{"id":"https://openalex.org/W140746738","doi":null,"title":"Analysis of germline and somatic PTEN profiles and their role in the racial disparity in endometrial cancer outcome","display_name":"Analysis of germline and somatic PTEN profiles and their role in the racial disparity in endometrial cancer outcome","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W140746738","mag":"140746738"},"language":"en","primary_location":{"id":"pmh:oai:kb.osu.edu:1811/24031","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/24031","pdf_url":"http://hdl.handle.net/1811/24031","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1811/24031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063098200","display_name":"Margaret Irene Liang","orcid":"https://orcid.org/0000-0001-9229-5181","observed_orcids":["https://orcid.org/0000-0001-9229-5181"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Margaret Liang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9229-5181","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063098200"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.6480000019073486},{"id":"https://openalex.org/keywords/african-american-women","display_name":"African American women","score":0.8130000233650208},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7020000219345093},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.8870000243186951},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9110000133514404},{"id":"https://openalex.org/keywords/endometrioid-histology","display_name":"endometrioid histology","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/host-genetic-factors","display_name":"host genetic factors","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8809077143669128},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.7662559151649475},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6544727683067322},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.5624431371688843},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45745646953582764},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.41480323672294617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.407740980386734},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3793397843837738},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3652154505252838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.361491322517395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34237074851989746},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.33961477875709534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3052554428577423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15440115332603455},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12313836812973022},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.07156190276145935},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.049930185079574585},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kb.osu.edu:1811/24031","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/24031","pdf_url":"http://hdl.handle.net/1811/24031","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:140746738","doi":null,"is_oa":false,"landing_page_url":"https://kb.osu.edu/dspace/handle/1811/24031","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kb.osu.edu:1811/24031","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/24031","pdf_url":"http://hdl.handle.net/1811/24031","source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7578999996185303}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W140746738.pdf","grobid_xml":"https://content.openalex.org/works/W140746738.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W159668801","https://openalex.org/W1508974456","https://openalex.org/W1558515869","https://openalex.org/W1580458764","https://openalex.org/W1593108703","https://openalex.org/W1607982711","https://openalex.org/W1911329982","https://openalex.org/W1946460195","https://openalex.org/W1969886373","https://openalex.org/W1970950714","https://openalex.org/W1981735626","https://openalex.org/W1987429587","https://openalex.org/W1995726115","https://openalex.org/W1998038367","https://openalex.org/W2007838802","https://openalex.org/W2014813076","https://openalex.org/W2015634396","https://openalex.org/W2016007187","https://openalex.org/W2017359926","https://openalex.org/W2019856908","https://openalex.org/W2022146756","https://openalex.org/W2025319925","https://openalex.org/W2035269440","https://openalex.org/W2037128041","https://openalex.org/W2039966201","https://openalex.org/W2041593090","https://openalex.org/W2044347713","https://openalex.org/W2044869180","https://openalex.org/W2067751798","https://openalex.org/W2072900847","https://openalex.org/W2077894633","https://openalex.org/W2079450135","https://openalex.org/W2081894694","https://openalex.org/W2082996759","https://openalex.org/W2091340273","https://openalex.org/W2101019828","https://openalex.org/W2105616976","https://openalex.org/W2106535853","https://openalex.org/W2113190292","https://openalex.org/W2117491472","https://openalex.org/W2122230708","https://openalex.org/W2122294028","https://openalex.org/W2123595693","https://openalex.org/W2126845172","https://openalex.org/W2128159111","https://openalex.org/W2128437500","https://openalex.org/W2128793721","https://openalex.org/W2130661390","https://openalex.org/W2132173772","https://openalex.org/W2139015332","https://openalex.org/W2141607880","https://openalex.org/W2144911879","https://openalex.org/W2150097377","https://openalex.org/W2150233389","https://openalex.org/W2151254090","https://openalex.org/