{"id":"https://openalex.org/W1421050221","doi":null,"title":"Functional Characterization of a Bidirectional Mammalian Promoter of Two Genes for the Mitochondrial Translational Apparatus","display_name":"Functional Characterization of a Bidirectional Mammalian Promoter of Two Genes for the Mitochondrial Translational Apparatus","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1421050221","mag":"1421050221"},"language":"en","primary_location":{"id":"pmh:oai:trepo.tuni.fi:10024/66473","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66473","pdf_url":"https://trepo.tuni.fi/bitstream/10024/66473/1/978-951-44-7710-2.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trepo.tuni.fi/bitstream/10024/66473/1/978-951-44-7710-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033461883","display_name":"Ernesto Zanotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Ernesto Zanotto","raw_affiliation_strings":["University of Tampere#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tampere#TAB#","institution_ids":["https://openalex.org/I4387153886"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033461883"],"corresponding_institution_ids":["https://openalex.org/I4387153886"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bidirectional-promoter","display_name":"bidirectional promoter","score":0.875},{"id":"https://openalex.org/keywords/seryl-trna-synthetase","display_name":"seryl-tRNA synthetase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nf-y","display_name":"NF-Y","score":0.6539999842643738},{"id":"https://openalex.org/keywords/ccaat-box","display_name":"CCAAT box","score":0.9079999923706055},{"id":"https://openalex.org/keywords/retrograde-signaling","display_name":"retrograde signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-nuclear-communication","display_name":"mitochondrial-nuclear communication","score":0.5920000076293945},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/promoter-mapping","display_name":"promoter mapping","score":0.3240000009536743},{"id":"https://openalex.org/keywords/nuclear-gene-expression","display_name":"nuclear gene expression","score":0.31200000643730164},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5761269927024841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49949097633361816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4829108715057373},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.46990200877189636},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43534302711486816},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.4272539019584656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34885135293006897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11773034930229187},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:trepo.tuni.fi:10024/66473","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66473","pdf_url":"https://trepo.tuni.fi/bitstream/10024/66473/1/978-951-44-7710-2.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"pmh:oai:tampub.uta.fi:10024/66473","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/66473","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"mag:1421050221","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66473","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:trepo.tuni.fi:10024/66473","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/66473","pdf_url":"https://trepo.tuni.fi/bitstream/10024/66473/1/978-951-44-7710-2.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322592","display_name":"Tampereen Yliopisto","ror":"https://ror.org/033003e23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1421050221.pdf","grobid_xml":"https://content.openalex.org/works/W1421050221.grobid-xml"},"referenced_works_count":235,"referenced_works":["https://openalex.org/W996206","https://openalex.org/W2931627","https://openalex.org/W4454459","https://openalex.org/W8098060","https://openalex.org/W58486508","https://openalex.org/W94071839","https://openalex.org/W153349786","https://openalex.org/W165621880","https://openalex.org/W183537572","https://openalex.org/W1523158326","https://openalex.org/W1548851567","https://openalex.org/W1557098204","https://openalex.org/W1558516755","https://openalex.org/W1561484646","https://openalex.org/W1576822037