{"id":"https://openalex.org/W141304358","doi":null,"title":"Exploring the complexity of functional hiv-1 specific t-cell responses and global virus-host genetic variability","display_name":"Exploring the complexity of functional hiv-1 specific t-cell responses and global virus-host genetic variability","publication_year":2011,"publication_date":"2011-02-18","ids":{"openalex":"https://openalex.org/W141304358","mag":"141304358"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26901421","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Exploring_the_complexity_of_functional_hiv-1_specific_t-cell_responses_and_global_virus-host_genetic_variability/26901421","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057030474","display_name":"Carina L. P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carina L. P\u00e9rez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057030474"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.5789999961853027},{"id":"https://openalex.org/keywords/hiv-specific-t-cell-responses","display_name":"HIV-specific T cell responses","score":0.968999981880188},{"id":"https://openalex.org/keywords/peptide-hla-binding","display_name":"HLA-peptide binding","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hiv-subtypes","display_name":"HIV subtypes","score":0.44200000166893005},{"id":"https://openalex.org/keywords/hla-polymorphism","display_name":"HLA polymorphism","score":0.5630000233650208},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.6909999847412109},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8479999899864197},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.3659999966621399},{"id":"https://openalex.org/keywords/t-cell-receptor-recognition","display_name":"T cell receptor recognition","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5744425654411316},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5674792528152466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5066226124763489},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4420683681964874},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42455971240997314},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3814445734024048},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36937570571899414},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3118237853050232}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26901421","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Exploring_the_complexity_of_functional_hiv-1_specific_t-cell_responses_and_global_virus-host_genetic_variability/26901421","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40441","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:141304358","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/40441","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40441","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W175794213","https://openalex.org/W617294916","https://openalex.org/W1541046939","https://openalex.org/W1558421445","https://openalex.org/W1573515701","https://openalex.org/W1650704517","https://openalex.org/W1655510925","https://openalex.org/W1664174075","https://openalex.org/W1963813930","https://openalex.org/W1967567225","https://openalex.org/W1970089737","https://openalex.org/W1975859313","https://openalex.org/W1976608858","https://openalex.org/W1976623095","https://openalex.org/W1977282539","https://openalex.org/W1978436252","https://openalex.org/W1978458547","https://openalex.org/W1979742563","https://openalex.org/W1982677586","https://openalex.org/W1983090549","https://openalex.org/W1984070291","https://openalex.org/W1984811742","https://openalex.org/W1986152436","https://openalex.org/W1990993204","https://openalex.org/W1991670386","https://openalex.org/W1993846907","https://openalex.org/W1995453