{"id":"https://openalex.org/W141012848","doi":"https://doi.org/10.1007/978-1-62703-071-7_11","title":"Aging Microglia: Relevance to Cognition and Neural Plasticity","display_name":"Aging Microglia: Relevance to Cognition and Neural Plasticity","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W141012848","doi":"https://doi.org/10.1007/978-1-62703-071-7_11","mag":"141012848","pmid":"https://pubmed.ncbi.nlm.nih.gov/22933148"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-62703-071-7_11","doi":"https://doi.org/10.1007/978-1-62703-071-7_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-071-7_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4301647458","display_name":"Psychoneuroimmunology"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057830583","display_name":"Rachel A. Kohman","orcid":"https://orcid.org/0000-0002-9737-3668","observed_orcids":["https://orcid.org/0000-0002-9737-3668"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachel A. Kohman","raw_affiliation_strings":["Department of Psychology, University of Illinois at Urbana-Champaign, Beckman Institute, Urbana, IL, USA. rakohman@illinois.edu","University of Illinois at Urbana-Champaign Beckman Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Illinois at Urbana-Champaign, Beckman Institute, Urbana, IL, USA. rakohman@illinois.edu","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana-Champaign Beckman Institute","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057830583"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":3.7993,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.92339261,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"934","issue":null,"first_page":"193","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7120000123977661},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.5720000267028809},{"id":"https://openalex.org/keywords/age-related-cognitive-decline","display_name":"age-related cognitive decline","score":0.597000002861023},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9556614756584167},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9375489950180054},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7644351124763489},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7250921726226807},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.6662921905517578},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5674490928649902},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5650367140769958},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5406749844551086},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5321715474128723},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46515780687332153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36989882588386536},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31071358919143677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25853431224823},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.15088555216789246},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10167771577835083},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07151848077774048}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-62703-071-7_11","doi":"https://doi.org/10.1007/978-1-62703-071-7_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-071-7_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:22933148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22933148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W1524059733","https://openalex.org/W1611000773","https://openalex.org/W1841551052","https://openalex.org/W1959902108","https://openalex.org/W1963918819","https://openalex.org/W1964186052","https://openalex.org/W1964229968","https://openalex.org/W1964413344","https://openalex.org/W1965801493","https://openalex.org/W1967369438","https://openalex.org/W1970891635","https://openalex.org/W1971642895","https://openalex.org/W1973216353","https://openalex.org/W1974214175","https://openalex.org/W1974700087","https://openalex.org/W1977604451","https://openalex.org/W1978853688","https://openalex.org/W1979615967","https://openalex.org/W1981142987","https://openalex.org/W1981462384","https://openalex.org/W1982216915","https://openalex.org/W1982528484","https://openalex.org/W1983915057","https://openalex.org/W1987925748","https://openalex.org/W1988015066","https://openalex.org/W1991805788","https://openalex.org/W1991963544","https://openalex.org/W1993441406","https://openalex.org/W1994215513","https://openalex.org/W1997713315","https://openalex.org/W1997962428","https://openalex.org/W1999459833","https://openalex.org/W2000276002","https://openalex.org/W2001334299","https://openalex.org/W2001512038","https://openalex.org/W2001809220","https://openalex.org/W2004349651","https://openalex.org/W2005474456","https://openalex.org/W2007197518","https://openalex.org/W2008329588","https://openalex.org/W2010053974","https://openalex.org/W2011495546","https://openalex.org/W2012029166","https://openalex.org/W2012221575","https://openalex.org/W2012445295","https://openalex.org/W2014473727","https://openalex.org/W2016111184","https://openalex.org/W2017298178","https://openalex.org/W2018521741","https://openalex.org/W2019932047","https://openalex.org/W2020722511","https://openalex.org/W2021551531","https://openalex.org/W2023572776","https://openalex.org/W2025604203","https://openalex.org/W2026141598","https://openalex.org/W2030171828","https://openalex.org/W2031743055","https://openalex.org/W2033124959","https://