{"id":"https://openalex.org/W139931093","doi":null,"title":"Mechanistic Study of The Small Molecule Inhibitor DX-52-1","display_name":"Mechanistic Study of The Small Molecule Inhibitor DX-52-1","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W139931093","mag":"139931093"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:gs_theses-1256","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/gs_theses/280","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012198652","display_name":"Junru Cui","orcid":"https://orcid.org/0000-0001-5872-2194","observed_orcids":["https://orcid.org/0000-0001-5872-2194"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Junru Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012198652"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/radixin","display_name":"radixin","score":0.925000011920929},{"id":"https://openalex.org/keywords/cell-migration-inhibition","display_name":"cell migration inhibition","score":0.9200000166893005},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/covalent-modification","display_name":"covalent modification","score":0.7789999842643738},{"id":"https://openalex.org/keywords/iminium-ions","display_name":"iminium ions","score":0.6389999985694885},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8399999737739563},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/inhibition-mechanism","display_name":"inhibition mechanism","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5545241832733154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4426492154598236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1190410852432251}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:gs_theses-1256","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/gs_theses/280","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:gs_theses-1256","doi":null,"is_oa":false,"landing_page_url":"https://opencommons.uconn.edu/gs_theses/280","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},{"id":"mag:139931093","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/gs_theses/280/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":195,"referenced_works":["https://openalex.org/W41353385","https://openalex.org/W44494951","https://openalex.org/W91334381","https://openalex.org/W130263754","https://openalex.org/W159318255","https://openalex.org/W176940681","https://openalex.org/W190994300","https://openalex.org/W1487549050","https://openalex.org/W1498131948","https://openalex.org/W1500690807","https://openalex.org/W1540649941","https://openalex.org/W1556368621","https://openalex.org/W1560179018","https://openalex.org/W1561407320","https://openalex.org/W1571679969","https://openalex.org/W1580246547","https://openalex.org/W1582832269","https://openalex.org/W1590118434","https://openalex.org/W1597787921","https://openalex.org/W1599507049","https://openalex.org/W1610264844","https://openalex.org/W1635520329","https://openalex.org/W1668266668","https://openalex.org/W1676103704","https://openalex.org/W1744354425","https://openalex.org/W1892937839","https://openalex.org/W1906875137","https://openalex.org/W1907668872","https://openalex.org/W1924095190","https://openalex.org/W1945339140","https://openalex.org/W1960862471","https://openalex.org/W1967265143","https://openalex.org/W1968249471","https://openalex.org/W1968577363","https://openalex.org/W1968584313","https://openalex.org/W1969957411","https://openalex.org/W1970018595","https://openalex.org/W1970092562","https://openalex.org/W1970917173","https://openalex.org/W1970923523","https://openalex.org/W1972999344","https://openalex.org/W1974089832","https://openalex.org/W1974112332","https://openalex.org/W1976201938","https://openalex.org/W1977019885","https://openalex.org/W1978525637","https://openalex.org/W1980316109","https://openalex.org/W1980434442","https://openalex.org/W1981763610","https://openalex.org/W1982615613","https://openalex.org/W1984613650","https://openalex.org/W1985296918","https://openalex.org/W1985411135","https://openalex.org/W1985666458","https://openalex.org/W1988342283","https://openalex.org/W1988369885","https://openalex.org/W1988650452","https://openalex.org/W1989183491","https://openalex.org/W1990015244","https://openalex.org/W1991221837","https://openalex.org/W1993357468","https://openalex.org/W1995699754","https://openalex.org/W1996016298","https://openalex.org/W1997224206","https://openalex.org/W1997790858","https://openalex.org/W2002534521","https://openalex.org/W2003475957","https://openalex.org/W2004051256","https://openalex.org/W2005252392","https://openalex.org/W2006051699","https://openalex.org/W2006315176","https://openalex.org/W2007586038","https://openalex.org/W2007897263","https://openalex.org/W2010160865","https://openalex.org/W2010896383","https://openalex.org/W2011017251","https://openalex.org/W2011995680","https://openalex.org/W2014446933","https://openalex.org/W2014893007","https://openalex.org/W2015490746","https://openalex.org/W2015918937","https://openalex.org/W2022491847","https://openalex.org/W2027126201","https://openalex.org/W2028905487","https://openalex.org/W2029042183","https://openalex.org/W2029622398","https://openalex.org/W2029736718","https://openalex.org/W2030635244","https://openalex.org/W2030768863","https://openalex.org/W2031296931","https://openalex.org/W2034759328","https://openalex.org/W2035091870","https://openalex.org/W2036048165","https://openalex.org/W2036631473","https://openalex.org/W2037457069","https://openalex.org/W2037906340","https://openalex.org/W2038940222","https://openalex.org/W2040142478","https://openalex.org/W2041004671","https://openalex.org/W2041206504","https://openalex.org/W2041920939","https://openalex.org/W2042202484","https://openalex.org/W2045164971","https://openalex.org/W2045377853","https://openalex.org/W2045617532","https://openalex.org/W2047578735","https://openalex.org/W2047831969","https://openalex.org/W2048827022","https://openalex.org/W2048835493","https://openalex.org/W2051016429","https://openalex.org/W2053993560","https://openalex.org/W2054446803","https://openalex.org/W2058263436","https://openalex.org/W2061355448","https://openalex.org/W2061413580","https://openalex.org/W2062937323","https://openalex.org/W2063220206","https://openalex.org/W2063538689","https://openalex.org/W2063949464","https://openalex.org/W2064666759","https://openalex.org/W2069904608","https://openalex.org/W2070516299","https://openalex.org/W2071156256","https://openalex.org/W2072096036","https://openalex.org/W2072128091","https://openalex.org/W2075119539","https://openalex.org/W2076428688","https://openalex.org/W2079671002","https://openalex.org/W2079944376","https://openalex.org/W2080161935","https://openalex.org/W2080513913","https://openalex.org/W2080597378","https://openalex.org/W2080666434","https://openalex.org/W2082421146","https://openalex.org/W2084483444","https://openalex.org/W2085313140","https://openalex.org/W2086641174","https://openalex.org/W2088544660","https://openalex.org/W2089613312","https://openalex.org/W2090355988","https://openalex.org/W2090712867","https://openalex.org/W2090772762","https://openalex.org/W2090863707","https://openalex.org/W2091400786","https://openalex.org/W2093822120","https://openalex.org/W2094188666","https://openalex.org/W2094460994","https://openalex.org/W2098136597","https://openalex.org/W2103446130","https://openalex.org/W2103595781","https://openalex.org/W2105503408","https://openalex.org/W2105789974","https://openalex.org/W2110596117","https://openalex.org/W2110726109","https://openalex.org/W2113389463","https://openalex.org/W2116403121","https://openalex.org/W2119632652","https://openalex.org/W2121378879","https://openalex.org/W2121889667","https://openalex.org/W2122263758","https://openalex.org/W2122782850","https://openalex.org/W2126496496","https://openalex.org/W2129105171","https://openalex.org/W2130236651","https://openalex.org/W2130405923","https://openalex.org/W2131456214","https://openalex.org/W2134241152","https://openalex.org/W2139969808","https://openalex.org/W2140428678","https://openalex.org/W2142796088","https://openalex.org/W2147469756","https://openalex.org/W2150280909","https://openalex.org/W2151271433","https://openalex.org/W2152306131","https://openalex.org/W2154766564","https://openalex.org/W2154814286","https://openalex.org/W2155181742","https://openalex.org/W2155653297","https://openalex.org/W2156820197","https://openalex.org/W2157319245","https://openalex.org/W2157860503","https://openalex.org/W2159493434","https://