{"id":"https://openalex.org/W140505441","doi":null,"title":"General Pharmacological Study of CJ-11828, an Amlodipine adipate","display_name":"General Pharmacological Study of CJ-11828, an Amlodipine adipate","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W140505441","mag":"140505441"},"language":"en","primary_location":{"id":"mag:140505441","doi":null,"is_oa":false,"landing_page_url":"http://dspace.kci.go.kr/handle/kci/476847","pdf_url":null,"source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules & Therapeutics","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023728138","display_name":"Jae Mook Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae Mook Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023527433","display_name":"Sung Hak Lee","orcid":"https://orcid.org/0000-0003-1020-5838","observed_orcids":["https://orcid.org/0000-0003-1020-5838","https://orcid.org/0000-0002-1030-381X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung Hak Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1020-5838","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026081443","display_name":"Il Hwan Kim","orcid":"https://orcid.org/0000-0002-4225-002X","observed_orcids":["https://orcid.org/0000-0002-4225-002X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Il Hwan Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081836930","display_name":"Jie Eun Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Eun Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057064123","display_name":"Choong Sil Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Choong Sil Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033957452","display_name":"Yong Sik Youn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Sik Youn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065055079","display_name":"Dong Kwon Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Kwon Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109482360","display_name":"Sung Hwan Cho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung Hwan Cho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061211716","display_name":"Jun Hwan Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Hwan Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022807309","display_name":"Sun Hee","orcid":"https://orcid.org/0000-0003-2372-5269","observed_orcids":["https://orcid.org/0000-0003-2372-5269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun Hee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2372-5269","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E. J. Kim","orcid":"https://orcid.org/0000-0003-1433-6018","observed_orcids":["https://orcid.org/0000-0003-1433-6018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. J. Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1433-6018","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100345275","display_name":"Young\u2010Hoon Kim","orcid":"https://orcid.org/0000-0002-4254-647X","observed_orcids":["https://orcid.org/0000-0002-4254-647X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young\u2010Hoon Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01738808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"2","first_page":"114","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14020","display_name":"Medical research and treatments","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pharmacological-safety","display_name":"pharmacological safety","score":0.6169999837875366},{"id":"https://openalex.org/keywords/sedative-effects","display_name":"sedative effects","score":0.5139999985694885},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/intestinal-motility","display_name":"intestinal motility","score":0.5609999895095825},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5789999961853027},{"id":"https://openalex.org/keywords/motor-activity","display_name":"motor activity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ileal-smooth-muscle-contraction","display_name":"ileal smooth muscle contraction","score":0.6890000104904175},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2777075361","wikidata":"https://www.wikidata.org/wiki/Q3819788","display_name":"Adipate","level":2,"score":0.6129533052444458},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6057853698730469},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5159841179847717},{"id":"https://openalex.org/C42533223","wikidata":"https://www.wikidata.org/wiki/Q1378064","display_name":"ED50","level":3,"score":0.5040656328201294},{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.48304349184036255},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45818275213241577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45749151706695557},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.4516042470932007},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.43352025747299194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3003774881362915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2018018662929535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08114495873451233},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:140505441","doi":null,"is_oa":false,"landing_page_url":"http://dspace.kci.go.kr/handle/kci/476847","pdf_url":null,"source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules & Therapeutics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2378971631","https://openalex.org/W1977872872","https://openalex.org/W354558122","https://openalex.org/W2119134456","https://openalex.org/W6995657508","https://openalex.org/W1963772301","https://openalex.org/W1976926964","https://openalex.org/W3211736223","https://openalex.org/W2030971938","https://openalex.org/W4385638348"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,95,110,131,169],"undertaken":[3],"to":[4,182],"evaluate":[5],"the":[6,80,87,183],"general":[7,27],"pharmacological":[8,101,175],"properties":[9],"of":[10,43,53,57,62,72,90,100,103,118,153],"CJ-11828,":[11],"an":[12],"amlodipine":[13],"adipate,":[14],"in":[15,19,38,65,83,113,127,133],"experimental":[16],"animals":[17],"and":[18,35,60,74,120,161],"vitro":[20,144],"system.":[21],"CJ-11828":[22,69,78,137,146,172],"had":[23,147,173],"no":[24,148,174],"effects":[25],"on":[26,107,150,165],"behavior,":[28],"motor":[29,129],"coordination,":[30],"writhing":[31],"syndromes,":[32],"pentetrazol-induced":[33],"chemoshock":[34],"electric":[36],"shock":[37],"mice":[39,66,134],"at":[40,70,86,116,138,158],"dose":[41,88],"levels":[42],"3,10,":[44,119],"anti":[45],"30":[46,75,121,141],"mg/kg,":[47,76,122],"po.":[48,77,123],"But":[49],"there":[50],"were":[51],"decrease":[52,126],"body":[54],"temperature,":[55],"prolongation":[56],"sleeping":[58],"time,":[59],"inhibition":[61],"intestinal":[63],"activity":[64,102,130],"treated":[67,135],"with":[68,136],"doses":[71,117],"10":[73,162],"decreased":[79],"blood":[81],"pressure":[82],"coscuous":[84],"fog":[85],"level":[89],"2mg/kg,":[91],"po,":[92],"but":[93],"it":[94,168],"expected":[96],"as":[97],"a":[98],"result":[99],"CJ-11828.":[104],"Any":[105],"effect":[106,149,176],"respiratory":[108],"system":[109],"not":[111],"observed":[112,132],"conscious":[114],"rat":[115],"The":[124],"slight":[125],"spontaneous":[128],"high":[139],"dose,":[140,187],"mg/kg.":[142,189],"In":[143],"experiments,":[145],"agonists-induced":[151],"contraction":[152],"isolated":[154],"guinea":[155],"pig":[156],"ileum":[157],"0.1,":[159],"1,":[160],"M.":[163],"Based":[164],"these":[166,178],"results,":[167],"concluded":[170],"that":[171],"ill":[177],"studies":[179],"even":[180],"up":[181],"36-fold":[184],"anticipated":[185],"clinical":[186],"3":[188]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}