{"id":"https://openalex.org/W14114698","doi":null,"title":"Longitudinal associations between antiretroviral treatments and quantification of tissue mitochondrial DNA from ambulatory subjects with HIV infection","display_name":"Longitudinal associations between antiretroviral treatments and quantification of tissue mitochondrial DNA from ambulatory subjects with HIV infection","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W14114698","mag":"14114698"},"language":"en","primary_location":{"id":"pmh:oai:alma.61MUN_INST:11135460970007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/conferencePresentation/Longitudinal-associations-between-antiretroviral-treatments-and/991005541568207891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009731100","display_name":"Catherine Louise Cherry","orcid":"https://orcid.org/0000-0001-9816-5193","observed_orcids":["https://orcid.org/0000-0001-9816-5193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine L. Cherry","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9816-5193","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039351765","display_name":"David A Nolan","orcid":"https://orcid.org/0000-0002-0743-8801","observed_orcids":["https://orcid.org/0000-0002-0743-8801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Nolan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0743-8801","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028760781","display_name":"I. James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Mallal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7036-1309","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000686504","display_name":"E. McKinnon","orcid":"https://orcid.org/0000-0002-8700-4447","observed_orcids":["https://orcid.org/0000-0002-8700-4447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. McKinnon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8700-4447","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038299372","display_name":"Martyn A. French","orcid":"https://orcid.org/0000-0002-4644-1982","observed_orcids":["https://orcid.org/0000-0002-4644-1982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martyn A. French","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4644-1982","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112309185","display_name":"E. Hammond","orcid":"https://orcid.org/0009-0006-8101-507X","observed_orcids":["https://orcid.org/0009-0006-8101-507X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Hammond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084905667","display_name":"Michelle Elizabeth Gahan","orcid":"https://orcid.org/0000-0002-1511-687X","observed_orcids":["https://orcid.org/0000-0002-1511-687X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle E. Gahan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038368249","display_name":"Justin C. McArthur","orcid":"https://orcid.org/0000-0002-3512-771X","observed_orcids":["https://orcid.org/0000-0002-3512-771X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. McArthur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076316809","display_name":"Steve L Wesselingh","orcid":"https://orcid.org/0000-0001-5605-1147","observed_orcids":["https://orcid.org/0000-0001-5605-1147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Wesselingh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5605-1147","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":93.5357,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.5289999842643738},{"id":"https://openalex.org/keywords/mitochondrial-dna-depletion","display_name":"mitochondrial DNA depletion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dideoxynucleosides","display_name":"dideoxynucleosides","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8820000290870667},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/zalcitabine","display_name":"zalcitabine","score":0.7799999713897705},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.6600000262260437},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.4449999928474426},{"id":"https://openalex.org/keywords/long-term-monitoring","display_name":"long-term monitoring","score":0.43700000643730164},{"id":"https://openalex.org/keywords/excisional-biopsy","display_name":"excisional biopsy","score":0.6019999980926514},{"id":"https://openalex.org/keywords/punch-biopsy","display_name":"punch