{"id":"https://openalex.org/W140074968","doi":null,"title":"Study the effect of phytochemical constituents of Piper betel leaves extracts on liver disorders by in vivo model.","display_name":"Study the effect of phytochemical constituents of Piper betel leaves extracts on liver disorders by in vivo model.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W140074968","mag":"140074968"},"language":"en","primary_location":{"id":"mag:140074968","doi":null,"is_oa":false,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20103127009","pdf_url":null,"source":{"id":"https://openalex.org/S2765036248","display_name":"Journal of Pharmacy Research","issn_l":"0974-6943","issn":["0974-6943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacy Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026132871","display_name":"Ashish Manigauha","orcid":"https://orcid.org/0000-0003-4122-2999","observed_orcids":["https://orcid.org/0000-0003-4122-2999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashish Manigauha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4122-2999","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022445788","display_name":"Sunita Patel","orcid":"https://orcid.org/0000-0002-8560-7703","observed_orcids":["https://orcid.org/0000-0002-8560-7703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunita Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8560-7703","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102899408","display_name":"Huma Ali","orcid":"https://orcid.org/0000-0002-6350-771X","observed_orcids":["https://orcid.org/0000-0002-6350-771X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huma Ali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047263296","display_name":"Anish Chandy","orcid":"https://orcid.org/0000-0002-1481-4254","observed_orcids":["https://orcid.org/0000-0002-1481-4254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anish Chandy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1481-4254","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078923561","display_name":"Mahima Maheshwari","orcid":"https://orcid.org/0000-0003-1531-4785","observed_orcids":["https://orcid.org/0000-0003-1531-4785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahima Maheshwari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1531-4785","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7942,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66926168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"3","first_page":"353","last_page":"356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.19460000097751617,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piper-betle","display_name":"Piper betle","score":0.9449999928474426},{"id":"https://openalex.org/keywords/betel-leaf-extract","display_name":"betel leaf extract","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9929999709129333},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.871999979019165},{"id":"https://openalex.org/keywords/oxidative-liver-injury","display_name":"oxidative liver damage","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.996999979019165},{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/phytochemical-constituents","display_name":"phytochemical constituents","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.6984903216362},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6159172654151917},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6096314787864685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.588181734085083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5873140692710876},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5589724183082581},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5413960218429565},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.5204101800918579},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5104812383651733},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5040613412857056},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4782068729400635},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.470040500164032},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.45549046993255615},{"id":"https://openalex.org/C2777155639","wikidata":"https://www.wikidata.org/wiki/Q159536","display_name":"Piper","level":2,"score":0.43406206369400024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4315837323665619},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.4254956841468811},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21141856908798218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20835205912590027},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2001422643661499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11554652452468872},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:140074968","doi":null,"is_oa":false,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20103127009","pdf_url":null,"source":{"id":"https://openalex.org/S2765036248","display_name":"Journal of Pharmacy Research","issn_l":"0974-6943","issn":["0974-6943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacy Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1538399032","https://openalex.org/W1546592314","https://openalex.org/W1983310681","https://openalex.org/W2033761244","https://openalex.org/W2036308994","https://openalex.org/W2473348377","https://openalex.org/W3001678335","https://openalex.org/W3135196271"],"related_works":["https://openalex.org/W2843043315","https://openalex.org/W4412800947","https://openalex.org/W1989986658","https://openalex.org/W2084764761","https://openalex.org/W111641795","https://openalex.org/W7097403042","https://openalex.org/W2466429761","https://openalex.org/W2012865011","https://openalex.org/W7217600327","https://openalex.org/W3171111176"],"abstract_inverted_index":{"An":[0],"in":[1,22,79,110,120,126],"vivo":[2],"study":[3],"was":[4,20,42,143],"conducted":[5],"to":[6,145],"evaluate":[7],"the":[8,127,147,150],"hepatoprotective":[9],"activity":[10],"of":[11,14,68,83],"ethanolic":[12],"extracts":[13],"Piper":[15,138],"betel":[16,85,139],"leaves.":[17],"Liver":[18],"damage":[19,41,152],"induced":[21],"male":[23],"Wistar":[24],"rats":[25],"weighed":[26],"150-200":[27],"gm":[28],"by":[29,44,154],"administering":[30],"CCl":[31,134,155],"4":[32,135,156],"(2ml/kg":[33],"i.p)":[34],"regularly":[35,93],"for":[36,94],"10":[37,95],"days":[38,96],"and":[39,88,97,118],"tissue":[40],"noted":[43],"various":[45],"biochemical":[46],"parameters":[47],"like":[48,71],"serum":[49,54,111],"glutamate":[50,55],"oxaloacetate":[51],"transaminase":[52,57],"(SGOT),":[53],"Pyruvate":[56],"(SGPT),":[58],"Alkaline":[59],"Phosphatase":[60,63],"(ALP),":[61],"Acid":[62],"(ACP),":[64],"Lipid":[65],"peroxidation,":[66],"Level":[67],"antioxidant":[69],"enzyme":[70],"catalase":[72],"(CAT),":[73],"Superoxide":[74],"dismutase":[75],"(SOD),":[76],"Glutathione":[77],"(GSH)":[78],"liver.":[80],"Ethanolic":[81],"extract":[82,141],"piper":[84],"100":[86],"mg/kg":[87,90,105],"200":[89],"i.p":[91],"administered":[92,136],"compared":[98,132],"with":[99,133],"a":[100],"control":[101],"group":[102],"silymarin":[103],"(25":[104],"i.p.).":[106],"A":[107],"significant":[108],"reduction":[109],"SGOT,":[112],"SGPT,":[113],"ALP,":[114],"ACP,":[115],"lipid":[116],"peroxidation":[117],"improvement":[119],"CAT,":[121],"SOD,":[122],"GSH,":[123],"MDA":[124],"level":[125],"liver":[128,148],"were":[129],"observed":[130],"when":[131],"rats.":[137],"leaves":[140],"(PBLE)":[142],"able":[144],"protect":[146],"against":[149],"oxidative":[151],"produced":[153],".":[157]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}