","https://openalex.org/W1598629558","https://openalex.org/W1599051410","https://openalex.org/W1878450308","https://openalex.org/W1881081860","https://openalex.org/W1940436875","https://openalex.org/W1964015820","https://openalex.org/W1964876127","https://openalex.org/W1967743590","https://openalex.org/W1968106162","https://openalex.org/W1968952472","https://openalex.org/W1969289872","https://openalex.org/W1969772407","https://openalex.org/W1971383450","https://openalex.org/W1972818734","https://openalex.org/W1974188155","https://openalex.org/W1974629239","https://openalex.org/W1974942240","https://openalex.org/W1975188682","https://openalex.org/W1976676780","https://openalex.org/W1978090920","https://openalex.org/W1979860433","https://openalex.org/W1980315965","https://openalex.org/W1983154266","https://openalex.org/W1983643913","https://openalex.org/W1983856769","https://openalex.org/W1985046929","https://openalex.org/W1985165444","https://openalex.org/W1986356700","https://openalex.org/W1990811092","https://openalex.org/W1991049622","https://openalex.org/W1993129179","https://openalex.org/W1993401855","https://openalex.org/W1995004764","https://openalex.org/W1996052541","https://openalex.org/W1996592585","https://openalex.org/W1996809767","https://openalex.org/W1996885665","https://openalex.org/W1997312454","https://openalex.org/W1999165695","https://openalex.org/W1999522584","https://openalex.org/W2001457226","https://openalex.org/W2001508320","https://openalex.org/W2001556707","https://openalex.org/W2001715545","https://openalex.org/W2002495914","https://openalex.org/W2002506451","https://openalex.org/W2002662437","https://openalex.org/W2004361129","https://openalex.org/W2007615156","https://openalex.org/W2008632158","https://openalex.org/W2009229814","https://openalex.org/W2010488656","https://openalex.org/W2010692012","https://openalex.org/W2011000183","https://openalex.org/W2011193031","https://openalex.org/W2011683509","https://openalex.org/W2012018808","https://openalex.org/W2012135330","https://openalex.org/W2013866322","https://openalex.org/W2014993721","https://openalex.org/W2015470310","https://openalex.org/W2015798899","https://openalex.org/W2018302460","https://openalex.org/W2019801761","https://openalex.org/W2020062503","https://openalex.org/W2021048682","https://openalex.org/W2022831345","https://openalex.org/W2023422390","https://openalex.org/W2026800490","https://openalex.org/W2027594215","https://openalex.org/W2028242823","https://openalex.org/W2028463380","https://openalex.org/W2028858498","https://openalex.org/W2029204107","https://openalex.org/W2030903461","https://openalex.org/W2031609964","https://openalex.org/W2032773883","https://openalex.org/W2032913442","https://openalex.org/W2033204304","https://openalex.org/W2033764083","https://openalex.org/W2035257545","https://openalex.org/W2036453577","https://openalex.org/W2037154461","https://openalex.org/W2037784192","https://openalex.org/W2037918628","https://openalex.org/W2038265456","https://openalex.org/W2038557175","https://openalex.org/W2040567801","https://openalex.org/W2040831177","https://openalex.org/W2042537629","https://openalex.org/W2042797800","https://openalex.org/W2043305070","https://openalex.org/W2043457799","https://openalex.org/W2044681822","https://openalex.org/W2044704400","https://openalex.org/W2045804941","https://openalex.org/W2046250502","https://openalex.org/W2049516586","https://openalex.org/W2050293721","https://openalex.org/W2050321932","https://openalex.org/W2051215197","https://openalex.org/W2053101001","https://openalex.org/W2056227034","https://openalex.org/W2056321541","https://openalex.org/W2056584805","https://openalex.org/W2057171606","https://openalex.org/W2057754020","https://openalex.org/W2058894035","https://openalex.org/W2060084840","https://openalex.org/W2060137763","https://openalex.org/W2060179384","https://openalex.org/W2060811345","https://openalex.org/W2062415168","https://openalex.org/W2064729564","https://openalex.org/W2065982902","https://openalex.org/W2066250257","https://openalex.org/W2066556485","https://openalex.org/W2067116931","https://openalex.org/W2067152194","https://openalex.org/W2067293718","https://openalex.org/W2068048197","https://openalex.org/W2068997