338","https://openalex.org/W1997585331","https://openalex.org/W1997897809","https://openalex.org/W1998529967","https://openalex.org/W2001375348","https://openalex.org/W2001815433","https://openalex.org/W2004669329","https://openalex.org/W2007021820","https://openalex.org/W2008791719","https://openalex.org/W2012139740","https://openalex.org/W2012659064","https://openalex.org/W2013815517","https://openalex.org/W2014578811","https://openalex.org/W2015125044","https://openalex.org/W2020943564","https://openalex.org/W2021301411","https://openalex.org/W2021581373","https://openalex.org/W2021932640","https://openalex.org/W2022434526","https://openalex.org/W2025481552","https://openalex.org/W2026444780","https://openalex.org/W2027855618","https://openalex.org/W2028352208","https://openalex.org/W2029353650","https://openalex.org/W2030844138","https://openalex.org/W2034858284","https://openalex.org/W2035852466","https://openalex.org/W2036032415","https://openalex.org/W2039473791","https://openalex.org/W2041320369","https://openalex.org/W2042414284","https://openalex.org/W2045551237","https://openalex.org/W2046775408","https://openalex.org/W2046966195","https://openalex.org/W2047422912","https://openalex.org/W2047489384","https://openalex.org/W2048660375","https://openalex.org/W2050531099","https://openalex.org/W2052321000","https://openalex.org/W2063286219","https://openalex.org/W2065608903","https://openalex.org/W2065933250","https://openalex.org/W2068005505","https://openalex.org/W2068366465","https://openalex.org/W2069926681","https://openalex.org/W2070676224","https://openalex.org/W2072131149","https://openalex.org/W2073378334","https://openalex.org/W2073474392","https://openalex.org/W2076120354","https://openalex.org/W2076225720","https://openalex.org/W2077599016","https://openalex.org/W2087866505","https://openalex.org/W2089596931","https://openalex.org/W2092434970","https://openalex.org/W2093343174","https://openalex.org/W2094197540","https://openalex.org/W2096130477","https://openalex.org/W2103059036","https://openalex.org/W2103181955","https://openalex.org/W2103182811","https://openalex.org/W2107383131","https://openalex.org/W2108446353","https://openalex.org/W2113613707","https://openalex.org/W2114153948","https://openalex.org/W2114720145","https://openalex.org/W2119295868","https://openalex.org/W2120315965","https://openalex.org/W2124601302","https://openalex.org/W2124627199","https://openalex.org/W2124969212","https://openalex.org/W2125586839","https://openalex.org/W2133233128","https://openalex.org/W2133919033","https://openalex.org/W2134496632","https://openalex.org/W2136848907","https://openalex.org/W2138265888","https://openalex.org/W2138634802","https://openalex.org/W2139257243","https://openalex.org/W2142405752","https://openalex.org/W2142831360","https://openalex.org/W2143071104","https://openalex.org/W2143329914","https://openalex.org/W2144386534","https://openalex.org/W2144799299","https://openalex.org/W2144882745","https://openalex.org/W2145031719","https://openalex.org/W2145067766","https://openalex.org/W2146428988","https://openalex.org/W2146724705","https://openalex.org/W2147134928","https://openalex.org/W2147179492","https://openalex.org/W2148148789","https://openalex.org/W2149951876","https://openalex.org/W2150484278","https://openalex.org/W2152048324","https://openalex.org/W2152640863","https://openalex.org/W2153389047","https://openalex.org/W2153670011","https://openalex.org/W2154963941","https://openalex.org/W2156141826","https://openalex.org/W2156557297","https://openalex.org/W2157096707","https://openalex.org/W2157586646","https://openalex.org/W2158666214","https://openalex.org/W2158882181","https://openalex.org/W2159271866","https://openalex.org/W2160538807","https://openalex.org/W2160822369","https://openalex