{"id":"https://openalex.org/W141501587","doi":null,"title":"Funktionelle Relevanz der genetischen Varianten von CD226 f\u00fcr die Pathogenese der Multiplen Sklerose","display_name":"Funktionelle Relevanz der genetischen Varianten von CD226 f\u00fcr die Pathogenese der Multiplen Sklerose","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W141501587","mag":"141501587"},"language":"de","primary_location":{"id":"mag:141501587","doi":null,"is_oa":false,"landing_page_url":"http://ediss.sub.uni-hamburg.de/volltexte/2014/6467/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046941728","display_name":"Melanie Pi\u00e9davent","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melanie Pi\u00e9davent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046941728"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01452625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd226","display_name":"CD226","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dnam-1","display_name":"DNAM-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.6190000176429749},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/t-cell-costimulation","display_name":"T cell costimulation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.5479999780654907},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.7879999876022339},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.722000002861023},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.4959999918937683},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5630000233650208},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.3540000021457672},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6323535442352295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4453509747982025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3032149076461792}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:141501587","doi":null,"is_oa":false,"landing_page_url":"http://ediss.sub.uni-hamburg.de/volltexte/2014/6467/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2290433395","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2014/6467/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":270,"referenced_works":["https://openalex.org/W61525684","https://openalex.org/W225312267","https://openalex.org/W1488353990","https://openalex.org/W1499151513","https://openalex.org/W1514064771","https://openalex.org/W1517758150","https://openalex.org/W1520670282","https://openalex.org/W1555988808","https://openalex.org/W1560277370","https://openalex.org/W1567420244","https://openalex.org/W1571402794","https://openalex.org/W1574058259","https://openalex.org/W1575585006","https://openalex.org/W1578917010","https://openalex.org/W1584051973","https://openalex.org/W1595915388","https://openalex.org/W1602273859","https://openalex.org/W1605073133","https://openalex.org/W1633194666","https://openalex.org/W1634951127","https://openalex.org/W1782419634","https://openalex.org/W1824529173","https://openalex.org/W1841418760","https://openalex.org/W1863751964","https://openalex.org/W1873524018","https://openalex.org/W1928582715","https://openalex.org/W1937650001","https://openalex.org/W1957917604","https://openalex.org/W1964047059","https://openalex.org/W1964066916","https://openalex.org/W1964885806","https://openalex.org/W1965307089","https://openalex.org/W1968110070","https://openalex.org/W1968412062","https://openalex.org/W1968768972","https://openalex.org/W1968897594","https://openalex.org/W1970673453","https://openalex.org/W1970835952","https://openalex.org/W1971425687","https://openalex.org/W1972338421","https://openalex.org/W1973154630","https://openalex.org/W1977899668","https://openalex.org/W1978895719","https://openalex.org/W1979049274","https://openalex.org/W1980311792","https://openalex.org/W1983494738","https://openalex.org/W1983704757","https://openalex.org/W1984320937","https://openalex.org/W1986913568","https://openalex.org/W1987004269","https://openalex.org/W1987470436","https://openalex.org/W1988530230","https://openalex.org/W1989162695","https://openalex.org/W1990227965","https://openalex.org/W1990260981","https://openalex.org/W1990785469","https://openalex.org/W1991361780","