428","https://openalex.org/W2069429452","https://openalex.org/W2070895853","https://openalex.org/W2072451938","https://openalex.org/W2072972072","https://openalex.org/W2072978915","https://openalex.org/W2074944043","https://openalex.org/W2078593792","https://openalex.org/W2080279037","https://openalex.org/W2082620184","https://openalex.org/W2084544581","https://openalex.org/W2085162903","https://openalex.org/W2085229930","https://openalex.org/W2087239127","https://openalex.org/W2090539672","https://openalex.org/W2091801017","https://openalex.org/W2092445607","https://openalex.org/W2092578153","https://openalex.org/W2094655287","https://openalex.org/W2098316218","https://openalex.org/W2098318347","https://openalex.org/W2098676867","https://openalex.org/W2100347985","https://openalex.org/W2101119157","https://openalex.org/W2101893734","https://openalex.org/W2102472842","https://openalex.org/W2102797065","https://openalex.org/W2104694506","https://openalex.org/W2104882897","https://openalex.org/W2105048034","https://openalex.org/W2105688529","https://openalex.org/W2105754268","https://openalex.org/W2107324877","https://openalex.org/W2107396843","https://openalex.org/W2108157217","https://openalex.org/W2108352951","https://openalex.org/W2108836442","https://openalex.org/W2109163588","https://openalex.org/W2109198983","https://openalex.org/W2112093095","https://openalex.org/W2112438801","https://openalex.org/W2115527168","https://openalex.org/W2115715931","https://openalex.org/W2116545115","https://openalex.org/W2117696416","https://openalex.org/W2119090089","https://openalex.org/W2120083461","https://openalex.org/W2120481130","https://openalex.org/W2121328520","https://openalex.org/W2124344505","https://openalex.org/W2124806192","https://openalex.org/W2124961252","https://openalex.org/W2126409180","https://openalex.org/W2126884280","https://openalex.org/W2126909650","https://openalex.org/W2128815118","https://openalex.org/W2128932167","https://openalex.org/W2129011493","https://openalex.org/W2129422215","https://openalex.org/W2131143886","https://openalex.org/W2132579877","https://openalex.org/W2132764312","https://openalex.org/W2135069609","https://openalex.org/W2138881473","https://openalex.org/W2138961575","https://openalex.org/W2139235231","https://openalex.org/W2140751228","https://openalex.org/W2141097619","https://openalex.org/W2144596746","https://openalex.org/W2145115717","https://openalex.org/W2145177140","https://openalex.org/W2146331332","https://openalex.org/W2148456347","https://openalex.org/W2149278013","https://openalex.org/W2152325979","https://openalex.org/W2154229994","https://openalex.org/W2155735073","https://openalex.org/W2156601566","https://openalex.org/W2158088166","https://openalex.org/W2158389310","https://openalex.org/W2158475521","https://openalex.org/W2159594136","https://openalex.org/W2159707559","https://openalex.org/W2160957799","https://openalex.org/W2161189845","https://openalex.org/W2164228620","https://openalex.org/W2167070526","https://openalex.org/W2167837420","https://openalex.org/W2168516136","https://openalex.org/W2169288112","https://openalex.org/W2171638979","https://openalex.org/W2173353469","https://openalex.org/W2183190091","https://openalex.org/W2233895164","https://openalex.org/W2237430945","https://openalex.org/W2330001687","https://openalex.org/W2397622552","https://openalex.org/W2402659307","https://openalex.org/W2941449697"],"related_works":["https://openalex.org/W2001864010","https://openalex.org/W2933830431","https://openalex.org/W2004361129","https://openalex.org/W2789303432","https://openalex.org/W3199743806","https://openalex.org/W3147326386","https://openalex.org/W2140751228","https://openalex.org/W7212195195","https://openalex.org/W4220918420","https://openalex.org/W1993139982"],"abstract_inverted_index":{"Despite":[0,204],"having":[1],"its":[2,11,387],"own":[3],"DNA,":[4],"the":[5,8,14,19,31,45,48,70,113,160,167,200,208,235,239,258,275,283,323,355,358,366,379,402,422,433,438,445,475,493,497,503,507,547,563,571,582,590,597,606,617,679,704,726,742,745,752,759,776,800,826,834,837,843,863,871,882],"mitochondrion":[6],"imports":[7],"majority":[9],"of":[10,37,66,78,109,136,157,159,169,202,210,213,220,257,269,326,328,357,383,418,437,474