{"id":"https://openalex.org/W1417618132","doi":null,"title":"A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration.","display_name":"A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration.","publication_year":2007,"publication_date":"2007-11-26","ids":{"openalex":"https://openalex.org/W1417618132","mag":"1417618132","pmid":"https://pubmed.ncbi.nlm.nih.gov/18079689"},"language":"en","primary_location":{"id":"pmid:18079689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064377356","display_name":"Andrea Jane Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105949","display_name":"Centre for Eye Research Australia","ror":"https://ror.org/01sqdef20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210105949"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrea J Richardson","raw_affiliation_strings":["Centre for Eye Research Australia, University of Melbourne, Australia. andreajr@unimelb.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Eye Research Australia, University of Melbourne, Australia. andreajr@unimelb.edu.au","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030198022","display_name":"Amirul F. M. Islam","orcid":"https://orcid.org/0000-0003-3897-3302","observed_orcids":["https://orcid.org/0000-0003-3897-3302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M Amirul Islam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051997081","display_name":"Robyn H. Guymer","orcid":"https://orcid.org/0000-0002-9441-4356","observed_orcids":["https://orcid.org/0000-0002-9441-4356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robyn H Guymer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001761986","display_name":"Melinda S. Cain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melinda Cain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101473901","display_name":"Paul Nigel Baird","orcid":"https://orcid.org/0000-0002-1305-3502","observed_orcids":["https://orcid.org/0000-0002-1305-3502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul N Baird","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7999,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.91755585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"2148","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":1.0},{"id":"https://openalex.org/keywords/neovascular-amd","display_name":"neovascular AMD","score":0.8009999990463257},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tag-snps","display_name":"tag SNPs","score":0.8880000114440918},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.9539999961853027},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.5609999895095825},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.8889999985694885},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8607795834541321},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8542710542678833},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.624475359916687},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5910482406616211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5424990057945251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4859715700149536},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.45553943514823914},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44255486130714417},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3903253674507141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34390532970428467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30063050985336304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21064704656600952},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.18925142288208008},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.14643403887748718},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:18079689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:researchbank.swinburne.edu.au:55ad9f01-46ea-4b8b-9f80-6ed434b8c3e8/1","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.3/399486","pdf_url":null,"source":{"id":"https://openalex.org/S4306401157","display_name":"Swinburne figshare (Swinburne University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57093077","host_organization_name":"Swinburne University of Technology","host_organization_lineage":["https://openalex.org/I57093077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Molecular Vision, Vol. 13 (2007), pp. 2148-2152","raw_type":null},{"id":"mag:1417618132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1560512588","https://openalex.org/W2490648658","https://openalex.org/W2078985579","https://openalex.org/W1567930658","https://openalex.org/W2111821329","https://openalex.org/W1978803715","https://openalex.org/W2090303330","https://openalex.org/W2159773036","https://openalex.org/W2098467127","https://openalex.org/W1973453386"],"abstract_inverted_index":{"PURPOSE:":[0],"Age-related":[1],"macular":[2],"degeneration":[3],"(AMD)":[4],"is":[5,29,36,51],"the":[6,13,44,59,76,130,134,167,196,226],"leading":[7],"cause":[8],"of":[9,25,39,61,65,125,133,160,195,207,219,222,236],"poor":[10],"vision":[11],"in":[12,58,165,180,200,239],"developed":[14],"world,":[15],"and":[16,99,102,203],"its":[17,140,208,237],"pathogenesis":[18],"remains":[19],"unknown.":[20],"The":[21],"most":[22],"devastating":[23],"form":[24],"end":[26],"stage":[27],"disease":[28],"neovascular":[30,100],"or":[31,234],"wet":[32],"AMD,":[33],"where":[34],"there":[35],"abnormal":[37,63],"growth":[38,48,64],"new":[40],"blood":[41,66],"vessels":[42],"under":[43],"retina.":[45],"Vascular":[46],"endothelial":[47],"factor":[49],"(VEGF)":[50],"thought":[52],"to":[53,74,118],"be":[54],"a":[55,70,79,112,123,146,212],"major":[56],"player":[57],"stimulus":[60],"this":[62,120],"vessels.":[67],"We":[68,91,110],"undertook":[69],"case-control":[71],"association":[72,190,221],"study":[73,182,202],"investigate":[75,119],"VEGF-A":[77,227],"gene,":[78],"known":[80],"angiogenic":[81],"gene":[82,121,136,228],"that":[83,128],"has":[84],"previously":[85],"been":[86],"associated":[87,230],"with":[88,95,231],"AMD.":[89],"METHODS:":[90],"recruited":[92],"577":[93],"individuals":[94],"AMD":[96,168,204,233],"(early,":[97],"atrophic,":[98],"AMD)":[101],"173":[103],"ethnically":[104],"matched":[105],"controls":[106],"for":[107,174],"our":[108,181,201,240],"study.":[109],"employed":[111],"tag-single":[113],"nucleotide":[114],"polymorphisms":[115],"(tSNP)":[116],"approach":[117,149],"using":[122],"series":[124],"seven":[126],"tSNPs":[127,198],"encompassed":[129],"coding":[131],"region":[132],"VEGF":[135,197],"as":[137,139],"well":[138],"promoter.":[141],"Alleles":[142],"were":[143],"determined":[144],"by":[145,151],"MALDI-TOF":[147],"based":[148],"followed":[150],"statistical":[152],"analysis.":[153,176],"RESULTS:":[154],"One":[155],"SNP":[156],"(rs3024997)":[157],"showed":[158,183],"evidence":[159,218],"departure":[161,185],"from":[162,186],"Hardy-Weinberg":[163,187],"equilibrium":[164],"only":[166],"cases.":[169],"Therefore,":[170],"it":[171],"was":[172,191],"retained":[173],"further":[175],"All":[177],"other":[178],"SNPs":[179,224],"no":[184,217],"equilibrium.":[188],"No":[189],"found":[192,216],"between":[193],"any":[194,206,235],"analyzed":[199],"nor":[205],"sub-types.":[209],"CONCLUSIONS:":[210],"Using":[211],"tSNP":[213],"approach,":[214],"we":[215],"an":[220],"these":[223],"within":[225],"being":[229],"either":[232],"subtypes":[238],"population.":[241]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}