{"id":"https://openalex.org/W140141082","doi":null,"title":"Ductular reaction and its diagnostic significance.","display_name":"Ductular reaction and its diagnostic significance.","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W140141082","mag":"140141082","pmid":"https://pubmed.ncbi.nlm.nih.gov/9845427"},"language":"en","primary_location":{"id":"pmid:9845427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9845427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in diagnostic pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067200658","display_name":"Tania Roskams","orcid":"https://orcid.org/0000-0002-2816-1530","observed_orcids":["https://orcid.org/0000-0002-2816-1530"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"T Roskams","raw_affiliation_strings":["Department of Pathology, University Hospital Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111667982","display_name":"Valeer J. Desmet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Desmet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2366,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.80201943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"15","issue":"4","first_page":"259","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductular-reaction","display_name":"ductular reaction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biliary-cirrhosis","display_name":"biliary cirrhosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/periportal-fibrosis","display_name":"periportal fibrosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/liver-progenitor-cells","display_name":"liver progenitor cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.5889999866485596},{"id":"https://openalex.org/keywords/diagnostic-algorithm","display_name":"diagnostic algorithm","score":0.6650000214576721},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7102007865905762},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6335114240646362},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.5946946740150452},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5589590072631836},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.5099722146987915},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.49351823329925537},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.43486344814300537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41938042640686035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3875117301940918},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.20905688405036926},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.15887197852134705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0874381959438324}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002780","descriptor_name":"Cholestasis, Intrahepatic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9845427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9845427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in diagnostic pathology","raw_type":"Journal Article"},{"id":"mag:140141082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9845427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309891655","https://openalex.org/W3025894748","https://openalex.org/W2885037168","https://openalex.org/W3121240871","https://openalex.org/W2078954880","https://openalex.org/W2132730975","https://openalex.org/W2039742298","https://openalex.org/W4309892214","https://openalex.org/W2952861926","https://openalex.org/W4393187888"],"abstract_inverted_index":{"Ductular":[0,58],"reaction":[1,59],"refers":[2],"to":[3,26],"an":[4,21],"increased":[5],"number":[6],"of":[7,12,43,55,65,76,95,114],"ductules":[8],"(the":[9],"finest":[10],"ramifications":[11],"the":[13,85,93,112],"biliary":[14,31],"tree),":[15],"accompanied":[16],"by":[17],"polymorphonuclear":[18],"leukocytes":[19],"and":[20,29,49,52,102,119],"increase":[22],"in":[23,40,79],"matrix,":[24],"leading":[25],"periportal":[27],"fibrosis":[28],"eventually":[30],"cirrhosis.":[32],"It":[33],"is":[34,38,90],"a":[35,41,80,107],"phenomenon":[36,113],"that":[37,122],"seen":[39],"variety":[42],"liver":[44,71],"diseases,":[45],"such":[46,83,98],"as":[47,84,99],"acute":[48],"chronic":[50],"cholestasis":[51],"variable":[53],"degrees":[54],"parenchymal":[56,120],"necrosis.":[57],"has":[60],"gained":[61],"new":[62],"interest":[63],"because":[64],"its":[66],"relationship":[67],"with":[68],"putative":[69],"human":[70],"progenitor":[72,77],"cells.":[73],"The":[74],"existence":[75],"cells":[78],"quiescent":[81],"organ":[82],"liver,":[86],"although":[87],"still":[88],"controversial,":[89],"important":[91],"for":[92],"understanding":[94],"biological":[96],"processes,":[97],"embryogenesis,":[100],"carcinogenesis,":[101],"regeneration.":[103],"This":[104],"article":[105],"provides":[106],"diagnostic":[108,124],"algorithm:":[109],"Starting":[110],"from":[111],"ductular":[115],"reaction,":[116],"portal":[117],"tract":[118],"changes":[121],"give":[123],"clues":[125],"are":[126],"systematically":[127],"described.":[128]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