openalex.org/W2159770012","https://openalex.org/W2168586729","https://openalex.org/W2170812873","https://openalex.org/W2189363641","https://openalex.org/W2257494244","https://openalex.org/W2264396671","https://openalex.org/W2333520403","https://openalex.org/W2395894883","https://openalex.org/W2396211831","https://openalex.org/W2415238087","https://openalex.org/W2616349296","https://openalex.org/W2949860131","https://openalex.org/W4206509728"],"related_works":["https://openalex.org/W188546241","https://openalex.org/W2079671002","https://openalex.org/W2011995680","https://openalex.org/W47849383","https://openalex.org/W7202094758","https://openalex.org/W4214522046","https://openalex.org/W4414608319","https://openalex.org/W3007246092","https://openalex.org/W2162635706","https://openalex.org/W3177562981"],"abstract_inverted_index":{"Cell":[0],"migration":[1,36,62,144,161,217],"is":[2,8,82],"a":[3,48,76,88,196,249],"basic":[4],"biological":[5],"process":[6],"that":[7,110,137,171,228,276],"fundamental":[9],"to":[10,199],"several":[11],"normal":[12],"and":[13,25,29,44,122,162,169,188,207,218,291],"disease":[14],"processes":[15],"such":[16],"as":[17,40,58,87],"embryonic":[18],"development,":[19],"tissue":[20],"repair,":[21],"immune":[22],"function,":[23],"angiogenesis":[24],"cancer":[26,166,186],"cell":[27,35,96,143,160,167,216],"invasion":[28],"metastasis.":[30],"Small":[31],"organic":[32],"molecules":[33],"inhibiting":[34],"can":[37],"be":[38],"used":[39],"both":[41,119],"research":[42],"probes":[43],"therapeutic":[45],"agents.":[46],"DX-52-1,":[47],"semisynthetic":[49],"derivative":[50],"of":[51,63,91,126,132,139,147,155,177,231,234,238,242,248,255,269,281,289],"the":[52,61,129,153,156,178,229,239,258,264,277],"natural":[53],"product":[54],"quinocarmycin":[55],"(also":[56],"known":[57],"quinocarcin),":[59],"inhibits":[60],"Madin-Darby":[64],"canine":[65],"kidney":[66],"epithelial":[67],"cells":[68],"with":[69,93,107],"nanomolar":[70],"concentration.":[71],"We":[72,151,224,262],"have":[73,101],"identified":[74,102],"galectin-3,":[75,133],"multifunctional":[77],"protein":[78],"whose":[79],"best-known":[80],"function":[81],"its":[83],"sugar":[84],"binding":[85,149,222],"ability,":[86],"secondary":[89],"target":[90,292],"DX-52-1":[92,203,243,290],"functions":[94,138],"in":[95,120,123,164,175,215,219,287],"motility.":[97],"In":[98],"addition,":[99],"we":[100,274],"HUK-921,":[103],"another":[104],"small":[105,193],"molecule":[106,194],"antimigratory":[108],"activity":[109],"has":[111,195],"far":[112],"greater":[113],"selectivity":[114],"for":[115,142,267],"galectin-3":[116,140,235,256],"over":[117],"radixin":[118,270],"vitro":[121,220],"cells.":[124],"Neither":[125],"them":[127],"targets":[128],"carbohydrate-binding":[130],"site":[131],"moreover,":[134],"results":[135],"indicate":[136],"required":[141],"are":[145],"independent":[146],"carbohydrate":[148],"ability.":[150],"investigated":[152],"effects":[154],"two":[157],"inhibitors":[158],"on":[159,257],"proliferation":[163],"different":[165],"lines":[168],"discovered":[170],"DX-52-1shows":[172],"promising":[173],"potency":[174],"serveral":[176],"tested":[179],"ones":[180],"especially":[181],"triple":[182],"negative":[183],"human":[184],"breast":[185],"BT20":[187],"MDA-MB-231":[189],"cells,":[190],"suggesting":[191],"this":[192],"great":[197],"potential":[198],"treat":[200],"cancers.":[201],"Six":[202],"analogs":[204],"were":[205,212],"synthesized":[206],"structure-activity":[208],"relationship":[209],"(SAR)":[210],"studies":[211],"carried":[213],"out":[214],"competitive":[221],"assays.":[223],"provided":[225],"strong":[226],"evidence":[227],"mechanism":[230,266],"covalent":[232],"modification":[233],"involves":[236],"elimination":[237],"nitrile":[240],"group":[241,279],"followed":[244],"by":[245,271],"an":[246,284],"attack":[247],"nucleophilic":[250],"amino":[251],"acid":[252],"side":[253],"chain":[254],"resulting":[259],"iminium":[260],"ion.":[261],"proposed":[263],"similar":[265],"alkylation":[268],"DX-52-1.":[272],"Furthermore,":[273],"demonstrated":[275],"hydroxyl":[278],"(-OH)":[280],"DX-52-1(C-19)":[282],"plays":[283],"important":[285],"role":[286],"recognition":[288],"proteins.":[293]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