W2154181923","https://openalex.org/W2156317352","https://openalex.org/W2159032347","https://openalex.org/W2163565167","https://openalex.org/W2166353145","https://openalex.org/W2169312351","https://openalex.org/W2206749611","https://openalex.org/W2288530326","https://openalex.org/W2400808877"],"related_works":["https://openalex.org/W1946460195","https://openalex.org/W2103669072","https://openalex.org/W2795322737","https://openalex.org/W1829267180","https://openalex.org/W2097245149","https://openalex.org/W4297776402","https://openalex.org/W2028227093","https://openalex.org/W4409979213","https://openalex.org/W4286293822","https://openalex.org/W4396945943"],"abstract_inverted_index":{"Endometrial":[0],"cancer":[1,86,97,249,435],"is":[2,68],"the":[3,9,73,103,167,175,237,244,255,263,305,321,326,372,380,387,410,420,429],"most":[4,278],"common":[5],"gynecological":[6],"malignancy":[7],"in":[8,21,26,33,72,84,102,124,154,171,198,281,325,336,355,375,433,456],"United":[10],"States.":[11],"Poorer":[12],"prognosis":[13],"and":[14,50,91,112,134,213,226,250,368,389,407,458],"higher":[15],"mortality":[16],"rates":[17],"for":[18,99,193,348,428],"endometrial":[19,85,96,248,356,434],"cancers":[20,357],"African-Americans":[22],"compared":[23,284],"to":[24,38,64,82,116,235,285,363,371,447],"those":[25],"whites":[27],"have":[28,45],"revealed":[29,259],"a":[30,69,138,346,352],"racial":[31,70,265,323,373,411,431],"disparity":[32,71,432],"this":[34,61,293,337,448],"disease.":[35],"In":[36,272],"contrast":[37],"other":[39],"solid":[40],"tumors,":[41],"several":[42],"studies":[43],"paradoxically":[44],"supported":[46],"somatic":[47,100,120,149,299,421],"PTEN":[48,104,150,245,300,327],"mutations":[49,101,121,151,168,301],"microsatellite":[51],"instability":[52],"(MSI)":[53],"as":[54,232,345,351],"favorable":[55,306],"prognostic":[56,366],"features.":[57],"The":[58],"aim":[59],"of":[60,75,107,126,140,144,156,166,200,239,243,257,292,313,419],"study":[62,294,350,391],"was":[63,191,277,343,383],"determine":[65],"whether":[66],"there":[67],"frequency":[74],"these":[76,439],"molecular":[77,422],"alterations":[78,423],"that":[79,298,358,400,417,442],"may":[80,360],"contribute":[81,370,446],"differences":[83,261,317,374],"outcome.\\nWe":[87],"scanned":[88],"paired":[89],"germline":[90,353],"tumor":[92],"DNA":[93],"from":[94,130,160],"53":[95],"patients":[98,217],"gene,":[105],"loss":[106],"heterozygosity":[108],"(LOH)":[109],"around":[110],"10q22-q24,":[111],"global":[113],"MSI":[114],"according":[115],"Bethesda":[117],"recommendations.":[118],"Fourteen":[119],"were":[122,135,152,218,230,318,334],"found":[123,153,335],"8":[125],"26":[127,201],"(31%)":[128],"tumors":[129,158],"African-American":[131],"(AA)":[132],"individuals":[133],"almost":[136],"exclusively":[137],"feature":[139],"endometrioid":[141,172,307,388],"cases":[142],"(11":[143],"14":[145],"mutations;":[146],"79%).":[147],"Eleven":[148],"7":[155],"27":[157],"(26%)":[159],"white":[161],"women":[162],"(NAA),":[163],"with":[164,207,247,304],"5/11":[165],"(45%)":[169],"present":[170],"cases.":[173],"Of":[174],"25":[176],"informative":[177,203],"AA":[178,212,282,362],"samples,":[179],"15":[180],"(60%)":[181],"exhibited":[182],"LOH":[183,190],"at":[184,194],"one":[185,196],"or":[186,454],"more":[187],"loci,":[188],"while":[189],"observed":[192,319,385,430],"least":[195],"locus":[197,246],"19":[199],"(73%)":[202],"NAA":[204,216,286],"samples.":[205],"Consistent":[206],"previous":[208,296],"studies,":[209],"5/25":[210],"(20%)":[211],"5/26":[214],"(19%)":[215],"MSI-positive.\\nIn":[219],"addition,":[220],"10":[221],"single":[222],"nucleotide":[223],"polymorphisms":[224],"(SNPs)":[225],"their":[227],"reconstructed":[228],"haplotypes":[229,258,402],"examined":[231],"host":[233],"factors":[234,367,444],"investigate":[236],"association":[238],"specific":[240,332],"genomic":[241],"regions":[242],"its":[251],"prognosis.":[252],"Most":[253],"importantly,":[254],"distribution":[256,382],"significant":[260],"between":[262,320,386],"two":[264,322],"groups":[266,324,392],"(\uf0632=":[267,393],"13.814,":[268],"P":[269,288,395],"=":[270,289,310,396],"0.032).":[271],"particular,":[273],"haplotype":[274,328,339,341,381],"3,":[275],"CTIAGTATCC,":[276],"clearly":[279],"over-represented":[280],"(37%)":[283],"(15%,":[287],"0.014).\\nThe":[290],"results":[291],"confirmed":[295],"evidence":[297],"are":[302],"associated":[303],"histology":[308,406],"(P":[309],"0.015),":[311],"irrespective":[312],"race.":[314],"Additionally,":[315],"novel":[316],"analysis.":[329],"Although":[330],"no":[331],"associations":[333],"limited":[338],"analysis,":[340],"3":[342],"identified":[344],"candidate":[347],"further":[349,398,461],"component":[354],"perhaps":[359,403,452],"predispose":[361],"certain":[364,401],"unfavorable":[365],"thus":[369],"outcome.":[376],"A":[377],"trend":[378],"among":[379],"also":[384],"non-endometrioid":[390],"11.870,":[394],"0.065),":[397],"suggesting":[399],"could":[404],"affect":[405],"consequently":[408],"influence":[409],"disparity.":[412],"Taken":[413],"together,":[414],"we":[415],"conclude":[416],"none":[418],"per":[424],"se":[425],"independently":[426],"account":[427],"outcome;":[436],"however,":[437],"cumulatively,":[438],"data":[440],"suggest":[441],"genetic":[443],"likely":[445],"disparate":[449],"clinical":[450],"outcome,":[451],"additively":[453],"acting":[455],"concert,":[457],"certainly":[459],"require":[460],"investigation.\\n\\nAdvisors:":[462],"Dr.":[463,466],"Wolfgang":[464],"Sadee,":[465],"Charis":[467],"Eng":[468]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}