{"id":"https://openalex.org/W141544617","doi":null,"title":"Live attenuated swine influenza vaccine by reverse genetics","display_name":"Live attenuated swine influenza vaccine by reverse genetics","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W141544617","mag":"141544617"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-07212010-142523","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-07212010-142523","pdf_url":"http://hdl.handle.net/10388/etd-07212010-142523","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10388/etd-07212010-142523","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070470679","display_name":"Aleksandar Ma\u0161i\u0107","orcid":"https://orcid.org/0000-0002-7943-1414","observed_orcids":["https://orcid.org/0000-0002-7943-1414"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aleksandar Ma\u0161i\u0107","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7943-1414","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070470679"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/swine-influenza-virus","display_name":"swine influenza virus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/reverse-genetics","display_name":"reverse genetics","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hemagglutinin-cleavage-site","display_name":"hemagglutinin cleavage site","score":0.9729999899864197},{"id":"https://openalex.org/keywords/h1n1","display_name":"H1N1","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cross-protective-immunity","display_name":"cross-protective immunity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.4740000069141388},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.3790000081062317},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.680718183517456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.507122278213501},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.4654430150985718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4325043559074402},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.42110657691955566},{"id":"https://openalex.org/C133239900","wikidata":"https://www.wikidata.org/wiki/Q2043512","display_name":"Live attenuated influenza vaccine","level":4,"score":0.416939914226532},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.3689306378364563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3538777232170105},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.3394702076911926},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.2351090908050537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2062925398349762},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.17128238081932068}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/etd-07212010-142523","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-07212010-142523","pdf_url":"http://hdl.handle.net/10388/etd-07212010-142523","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/etd-07212010-142523","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10388/etd-07212010-142523","pdf_url":"https://harvest.usask.ca/bitstreams/3194d0a1-6007-40a4-a346-966113e6b2d8/download","source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:141544617","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/bitstream/10388/etd-07212010-142523/1/Thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-07212010-142523","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-07212010-142523","pdf_url":"http://hdl.handle.net/10388/etd-07212010-142523","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310866","display_name":"Ministry of Agriculture - Saskatchewan","ror":"https://ror.org/02g5xq267"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W141544617.pdf","grobid_xml":"https://content.openalex.org/works/W141544617.grobid-xml"},"referenced_works_count":216,"referenced_works":["https://openalex.org/W21163204","https://openalex.org/W22632941","https://openalex.org/W37065802","https://openalex.org/W141226909","https://openalex.org/W177909858","https://openalex.org/W179501628","https://openalex.org/W213285565","https://openalex.org/W233177974","https://openalex.org/W1483301458","https://openalex.org/W1494509082","https://openalex.org/W1510714876","https://openalex.org/W1525947002","https://openalex.org/W1526204580","https://openalex.org/W1526531594","https://openalex.org/W1527335549","https://openalex.org/W1528