{"id":"https://openalex.org/W140959275","doi":null,"title":"Neuropatia diab\u00e9tica : estudo dos mecanismos moleculares envolvidos com a neurotoxicidade do metilglioxal e do glicolalde\u00eddo em c\u00e9lulas diferenciadas de neuroblastoma humano SH-SY5Y","display_name":"Neuropatia diab\u00e9tica : estudo dos mecanismos moleculares envolvidos com a neurotoxicidade do metilglioxal e do glicolalde\u00eddo em c\u00e9lulas diferenciadas de neuroblastoma humano SH-SY5Y","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W140959275","mag":"140959275"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3170497","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/66079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/66079","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048193007","display_name":"Giovana Ferreira Londero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giovana Ferreira Londero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048193007"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glycolaldehyde","display_name":"glycolaldehyde","score":0.9739999771118164},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.8880000114440918},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.652999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8330000042915344},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4259999990463257},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6060000061988831},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.5879999995231628},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.6639999747276306},{"id":"https://openalex.org/keywords/neuroblastoma-cell-differentiation","display_name":"neuroblastoma cell differentiation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/molecular-mechanisms-of-toxicity","display_name":"molecular mechanisms of toxicity","score":0.609000027179718},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.4050000011920929},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2779083432","wikidata":"https://www.wikidata.org/wiki/Q7390126","display_name":"SH-SY5Y","level":4,"score":0.7504251003265381},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5066662430763245},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4907780587673187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3712421655654907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3384043872356415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23154449462890625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06494823098182678},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3170497","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/66079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/66079","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/66079","pdf_url":"http://hdl.handle.net/10183/66079","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/66079","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/66079","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o"},{"id":"mag:140959275","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/handle/10183/66079","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3170497","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/66079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1553478027","display_name":null,"funder_award_id":"10/0027-4","funder_id":"https://openalex.org/F4320322502","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul"},{"id":"https://openalex.org/G182042024","display_name":null,"funder_award_id":"573671/2008-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5806861982","display_name":null,"funder_award_id":"1000274","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W140959275.pdf","grobid_xml":"https://content.openalex.org/works/W140959275.grobid-xml"},"referenced_works_count":175,"referenced_works":["https://openalex.org/W11717491","https://openalex.org/W23119973","https://openalex.org/W191793640","https://openalex.org/W299810438","https://openalex.org/W998869602","https://openalex.org/W1487088539","https://openalex.org/W1504571050","https://openalex.org/W1513558075","https://openalex.org/W1524128957","https://openalex.org/W1532356050","https://openalex.org/W1562556996","https://openalex.org/W1584529073","https://openalex.org/W1769327505","https://openalex.org/W1776564239","https://openalex.org/W1841957993","https://openalex.org/W1928266484","https://openalex.org/W1931505520","https://openalex.org/W1948203460","https://openalex.org/W1967165953","https://openalex.org/W1967322125","https://openalex.org/W1969250416","https://openalex.org/W1970007627","https://openalex.org/W1970103021","https://openalex.org/W1970221438","https://openalex.org/W1970234544","https://openalex.org/W1970444794","https://openalex.org/W1973924126","https://openalex.org/W1975456766","https://openalex.org/W1976209338","https://openalex.org/W1976814561","https://openalex.org/W1976828967","https://openalex.org/W1980093324","https://openalex.org/W1980189058","https://