{"id":"https://openalex.org/W139877098","doi":null,"title":"Kinetic mechanism of DNA polymerase I","display_name":"Kinetic mechanism of DNA polymerase I","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W139877098","mag":"139877098"},"language":"en","primary_location":{"id":"mag:139877098","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6076401-kinetic-mechanism-dna-polymerase","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056457744","display_name":"Robert D. Kuchta","orcid":"https://orcid.org/0000-0003-3179-0239","observed_orcids":["https://orcid.org/0000-0003-3179-0239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert D. Kuchta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3179-0239","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072243737","display_name":"Valerie Mizrahi","orcid":"https://orcid.org/0000-0003-4824-9115","observed_orcids":["https://orcid.org/0000-0003-4824-9115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie Mizrahi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4824-9115","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057047461","display_name":"Stephen J. Benkovic","orcid":"https://orcid.org/0000-0003-3680-3481","observed_orcids":["https://orcid.org/0000-0003-3680-3481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen J. Benkovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066251226","display_name":"Patricia A. Benkovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia A. Benkovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054934658","display_name":"Kenneth Allen Johnson","orcid":"https://orcid.org/0000-0002-6575-2823","observed_orcids":["https://orcid.org/0000-0002-6575-2823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth A. Johnson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6575-2823","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.00821685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.2838999927043915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.14659999310970306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-i","display_name":"DNA polymerase I","score":0.9229999780654907},{"id":"https://openalex.org/keywords/klenow-fragment","display_name":"Klenow fragment","score":1.0},{"id":"https://openalex.org/keywords/polymerization-kinetics","display_name":"polymerization kinetics","score":0.7599999904632568},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.5400000214576721},{"id":"https://openalex.org/keywords/pyrophosphorolysis","display_name":"pyrophosphorolysis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.6060000061988831},{"id":"https://openalex.org/keywords/dna-dissociation","display_name":"DNA dissociation","score":0.46399998664855957},{"id":"https://openalex.org/keywords/misincorporation","display_name":"misincorporation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/polymerase-fidelity","display_name":"polymerase fidelity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/exonuclease","display_name":"exonuclease","score":0.6710000038146973},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7160000205039978},{"id":"https://openalex.org/keywords/nucleotide-incorporation","display_name":"nucleotide incorporation","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C54415193","wikidata":"https://www.wikidata.org/wiki/Q424989","display_name":"Klenow fragment","level":5,"score":0.7607145309448242},{"id":"https://openalex.org/C164965036","wikidata":"https://www.wikidata.org/wiki/Q2529148","display_name":"DNA polymerase I","level":5,"score":0.703970193862915},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.6121487021446228},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5862172842025757},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5837209224700928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5699321031570435},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.5331420302391052},{"id":"https://openalex.org/C93391505","wikidata":"https://www.wikidata.org/wiki/Q658700","display_name":"Reaction rate constant","level":3,"score":0.5034636855125427},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.47667574882507324},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.4538522958755493},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.42508402466773987},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4176710844039917},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3476964831352234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19273248314857483},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.14611461758613586},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12318143248558044},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.06976598501205444},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:139877098","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6076401-kinetic-mechanism-dna-polymerase","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089898350","https://openalex.org/W1999052302","https://openalex.org/W2022280116","https://openalex.org/W1969826188","https://openalex.org/W1605800306","https://openalex.org/W1994304491","https://openalex.org/W2079457507","https://openalex.org/W2005591468","https://openalex.org/W2000034252","https://openalex.org/W2074507088"],"abstract_inverted_index":{"The":[0,63,108,133],"minimal":[1,38],"kinetic":[2],"scheme":[3,35,156],"for":[4,42,83,136],"DNA":[5,13,25,112,137],"polymerization":[6,71],"catalyzed":[7],"by":[8,68,88,129],"the":[9,43,46,69,89,104,124,148,162,172,179],"Klenow":[10],"fragment":[11],"of":[12,27,33,45,91,103,111,164],"polymerase":[14],"I":[15],"(KF)":[16],"from":[17,123,139],"E.":[18],"coli":[19],"has":[20],"been":[21],"determined":[22],"with":[23],"short":[24],"oligomers":[26],"defined":[28],"sequence.":[29],"A":[30],"key":[31],"feature":[32],"this":[34,84,155],"is":[36,65,86,141,152,168],"a":[37,74],"two":[39],"step":[40,76,175],"sequence":[41,85,142],"interconversion":[44],"ternary":[47],"KF":[48,55,140],"x":[49,52,56,59],"DNA/sub":[50,57],"n/":[51],"dNTP":[53,115],"and":[54,118,144,178],"n+1/":[58],"PP/sub":[60,119],"i/":[61,120],"complexes.":[62],"rate":[64,134,145,173],"not":[66,185],"limited":[67],"actual":[70],"process":[72],"but":[73],"separate":[75],"possibly":[77],"important":[78],"in":[79,94,171],"insuring":[80],"fidelity.":[81],"Evidence":[82],"supplied":[87],"observation":[90],"biphasic":[92],"kinetics":[93],"single-turnover":[95],"pyrophosphorolysis":[96],"experiments.":[97,132],"Data":[98],"analysis":[99],"provides":[100],"an":[101],"estimate":[102],"internal":[105],"equilibrium":[106],"constant.":[107],"dissociation":[109,138],"constants":[110],"(5":[113,116],"nM),":[114],"..mu..M)":[117,122],"(100":[121],"various":[125],"complexes":[126],"were":[127],"measured":[128],"isotope":[130],"trapping":[131],"constant":[135],"dependent":[143],"limiting":[146],"when":[147],"next":[149],"required":[150],"nucleotide":[151],"missing.":[153],"Finally,":[154],"can":[157],"be":[158],"used":[159],"to":[160],"describe":[161],"incorporation":[163],"incorrect":[165],"nucleotides;":[166],"there":[167],"no":[169],"change":[170],"determining":[174],"during":[176],"misincorporation,":[177],"3'":[180],"..-->..":[181],"5'":[182],"exonuclease":[183],"does":[184],"rapidly":[186],"remove":[187],"misincorporated":[188],"nucleotides.":[189]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
