{"id":"https://openalex.org/W141576842","doi":null,"title":"Acetate levels in human plasma.","display_name":"Acetate levels in human plasma.","publication_year":1976,"publication_date":"1976-11-19","ids":{"openalex":"https://openalex.org/W141576842","mag":"141576842","pmid":"https://pubmed.ncbi.nlm.nih.gov/1029892"},"language":"en","primary_location":{"id":"pmid:1029892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1029892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Clinical Dialysis and Transplant Forum","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090329693","display_name":"R. Henry Richards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J A Dowling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Dowling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004500107","display_name":"Hendrik Jan Vreman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Vreman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Feldman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Feldman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102977342","display_name":"Michael Walter Weiner","orcid":"https://orcid.org/0000-0002-0144-1954","observed_orcids":["https://orcid.org/0000-0002-0144-1954","https://orcid.org/0000-0002-7601-0702","https://orcid.org/0000-0002-0877-4583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M W Weiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5194,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.6328807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":null,"first_page":"73","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-acetate","display_name":"plasma acetate","score":0.9710000157356262},{"id":"https://openalex.org/keywords/acetate-metabolism","display_name":"acetate metabolism","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/arteriovenous-differences","display_name":"arteriovenous differences","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dialysis-patients","display_name":"dialysis patients","score":0.6859999895095825},{"id":"https://openalex.org/keywords/first-order-kinetics","display_name":"first-order kinetics","score":0.7049999833106995},{"id":"https://openalex.org/keywords/venous-plasma","display_name":"venous plasma","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.7602790594100952},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.7307485342025757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5719459056854248},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.5237671732902527},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4211319088935852},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.41711196303367615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4050274193286896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37181398272514343},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3430343270301819},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33082813024520874}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1029892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1029892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Clinical Dialysis and Transplant Forum","raw_type":"Comparative Study"},{"id":"mag:141576842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1029892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977965970","https://openalex.org/W6902586359","https://openalex.org/W1997394158","https://openalex.org/W7135393147","https://openalex.org/W2415829609","https://openalex.org/W2416955021","https://openalex.org/W2468430197","https://openalex.org/W2471962835","https://openalex.org/W1964164491","https://openalex.org/W2084227076"],"abstract_inverted_index":{"We":[0,187],"have":[1],"developed":[2],"a":[3,17,61,76,125,157,168,199],"gas":[4],"liquid":[5],"chromatographic":[6],"assay":[7],"for":[8],"plasma":[9,69],"acetate":[10,31,54,65,105,114,140,163,173],"which":[11,195],"detects":[12],"0.01":[13],"mM":[14],"and":[15,206],"has":[16],"standard":[18],"deviation":[19],"of":[20,24,33,56,67,92,112,132,138,153,202],"less":[21,97],"than":[22,88,98,182],"16%":[23],"the":[25,52,89,110,130,136,179,184,192],"mean":[26],"at":[27],"0.05":[28],"mM.":[29,44,83,134],"The":[30,45,64,151],"concentration":[32,55,66,91],"venous":[34,53,90],"blood":[35],"obtained":[36,70,197],"from":[37,51,71],"normal":[38,185],"subjects":[39,203],"was":[40,47,79,85,155,175],"0.025":[41],"+/-":[42,81,94],"0.002":[43,95],"value":[46,128],"not":[48,156,166],"significantly":[49,86],"different":[50],"dialysis":[57,62,72,180],"patients,":[58],"prior":[59,74],"to":[60,75,189],"treatment.":[63],"arterial":[68],"patients":[73,181],"hemodialysis":[77],"treatment":[78],"0.048":[80],"0.006":[82],"This":[84,100],"greater":[87],"0.027":[93],"(p":[96],"0.01).":[99],"arteriovenous":[101],"difference":[102],"suggests":[103],"that":[104,162,191],"is":[106,165],"utilized":[107],"peripherally.":[108],"At":[109,135],"onset":[111],"hemodialysis,":[113],"concentrations":[115,141],"rapidly":[116],"rose":[117],"and,":[118],"in":[119,129,178,183],"all":[120],"but":[121],"one":[122,149],"case,":[123],"reached":[124],"steady":[126],"state":[127],"range":[131],"1.5-5.1":[133],"termination":[137],"dialysis,":[139],"fell":[142],"rapidly,":[143],"usually":[144],"achieving":[145],"baseline":[146],"values":[147],"within":[148],"hr.":[150],"rate":[152],"decrease":[154],"simple":[158],"logarithmic":[159],"function,":[160],"suggesting":[161],"metabolism":[164],"solely":[167],"first":[169],"order":[170],"function.":[171],"Furthermore,":[172],"disappearance":[174],"more":[176],"rapid":[177],"subjects.":[186],"wish":[188],"emphasize":[190],"present":[193],"data,":[194],"were":[196],"on":[198],"small":[200],"number":[201],"are":[204],"preliminary":[205],"should":[207],"be":[208],"interpreted":[209],"with":[210],"caution.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}