openalex.org/W1980611994","https://openalex.org/W1982173940","https://openalex.org/W1983072558","https://openalex.org/W1986080564","https://openalex.org/W1987187257","https://openalex.org/W1987973555","https://openalex.org/W1988979613","https://openalex.org/W1989687638","https://openalex.org/W1990003005","https://openalex.org/W1990578421","https://openalex.org/W1993428219","https://openalex.org/W1993499390","https://openalex.org/W1994542906","https://openalex.org/W1994685754","https://openalex.org/W1995165032","https://openalex.org/W1997441748","https://openalex.org/W1998350079","https://openalex.org/W1999723121","https://openalex.org/W2000314257","https://openalex.org/W2000596658","https://openalex.org/W2002263665","https://openalex.org/W2005273684","https://openalex.org/W2007995522","https://openalex.org/W2010919246","https://openalex.org/W2011234242","https://openalex.org/W2011886795","https://openalex.org/W2012372521","https://openalex.org/W2012500681","https://openalex.org/W2013136542","https://openalex.org/W2017214714","https://openalex.org/W2021538179","https://openalex.org/W2022849871","https://openalex.org/W2024296992","https://openalex.org/W2026983868","https://openalex.org/W2030110536","https://openalex.org/W2030440930","https://openalex.org/W2030531016","https://openalex.org/W2031418608","https://openalex.org/W2031503758","https://openalex.org/W2032128264","https://openalex.org/W2034138847","https://openalex.org/W2034914370","https://openalex.org/W2038774327","https://openalex.org/W2041476358","https://openalex.org/W2043353593","https://openalex.org/W2044437167","https://openalex.org/W2046696671","https://openalex.org/W2047546483","https://openalex.org/W2049568996","https://openalex.org/W2052438130","https://openalex.org/W2052644645","https://openalex.org/W2052939510","https://openalex.org/W2054260401","https://openalex.org/W2056964101","https://openalex.org/W2057093372","https://openalex.org/W2061204921","https://openalex.org/W2061803566","https://openalex.org/W2061895500","https://openalex.org/W2061968178","https://openalex.org/W2062548885","https://openalex.org/W2062605045","https://openalex.org/W2064579441","https://openalex.org/W2066350263","https://openalex.org/W2066558884","https://openalex.org/W2070762574","https://openalex.org/W2071474384","https://openalex.org/W2073715063","https://openalex.org/W2077087960","https://openalex.org/W2079761925","https://openalex.org/W2079847286","https://openalex.org/W2080294402","https://openalex.org/W2080632589","https://openalex.org/W2084631258","https://openalex.org/W2085222358","https://openalex.org/W2085232289","https://openalex.org/W2087666481","https://openalex.org/W2087854721","https://openalex.org/W2087868042","https://openalex.org/W2090495023","https://openalex.org/W2093073023","https://openalex.org/W2093102386","https://openalex.org/W2094317381","https://openalex.org/W2094910547","https://openalex.org/W2095203090","https://openalex.org/W2099512544","https://openalex.org/W2099548046","https://openalex.org/W2099905857","https://openalex.org/W2100898704","https://openalex.org/W2105954005","https://openalex.org/W2112022806","https://openalex.org/W2112100252","https://openalex.org/W2112105892","https://openalex.org/W2112841292","https://openalex.org/W2113714326","https://openalex.org/W2113716304","https://openalex.org/W2114787445","https://openalex.org/W2115341402","https://openalex.org/W2119590183","https://openalex.org/W2119912357","https://openalex.org/W2122131495","https://openalex.org/W2125316317","https://openalex.org/W2128749891","https://openalex.org/W2130550927","https://openalex.org/W2131096470","https://openalex.org/W2131879537","https://openalex.org/W2133022777","https://openalex.org/W2133237042","https://openalex.org/W2135562071","https://openalex.org/W2136419196","https://openalex.org/W2137051596","https://openalex.org/W2137091464","https://openalex.org/W2137367321","https://openalex.org/W2138455883","https://openalex.org/W2138526449","https://openalex.org/W2139163490","https://openalex.org/W2140491925","https://openalex.org/W2140603115","https://openalex.org/W2140720733","https://openalex.org/W2140903224","https://openalex.org/W2142060886","https://openalex.org/W2143278366","https://openalex.org/W2144138736","https://openalex.org/W2144463858","https://openalex.org/W2147294760","https://openalex.org/W2152233222","https://openalex.org/W2153444114","https://openalex.org/W2153943744","https://openalex.org/W2154682611","https://openalex.org/W2157877381","https://openalex.org/W2158110797","https://openalex.org/W2159904588","https://openalex.org/W2160836484","https://openalex.org/W2165156238","https://openalex.org/W2171316300","https://openalex.org/W2252766049","https://openalex.org/W2316317840","https://openalex.org/W2319987782","https://openalex.org/W2336682594","https://openalex.org/W2341637731","https://openalex.org/W2417115050","https://openalex.org/W2471605942","https://openalex.org/W2476941386"],"related_works":["https://openalex.org/W2276651867","https://