420002","https://openalex.org/W2068790458","https://openalex.org/W2068878007","https://openalex.org/W2069438724","https://openalex.org/W2070692501","https://openalex.org/W2070827848","https://openalex.org/W2071143997","https://openalex.org/W2072701839","https://openalex.org/W2072875069","https://openalex.org/W2077523280","https://openalex.org/W2077855655","https://openalex.org/W2078499524","https://openalex.org/W2078907530","https://openalex.org/W2080374512","https://openalex.org/W2083447043","https://openalex.org/W2083659258","https://openalex.org/W2083695389","https://openalex.org/W2083828397","https://openalex.org/W2084998600","https://openalex.org/W2085318506","https://openalex.org/W2085993193","https://openalex.org/W2087855026","https://openalex.org/W2088794972","https://openalex.org/W2089049866","https://openalex.org/W2089152452","https://openalex.org/W2089828703","https://openalex.org/W2091903217","https://openalex.org/W2092538668","https://openalex.org/W2092978660","https://openalex.org/W2093411760","https://openalex.org/W2097459779","https://openalex.org/W2103124605","https://openalex.org/W2103212315","https://openalex.org/W2103614078","https://openalex.org/W2104311488","https://openalex.org/W2105174239","https://openalex.org/W2111095033","https://openalex.org/W2112385195","https://openalex.org/W2114330392","https://openalex.org/W2114366652","https://openalex.org/W2115271248","https://openalex.org/W2117335373","https://openalex.org/W2117860217","https://openalex.org/W2121134774","https://openalex.org/W2121403142","https://openalex.org/W2121732070","https://openalex.org/W2121878074","https://openalex.org/W2123380538","https://openalex.org/W2124361446","https://openalex.org/W2129337004","https://openalex.org/W2132750002","https://openalex.org/W2138714201","https://openalex.org/W2138882887","https://openalex.org/W2139840896","https://openalex.org/W2146292332","https://openalex.org/W2148013398","https://openalex.org/W2148827215","https://openalex.org/W2152375673","https://openalex.org/W2154072252","https://openalex.org/W2156535756","https://openalex.org/W2161639078","https://openalex.org/W2163815564","https://openalex.org/W2164183982","https://openalex.org/W2164607432","https://openalex.org/W2169102621","https://openalex.org/W2169557485","https://openalex.org/W2170929427","https://openalex.org/W2307177664","https://openalex.org/W2310458896","https://openalex.org/W2314151299","https://openalex.org/W2322980330","https://openalex.org/W2333635193","https://openalex.org/W2339039268","https://openalex.org/W2399141921","https://openalex.org/W2403741149","https://openalex.org/W2411408755","https://openalex.org/W2412137379","https://openalex.org/W2432912489","https://openalex.org/W2503099426","https://openalex.org/W2944381530"],"related_works":["https://openalex.org/W2067571622","https://openalex.org/W197741402","https://openalex.org/W2105174239","https://openalex.org/W7101161550","https://openalex.org/W1983516120","https://openalex.org/W252333761","https://openalex.org/W2249820965","https://openalex.org/W1972853292","https://openalex.org/W2586385102","https://openalex.org/W2072296622"],"abstract_inverted_index":{"Previous":[0],"experiments":[1],"have":[2,342],"shown":[3],"that":[4,53,75,93,156,209,239,271,285,332],"enhanced":[5],"glutamate":[6,15,56,112,158,179,210,240,287,362],"neurotransmission":[7],"in":[8,28,58,64,71,83,119,172,181,227,264,311,350,365],"the":[9,51,59,65,80,84,106,120,129,161,176,182,237,265,281,315,330,337,351,366],"ventromedial":[10,54,85,121,183,266,