{"id":"https://openalex.org/W1413896342","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p3.017","title":"White matter abnormalities as a marker of Parkinson\u2019s disease cognitive impairment: a diffusion tensor imaging study (P3.017)","display_name":"White matter abnormalities as a marker of Parkinson\u2019s disease cognitive impairment: a diffusion tensor imaging study (P3.017)","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W1413896342","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p3.017","mag":"1413896342"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.84.14_supplement.p3.017","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p3.017","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.84.14_supplement.p3.017","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061596611","display_name":"Jennifer G. Goldman","orcid":"https://orcid.org/0000-0001-5014-7535","observed_orcids":["https://orcid.org/0000-0001-5014-7535"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Goldman","raw_affiliation_strings":["Rush University Medical Ctr Chicago IL United States","3Rush University Medical Ctr Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Ctr Chicago IL United States","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]},{"raw_affiliation_string":"3Rush University Medical Ctr Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033812354","display_name":"Douglas Merkitch","orcid":"https://orcid.org/0000-0003-1046-3685","observed_orcids":["https://orcid.org/0000-0003-1046-3685"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doug Merkitch","raw_affiliation_strings":["Neurological Sciences Rush University Medical Center Chicago IL United States","2Neurological Sciences Rush University Medical Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Sciences Rush University Medical Center Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"2Neurological Sciences Rush University Medical Center Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007792436","display_name":"Bryan A. Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Bernard","raw_affiliation_strings":["Rush University Medical Center Chicago IL United States","1Rush University Medical Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"1Rush University Medical Center Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069469923","display_name":"Glenn T. Stebbins","orcid":"https://orcid.org/0000-0001-7905-9336","observed_orcids":["https://orcid.org/0000-0001-7905-9336"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Stebbins","raw_affiliation_strings":["Rush University Medical Center Chicago IL United States","1Rush University Medical Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"1Rush University Medical Center Chicago IL United States","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2352,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57413625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"84","issue":"14_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.11980000138282776,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/white-matter-microstructural-integrity","display_name":"white matter microstructural integrity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/parkinson-s-disease-dementia","display_name":"Parkinson's disease dementia","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.8100000023841858},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/corona-radiata","display_name":"corona radiata","score":0.8949999809265137},{"id":"https://openalex.org/keywords/superior-longitudinal-fasciculus","display_name":"superior longitudinal fasciculus","score":0.8679999709129333},{"id":"https://openalex.org/keywords/uncinate-fasciculus","display_name":"uncinate fasciculus","score":0.7580000162124634},{"id":"https://openalex.org/keywords/thalamic-radiation","display_name":"thalamic radiation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.5389999747276306},{"id":"https://openalex.org/keywords/attention-and-working-memory","display_name":"attention and working