https://openalex.org/W1991500494","https://openalex.org/W1993322661","https://openalex.org/W1993764727","https://openalex.org/W1994183414","https://openalex.org/W1994818462","https://openalex.org/W1995179623","https://openalex.org/W1996087599","https://openalex.org/W1996717063","https://openalex.org/W1997121717","https://openalex.org/W1997192647","https://openalex.org/W1997880415","https://openalex.org/W1998000193","https://openalex.org/W1999689279","https://openalex.org/W2001766826","https://openalex.org/W2002301651","https://openalex.org/W2002551198","https://openalex.org/W2002726823","https://openalex.org/W2003793374","https://openalex.org/W2004188003","https://openalex.org/W2006732787","https://openalex.org/W2007825988","https://openalex.org/W2012365353","https://openalex.org/W2014077667","https://openalex.org/W2015506496","https://openalex.org/W2016474895","https://openalex.org/W2018011490","https://openalex.org/W2018027744","https://openalex.org/W2019060341","https://openalex.org/W2019379391","https://openalex.org/W2020014005","https://openalex.org/W2021616480","https://openalex.org/W2022959807","https://openalex.org/W2023283620","https://openalex.org/W2030282026","https://openalex.org/W2032406291","https://openalex.org/W2037609100","https://openalex.org/W2037907937","https://openalex.org/W2039084448","https://openalex.org/W2040547343","https://openalex.org/W2041482977","https://openalex.org/W2042037279","https://openalex.org/W2045932062","https://openalex.org/W2046413321","https://openalex.org/W2046423041","https://openalex.org/W2047899819","https://openalex.org/W2048659881","https://openalex.org/W2049478216","https://openalex.org/W2049979984","https://openalex.org/W2050457398","https://openalex.org/W2050638098","https://openalex.org/W2052249831","https://openalex.org/W2052386553","https://openalex.org/W2052840092","https://openalex.org/W2053763669","https://openalex.org/W2055264495","https://openalex.org/W2055553707","https://openalex.org/W2056030494","https://openalex.org/W2062638526","https://openalex.org/W2062656174","https://openalex.org/W2062659196","https://openalex.org/W2063514287","https://openalex.org/W2063516590","https://openalex.org/W2065186655","https://openalex.org/W2066118829","https://openalex.org/W2068046103","https://openalex.org/W2068697382","https://openalex.org/W2069574509","https://openalex.org/W2069606030","https://openalex.org/W2070229951","https://openalex.org/W2071894801","https://openalex.org/W2073621589","https://openalex.org/W2076248543","https://openalex.org/W2076434196","https://openalex.org/W2076615466","https://openalex.org/W2076789092","https://openalex.org/W2076889715","https://openalex.org/W2076924176","https://openalex.org/W2077061434","https://openalex.org/W2077812123","https://openalex.org/W2078699094","https://openalex.org/W2079214563","https://openalex.org/W2080439683","https://openalex.org/W2081060219","https://openalex.org/W2081484203","https://openalex.org/W2081632246","https://openalex.org/W2081703273","https://openalex.org/W2081788499","https://openalex.org/W2082252308","https://openalex.org/W2084388036","https://openalex.org/W2084416533","https://openalex.org/W2085599672","https://openalex.org/W2086132113","https://openalex.org/W2086526128","https://openalex.org/W2087347342","https://openalex.org/W2087985268","https://openalex.org/W2088570448","https://openalex.org/W2091869267","https://openalex.org/W2092019188","https://openalex.org/W2093930603","https://openalex.org/W2094633968","https://openalex.org/W2096005822","https://openalex.org/W2097021075","https://openalex.org/W2097811455","https://openalex.org/W2098079712","https://openalex.org/W2098658552","https://openalex.org/W2099126386","https://openalex.org/W2099668524","https://openalex.org/W2099854994","https://openalex.org/W2101515831","https://openalex.org/W2101662803","https://openalex.org/W2102650038","https://openalex.org/W2103758700","https://openalex.org/W2103904373","https://openalex.org/W2104388996","https://openalex.org/W2104680582","https://openalex.org/W2104690945","https://openalex.org/W2104794630","https://openalex.org/W2104948944","https://openalex.org/W2105440238","https://openalex