{"id":"https://openalex.org/W141387569","doi":"https://doi.org/10.1016/b978-012088523-7/50010-7","title":"Physiologically Based Pharmacokinetic Modeling of Organophosphorus and Carbamate Pesticides","display_name":"Physiologically Based Pharmacokinetic Modeling of Organophosphorus and Carbamate Pesticides","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W141387569","doi":"https://doi.org/10.1016/b978-012088523-7/50010-7","mag":"141387569"},"language":"en","primary_location":{"id":"doi:10.1016/b978-012088523-7/50010-7","doi":"https://doi.org/10.1016/b978-012088523-7/50010-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012088523-7/50010-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology of Organophosphate & Carbamate Compounds","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047337288","display_name":"Charles A. Timchalk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles Timchalk","raw_affiliation_strings":["Pacific Northwest National Laboratory, Richland, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory, Richland, Washington","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047337288"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":null,"apc_paid":null,"fwci":2.3178,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.85471491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"103","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organophosphate-pesticides","display_name":"organophosphorus pesticides","score":0.8640000224113464},{"id":"https://openalex.org/keywords/carbamate-pesticides","display_name":"carbamate pesticides","score":0.9610000252723694},{"id":"https://openalex.org/keywords/insecticides","display_name":"insecticides","score":0.8100000023841858},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pharmacodynamic-modeling","display_name":"pharmacodynamic modeling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9850000143051147},{"id":"https://openalex.org/keywords/human-health-risk-assessment","display_name":"human health risk assessment","score":0.9449999928474426},{"id":"https://openalex.org/keywords/adme","display_name":"ADME","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cross-species-extrapolation","display_name":"interspecies extrapolation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/exposure-pathways","display_name":"exposure pathways","score":0.6159999966621399},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.9446635842323303},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8262892365455627},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.8128091096878052},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7083842158317566},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.5893930196762085},{"id":"https://openalex.org/C2779303437","wikidata":"https://www.wikidata.org/wiki/Q422899","display_name":"Carbamate","level":2,"score":0.42811524868011475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4164554476737976},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4150252640247345},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3946542739868164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.265286386013031},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.23676416277885437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0898246169090271},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-012088523-7/50010-7","doi":"https://doi.org/10.1016/b978-012088523-7/50010-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012088523-7/50010-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology of Organophosphate & Carbamate Compounds","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W1529163","https://openalex.org/W88966087","https://openalex.org/W115887152","https://openalex.org/W642385766","https://openalex.org/W656629024","https://openalex.org/W831036996","https://openalex.org/W953544717","https://openalex.org/W1483045886","https://openalex.org/W1526713675","https://openalex.org/W1550759179","https://openalex.org/W1558081732","https://openalex.org/W1597247970","https://openalex.org/W1625479408","https://openalex.org/W1963541250","https://openalex.org/W1963901635","https://openalex.org/W1964102223","https://openalex.org/W1964458064","https://openalex.org/W1965230909","https://openalex.org/W1965898239","https://openalex.org/W1966249306","https://openalex.org/W1968417548","https://openalex.org/W1968731162","https://openalex.org/W1970035422","https://openalex.org/W1970601907","https://openalex.org/W1971108701","https://openalex.org/W1971295796","https://openalex.org/W1978388141","https://openalex.org/W1978508973","https://openalex.org/W1979141008","https://openalex.org/W1979264461","https://openalex.org/W1979610882","https://openalex.org/W1982550075","https://openalex.org/W1989080288","https://openalex.org/W1989836353","https://openalex.org/W1991080670","https://openalex.org/W1992297651","https://openalex.org/W1992356089","https://openalex.org/W1993092345","https://openalex.org/W1993552656","https://openalex.org/W1994919131","https://openalex.org/W1996149196","https://openalex.org/W1996742027","https://openalex.org/W2000582171","https://openalex.org/W2001440173","https://openalex.org/W2004578970","https://openalex.org/W2005404761","https://openalex.org/W2007213914","https://openalex.org/W2008895410","https://openalex.org/W2009489336","https://openalex.org/W2009616503","https://openalex.org/W2020741506","https://openalex.org/W2023217836","https://openalex.org/W2031961699","https://openalex.org/W2033247996","https://openalex.org/W2034346077","https://openalex.org/W2035776787","https://openalex.org/W2037768038","https://openalex.org/W2038729091","https://openalex.org/W2042431932","https://openalex.org/W2048349812","https://openalex.org/W2048879487","https://openalex.org/W2049243760","https://openalex.org/W2049931223","https://openalex.org/W2050254455","https://openalex.org/W2053351861","https://openalex.org/W2055101723","https://openalex.org/W2055360296","https://openalex.org/W2056005637","https://openalex.org/W2056500685","https://openalex.org/W2057277982","https://openalex.org/W2059962070","https://openalex.org/W2060759212","https://openalex.org/W2062048144","https://openalex.org/W2066360513","https://openalex.org/W2069127747","https://openalex.org/W2070000009","https://openalex.org/W2070500243","https://openalex.org/W2071366248","https://openalex.org/W2074619987","https://openalex.org/W2075643141","https://openalex.org/W2076384723","https://openalex.org/W2076812902","https://openalex.org/W2078125336","https://openalex.org/W2078168115","https://openalex.org/W2078234649","https://openalex.org/W2079883385","https://openalex.org/W2080004406","https://openalex.org/W2080163237","https://openalex.org/W2080425697","https://openalex.org/W2080441447","https://openalex.org/W2082986897","https://openalex.org/W2083204513","https://openalex.org/W2085160846","https://openalex.org/W2086071651","https://openalex.org/W2086949833","https://openalex.org/W2089736357","https://openalex.org/W2091317706","https://openalex.org/W2093343711","https://openalex.org/W2095100241","https://openalex.org/W2110403403","https://openalex.org/W2111463499","https://openalex.org/W2111594338","https://openalex.org/W2128964504","https://openalex.org/W2129172494","https://openalex.org/W2132348364","https://openalex.org/W2132759637","https://openalex.org/W2132775492","https://openalex.org/W2140955116","https://openalex.org/W2141301177","https://openalex.org/W2145643191","https://openalex.org/W2151681853","https://openalex.org/W2157502696","https://openalex.org/W2163945903","https://openalex.org/W2172020767","https://openalex.org/W2267117609","https://openalex.org/W2314821190","https://openalex.org/W2322343077","https://openalex.org/W2340629065","https://openalex.org/W2483076084","https://openalex.org/W2486032751","https://openalex.org/W2486247372","https://openalex.org/W2487846538","https://openalex.org/W2618402469","https://openalex.org/W2803124371","https://openalex.org/W2901961159","https://openalex.org/W3111232738","https://openalex.org/W4237635554","https://openalex.org/W4240694390","https://openalex.org/W4241154463","https://openalex.org/W4243737610","https://openalex.org/W4253771623","https://openalex.org/W6602596909","https://openalex.org/W6623363556","https://openalex.org/W6693700909","https://openalex.org/W6722967118"],"related_works":["https://openalex.org/W150421770","https://openalex.org/W1836210732","https://openalex.org/W2111463499","https://openalex.org/W3134976622","https://openalex.org/W2051773722","https://openalex.org/W4389056172","https://openalex.org/W2000582171","https://openalex.org/W4403173604","https://openalex.org/W2057244433","https://openalex.org/W2139478552"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}