memory","score":0.6039999723434448},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.8288086652755737},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7536119222640991},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5878499746322632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4950930178165436},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4824238717556},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.47017353773117065},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4498146176338196},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.436884343624115},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4259123206138611},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3659675121307373},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27489566802978516},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.272964745759964},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10946419835090637}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.84.14_supplement.p3.017","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p3.017","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.84.14_supplement.p3.017","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133195405","https://openalex.org/W2796272698","https://openalex.org/W2323845838","https://openalex.org/W2375759623","https://openalex.org/W1973694068","https://openalex.org/W1991073726","https://openalex.org/W2785238431","https://openalex.org/W1742255209","https://openalex.org/W2065472078","https://openalex.org/W2009640274"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"markers":[3],"of":[4,23,37,114,246,281],"white":[5],"matter":[6],"(WM)":[7],"microstructural":[8,258],"integrity":[9],"across":[10],"the":[11,115,180,203,221],"Parkinson\u2019s":[12],"disease":[13],"(PD)":[14],"cognitive":[15,50,68,86,98,288],"spectrum":[16],"using":[17],"diffusion":[18],"tensor":[19],"imaging":[20,82],"(DTI)":[21],"measures":[22],"fractional":[24],"anisotropy":[25],"(FA)":[26],"and":[27,52,78,85,111,119,176,190,193,199,225,231,238,248,275],"mean":[28],"diffusivity":[29],"(MD).":[30],"Background:":[31],"Dementia":[32],"develops":[33],"in":[34,40,44,128,137,155,172,196,216,228,261,267],"about":[35],"80[percnt]":[36],"PD":[38,49,67,72,124,138,264,287],"patients":[39,73],"longitudinal":[41,205,240],"studies.":[42],"Abnormalities":[43],"WM":[45,257,283],"may":[46,285],"contribute":[47],"to":[48,208,243],"impairment":[51],"can":[53],"be":[54],"identified":[55],"with":[56,109],"neuroimaging":[57],"techniques.":[58],"Thus,":[59],"DTI":[60,105],"holds":[61],"promise":[62],"as":[63],"a":[64],"biomarker":[65],"for":[66,123],"decline.":[69,289],"Methods:":[70],"Sixty-three":[71],"underwent":[74],"clinical/neuropsychological":[75],"evaluations,":[76],"T1-":[77],"diffusion-weighted":[79],"magnetic":[80],"resonance":[81],"brain":[83],"scans,":[84],"classification":[87],"by":[88],"Movement":[89],"Disorder":[90],"Society":[91],"criteria":[92],"(cognitively":[93],"normal":[94],"(PD-NC),":[95],"n=20;":[96],"mild":[97],"impaired":[99,263],"(PD-MCI),":[100],"n=28;":[101],"demented":[102],"(PDD),":[103],"n=15).":[104],"data":[106],"were":[107,126],"processed":[108],"mrDiffusion,":[110],"whole-brain":[112],"comparisons":[113],"resulting":[116],"smoothed":[117],"FA":[118,171,215],"MD":[120,195,227],"maps,":[121],"controlling":[122],"duration,":[125],"analyzed":[127],"SPM8":[129],"(p<0.001,":[130],"uncorrected,":[131],"k=10).":[132],"Results:":[133],"The":[134,166,210],"groups":[135,250],"differed":[136],"duration":[139],"(mean":[140],"[SD]:":[141],"PD-NC":[142],"8.8":[143],"[3.6],":[144],"PD-MCI":[145,167,247],"9.4":[146],"[4.2],":[147],"PDD":[148,211,249],"13.4":[149],"[5.5]":[150],"years,":[151],"p=0.007),":[152],"but":[153,219],"not":[154],"gender,":[156],"age":[157],"(73.4":[158],"[6.2]":[159],"years)":[160],"or":[161],"education":[162],"(15.3":[163],"[3.1]":[164],"years).":[165],"group":[168,212],"showed":[169],"decreased":[170,214],"frontal,":[173,197,229],"temporal,":[174],"parietal,":[175,198],"occipital":[177],"lobes,":[178,201,233],"including":[179,202,234],"anterior":[181,184],"corona":[182,223],"radiata,":[183,224],"thalamic":[185],"radiation,":[186],"inferior":[187],"fronto-occipital":[188],"fasciculus,":[189,192,206,241],"uncinate":[191],"increased":[194,226],"temporal":[200],"superior":[204,239],"compared":[207,242],"PD-NCs.":[209,244],"had":[213],"similar":[217],"regions":[218,268],"also":[220],"posterior":[222,282],"temporal/parietal,":[230],"limbic":[232],"corpus":[235],"callosum":[236],"splenium":[237],"Comparisons":[245],"revealed":[251],"no":[252],"significant":[253],"FA/MD":[254],"differences.":[255],"Conclusion:":[256],"abnormalities":[259],"occur":[260],"cognitively":[262],"patients,":[265],"particularly":[266],"underlying":[269],"attention/working":[270],"memory,":[271,274],"executive":[272],"function,":[273],"visuospatial":[276],"processing.":[277],"Furthermore,":[278],"greater":[279],"disruption":[280],"pathways":[284],"signify":[286],"Acknowledgments:":[290],"K23NS060949,":[291],"Parkinson's":[292],"Disease":[293],"Foundation":[294]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