.org/W2105490558","https://openalex.org/W2108240302","https://openalex.org/W2108335498","https://openalex.org/W2109978145","https://openalex.org/W2110343195","https://openalex.org/W2111975769","https://openalex.org/W2112165124","https://openalex.org/W2112837750","https://openalex.org/W2113624682","https://openalex.org/W2114569569","https://openalex.org/W2114951922","https://openalex.org/W2115037258","https://openalex.org/W2116628473","https://openalex.org/W2117358851","https://openalex.org/W2119172537","https://openalex.org/W2119839841","https://openalex.org/W2122445377","https://openalex.org/W2122545833","https://openalex.org/W2123089812","https://openalex.org/W2123859694","https://openalex.org/W2125340470","https://openalex.org/W2126794731","https://openalex.org/W2127502418","https://openalex.org/W2128718939","https://openalex.org/W2130473166","https://openalex.org/W2133621763","https://openalex.org/W2134724009","https://openalex.org/W2135513801","https://openalex.org/W2135944439","https://openalex.org/W2136392288","https://openalex.org/W2137277521","https://openalex.org/W2138547625","https://openalex.org/W2139273514","https://openalex.org/W2140830894","https://openalex.org/W2140869289","https://openalex.org/W2141649011","https://openalex.org/W2141664407","https://openalex.org/W2142594520","https://openalex.org/W2144201925","https://openalex.org/W2144761208","https://openalex.org/W2145002703","https://openalex.org/W2146293362","https://openalex.org/W2146702689","https://openalex.org/W2147638016","https://openalex.org/W2147690495","https://openalex.org/W2148245227","https://openalex.org/W2148732309","https://openalex.org/W2148819836","https://openalex.org/W2149312162","https://openalex.org/W2149618357","https://openalex.org/W2149748445","https://openalex.org/W2150747144","https://openalex.org/W2150914203","https://openalex.org/W2151293773","https://openalex.org/W2151340435","https://openalex.org/W2151979527","https://openalex.org/W2152014155","https://openalex.org/W2152655560","https://openalex.org/W2154224978","https://openalex.org/W2154911070","https://openalex.org/W2156415043","https://openalex.org/W2156860214","https://openalex.org/W2157342679","https://openalex.org/W2157837362","https://openalex.org/W2157929834","https://openalex.org/W2158092720","https://openalex.org/W2158157702","https://openalex.org/W2158345511","https://openalex.org/W2159252214","https://openalex.org/W2159598329","https://openalex.org/W2160458616","https://openalex.org/W2161633633","https://openalex.org/W2161929126","https://openalex.org/W2162179880","https://openalex.org/W2162655879","https://openalex.org/W2163429086","https://openalex.org/W2164392039","https://openalex.org/W2166781388","https://openalex.org/W2168033261","https://openalex.org/W2168231169","https://openalex.org/W2168459600","https://openalex.org/W2168914393","https://openalex.org/W2169800587","https://openalex.org/W2169887956","https://openalex.org/W2170321275","https://openalex.org/W2170752301","https://openalex.org/W2171139401","https://openalex.org/W2171548752","https://openalex.org/W2172079193","https://openalex.org/W2405233411","https://openalex.org/W2526186806","https://openalex.org/W2916040650","https://openalex.org/W2955331105","https://openalex.org/W3133604687"],"related_works":["https://openalex.org/W2192541999","https://openalex.org/W2898256886","https://openalex.org/W2581399629","https://openalex.org/W1423524314","https://openalex.org/W4402210974","https://openalex.org/W2580093747","https://openalex.org/W2150074269","https://openalex.org/W1980011282","https://openalex.org/W1535333898","https://openalex.org/W2015506496"],"abstract_inverted_index":{"Multiple":[0],"Sklerose":[1,124],"ist":[2,78],"eine":[3,14,39,44,160,177,255,262,294],"entzundliche,":[4],"demyelinisierende":[5],"Autoimmunerkrankung":[6],"des":[7,133,138,158,168],"zentralen":[8],"Nervensystems":[9],"(ZNS),":[10],"an":[11,55,100,210,364,423,623,631,659],"deren":[12],"Pathologie":[13],"Infiltration":[15],"myelinspezifischer":[16],"T-Zellen":[17,93,240,286,349],"ins":[18],"ZNS":[19],"beteiligt":[20,108],"ist.":[21,109],"Es":[22],"wird":[23,97],"angenommen,":[24],"dass":[25,148,293],"Menschen