{"id":"https://openalex.org/W140433342","doi":null,"title":"On the pathogenesis of obstructive lung disease. A study on the immotile-cilia syndrome.","display_name":"On the pathogenesis of obstructive lung disease. A study on the immotile-cilia syndrome.","publication_year":1978,"publication_date":"1978-04-01","ids":{"openalex":"https://openalex.org/W140433342","mag":"140433342","pmid":"https://pubmed.ncbi.nlm.nih.gov/684380"},"language":"en","primary_location":{"id":"pmid:684380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/684380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of respiratory diseases","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112159059","display_name":"B Mossberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Mossberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049216818","display_name":"B A Afzelius","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Afzelius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402819","display_name":"ROLF ELIASSON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Eliasson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030008039","display_name":"Per Camner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Camner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0336,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.9617915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"59","issue":"2","first_page":"55","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-ciliary-dyskinesia","display_name":"primary ciliary dyskinesia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.984000027179718},{"id":"https://openalex.org/keywords/obstructive-pulmonary-disease","display_name":"obstructive lung disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chronic-bronchitis","display_name":"chronic bronchitis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/situs-inversus","display_name":"situs inversus","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ciliary-ultrastructure","display_name":"ciliary ultrastructure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/sperm-immotility","display_name":"sperm immotility","score":0.6740000247955322},{"id":"https://openalex.org/keywords/respiratory-tract-infections","display_name":"respiratory infections","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8902816772460938},{"id":"https://openalex.org/C114682108","wikidata":"https://www.wikidata.org/wiki/Q1952044","display_name":"Mucociliary clearance","level":3,"score":0.8166724443435669},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.696223795413971},{"id":"https://openalex.org/C2992694001","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Chronic bronchitis","level":2,"score":0.619726836681366},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.562052309513092},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.5576333403587341},{"id":"https://openalex.org/C2779993553","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Bronchitis","level":2,"score":0.5494751334190369},{"id":"https://openalex.org/C2777104659","wikidata":"https://www.wikidata.org/wiki/Q3508797","display_name":"Obstructive lung disease","level":3,"score":0.4592134952545166},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38176077604293823},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.34900498390197754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3037075996398926},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.19354704022407532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05147075653076172},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008176","descriptor_name":"Lung Volume Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012857","descriptor_name":"Situs Inversus","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013082","descriptor_name":"Sperm Tail","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:684380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/684380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of respiratory diseases","raw_type":"Journal Article"},{"id":"mag:140433342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/684380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974095583","https://openalex.org/W2398179919","https://openalex.org/W2405594845","https://openalex.org/W2021717030","https://openalex.org/W2438044508","https://openalex.org/W113870192","https://openalex.org/W2407972080","https://openalex.org/W2410571256","https://openalex.org/W277440657","https://openalex.org/W2319668614"],"abstract_inverted_index":{"The":[0,131,163],"role":[1,78],"of":[2,26,36,55,79,87,122,128,143,181,186],"mucociliary":[3,82,137,161,178],"transport":[4,83,104,138,179],"in":[5,72,105,111,118,166,193],"man":[6],"can":[7],"be":[8],"evaluated":[9],"by":[10],"studying":[11],"persons":[12,20,63],"with":[13,64,148,168,195],"the":[14,27,44,56,65,77,85,106,141,187],"recently":[15],"recognised":[16],"\"immotile-cilia":[17],"syndrome\".":[18],"Such":[19],"have":[21,33,50,58,68,152,157],"chronic":[22,150,196],"or":[23],"recurrent":[24],"infections":[25],"upper":[28],"and":[29,32,38,49,100],"lower":[30],"airways":[31],"ultrastructural":[34],"defects":[35],"cilia":[37],"sperm":[39],"tails.":[40],"Men":[41],"suffering":[42],"from":[43],"syndrome":[45,67],"usually":[46],"are":[47],"sterile":[48],"immotile":[51],"spermatozoa.":[52],"About":[53],"half":[54],"subjects":[57,124,167],"complete":[59],"situs":[60],"inversus.":[61],"Fourteen":[62],"immotile-cilia":[66],"been":[69,154],"studied":[70],"here":[71],"an":[73,80,135],"attempt":[74],"to":[75,140,156],"evaluate":[76],"impaired":[81,160,177],"for":[84,184],"development":[86,142,185],"obstructive":[88,144,188],"lung":[89,145,189],"disease.":[90,146],"Age":[91],"range":[92],"was":[93,108],"25-40":[94],"years;":[95],"there":[96],"were":[97],"ten":[98],"men":[99],"four":[101],"women.":[102],"Mucociliary":[103],"lungs":[107],"extremely":[109],"slow":[110],"all":[112],"subjects.":[113,120],"Spirometry":[114],"demonstrated":[115],"airway":[116],"obstruction":[117],"nine":[119],"Two":[121],"these":[123],"had":[125],"radiological":[126],"evidence":[127],"pulmonary":[129],"emphysema.":[130],"results":[132],"indicate":[133],"that":[134,175],"absent":[136],"predisposes":[139],"Patients":[147],"classic":[149],"bronchitis":[151],"earlier":[153],"shown":[155],"a":[158],"severely":[159],"transport.":[162],"present":[164],"findings":[165],"primary":[169],"ciliary":[170],"immotility":[171],"make":[172],"it":[173],"probable":[174],"this":[176],"is":[180],"pathogenetic":[182],"importance":[183],"disease":[190],"often":[191],"found":[192],"patients":[194],"bronchitis.":[197]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}