,496,502,518,565,570,635,639,656,689,741,747,761,799,829,862,885],"proteins":[12,67,174],"from":[13,112,426],"nucleus":[15,32,844],"which,":[16,278],"thus,":[17],"controls":[18],"organellar":[20],"activities,":[21],"and":[22,61,99,120,123,141,180,193,225,247,285,311,335,452,472,552,612,641,660,685,766,836,842,852,856,870,888],"in":[23,34,55,116,148,153,294,307,332,338,347,365,369,392,516,530,537,562,596,605,609,678,703,729,750,773,789,794,833],"a":[24,35,52,191,302,411,513,559,602,631,695,721,770,891],"reciprocal":[25,838],"manner":[26],"mitochondria":[27,841],"send":[28],"signals":[29,110],"to":[30,97,102,118,125,134,182,233,321,344,378,385,414,428,557,581,738,854],"resulting":[33],"coordination":[36,77],"both":[38,524,610],"genomes.":[39],"Although":[40],"mitochondrial":[41,83,259,333,349,572,579,627,636,651,657,778,820],"function":[42,84,580],"depends":[43],"on":[44,401,675,808],"nuclear":[46,114,137,162,253,329,548,566],"genome,":[47,115],"organelle":[49],"still":[50,145],"plays":[51],"pivotal":[53],"role":[54,561],"energy":[56,585],"production,":[57],"cell":[58,86,583,632,681,848],"proliferation,":[59,850],"maintenance":[60],"death.":[62],"The":[63,89,105,127,155,291,313,457,797],"functional":[64],"coexistence":[65],"encoded":[68],"by":[69,354,373,465,626,865,873],"two":[71],"separate":[72],"genomes":[73],"requires":[74],"an":[75,267],"efficient":[76],"gene":[79,138,368,830],"expression":[80,156,201,831],"ensuring":[81],"correct":[82],"upon":[85],"specific":[87,184,892],"needs.":[88],"mitochondrianucleus":[90],"networking":[91],"includes":[92],"interconnection":[93],"between":[94],"anterograde":[95,106,140],"(nucleus":[96],"mitochondria)":[98],"retrograde":[100,128,142],"(mitochondria":[101],"nucleus)":[103],"signals.":[104],"system":[107,129],"consists":[108],"generated":[111],"response":[117,754],"endogenous":[119,855],"exogenous":[121,857],"stimuli,":[122],"transmitted":[124],"mitochondria.":[126],"links":[130],"mitochondrially":[131],"originated":[132],"stimuli":[133],"coregulation":[135],"expression.\\n\\nNevertheless,":[139],"signalling":[143,868],"are":[144,252,845,876],"poorly":[146],"understood":[147],"mammals,":[149,546],"if":[150],"better":[151],"characterized":[152],"yeast.":[154],"most":[158],"eukaryotic":[161],"genes":[163,254,330,567,622],"is":[164,441],"controlled":[165],"at":[166,686,881],"level":[168,884],"transcription":[170,209,327,477],"through":[171],"transacting":[172],"regulatory":[173],"(transcription":[175],"factors)":[176],"which":[177,648,786,866,874],"can":[178,195,462,623],"recognize":[179,386],"bind":[181],"short":[183],"nucleotide":[185],"sequences":[186],"(cisacting":[187],"binding":[188,389,424,460,592],"sites)":[189],"within":[190,506],"promoter,":[192],"consequently":[194],"modulate":[196],"(activate":[197],"or":[198,398,509,529,666,710,716,718,732,792],"suppress)":[199],"genes.":[203,241],"bidirectional":[205,236,288,381,416,519,618],"promoters":[206,417,520,539],"controlling":[207],"around":[211],"11%":[212],"mammalian":[214],"genes,":[215],"so":[216],"far":[217],"only":[218,450,601],"few":[219],"them":[221],"have":[222,558],"been":[223],"studied":[224],"properly":[226],"characterized.":[227],"I":[228,265,405,430,483,629,683],"addressed":[229],"my":[230,263],"research":[231],"study":[232,615],"mapping":[234],"promoter":[237,289,296,440,447,599,619,676,727,784,810],"for":[238,523,594,620,775,847],"Mrps12/Sarsm":[240,287,295,439,498,598,621,809],"Mrps12":[242],"(mitochondrial":[243],"ribosomal":[244],"protein":[245,658],"s12)":[246],"Sarsm":[248],"(seryl":[249],"tRNA":[250],"synthetase)":[251],"encoding":[255,568],"components":[256,569],"translational":[260],"apparatus.":[261],"In":[262,545],"study,":[264],"identified":[266],"array":[268,798],"four":[270,801],"CCAAT":[271,397,427,434,458,494,504,527,534,542,802,823],"boxes,":[272,535],"all":[273],"with":[274,280,309,485,492,532,646,758],"same":[276,777],"orientation":[277,436],"interacting":[279],"NFY,":[281],"regulate":[282],"human":[284,370,510,640,713,733,886],"mouse":[286,508,611,642,707,730],"activities.":[290],"NFY":[292,314,375,384,471,525],"involvement":[293],"transcriptional":[297,453,607,701,753,816],"regulation":[298,564],"was":[299,318,342,455,755,787,804,822],"confirmed":[300],"using