398343","https://openalex.org/W1538039638","https://openalex.org/W1541595517","https://openalex.org/W1551079922","https://openalex.org/W1566744867","https://openalex.org/W1567087314","https://openalex.org/W1580494158","https://openalex.org/W1582945715","https://openalex.org/W1603867145","https://openalex.org/W1606498438","https://openalex.org/W1617036379","https://openalex.org/W1771500607","https://openalex.org/W1811768630","https://openalex.org/W1820541549","https://openalex.org/W1916389848","https://openalex.org/W1929762014","https://openalex.org/W1957614367","https://openalex.org/W1963978160","https://openalex.org/W1966818542","https://openalex.org/W1967280262","https://openalex.org/W1967338600","https://openalex.org/W1969295709","https://openalex.org/W1973941379","https://openalex.org/W1974202095","https://openalex.org/W1975461687","https://openalex.org/W1977162639","https://openalex.org/W1977548126","https://openalex.org/W1980494339","https://openalex.org/W1980823976","https://openalex.org/W1985336857","https://openalex.org/W1988346187","https://openalex.org/W1988725751","https://openalex.org/W1989626884","https://openalex.org/W1989938774","https://openalex.org/W1990119716","https://openalex.org/W1990747840","https://openalex.org/W1991159506","https://openalex.org/W1991640342","https://openalex.org/W1992433051","https://openalex.org/W1992586129","https://openalex.org/W1993728991","https://openalex.org/W1995003146","https://openalex.org/W1997118380","https://openalex.org/W1997432472","https://openalex.org/W1997467911","https://openalex.org/W1998800643","https://openalex.org/W2002275066","https://openalex.org/W2004067557","https://openalex.org/W2004356694","https://openalex.org/W2005960026","https://openalex.org/W2006862221","https://openalex.org/W2007304389","https://openalex.org/W2007802775","https://openalex.org/W2008492018","https://openalex.org/W2008611427","https://openalex.org/W2009389809","https://openalex.org/W2011122527","https://openalex.org/W2011669321","https://openalex.org/W2012802607","https://openalex.org/W2013800646","https://openalex.org/W2015450109","https://openalex.org/W2016821690","https://openalex.org/W2018234381","https://openalex.org/W2020316997","https://openalex.org/W2023534522","https://openalex.org/W2024251630","https://openalex.org/W2024430413","https://openalex.org/W2028051260","https://openalex.org/W2028568558","https://openalex.org/W2033005386","https://openalex.org/W2035524082","https://openalex.org/W2036000228","https://openalex.org/W2037831301","https://openalex.org/W2039200386","https://openalex.org/W2039346617","https://openalex.org/W2040713692","https://openalex.org/W2040897181","https://openalex.org/W2041753380","https://openalex.org/W2042469110","https://openalex.org/W2042596301","https://openalex.org/W2044397990","https://openalex.org/W2045670639","https://openalex.org/W2045814444","https://openalex.org/W2045839777","https://openalex.org/W2047146998","https://openalex.org/W2049528013","https://openalex.org/W2051000628","https://openalex.org/W2054479806","https://openalex.org/W2054604776","https://openalex.org/W2054733960","https://openalex.org/W2055959907","https://openalex.org/W2056597222","https://openalex.org/W2057296144","https://openalex.org/W2058837218","https://openalex.org/W2059598864","https://openalex.org/W2059777229","https://openalex.org/W2063036448","https://openalex.org/W2065193241","https://openalex.org/W2067100852","https://openalex.org/W2067341120","https://openalex.org/W2067959883","https://openalex.org/W2071033603","https://openalex.org/W2072279890","https://openalex.org/W2074252992","https://openalex.org/W2074659048","https://openalex.org/W2075933757","https://openalex.org/W2077291760","https://openalex.org/W2077332396","https://openalex.org/W2078421568","https://openalex.org/W2078796009","https://openalex.org/W2080378748","https://openalex.org/W2084444709","https://openalex.org/W2084465880","https://openalex.org/W2085126545","https://openalex.org/W2086057785","https://openalex.org/W2086414208","https://openalex.org/W2087108871","https://openalex.org/W2090325219","https://openalex.org/W2090996867","https://openalex.org/W2091527885","https://openalex.org/W2092343874","https://openalex.org/W2093710916","https://openalex.org/W2095096869","https://openalex.org/W2095611535","https://openalex.org/W2096372976","https://openalex