{"id":"https://openalex.org/W139966627","doi":null,"title":"Imaging dynamic volume changes in astrocytes","display_name":"Imaging dynamic volume changes in astrocytes","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W139966627","mag":"139966627"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-12232010-223316","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-12232010-223316","pdf_url":"http://hdl.handle.net/10388/etd-12232010-223316","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10388/etd-12232010-223316","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052755260","display_name":"Clare M. Florence","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Clare M. Florence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052755260"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte-swelling","display_name":"astrocyte swelling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/extracellular-potassium","display_name":"extracellular potassium","score":0.8949999809265137},{"id":"https://openalex.org/keywords/inwardly-rectifying-potassium-channels","display_name":"inwardly rectifying potassium channels","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bicarbonate","display_name":"bicarbonate","score":0.8569999933242798},{"id":"https://openalex.org/keywords/carbonic-anhydrase","display_name":"carbonic anhydrase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/sodium-bicarbonate-cotransporter","display_name":"sodium bicarbonate cotransporter","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"neurostimulation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/potassium-homeostasis","display_name":"potassium homeostasis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ph-homeostasis","display_name":"pH homeostasis","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.5383798480033875},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13157352805137634},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/etd-12232010-223316","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-12232010-223316","pdf_url":"http://hdl.handle.net/10388/etd-12232010-223316","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/etd-12232010-223316","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/etd-12232010-223316","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:139966627","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/bitstream/10388/etd-12232010-223316/1/ClareFlorenceImagingDynamicVolumeChangesInAstrocytes.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-12232010-223316","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-12232010-223316","pdf_url":"http://hdl.handle.net/10388/etd-12232010-223316","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322648","display_name":"Universit\u00e0 degli Studi di Firenze","ror":"https://ror.org/04jr1s763"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W139966627.pdf","grobid_xml":"https://content.openalex.org/works/W139966627.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W40685760","https://openalex.org/W120845308","https://openalex.org/W161471264","https://openalex.org/W1535419310","https://openalex.org/W1535641516","https://openalex.org/W1538554858","https://openalex.org/W1566430653","https://openalex.org/W1569697153","https://openalex.org/W1646272776","https://openalex.org/W1651958095","https://openalex.org/W1674335052","https://openalex.org/W1864765563","https://openalex.org/W1900227502","https://openalex.org/W1919877497","https://openalex.org/W1937363507","https://openalex.org/W1941392759","https://openalex.org/W1963614683","https://openalex.org/W1971931358","https://openalex.org/W1975005653","https://openalex.org/W1975239722","https://openalex.org/W1975888261","https://openalex.org/W1975934006","https://openalex.org/W1976833922","https://openalex.org/W1977571678","https://openalex.org/W1977873342","https://openalex.org/W1978505795","https://openalex.org/W1980519470","https://openalex.org/W1980590101","https://openalex.org/W1981066873","https://openalex.org/W1981893433","https://openalex.org/W1983836947","https://openalex.org/W1984878857","https://openalex.org/W1992321658","https://openalex.org/W1998638899","https://openalex.org/W2001422973","https://openalex.org/W2007114154","https://openalex.org/W2007654857","https://openalex.org/W2009327894","https://openalex.org/W2015794252","https://openalex.org/W2017523469","https://openalex.org/W2017791457","https://openalex.org/W2019854826","https://openalex.org/W2020138925","https://openalex.org/W2021706041","https://openalex.org/W2025392492","https://openalex.org/W2025474716","https://openalex.org/W2026765475","https://openalex.org/W2027919106","https://openalex.org/W2030352252","https://openalex.org/W2032291923","https://openalex.org/W2032730787","https://openalex.org/W2033794046","https://openalex.org/W2034153487","https://openalex.org/W2035288360","https://openalex.org/W2035920166","https://openalex.org/W2037279364","https://openalex.org/W2039392894","https://openalex.org/W2046383732","https://openalex.org/W2048713890","https://openalex.org/W2049348365","https://openalex.org/W2050706464","https://openalex.org/W2050767626","https://openalex.org/W2051143596","https://openalex.org/W2055891615","https://openalex.org/W2056111826","https://openalex.org/W2056251473","https://openalex.org/W2058539880","https://openalex.org/W2060689618","https://openalex.org/W2061473211","https://openalex.org/W2064130404","https://openalex.org/W2065288115","https://openalex.org/