.org/W2160925670","https://openalex.org/W2162457545","https://openalex.org/W2162774944","https://openalex.org/W2165895151","https://openalex.org/W2240372320","https://openalex.org/W2314893245","https://openalex.org/W2320418919","https://openalex.org/W2334860476"],"related_works":["https://openalex.org/W2070126939","https://openalex.org/W7095822395","https://openalex.org/W2027855618","https://openalex.org/W2049073405","https://openalex.org/W4221111208","https://openalex.org/W1970706048","https://openalex.org/W2151651155","https://openalex.org/W2011464416","https://openalex.org/W4236036050","https://openalex.org/W2164438603"],"abstract_inverted_index":{"HIV":[0,22,75,93,102,132,141,175,203,218,227,241,256,292,306,362,392,427,523,671],"has":[1,198,510],"become":[2],"one":[3,197,331],"of":[4,15,20,30,39,47,101,155,178,187,191,255,265,305,317,339,350,371,390,409,468,483,503,522,529,544,557,626,666],"the":[5,18,31,35,40,45,52,54,63,67,90,116,121,126,140,153,185,189,252,263,303,318,322,337,346,361,369,388,391,405,481,492,515,520,554],"biggest":[6],"health":[7],"problems":[8],"up":[9,433],"to":[10,56,83,174,202,214,237,301,434,494,514],"date.":[11],"After":[12],"30":[13],"years":[14],"tremendous":[16],"effort,":[17],"development":[19,482],"an":[21,70,226],"vaccine":[23],"is":[24,34,129,235,326,477,673],"still":[25],"far":[26],"from":[27,58,139,216],"achieved.":[28],"One":[29],"main":[32],"issues":[33],"high":[36,347],"mutation":[37,334,348],"rate":[38,349],"virus":[41,53,91],"which":[42],"results":[43],"in":[44,88,92,120,166,184,222,284,365,425,553,594,669],"selection":[46],"mutated":[48],"variants.":[49],"This":[50,508],"gives":[51],"ability":[55],"escape":[57],"selective":[59],"pressures,":[60],"such":[61,379],"as":[62,103],"immune":[64,72,548],"system.":[65],"Also":[66],"correlates":[68],"for":[69,432,480],"effective":[71],"response":[73,342],"against":[74,295,632],"remain":[76],"uncertain.":[77],"T":[78,96,158,209,246,310,323,401,410,463,525,629,683],"cells":[79,97,402],"have":[80,180,368],"been":[81,181],"proven":[82],"play":[84],"a":[85,223,239,285,341,422,440,451,455,460,484,595],"key":[86],"role":[87],"controlling":[89],"infected":[94,133,228,289,598],"individuals.":[95],"recognize":[98],"small":[99],"fragments":[100],"antigenic":[104],"peptides":[105,138,280,297],"bound":[106],"and":[107,161,244,258,271,329,407,413,459,470,501,505,680],"presented":[108],"on":[109,144,309,491],"HLA":[110,113,146,259,586],"molecules.":[111],"The":[112,466],"molecules":[114],"are":[115,353,357,489],"most":[117],"polymorphic":[118],"proteins":[119,142],"entire":[122],"human":[123],"genome.":[124,363],"As":[125],"HLA-peptide":[127,319],"interaction":[128],"highly":[130,278,327,478],"specific,":[131],"individuals":[134,220],"will":[135,335],"present":[136],"different":[137,167,600],"dependent":[143],"their":[145,192,430,444],"repertoire.":[147],"In":[148],"this":[149],"thesis":[150,509],"we":[151,230,261],"explore":[152],"complexity":[154,521],"functional":[156],"HIV-specific":[157,627],"cell":[159,210,247,311,324,411,464,526,630,684],"responses":[160,431,445,549,631],"global":[162],"virus-host":[163],"genetic":[164],"variability":[165,254],"study":[168,287],"cohorts.":[169],"Individuals":[170],"with":[171,225,251,268,290,599,675],"frequent":[172],"exposure":[173,201,234,552],"without":[176],"establishment":[177],"infection":[179,428,672],"well":[182],"studied":[183,199],"hope":[186],"finding":[188],"secret":[190],"reduced":[193],"susceptibility.":[194],"However,":[195],"no":[196],"if":[200],"through":[204,498],"oral":[205,233,551],"sex":[206],"can":[207],"induce":[208],"responses.":[211,527],"Through":[212],"access":[213,493],"samples":[215],"healthy":[217],"negative":[219],"living":[221],"relationship":[224],"partner":[229,556],"show":[231,314,418],"that