":[26],"unter":[27,84],"dem":[28],"Einfluss":[29,224],"einer":[30,235,315,320,334],"komplexen":[31],"genetischen":[32],"Pradisposition":[33],"im":[34,64,117,126,242,250,298,351],"Zusammenspiel":[35],"mit":[36,135,193,234,332],"diversen":[37],"Umweltfaktoren":[38],"MS":[40,56,211,545],"entwickeln.":[41],"Assoziationsstudien":[42],"haben":[43],"Reihe":[45],"von":[46,89,143,156,166,183,208,355],"Genen":[47],"identifiziert,":[48],"die":[49,120,248,330,337],"zu":[50,57,201,252,264,314,319],"einem":[51,194,265,273,278],"erhohten":[52,236],"Risiko":[53],"beitragen":[54,323],"erkranken.":[58],"Unter":[59],"anderem":[60,85],"wurde":[61,125],"ein":[62,79,205],"Polymorphismus":[63,116],"Gen,":[65],"welches":[66],"fur":[67,119],"das":[68,83,99],"Protein":[69],"DNAX-accessory":[70],"molecule":[71,405,427],"1":[72,406],"(DNAM-1;":[73],"CD226)":[74,409],"codiert,":[75],"identifiziert.":[76],"CD226":[77,325,421,470,490,513,550,694,727],"Adhasions-":[80],"und":[81,91,94,98,104,218,244,312,318],"Kostimulationsmolekul,":[82],"auf":[86,140,180],"der":[87,101,112,122,136,141,223,246,268,275,300,304,346,353],"Oberflache":[88,142],"CD4+":[90,150,153,442,522,612,655],"CD8+":[92,444],"NK-Zellen":[95],"exprimiert":[96],"Aktivierung,":[102],"Differenzierung":[103],"Effektormechanismen":[105],"dieser":[106,128],"Zellen":[107,165,182],"Die":[110],"Untersuchung":[111],"funktionellen":[113],"Relevanz":[114],"dieses":[115],"CD226-Gen":[118],"Pathogenese":[121],"Multiplen":[123,301],"Rahmen":[127],"Arbeit":[129],"analysiert.":[130],"\r\nDurch":[131],"Korrelation":[132],"Haplotyps":[134],"Expressionsintensitat":[137],"Proteins":[139],"Immunzellen":[144],"konnte":[145,222,290],"gezeigt":[146],"werden,":[147],"neben":[149],"Gedachtnis-T-Helferzellen":[151],"auch":[152],"regulatorische":[154,285],"Gedachtnis-T-Zellen":[155,209],"Tragern":[157,167],"CD226-Risikohaplotyps":[159],"verringerte":[161],"CD226-Expression":[162,179,188,289],"aufweisen":[163],"als":[164,181],"protektiven":[169],"Haplotyps.":[170],"Zudem":[171],"wiesen":[172],"MS-Patienten":[173],"unabhangig":[174],"vom":[175],"Haplotyp":[176],"niedrigere":[178],"gesunden":[184,198],"Individuen.":[185],"Eine":[186,231],"geringe":[187],"scheint":[189],"demnach":[190],"nicht":[191,307,328],"nur":[192],"potentiellen":[195],"Risikohaplotyp":[196],"in":[197,227,245,277,345,383,401,450,471,544,622,636,639,681,707,745],"Individuen":[199],"assoziiert":[200],"sein,":[202],"sondern":[203],"sogar":[204],"spezifisches":[206],"Charakteristikum":[207],"erkrankter":[212],"Patienten":[213],"darzustellen.":[214],"Durch":[215],"Verwendung":[216],"heterozygot":[217],"homozygot":[219],"CD226-defizienter":[220],"Mause":[221,343],"unterschiedlicher":[225],"CD226-Expressionsniveaus":[226],"vivo":[228],"untersucht":[229],"werden.":[230],"CD226-Defizienz":[232,263],"korrelierte":[233],"Frequenz":[237,347],"Foxp3+":[238,587],"regulatorischer":[239,348],"(Treg-Zellen)":[241],"Thymus":[243],"Milz,":[247],"jedoch":[249],"Vergleich":[251],"CD226-suffizienten":[253],"Treg-Zellen":[254],"verminderte":[256],"inhibitorische":[257],"Kapazitat":[258],"aufwiesen.":[259],"Gleichzeitig":[260],"fuhrte":[261],"verschlechterten":[266],"Verlauf":[267,352],"experimentellen":[269],"autoimmunen":[270],"Enzephalomyelitis":[271],"(EAE),":[272],"Mausmodell":[274],"MS,":[276,635],"Gen-Dosis-abhangigen":[279],"Zusammenhang.":[280],"Diese":[281],"eingeschrankte":[282],"Inhibition":[283],"durch":[284],"bei":[287],"niedriger":[288],"dazu":[291],"fuhren,":[292],"Autoimmunantwort,":[295],"wie":[296],"sie":[297],"Laufe":[299],"Sklerose,":[302],"bzw.":[303],"EAE":[305,354,679],"ablauft,":[306],"adaquat":[308],"gebremst":[309],"werden":[310],"kann":[311],"diese":[313],"uberschiesenden":[316],"Immunantwort":[317],"gesteigerten":[321],"Immunpathogenese":[322],"konnte.":[324],"vermittelt":[326],"dabei":[327],"uber":[329],"Interaktion":[331],"CD155,":[333],"seiner":[335],"Liganden,":[336],"beschriebenen":[338],"Effekte,":[339],"da":[340],"sich":[341],"CD155-defiziente":[342],"weder":[344],"noch":[350],"CD155-suffizienten":[356],"Mausen":[357],"unterschieden.