.org/W2098076879","https://openalex.org/W2098188064","https://openalex.org/W2100487494","https://openalex.org/W2102335249","https://openalex.org/W2102430683","https://openalex.org/W2102750406","https://openalex.org/W2103971177","https://openalex.org/W2104641026","https://openalex.org/W2105910482","https://openalex.org/W2106389211","https://openalex.org/W2107174712","https://openalex.org/W2108036827","https://openalex.org/W2108358599","https://openalex.org/W2108953411","https://openalex.org/W2109111327","https://openalex.org/W2109576136","https://openalex.org/W2110214166","https://openalex.org/W2111959741","https://openalex.org/W2112280022","https://openalex.org/W2114826489","https://openalex.org/W2119298818","https://openalex.org/W2120090099","https://openalex.org/W2120554712","https://openalex.org/W2120621132","https://openalex.org/W2121009566","https://openalex.org/W2123275564","https://openalex.org/W2126052872","https://openalex.org/W2126187597","https://openalex.org/W2126669556","https://openalex.org/W2127919461","https://openalex.org/W2128677433","https://openalex.org/W2129402364","https://openalex.org/W2129971249","https://openalex.org/W2130560148","https://openalex.org/W2133106116","https://openalex.org/W2134127448","https://openalex.org/W2134768631","https://openalex.org/W2135243016","https://openalex.org/W2135751163","https://openalex.org/W2138383643","https://openalex.org/W2138677670","https://openalex.org/W2139398202","https://openalex.org/W2141594234","https://openalex.org/W2143388736","https://openalex.org/W2146389912","https://openalex.org/W2147352789","https://openalex.org/W2151361740","https://openalex.org/W2152532651","https://openalex.org/W2153203193","https://openalex.org/W2153398168","https://openalex.org/W2154818144","https://openalex.org/W2156316331","https://openalex.org/W2158920256","https://openalex.org/W2159264837","https://openalex.org/W2160881014","https://openalex.org/W2160898409","https://openalex.org/W2162101630","https://openalex.org/W2163094991","https://openalex.org/W2163413830","https://openalex.org/W2163435267","https://openalex.org/W2163878817","https://openalex.org/W2164655171","https://openalex.org/W2164759261","https://openalex.org/W2167017590","https://openalex.org/W2167216566","https://openalex.org/W2167899023","https://openalex.org/W2168020376","https://openalex.org/W2168233468","https://openalex.org/W2168629186","https://openalex.org/W2169411157","https://openalex.org/W2170472829","https://openalex.org/W2171369029","https://openalex.org/W2172286296","https://openalex.org/W2178128154","https://openalex.org/W2320976250","https://openalex.org/W2412890288"],"related_works":["https://openalex.org/W7097715773","https://openalex.org/W2165808139","https://openalex.org/W2081560806","https://openalex.org/W2531510068","https://openalex.org/W3116872655","https://openalex.org/W7099725276","https://openalex.org/W1967280262","https://openalex.org/W2002727536","https://openalex.org/W2163878817","https://openalex.org/W6999414720"],"abstract_inverted_index":{"Swine":[0],"influenza":[1,20,28,53,149,172,182,197,522],"(SI)":[2],"is":[3,18,24,36,57,107,189,200,227,237,266],"an":[4,37,83,201,304],"acute,":[5],"highly":[6,451],"contagious,":[7],"respiratory":[8,72],"disease":[9,54,73],"of":[10,15,44,52,88,114,124,135,146,171,216,317,360,382,400,443,457,496],"swine.":[11],"The":[12,49,133,193],"causative":[13],"agent":[14],"SI":[16,67,98,120],"infections":[17,68,99],"swine":[19,521],"virus":[21,29,198,205,223,270],"(SIV).":[22],"SIV":[23,483,512],"a":[25,41,122,241,277,282,285,322,333],"type":[26,410],"A":[27,173],"classified":[30],"into":[31,225,258],"the":[32,86,108,112,217,230,308,351,380,408,441,507],"Orthomyxoviridae":[33],"family":[34],"and":[35,155,160,180,206,214,219,260,403,461,471,493,499],"enveloped":[38],"particle":[39],"with":[40,130,284,480],"genome":[42],"composed":[43],"eight":[45],"negative-orientated":[46],"RNA":[47],"segments.":[48],"mortality":[50],"rate":[51],"in":[55,74,85,196,243,301,373,386,398,424,440,453,524],"pigs":[56,90,454],"generally":[58],"low":[59],"but":[60,184,296,455],"morbidity":[61],"can":[62,298],"reach":[63,93],"up":[64],"to":[65,71,82,92,248,275,291,347,407,417,486],"100%.":[66],"considerably":[69],"contribute":[70],"post-weaning":[75],"pigs,":[76],"causing":[77],"significant":[78,101,459],"economic":[79],"losses":[80],"due":[81