":[232,281,315,330,356,387,419,473],"enough":[236],"mount":[238],"systemic":[240,545],"specific":[242,524],"CD4+":[243,462,682],"CD8+":[245,400,628],"response.":[248],"To":[249],"cope":[250],"enormous":[253],"sequences":[257],"alleles":[260],"combined":[262],"use":[264],"bioinformatic":[266],"tools":[267],"molecular":[269],"biology,":[270],"immunological":[272,471,506],"assays.":[273,507],"We":[274,313,385,417],"successfully":[275],"identified":[276],"several":[277,291],"immunogenic":[279,585],"were":[282,298],"recognized":[283,593],"diverse":[286,596],"population":[288,597],"subtypes.":[293,602],"Responses":[294],"these":[296,366],"further":[299],"investigated":[300],"address":[302],"effects":[304],"point":[307,333],"mutations":[308,380],"recognition.":[312],"recognition":[316],"complex":[320],"by":[321,343,399,550],"receptor":[325],"sensitive":[328],"single":[332],"reduce":[336],"chance":[338],"inducing":[340],"40%.":[344],"Despite":[345],"HIV,":[351],"there":[352],"some":[354],"regions":[355,367],"more":[358],"conserved":[359,423,452,667],"within":[360],"Mutations":[364],"potential":[370],"reducing":[372],"viral":[373,376,457,678],"fitness,":[374],"why":[375],"variant":[377,633],"carrying":[378],"may":[381],"be":[382],"less":[383],"pathogenic.":[384],"hypothesized":[386],"character":[389],"peptide":[393,424,442,453],"(i.e.":[394],"variable":[395,441],"or":[396],"conserved)":[397],"targeted":[398],"would":[403],"influence":[404],"quality":[406],"quantity":[408],"responses,":[412],"affect":[414],"disease":[415,475],"progression.":[416],"patients":[420,438,449],"targeting":[421,439,450,665],"early":[426,670],"maintain":[429],"four":[435],"years,":[436],"while":[437],"lose":[443],"over":[446],"time.":[447],"Importantly,":[448],"had":[454],"lower":[456,676],"load":[458,679],"slower":[461,681],"decline.":[465],"identification":[467],"virological":[469],"characteristics":[472],"influences":[474],"outcome":[476],"relevant":[479],"therapeutic":[485],"vaccine.":[486],"These":[487],"studies":[488],"based":[490],"exclusive":[495],"patient":[496],"material":[497],"excellent":[499],"collaborations,":[500],"combination":[502],"bioinformatics":[504],"brought":[511],"new":[512],"knowledge":[513],"field,":[516],"but":[517],"also":[518],"addressed":[519],"List":[528],"scientific":[530],"papers":[531],"I.":[532],"P\u00e9rez":[533,566,612,646],"CL,":[534,567,613,647],"Hasselrot":[535],"K,":[536,540],"Bratt":[537],"G,":[538],"Broliden":[539],"Karlsson":[541,582,622,662],"AC.":[542,583,623,663],"Induction":[543],"HIV-1-specific":[546],"cellular":[547],"uninfected":[555],"discordant":[558],"couples.":[559],"AIDS.":[560],"2010":[561,641],"Apr":[562,606],"24;24(7):969-74.":[563],"https://doi.org/10.1097/QAD.0b013e328337aff8":[564],"II.":[565],"Larsen":[568,652],"MV,":[569,653],"Gustafsson":[570,616],"R,":[571],"Norstr\u00f6m":[572],"MM,":[573],"Atlas":[574],"A,":[575],"Nixon":[576,660],"DF,":[577,661],"Nielsen":[578,618],"M,":[579,615,619],"Lund":[580,620,656],"O,":[581,621,657],"Broadly":[584],"class":[587],"I":[588],"supertype-restricted":[589],"elite":[590],"CTL":[591],"epitopes":[592,634,668],"HIV-1":[601],"J":[603,639],"Immunol.":[604,640],"2008":[605],"1;180(7):5092-100.":[607],"https://pubmed.ncbi.nlm.nih.gov/18354235":[608],"III.":[609],"Hoof":[610],"I,":[611],"Buggert":[614],"RK,":[617],"Interdisciplinary":[624],"analysis":[625],"reveals":[635],"restricted":[636],"TCR":[637],"promiscuity.":[638],"May":[642],"1;184(9):5383-91.":[643],"https://doi.org/10.4049/jimmunol.0903516":[644],"IV.":[645],"Milush":[648],"JM,":[649],"Eriksson":[650],"EM,":[651],"Liegler":[654],"T,":[655],"Hecht":[658],"FM,":[659],"Immunodominant":[664],"associated":[674],"plasma":[677],"depletion.":[685],"[Manuscript]":[686]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}