\r\n":[358],"\nMultiple":[359],"sclerosis":[360],"(MS)":[361],"is":[362,381,411,422,433,448,731],"considered":[363],"autoimmune":[365,417,626],"disease,":[366],"characterized":[367,603],"by":[368,604],"inflammatory":[369],"demyelination":[370],"and":[371,425,443,447,455,465,478,524,593],"axonal":[372],"degeneration":[373],"of":[374,416,428,439,461,469,485,489,499,505,518,520,531,548,557,565,579,586,611,634,651,678,693,702,710,718,726,736,753,763],"the":[375,402,429,437,459,466,482,506,516,532,554,562,618,751,761],"central":[376],"nervous":[377],"system":[378],"(CNS).":[379],"It":[380],"evolving":[382],"genetically":[384],"susceptible":[385],"individuals":[386],"under":[387],"certain":[388,398],"environmental":[389],"conditions.":[390],"Recent":[391],"association":[392],"studies":[393],"have":[394],"shown":[395],"that":[396,503,689,723],"a":[397,414,510,573,605,682,698,734],"SNP":[399],"haplotype":[400,508],"DNAX":[403],"accessory":[404],"(DNAM-1":[407],"or":[408,576,760],"gene":[410],"associated":[412],"with":[413,617,721],"variety":[415,735],"diseases,":[418],"including":[419],"MS.":[420],"adhesion":[424],"costimulatory":[426],"immunoglobulin":[430],"superfamily,":[431],"which":[432,571],"constitutively":[434,574],"expressed":[435,732],"on":[436,493,515,733],"surface":[438,517],"NK":[440],"cells,":[441,705,743,756],"T":[445,526,589,656,704,711,742,755],"cells":[446,495,527,590,597,657,666,738],"involved":[449],"their":[451,549,757],"activation,":[452],"expansion,":[453],"differentiation,":[454],"effector":[456,523],"functions.":[457],"However,":[458],"implication":[460],"CD226-genotype":[462],"induced":[463],"alterations":[464],"functional":[467,555],"role":[468],"autoimmunity":[472,566],"has":[473],"not":[474,749],"yet":[475],"been":[476],"defined":[477],"its":[479],"elucidation":[480],"was":[481],"primary":[483],"goal":[484],"this":[486,536,558],"thesis.":[487],"\r\nComparison":[488],"expression":[491,514,538,578,691,747],"levels":[492,692],"immune":[494],"from":[496,599],"peripheral":[497],"blood":[498],"healthy":[500],"donors":[501],"showed":[502,583,658],"carriers":[504,530],"risk":[507],"possess":[509],"significantly":[511],"reduced":[512,537,575,606,690,699],"subpopulations":[519],"memory":[521],"regulatory":[525,588,703,754],"compared":[528],"to":[529,608,641,697],"protective":[533],"haplotype.":[534,551],"Moreover,":[535,595],"level":[539],"can":[540],"also":[541],"be":[542],"observed":[543,714],"patients":[546],"irrespective":[547],"To":[552],"understand":[553],"relevance":[556],"phenotypical":[559],"difference":[560],"for":[561],"disease":[563,629,661],"development":[564],"CD226-deficient":[567,637,664],"mice":[568,582,601,638],"were":[569,602,667],"used,":[570],"exhibit":[572],"absent":[577],"CD226.":[580],"These":[581,686],"elevated":[584],"frequencies":[585],"among":[591],"thymocytes":[592],"splenocytes.":[594],"Treg":[596],"isolated":[598],"Cd226-deficient":[600],"capacity":[607,701],"suppress":[609],"proliferation":[610],"Teff":[613],"cells.":[614,712],"Active":[615],"immunization":[616,647],"MOG35-55":[619],"peptide":[620],"resulted":[621],"aggravated":[624],"experimental":[625],"encephalomyelitis":[627],"(EAE)":[628],"course,":[630],"animal":[632],"model":[633],"comparison":[640],"wildtype":[642,670],"littermate":[643],"controls.":[644],"Additionally,":[645],"passive":[646],"using":[648],"adoptive":[649],"transfer":[650],"encephalitogenic":[652],"MOG35-55-specific":[653],"2D2-transgenic":[654],"earlier":[660],"onset":[662],"when":[663],"2D2":[665],"injected":[668],"into":[669],"recipient":[671],"mice.":[672],"Both":[673],"effects":[674,715],"seen":[675],"after":[676],"induction":[677],"emerge":[680],"gene-dose":[683],"dependent":[684],"manner.":[685],"results":[687],"suggest":[688],"may":[695],"lead":[696],"suppressive":[700,758],"culminating":[706],"enhanced":[708],"autoreactivity":[709],"The":[713],"appeared":[716],"independently":[717],"ligand":[719],"interactions":[720],"CD155":[722,730,746],"represents":[724],"one":[725],"ligands.":[728],"Although":[729],"antigen-presenting":[737],"as":[739,741],"well":[740],"deficiency":[744],"does":[748],"alter":[750],"frequency":[752],"behaviour":[759],"course":[762],"EAE.":[764]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}