],"increase":[84],"number":[87],"days":[89],"need":[91],"market":[94],"weight.":[95],"In":[96,143,246],"addition,":[97],"possess":[100],"human":[102,179,383],"public":[103],"health":[104],"concerns.":[105],"Vaccination":[106],"primary":[109,238],"method":[110],"for":[111,178,191,269],"prevention":[113],"SI.":[115],"Currently":[116],"available":[117,190],"vaccines":[118,137,150],"against":[119,168,490,518],"are":[121,176],"combination":[123],"two":[125,314,466],"inactivated":[126],"antigenically":[127,519],"distinct":[128,520],"SIVs":[129,316,393,414,449,498],"oil":[131],"adjuvant.":[132],"application":[134,145],"these":[136,447],"induce":[138,156],"mainly":[139],"humoral":[140,161,462],"immune":[141,463],"responses.":[142],"contrast,":[144],"live":[147,278,516],"attenuated":[148,279,452],"(LAIV)":[151],"mimics":[152],"natural":[153,294],"infection":[154,199,295],"strong,":[157],"long-lived":[158],"cell-mediated":[159,460],"immunity.":[162],"Furthermore,":[163,446],"LAIV":[164,188],"induces":[165],"cross-protective":[166],"immunity":[167],"different":[169],"subtypes":[170],"viruses.":[174],"LAIVs":[175],"developed":[177],"equine":[181],"viruses":[183,283,523],"at":[185,338,363],"present":[186],"no":[187],"SIVs.":[192],"critical":[194],"step":[195],"initial":[202],"interaction":[203],"between":[204],"cell":[207],"surface":[208,232],"carbohydrates":[209],"followed":[210],"by":[211,229,255,303,478],"receptor-mediated":[212],"endocytosis":[213],"fusion":[215],"viral":[218,231],"endosomal":[220],"membranes.":[221],"Influenza":[222],"entry":[224],"cells":[226],"mediated":[228],"glycoprotein":[233],"hemagglutinin":[234],"(HA).":[235],"HA":[236,287,336,371,432],"synthesized":[239],"as":[240,515],"polypeptide":[242],"HA0":[244,251],"form.":[245],"order":[247],"be":[249,253,299],"infectious,":[250],"must":[252],"cleaved":[254],"host":[256],"proteases":[257],"HA1":[259],"HA2":[261],"subunits.":[262],"Therefore,":[263,509],"this":[264],"process":[265],"crucial":[267],"determinant":[268],"pathogenicity.":[271],"Our":[272],"objective":[273],"was":[274,376],"generate":[276],"SIVs,":[280],"particularly":[281],"modified":[286,323],"cleavage":[288,324,372,433],"site":[289,325,434],"resistant":[290],"activation":[292],"during":[293],"which":[297],"activated":[300],"vitro":[302],"exogenous":[305],"protease.":[306,445],"Using":[307],"reverse":[309],"genetics":[310],"technique,":[311],"we":[312],"generated":[313],"mutant":[315,392,413,448,511],"strain":[318],"A/SW/SK/18789/02":[319],"(H1N1)":[320],"containing":[321],"within":[326,335,431],"their":[327],"HA.":[328,367],"Mutant":[329],"A/SW/SK-R345V":[330],"(R345V)":[331],"contained":[332],"mutation":[334],"segment":[337],"amino":[339],"acid":[340],"(AA)":[341],"position":[342,364],"345":[343],"from":[344,502],"Arginine":[345,361],"(Arg)":[346,362],"Valine":[348],"(Val)":[349],"while":[350],"second":[352],"mutant,":[353],"A/SW/SK-R345A":[354],"(R345A)":[355],"encoded":[356],"Alanine":[357],"(Ala)":[358],"instead":[359],"AA345":[365],"on":[366,379],"We":[368],"showed":[369,394],"that":[370,428],"both":[374],"mutants":[375],"strictly":[377],"dependent":[378,482],"presence":[381,442],"neutrophil":[384],"elastase":[385,481],"tissue":[387,425],"culture.":[388],"These":[389],"tissue-culture":[390],"grown":[391],"similar":[395],"growth":[396,404],"properties":[397],"terms":[399],"plaque":[401],"size":[402],"kinetics,":[405],"compared":[406],"wild":[409],"virus.":[411],"Both":[412],"were":[415,450,484],"able":[416],"preserve":[418],"introduced":[419],"mutations":[420],"after":[421,465,506],"multiple":[422],"passages":[423],"culture":[426],"suggesting":[427],"AA":[429],"substitution":[430],"did":[435],"not":[436],"alter":[437],"genetic":[438],"stability":[439],"appropriate":[444],"capable":[456],"inducing":[458],"responses":[464,476],"vaccinations":[467],"via":[468],"intratracheal":[469],"(IT)":[470],"intranasal":[472],"(IN)":[473],"routes.":[474],"Immune":[475],"induced":[477],"vaccination":[479],"sufficient":[485],"confer":[487],"full":[488],"protection":[489,501],"parental":[491],"homologous":[492],"antigenic":[494],"variant":[495],"H1N1":[497],"partial":[500],"heterologous":[503],"subtypic":[504],"H3N2":[505],"challenge.":[508],"elastase-dependent":[510],"could":[513],"serve":[514],"vaccine":[517],"pigs.":[525]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}