biopsy","score":0.800000011920929},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.8051007986068726},{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.7418941259384155},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6346887946128845},{"id":"https://openalex.org/C2779889181","wikidata":"https://www.wikidata.org/wiki/Q423984","display_name":"Stavudine","level":5,"score":0.5229421854019165},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4943709373474121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4835752844810486},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.469316691160202},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.46487167477607727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4460323452949524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4445532262325287},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3800418972969055},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3414255380630493},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2501488924026489},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.24553611874580383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20086383819580078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11156439781188965},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.61MUN_INST:11135460970007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/conferencePresentation/Longitudinal-associations-between-antiretroviral-treatments-and/991005541568207891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:15634","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/15634/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Item"},{"id":"mag:14114698","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.murdoch.edu.au/id/eprint/15634/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072141531","https://openalex.org/W1834936788","https://openalex.org/W2016405286","https://openalex.org/W409517454","https://openalex.org/W2885384452","https://openalex.org/W4243072854","https://openalex.org/W32265888","https://openalex.org/W43002397","https://openalex.org/W2009494928","https://openalex.org/W2412751943"],"abstract_inverted_index":{"Background:":[0],"The":[1,287],"proposed":[2],"basis":[3],"for":[4,23,119],"NRTI-associated":[5],"clinical":[6,313],"toxicities":[7],"involves":[8],"cellular":[9],"mitochondrial":[10,15,24],"DNA":[11],"(mtDNA)":[12],"depletion":[13,40,303,327],"and":[14,45,47,74,83,334],"dysfunction.":[16],"Critical":[17],"questions":[18],"remain":[19],"about":[20],"optimal":[21],"monitoring":[22],"toxicity.":[25],"Results":[26],"are":[27,297],"presented":[28],"from":[29,99,132],"two":[30],"Australian":[31],"sites":[32],"investigating":[33],"effects":[34,116],"of":[35,211,224,267,289,317,323,340],"antiretroviral":[36],"treatment":[37,153,218,271],"on":[38,122,170,174,191,228,248,257,269,272,330,338],"mtDNA":[39,102,126,157,161,184,229,250,273,282,302,326],"in":[41,62,75,129,158,162,168,189,197,230,253,274,281,299,304],"adipose":[42,305],"tissue":[43,232,306],"(Perth":[44],"Melbourne)":[46],"peripheral":[48,91],"blood":[49,92],"(Melbourne)":[50],"using":[51,106,113],"real":[52,107],"time-PCR":[53],"assays.":[54],"\\n":[55,124,285],"\\nMethods:":[56],"Adipose":[57],"samples":[58,96,255,296],"were":[59,97,104,111],"prospectively":[60],"collected":[61],"Perth":[63],"via":[64,77],"suprailiac":[65,163],"excisional":[66],"biopsy":[67,295],"(72":[68],"study":[69,86],"visits,":[70,87],"60":[71],"patients":[72],"[pts])":[73],"Melbourne":[76,100],"punch":[78],"biopsies":[79],"at":[80,135],"the":[81,151,201],"thigh":[82],"calf":[84],"(160":[85],"62":[88],"pts).":[89],"Concurrent":[90],"mononuclear":[93],"cell":[94,214],"(PBMC)":[95],"obtained":[98],"pts.":[101],"copies/cell":[103],"determined":[105],"time-PCR.":[108],"Statistical":[109],"analyses":[110],"performed":[112],"linear":[114],"mixed":[115],"models,":[117],"accounting":[118],"multiple":[120],"measures":[121],"individuals.":[123],"\\nResults:":[125],"was":[127,150,165,200,208,251,264],"lower":[128,167,188,252],"all":[130],"tissues":[131],"those":[133,169,173,190,196],"receiving":[134],"least":[136],"one":[137],"dideoxynucleotide":[138],"(dNRTI,":[139],"d4T,":[140],"ddI":[141,192],"or":[142,193,222,241],"ddC)":[143],"(p":[144,179,204,259],"<":[145],"0.005).":[146],"Current":[147],"dNRTI":[148,203,246,309],"use":[149],"only":[152,202],"association":[154],"with":[155,219,308,312],"lowered":[156],"limb":[159],"fat.":[160],"fat":[164,254],"also":[166],"AZT":[171,176],"than":[172,195],"neither":[175],"nor":[177],"dNRTIs":[178,258],"=":[180,205,239,244,260],"0.0002).":[181],"In":[182],"PBMCs,":[183],"tended":[185],"to":[186,332],"be":[187],"ddC":[194],"whom":[198],"d4T":[199],"0.07).":[206],"There":[207],"no":[209,265],"effect":[210,266],"age,":[212],"CD4":[213],"count,":[215],"viral":[216],"load,":[217],"protease":[220],"inhibitors,":[221],"duration":[223],"known":[225],"HIV":[226],"infection":[227],"any":[231,275,279],"examined.":[233],"Among":[234],"subjects":[235],"who":[236],"initiated":[237],"(n":[238,243],"5)":[240],"ceased":[242],"13)":[245],"therapy":[247],"study,":[249],"taken":[256],"0.02),":[261],"but":[262],"there":[263],"time":[268],"current":[270],"tissue,":[276],"suggesting":[277],"that":[278],"changes":[280],"occur":[283],"rapidly.":[284],"\\nConclusions:":[286],"findings":[288],"these":[290],"independent":[291],"studies":[292],"involving":[293],"232":[294],"concordant":[298],"demonstrating":[300],"significant":[301],"associated":[307],"therapy,":[310],"consistent":[311],"data":[314],"implicating":[315],"choice":[316],"NRTI":[318],"as":[319],"an":[320],"important":[321],"determinant":[322],"lipodystrophy":[324],"risk.":[325],"occurs":[328],"rapidly":[329],"exposure":[331],"dNRTIs,":[333],"this":[335],"is":[336],"reversible":[337],"cessation":[339],"drug.":[341]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