":[301],"dual":[303],"luciferase":[304],"reporter":[305],"vector":[306],"combination":[308,531],"EMSA":[310],"Chip.":[312],"yeast":[315],"counterpart,":[316],"Hap2/3/5,":[317],"previously":[319,555],"shown":[320,352,556],"be":[322,345,410,463,624,739],"main":[324],"activator":[325],"involved":[331,807],"biogenesis":[334],"OXPHOS.":[336],"Also":[337],"humans,":[339],"NF":[340],"Y":[341],"demonstrated":[343,431,484],"important":[346,443],"regulating":[348],"function,":[350,652],"as":[351,396,399,654],"elsewhere":[353],"rescue":[356],"pathological":[359],"cytochrome":[360],"c":[361],"oxidase":[362],"assembly":[363],"mutant":[364],"SURF1":[367],"fibroblasts,":[371],"obtained":[372],"overexpressing":[374],"subunits.":[376],"Due":[377],"particular":[380],"property":[382],"core":[388,423,459],"site":[390,425,461,593],"sequence":[391],"either":[393],"orientation,":[394],"i.e.":[395],"ATTGG":[400],"coding":[403],"strand,":[404],"hypothesize":[406],"that":[407,432,487,662],"it":[408],"could":[409,489],"suitable":[412],"factor":[413,478],"govern":[415],"this":[419],"class.":[420],"Inverting":[421],"ATTGG,":[429],"box":[435,543],"not":[442,805],"since,":[444],"overall":[446],"activity":[448,608,677,702,728],"changed":[449],"minimally":[451],"directionality":[454],"maintained.":[456],"recognized":[464],"several":[466],"multiprotein":[467],"complex":[468,827],"factors;":[469],"including":[470],"members":[473],"C/EBP":[476],"family":[479],"(CCAAT/Enhancer":[480],"Binding":[481],"Protein).":[482],"EMSA,":[486],"C/EBP?":[488],"also":[490],"interact":[491],"boxes":[495,528,803],"promoter.":[499],"Bioinformatic":[500],"analyses":[501],"box,":[505],"genomes,":[511],"revealed":[512],"preferential":[514],"distribution":[515],"favour":[517],"over":[521],"unidirectional":[522],"type":[526],"C/EBPtype":[533],"especially":[536],"those":[538],"presenting":[540],"multiple":[541,673],"sites.":[544],"respiratory":[549,667],"factors,":[550],"NRF1":[551],"NRF2,":[553],"were":[554,644],"key":[560],"oxidative":[573],"phosphorylation":[574],"(OXPHOS)":[575],"system,":[576],"thus":[577,889],"linking":[578],"s":[584],"demand.":[586],"However,":[587,720,815],"mutations":[588],"affecting":[589],"putative":[591],"NRF2":[595],"produced":[600,672],"small":[603],"change":[604],"human.":[613],"To":[614],"how":[616],"affected":[625],"dysfunction,":[628],"established":[630],"culture":[633],"model":[634],"stress.\\n\\nSeveral":[637],"types":[638],"cells":[643,715,768,791],"treated":[645],"toxins":[647],"differently":[649],"affect":[650],"such":[653],"inhibitors":[655],"synthesis,":[659],"agents":[661],"bring":[663],"about":[664],"uncoupling":[665],"chain":[668],"inhibition.":[669],"Mitochondrial":[670],"stress":[671,779,821],"effects":[674],"different":[680,687,748],"lines":[682],"tested":[684,705],"times":[688],"exposure.":[690],"High":[691],"drug":[692,697,723],"doses":[693],"and/or":[694],"prolonged":[696,819],"exposure":[698],"generally":[699],"suppressed":[700,793],"celltypes:":[706],"NIH":[708],"3T3":[709,731,767,790],"C2C12":[711],"myoblasts,":[712],"HEK293":[714],"U2OS":[717],"Hela.":[719],"shorter":[722],"treatment":[724],"stimulated":[725,788],"Hela":[734],"cells.":[735],"ROS":[736,762,774],"seemed":[737],"part":[740],"signaling,":[743],"since":[744],"potency":[746],"drugs":[749],"producing":[751],"well":[756],"correlated":[757],"amount":[760],"production.":[763],"HEK":[764,795],"293":[765],"gave":[769],"similar":[771],"increase":[772],"induction":[780],"although":[781],"exhibiting":[782],"opposite":[783],"modulation,":[785],"293.":[796],"directly":[806],"stimulation":[811],"under":[812,818],"OXPHOS":[813],"stress.":[814],"downregulation":[817],"boxdependent.\\n\\nIn":[824],"conclusion:":[825],"mechanism":[828],"modulationcoregulation":[832],"nuclei":[835],"tight":[839],"communication":[840],"vital":[846],"biogenesis,":[849],"death":[851],"adaptation":[853],"stimuli.":[858],"A":[859],"clear":[860],"understanding":[861],"mechanisms":[864],"nucleusmitochondrial":[867],"occurs,":[869],"pathways":[872],"perturbations":[875],"signaled,":[877],"may":[878],"allow":[879],"knowledge":[880],"molecular":[883],"diseases":[887],"permit":[890],"therapeutic":[893],"intervention.":[894]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}