{"id":"https://openalex.org/W141011590","doi":null,"title":"Abstract 164: Sodium Nitroprusside Improves Carotid Blood Flow and 24-Hour Neurological Intact Survival in a Porcine Model of Prolonged CPR.","display_name":"Abstract 164: Sodium Nitroprusside Improves Carotid Blood Flow and 24-Hour Neurological Intact Survival in a Porcine Model of Prolonged CPR.","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W141011590","mag":"141011590"},"language":"en","primary_location":{"id":"mag:141011590","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/content/122/Suppl_21/A164","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011955638","display_name":"Demetris Yannopoulos","orcid":"https://orcid.org/0000-0002-7131-2015","observed_orcids":["https://orcid.org/0000-0002-7131-2015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Demetris Yannopoulos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7131-2015","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109073025","display_name":"Timothy R. Matsuura","orcid":"https://orcid.org/0000-0003-1813-6451","observed_orcids":["https://orcid.org/0000-0003-1813-6451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Matsuura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000494547","display_name":"Scott H. McKnite","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott McKnite","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082870274","display_name":"Tom P. Aufderheide","orcid":"https://orcid.org/0000-0001-6086-0932","observed_orcids":["https://orcid.org/0000-0001-6086-0932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom P. Aufderheide","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6086-0932","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023235123","display_name":"Menekhem M. Zviman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Menekhem M. Zviman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054743614","display_name":"Henry R. Halperin","orcid":"https://orcid.org/0000-0002-5002-2000","observed_orcids":["https://orcid.org/0000-0002-5002-2000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry R. Halperin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058743601","display_name":"Keith G. Lurie","orcid":"https://orcid.org/0000-0002-2689-3973","observed_orcids":["https://orcid.org/0000-0002-2689-3973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith G. Lurie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10177","display_name":"Palliative Care and End-of-Life Issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":1.0},{"id":"https://openalex.org/keywords/prolonged-cardiopulmonary-resuscitation","display_name":"prolonged cardiopulmonary resuscitation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.878000020980835},{"id":"https://openalex.org/keywords/active-compression-decompression","display_name":"active compression-decompression","score":0.7210000157356262},{"id":"https://openalex.org/keywords/carotid-blood-flow","display_name":"carotid blood flow","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cerebral-perfusion","display_name":"cerebral perfusion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/neurological-outcome","display_name":"neurological outcome","score":0.6650000214576721},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.6159999966621399},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9585901498794556},{"id":"https://openalex.org/C2777055891","wikidata":"https://www.wikidata.org/wiki/Q185325","display_name":"Cardiopulmonary resuscitation","level":3,"score":0.7013182640075684},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.6853190064430237},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6168742775917053},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.47874897718429565},{"id":"https://openalex.org/C2777862461","wikidata":"https://www.wikidata.org/wiki/Q5172193","display_name":"Coronary perfusion pressure","level":4,"score":0.4401461184024811},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.3783864378929138},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36354494094848633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3258408308029175},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.0819186270236969}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:141011590","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/content/122/Suppl_21/A164","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1550153428","https://openalex.org/W2444386499","https://openalex.org/W2803223080","https://openalex.org/W3030445371","https://openalex.org/W2581652241","https://openalex.org/W178897288","https://openalex.org/W2171671948","https://openalex.org/W2382051136","https://openalex.org/W2347251093","https://openalex.org/W2358713207","https://openalex.org/W1969882738","https://openalex.org/W3031667243","https://openalex.org/W3030853763","https://openalex.org/W2411971552","https://openalex.org/W2378882515","https://openalex.org/W2286071830","https://openalex.org/W2377498810","https://openalex.org/W2374447699","https://openalex.org/W2320928316","https://openalex.org/W2896304456"],"abstract_inverted_index":{"Introduction:":[0],"Sodium":[2],"nitroprusside":[3],"(SNP)":[4],"is":[5],"a":[6],"powerful":[7],"vasodilator.":[8],"In":[9],"an":[10,92],"effort":[11],"to":[12,46,190,212],"improve":[13,214],"vital":[14,215,233],"organ":[15,216,234],"blood":[16,48,145],"flow":[17,146],"during":[18,52,236],"CPR":[19,90,107],"and":[20,43,50,63,127,143,154,170,187,195,218],"optimize":[21],"microcirculation,":[22],"we":[23],"tested":[24],"the":[25,133],"hypothesis":[26],"that":[27],"high":[28],"doses":[29],"of":[30,69],"SNP":[31,115,205],"would":[32],"be":[33,208],"beneficial":[34],"for":[35,108,159],"treating":[36],"cardiac":[37],"arrest":[38],"when":[39,222],"administered":[40],"with":[41,226],"devices":[42],"techniques":[44],"known":[45],"enhance":[47],"pressure":[49,142],"circulation":[51],"CPR.":[53,238],"Methods:":[56],"Twenty":[58],"one":[59],"(30\u00b11Kg)":[60],"pigs,":[61],"intubated":[62],"isofluorane":[64],"anesthetized,":[65],"had":[66],"6":[67],"minutes":[68,110],"untreated":[70],"ventricular.":[71],"Group":[72,82,102],"A:":[73],"5":[74,121],"animals":[75,151],"received":[76,85,105,129],"standard":[77],"(S-)":[78],"cardiopulmonary":[79],"resuscitation":[80],"(CPR).":[81],"B:":[83],"8":[84,104],"active":[86],"compression":[87],"decompression":[88],"(ACD)":[89],"plus":[91,98],"inspiratory":[93],"impedance":[94],"threshold":[95],"device":[96],"(ITD)":[97],"abdominal":[99],"binding":[100],"(AB).":[101],"C:":[103],"ACD+ITD+AB+SNP":[106],"25":[109],"before":[111,137],"defibrillation":[112],"was":[113,118],"attempted.":[114],"(1mg":[116],"iv)":[117],"given":[119],"every":[120],"minutes.":[122],"Animals":[123],"in":[124,184,210,224],"groups":[125,185],"A":[126,191],"B":[128,186],"epinephrine":[130],"based":[131],"on":[132],"2005":[134],"AHA":[135],"guidelines":[136],"defibrillation.":[138],"Right":[139],"atrial,":[140],"aortic":[141],"carotid":[144],"were":[147,152,166,181],"recorded.":[148],"Successfully":[149],"resuscitated":[150],"recovered":[153],"evaluated":[155],"24":[156,219],"hours":[157],"later":[158],"cerebral":[160],"performance":[161],"category":[162],"score.":[163],"Statistical":[164],"comparisons":[165],"performed":[167],"by":[168],"ANOVA":[169],"Fisher9s":[171],"exact":[172],"test.":[173],"Results:":[176],"Systolic/diastolic":[178],"pressures":[179],"(mmHg)":[180],"significantly":[182,213],"higher":[183],"C":[188],"compared":[189],"(mean\u00b1":[192],"SD:":[193],"82\u00b17/34\u00b13":[194],"78\u00b111/38\u00b15":[196],"vs":[197],"42\u00b16/18\u00b15,":[198],"respectively,":[199],"Conclusions:":[203],"can":[206],"safely":[207],"used":[209,223],"pigs":[211],"perfusion":[217],"hour":[220],"survival":[221],"conjunction":[225],"ACD":[227],"CPR+ITD+AB.":[228],"This":[229],"mechano-pharmacological":[230],"therapy":[231],"maintains":[232],"viability":[235],"prolonged":[237]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}