openalex.org/W2033703384","https://openalex.org/W2034337512","https://openalex.org/W2036586619","https://openalex.org/W2039296833","https://openalex.org/W2039390013","https://openalex.org/W2044028053","https://openalex.org/W2044488773","https://openalex.org/W2045955332","https://openalex.org/W2047281885","https://openalex.org/W2050015055","https://openalex.org/W2053006049","https://openalex.org/W2053513371","https://openalex.org/W2054552572","https://openalex.org/W2055166555","https://openalex.org/W2056200351","https://openalex.org/W2059109913","https://openalex.org/W2060968640","https://openalex.org/W2061194161","https://openalex.org/W2061576298","https://openalex.org/W2061931936","https://openalex.org/W2061941265","https://openalex.org/W2062610934","https://openalex.org/W2062790940","https://openalex.org/W2063827358","https://openalex.org/W2065470571","https://openalex.org/W2065569093","https://openalex.org/W2067267561","https://openalex.org/W2069776467","https://openalex.org/W2071129128","https://openalex.org/W2071130613","https://openalex.org/W2071695496","https://openalex.org/W2072495086","https://openalex.org/W2073440628","https://openalex.org/W2078141958","https://openalex.org/W2078514181","https://openalex.org/W2078960721","https://openalex.org/W2082110777","https://openalex.org/W2082504230","https://openalex.org/W2083647875","https://openalex.org/W2084838884","https://openalex.org/W2087658385","https://openalex.org/W2087771052","https://openalex.org/W2088719066","https://openalex.org/W2089406620","https://openalex.org/W2091057535","https://openalex.org/W2092358120","https://openalex.org/W2093184859","https://openalex.org/W2093207195","https://openalex.org/W2094660330","https://openalex.org/W2094946361","https://openalex.org/W2097456438","https://openalex.org/W2099555137","https://openalex.org/W2101853437","https://openalex.org/W2101898118","https://openalex.org/W2101958789","https://openalex.org/W2106116591","https://openalex.org/W2108398194","https://openalex.org/W2110463517","https://openalex.org/W2116956848","https://openalex.org/W2120766938","https://openalex.org/W2121259136","https://openalex.org/W2127401575","https://openalex.org/W2127854743","https://openalex.org/W2128250419","https://openalex.org/W2128855448","https://openalex.org/W2130958057","https://openalex.org/W2131196982","https://openalex.org/W2131922688","https://openalex.org/W2137399557","https://openalex.org/W2142771923","https://openalex.org/W2144041807","https://openalex.org/W2145384905","https://openalex.org/W2146394305","https://openalex.org/W2147904592","https://openalex.org/W2148389554","https://openalex.org/W2148727841","https://openalex.org/W2151400960","https://openalex.org/W2151551770","https://openalex.org/W2154653323","https://openalex.org/W2157678817","https://openalex.org/W2159744102","https://openalex.org/W2160779535","https://openalex.org/W2162038554","https://openalex.org/W2163329040","https://openalex.org/W2163487275","https://openalex.org/W2167314970","https://openalex.org/W2167485774","https://openalex.org/W2171314958","https://openalex.org/W2275825473","https://openalex.org/W2329276406","https://openalex.org/W2900421037","https://openalex.org/W3149326883","https://openalex.org/W4214891130","https://openalex.org/W4406054925"],"related_works":["https://openalex.org/W1622777525","https://openalex.org/W2604456007","https://openalex.org/W2175331109","https://openalex.org/W3133413580","https://openalex.org/W3029980229","https://openalex.org/W2046156250","https://openalex.org/W2529375487","https://openalex.org/W2036956824","https://openalex.org/W2250088334","https://openalex.org/W2051504363"],"abstract_inverted_index":{"Over":[0],"the":[1,8,13,16,31,40,62,137,145],"years":[2],"it":[3],"has":[4],"become":[5],"evident":[6],"that":[7,54,125],"immune":[9,28,43],"system":[10,19],"can":[11],"affect":[12],"function":[14],"of":[15,27,70,101,139],"central":[17],"nervous":[18],"(CNS),":[20],"including":[21],"altering":[22],"cognitive":[23,65,97],"processes.":[24],"The":[25,50],"impact":[26],"activation":[29,89],"on":[30,96],"CNS":[32],"is":[33,90,133],"particularly":[34],"important":[35],"for":[36],"aged":[37,146],"individuals,":[38],"as":[39],"brain's":[41],"resident":[42],"cells,":[44],"microglia,":[45],"acquire":[46],"a":[47,68],"pro-inflammatory":[48],"profile.":[49],"low-grade":[51],"chronic":[52],"neuroinflammation":[53,127],"develops":[55],"with":[56],"normal":[57,141],"aging":[58],"likely":[59],"contributes":[60],"to":[61,64,86,92,135],"susceptibility":[63],"deficits":[66],"and":[67,82,99,128],"host":[69],"age-related":[71],"pathologies.":[72],"Understanding":[73],"why":[74],"microglia":[75,88,105,142],"show":[76],"increased":[77],"inflammatory":[78,116],"activity":[79,117,143],"(i.e.,":[80],"neuroinflammation)":[81],"identifying":[83],"effective":[84,112],"treatments":[85,113],"reduce":[87],"expected":[91,134],"have":[93],"beneficial":[94],"effects":[95],"performance":[98],"measures":[100],"neural":[102],"plasticity.":[103],"However,":[104],"also":[106],"promote":[107],"regeneration":[108],"after":[109],"injury.":[110],"Therefore,":[111],"must":[114],"dampen":[115],"while":[118],"preserving":[119],"microglia's":[120],"neuroprotective":[121],"function.":[122],"Discovering":[123],"factors":[124],"induce":[126],"investigating":[129],"potential":[130],"preventative":[131],"therapies":[132],"uncover":[136],"ways":[138],"maintaining":[140],"in":[144],"brain.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}