openalex.org/W7053122015","https://openalex.org/W4401324242","https://openalex.org/W3095032647","https://openalex.org/W4400503998","https://openalex.org/W2963312742","https://openalex.org/W1763406893","https://openalex.org/W2040542577","https://openalex.org/W3187822740","https://openalex.org/W1526073251"],"abstract_inverted_index":{"Neuropatia":[0],"\u00e9":[1,228,378],"a":[2,12,24,36,49,178,192,203,218,241,270,278,286,338,349,360],"complica\u00e7\u00e3o":[3],"mais":[4,7,17,343],"comum":[5],"e":[6,79,116,119,135,144,155,171,199,202,208,249,256,275,277,285,312,323,386],"debilitante":[8],"da":[9,65,76,252,254,330,382],"Diabetes":[10],"Mellitus,":[11],"longo":[13],"prazo":[14],"presente":[15],"em":[16,93,96],"de":[18,33,38,67,70,98,109,151,153,156,180,205,213,221,236,243,264,280,309,316,397,401],"50%":[19],"dos":[20],"pacientes":[21],"que":[22,54,122,297,337,354,359,374,394],"possuem":[23],"doen\u00e7a.":[25],"A":[26],"hiperglicemia":[27],"induz":[28],"estresse":[29,62,129,376],"oxidativo":[30,63,377],"nos":[31],"neur\u00f4nios":[32],"diab\u00e9ticos":[34],"acarretando":[35],"ativa\u00e7\u00e3o":[37,271,320,329],"m\u00faltiplas":[39],"vias":[40,173],"bioqu\u00edmicas,":[41],"as":[42,172,210],"quais":[43,90,175],"s\u00e3o":[44,58,81,91],"potenciais":[45],"alvos":[46],"terap\u00eauticos":[47],"para":[48,106,127,234],"neuropatia":[50],"diab\u00e9tica.":[51],"Est\u00e1":[52],"claro":[53],"compostos":[55,82,237],"carbonil":[56,83],"reativos":[57,84],"mediadores":[59],"glicot\u00f3xicos":[60],"do":[61,114,117,197,200,314,351,353,384,387],"atrav\u00e9s":[64,251],"forma\u00e7\u00e3o":[66,179],"produtos":[68],"finais":[69],"glica\u00e7\u00e3o":[71],"avan\u00e7ada":[72],"como":[73],"resultado":[74],"direto":[75],"hiperglicemia.":[77,99],"Metilglioxal":[78],"glicolalde\u00eddo":[80,146,201,250,388],"inevitavelmente":[85],"produzidos":[86],"pelo":[87,332],"metabolismo,":[88],"os":[89,162],"encontrados":[92],"maior":[94],"quantidade":[95],"situa\u00e7\u00f5es":[97],"Recentemente,":[100],"tem":[101,362],"sido":[102],"dada":[103],"muita":[104],"aten\u00e7\u00e3o":[105],"o":[107,132,145,195,262,298,356,375],"envolvimento":[108],"esp\u00e9cies":[110,181,206,244,310],"reativas":[111,182,245,311],"na":[112,288,307,345,365,404],"toxicidade":[113,350,383],"metilglioxal":[115,143,198,248,352,385],"glicolalde\u00eddo,":[118,357],"tem-se":[120],"demonstrado":[121],"essas":[123,292],"glicotoxinas":[124,170,302],"t\u00eam":[125],"potencial":[126],"induzir":[128],"oxidativo,":[130],"parar":[131],"crescimento":[133],"celular":[134,215,220,347,367,406],"promover":[136],"morte":[137,214],"por":[138,247],"apoptose":[139],"ou":[140],"necrose.":[141],"O":[142],"interagem":[147],"com":[148,300,318,334],"grupamentos":[149,398],"sulfidril":[150,399],"mol\u00e9culas":[152],"glutationa":[154,265],"enzimas,":[157],"inibindo":[158],"sua":[159],"atividade;":[160],"entretanto,":[161],"mecanismos":[163],"moleculares":[164],"relacionados":[165],"aos":[166],"efeitos":[167,260],"t\u00f3xicos":[168],"dessas":[169,410],"pelas":[174],"elas":[176],"levam":[177],"n\u00e3o":[183],"est\u00e3o":[184],"completamente":[185],"elucidados.":[186],"Neste":[187],"estudo":[188],"n\u00f3s":[189],"buscamos":[190],"esclarecer":[191],"rela\u00e7\u00e3o":[193],"entre":[194],"metabolismo":[196],"produ\u00e7\u00e3o":[204,242,308],"reativas,":[207],"investigamos":[209,269],"poss\u00edveis":[211],"rotas":[212],"envolvidas.":[216],"Utilizamos":[217],"linhagem":[219],"neuroblastoma":[222],"humano":[223],"SH-SY5Y":[224],"diferenciada,":[225],"pois":[226],"este":[227],"um":[229,305,341,379],"modelo":[230],"neuronal":[231,290],"bem":[232],"caracterizado":[233],"estudos":[235],"neurot\u00f3xicos.":[238],"N\u00f3s":[239],"avaliamos":[240],"induzida":[246],"t\u00e9cnica":[253],"diclorofluoresce\u00edna,":[255],"avaliamos,":[257],"tamb\u00e9m,":[258],"seus":[259],"sob":[261],"conte\u00fado":[263,315],"celular.":[266],"Al\u00e9m":[267],"disso,":[268],"das":[272,321],"caspase-3,":[273],"-8":[274],"-9":[276,324],"contribui\u00e7\u00e3o":[279],"diferentes":[281,402],"sistemas":[282],"peroxidases":[283],"(glutationa-redutase":[284],"tioredoxina-redutase),":[287],"defesa":[289,346,366,405],"contra":[291,348,355,368,407],"glicotoxinas.":[293,370,411],"Como":[294],"resultados":[295,372],"encontramos":[296],"tratamento":[299,333],"ambas":[301,369],"rapidamente":[303],"provocou":[304],"aumento":[306],"diminui\u00e7\u00e3o":[313],"glutationa,":[317],"concomitante":[319],"caspases-8":[322],"e,":[325,393],"posteriormente,":[326],"tamb\u00e9m":[327],"houve":[328],"caspase-3":[331],"metilglioxal.":[335],"Vimos":[336],"tioredoxina-redutase":[339],"possui":[340],"papel":[342,363],"importante":[344,380],"enquanto":[358],"glutationa-redutase":[361],"semelhante":[364],"Nossos":[371],"demonstraram":[373],"mecanismo":[381],"nas":[389],"c\u00e9lulas":[390],"diferenciadas":[391],"SHSY5Y":[392],"enzimas":[395],"redutoras":[396],"contribuem":[400],"formas":[403],"cada":[408],"uma":[409]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}