W2065372694","https://openalex.org/W2066936960","https://openalex.org/W2067018626","https://openalex.org/W2070004275","https://openalex.org/W2072278357","https://openalex.org/W2075603142","https://openalex.org/W2075952655","https://openalex.org/W2081212941","https://openalex.org/W2081574933","https://openalex.org/W2081895884","https://openalex.org/W2082969312","https://openalex.org/W2083002996","https://openalex.org/W2085234617","https://openalex.org/W2087786050","https://openalex.org/W2088125189","https://openalex.org/W2089450477","https://openalex.org/W2090971379","https://openalex.org/W2091570536","https://openalex.org/W2092635505","https://openalex.org/W2094784513","https://openalex.org/W2094997830","https://openalex.org/W2098237962","https://openalex.org/W2098922689","https://openalex.org/W2099771668","https://openalex.org/W2101174197","https://openalex.org/W2103915054","https://openalex.org/W2110921852","https://openalex.org/W2116447221","https://openalex.org/W2117088742","https://openalex.org/W2119737459","https://openalex.org/W2120741241","https://openalex.org/W2123369785","https://openalex.org/W2123781965","https://openalex.org/W2124940469","https://openalex.org/W2128744963","https://openalex.org/W2128790805","https://openalex.org/W2129567809","https://openalex.org/W2130525167","https://openalex.org/W2130630814","https://openalex.org/W2133315293","https://openalex.org/W2136077454","https://openalex.org/W2137928448","https://openalex.org/W2141199312","https://openalex.org/W2142119080","https://openalex.org/W2147372806","https://openalex.org/W2148981717","https://openalex.org/W2156302680","https://openalex.org/W2160644313","https://openalex.org/W2161998020","https://openalex.org/W2163334026","https://openalex.org/W2163755116","https://openalex.org/W2165059130","https://openalex.org/W2167368466","https://openalex.org/W2169759057","https://openalex.org/W2171557729","https://openalex.org/W2179555289","https://openalex.org/W2297890963","https://openalex.org/W2312098387","https://openalex.org/W2326192620","https://openalex.org/W2425882825","https://openalex.org/W2475105597"],"related_works":["https://openalex.org/W2033171244","https://openalex.org/W4281839584","https://openalex.org/W2972738047","https://openalex.org/W2739217836","https://openalex.org/W3094186027","https://openalex.org/W7045336433","https://openalex.org/W4286447700","https://openalex.org/W2063400281","https://openalex.org/W2136080744","https://openalex.org/W2058952497"],"abstract_inverted_index":{"Astrocytes,":[0],"the":[1,8,16,51,67,71,75,97,125,134,146,159,175,188,191,238,275],"major":[2],"type":[3],"of":[4,70,74,99,124,161,177,190,277],"non-neuronal":[5],"cells":[6],"in":[7,15,45,66,88,96,120,145,165,174,207,231,244,260],"brain,":[9],"play":[10,141],"an":[11,178],"important":[12,272],"functional":[13],"role":[14,144],"brain\u2019s":[17],"extracellular":[18,100,170,179,264],"potassium":[19],"(K+)":[20],"and":[21,79,185,283],"pH":[22],"homeostasis.":[23],"Pathological":[24],"brain":[25,278,285],"states":[26],"have":[27,38,271],"been":[28,41],"shown":[29,236],"to":[30,43,47,60,84,90,140,203,209,223,246,258],"cause":[31],"astrocyte":[32,63,129,150,153,218,253,267],"swelling.":[33,151],"However,":[34],"these":[35],"volume":[36,64,268],"changes":[37,65,269],"never":[39],"before":[40],"verified":[42],"occur":[44],"response":[46,89,208,245],"physiological":[48,92,282],"activity.":[49],"In":[50,132],"present":[52],"thesis,":[53],"two-photon":[54],"laser":[55],"scanning":[56],"microscopy":[57],"was":[58,104,138,155,163,195,220,228,235,255],"used":[59],"visualize":[61],"real-time":[62],"stratum":[68],"radiatum":[69],"CA1":[72],"region":[73],"hippocampus.":[76],"Astrocyte":[77,102],"somas":[78],"primary":[80],"processes":[81],"were":[82,201],"observed":[83],"swell":[85,243],"by":[86,107,205],"19.0\u00b10.9%":[87],"a":[91,121,142,167,261],"(3":[93],"mM)":[94],"increase":[95],"concentration":[98],"K+.":[101],"swelling":[103,130,154,254],"partially":[105],"mediated":[106,217],"K+":[108,113,127,148],"influx":[109,160],"through":[110],"inwardly":[111],"rectifying":[112],"channels":[114],"(Kir),":[115],"as":[116],"their":[117],"inhibition":[118],"resulted":[119],"significant":[122,143],"decrease":[123],"increased":[126,147],"induced":[128,149,252],"(13.9\u00b10.9%).":[131],"addition,":[133],"bicarbonate":[135],"ion":[136],"(HCO3-)":[137],"found":[139,202],"The":[152],"significantly":[156,221,256],"decreased":[157,164,222,257],"when":[158,187,225],"HCO3-":[162,168,226,262],"1)":[166],"free":[169,263],"solution":[171],"(5.4\u00b10.7%),":[172],"2)":[173],"presence":[176],"carbonic":[180],"anhydrase":[181],"inhibitor":[182],"(11.4\u00b10.6%":[183],"),":[184],"3)":[186],"activity":[189,251,279],"sodium-bicarbonate":[192],"cotransporter":[193],"(NBC)":[194],"blocked":[196],"(8.3\u00b10.7%)":[197],".":[198],"Conversely,":[199],"astrocytes":[200,242],"shrink":[204],"7.7\u00b10.5%":[206],"\u00e3-Amino-butyric":[210],"Acid":[211],"(GABA)":[212],"receptor":[213,216],"activation.":[214],"GABAA":[215],"shrinkage":[219],"5.0\u00b10.6%":[224],"efflux":[227],"reduced.":[229],"Furthermore,":[230],"this":[232],"thesis":[233],"it":[234],"for":[237,274],"first":[239],"time":[240],"that":[241],"neuronal":[247],"stimulation":[248],"(4.0\u00b10.4%).":[249],"This":[250],"1.5\u00b10.2%":[259],"solution.":[265],"These":[266],"may":[270],"implications":[273],"regulation":[276],"under":[280],"both":[281],"pathological":[284],"states.":[286]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}