338,360],"hypothalamus":[11,86,122,184],"by":[12,87,247,277],"administration":[13],"of":[14,32,50,61,79,108,123,131,166,178,217,229,283,353,359],"or":[16,24,150,201,300],"its":[17],"selective":[18],"receptor":[19,163],"agonists":[20],"kainate,":[21],"N-methyl-D-aspartic":[22],"acid":[23,249],"\u00dc-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate":[25],"(AMPA),":[26],"results":[27,154,207,269],"a":[29,76,111,186,191,215,230,251],"pronounced":[30],"inhibition":[31],"proceptive":[33],"and":[34,92,98,139,204,257,288,303,326],"consummatory":[35],"sexual":[36,62,355],"behaviors.":[37],"The":[38,68,169,206,268,308,357],"five":[39],"chapters":[40],"encompassing":[41],"this":[42,101],"thesis":[43],"were":[44,295],"designed":[45],"to":[46,245,306,336,346],"expand":[47],"our":[48],"comprehension":[49],"role":[52],"hypothalamic":[55,320,361],"plays":[57],"control":[60,352],"behavior":[63],"female":[66,124,354],"rat.":[67],"experiment":[69,170,309],"presented":[70,171,310],"Chapter":[72,103,173,234,312],"1":[73],"shows":[74],"substantial":[77],"proportion":[78],"neurons":[81,284],"activated":[82],"vaginocervical":[88,132],"stimulation":[89,133,223],"are":[90,275],"glutamatergic,":[91],"priming":[94,196,219],"with":[95,190,197,253,297],"estradiol":[96,199,278,298,301],"benzoate":[97,200,203,279,299,302],"progesterone":[99,304],"inhibits":[100],"activation.":[102],"2":[104],"investigated":[105],"effect":[107,130,145],"6,7-Dinitroquinoxaline-2,3-dione":[109],"(DNQX),":[110],"antagonist,":[113],"on":[114,134,146,260],"estrus":[115,167],"termination,":[116],"when":[117,293],"infused":[118],"rats.":[125],"DNQX":[126],"effectively":[127],"reversed":[128],"appetitive":[135],"behaviors,":[136,149],"lordosis":[137,140,261],"quotient":[138],"magnitude,":[141],"but":[142],"had":[143],"no":[144],"pacing,":[147],"defensive":[148],"male":[151,194],"ejaculations.":[152],"These":[153,340],"suggest":[155,208],"blocking":[157],"transmission":[159],"at":[160],"AMPA/kainate":[162],"delays":[164],"onset":[165],"termination.":[168],"3":[174],"analyzed":[175],"pattern":[177],"release":[180,211,241],"during":[185],"2-hour":[187],"copulation":[188],"session":[189],"sexually":[192,231],"vigorous":[193],"following":[195],"oil,":[198],"extradiol":[202],"progesterone.":[205],"patterns":[212],"vary":[213],"as":[214,220,222,329],"function":[216,358],"hormonal":[218],"well":[221],"received":[224],"from":[225],"being":[226],"proximity":[228],"mature":[232],"male.":[233],"4":[235],"tested":[236],"hypothesis":[238],"may":[242],"be":[243],"subject":[244],"regulation":[246],"\u00de-aminobutryic":[248],"(GABA),":[250],"neurotransmitter":[252],"cellular":[254],"inhibitory":[255],"properties":[256],"facilitative":[258],"effects":[259],"upon":[262],"infusion":[263],"hypothalamus.":[267,339],"indicate":[270],"GABA":[272],"A":[273],"R\u00dc1":[274],"upregulated":[276],"because":[280],"percentage":[282],"contained":[286],"expressed":[289],"those":[290],"receptors":[291],"doubled":[292],"animals":[294],"primed":[296],"relative":[305],"oil.":[307],"5":[313],"identified":[314],"medial":[316,327],"preoptic":[317],"area,":[318,321],"anterior":[319,324],"paraventricular":[322],"nucleus,":[323],"hippocampus,":[325],"amygdala":[328],"nuclei":[331,341],"send":[333],"GABAergic":[334],"projections":[335],"previously":[343],"been":[344],"found":[345],"play":[347],"important":[348],"roles":[349],"behavior.":[356],"is":[363],"explored":[364],"general":[367],"discussion.":[368]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}