{"id":"https://openalex.org/W139444150","doi":null,"title":"Exploring the synthetic possibilities and siRNA delivery potential of small molecule carriers (SMoCs)","display_name":"Exploring the synthetic possibilities and siRNA delivery potential of small molecule carriers (SMoCs)","publication_year":2011,"publication_date":"2011-10-28","ids":{"openalex":"https://openalex.org/W139444150","mag":"139444150"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1333223","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1333223/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005981140","display_name":"Matt Gooding","orcid":"https://orcid.org/0000-0002-4425-2221","observed_orcids":["https://orcid.org/0000-0002-4425-2221"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matt Gooding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4425-2221","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005981140"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.7649999856948853},{"id":"https://openalex.org/keywords/guanidine","display_name":"guanidine","score":0.5950000286102295},{"id":"https://openalex.org/keywords/alpha-helix-mimetics","display_name":"\u03b1-helix mimetics","score":0.8289999961853027},{"id":"https://openalex.org/keywords/penetratin","display_name":"penetratin","score":0.48399999737739563},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mrna-knockdown","display_name":"mRNA knockdown","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cation-pi-interactions","display_name":"cation-\u03c0 interactions","score":0.5989999771118164},{"id":"https://openalex.org/keywords/anion-binding","display_name":"anion binding","score":0.609000027179718},{"id":"https://openalex.org/keywords/proteoglycan-binding","display_name":"proteoglycan binding","score":0.7120000123977661},{"id":"https://openalex.org/keywords/targeting-peptides","display_name":"targeting peptides","score":0.6650000214576721},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6260632276535034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5989271998405457},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.594390332698822},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5815569758415222},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4984164237976074},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.496620237827301},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.49138155579566956},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4568314552307129},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.42874252796173096},{"id":"https://openalex.org/C2779463914","wikidata":"https://www.wikidata.org/wiki/Q183309","display_name":"Guanidine","level":2,"score":0.420343279838562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3917601704597473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3893562853336334},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31146758794784546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24840953946113586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18035423755645752}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1333223","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1333223/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:139444150","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1333223/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W14759517","https://openalex.org/W1491459594","https://openalex.org/W1538202910","https://openalex.org/W1554933414","https://openalex.org/W1571171030","https://openalex.org/W1584683177","https://openalex.org/W1611419331","https://openalex.org/W1647075334","https://openalex.org/W1655307540","https://openalex.org/W1819932851","https://openalex.org/W1877090369","https://openalex.org/W1916491745","https://openalex.org/W1963662573","https://openalex.org/W1964146045","https://openalex.org/W1964868149","https://openalex.org/W1967847890","https://openalex.org/W1971290197","https://openalex.org/W1971409649","https://openalex.org/W1971775991","https://openalex.org/W1971919281","https://openalex.org/W1972761175","https://openalex.org/W1973920331","https://openalex.org/W1973998666","https://openalex.org/W1974791635","https://openalex.org/W1976800296","https://openalex.org/W1977405363","https://openalex.org/W1979401775","https://openalex.org/W1979519758","https://openalex.org/W1979892746","https://openalex.org/W1982514381","https://openalex.org/W1985863961","https://openalex.org/W1987349623","https://openalex.org/W1987480666","https://openalex.org/W1987678987","https://openalex.org/W1987979592","https://openalex.org/W1988034490","https://openalex.org/W1988176449","https://openalex.org/W1988594716","https://openalex.org/W1989454102","https://openalex.org/W1990587707","https://openalex.org/W1991303534","https://openalex.org/W1994354502","https://openalex.org/W1994869675","https://openalex.org/W1995566893","https://openalex.org/W1996609303","https://openalex.org/W1996805840","https://openalex.org/W2000329862","https://openalex.org/W2000685834","https://openalex.org/W2000918892","https://openalex.org/W2001582257","https://openalex.org/W2003162601","https://openalex.org/W2006464022","https://openalex.org/W2007836674","https://openalex.org/W2007888673","https://openalex.org/W2010502236","https://openalex.org/W2010847164","https://openalex.org/W2011787057","https://openalex.org/W2014509855","https://openalex.org/W2015380256","https://openalex.org/W2016938173","https://openalex.org/W2017142348","https://openalex.org/W2017209720","https://openalex.org/W2019303202","https://openalex.org/W2019631541","https://openalex.org/W2021711447","https://openalex.org/W2023281720","https://openalex.org/W2023985105","https://openalex.org/W2025629542","https://openalex.org/W2027233992","https://openalex.org/W2028035233","https://openalex.org/W2029925140","https://openalex.org/W2030239964","https://openalex.org/W2034342858","https://openalex.org/W2034642422","https://openalex.org/W2035029137","https://openalex.org/W2035328561","https://openalex.org/W2035840418","https://openalex.org/W2037305018","https://openalex.org/W2038373216","https://openalex.org/W2038720675","https://openalex.org/W2040198233","https://openalex.org/W2042038841","https://openalex.org/W2042066381","https://openalex.org/W2042143995","https://openalex.org/W2046182857","https://openalex.org/W2046763396","https://openalex.org/W2048369172","https://openalex.org/W2050314347","https://openalex.org/W2051091654","https://openalex.org/W2054248976","https://openalex.org/W2054525948","https://openalex.org/W2056077842","https://openalex.org/W2062282451","https://openalex.org/W2062459882","https://openalex.org/W2062564039","https://openalex.org/W2063212792","https://openalex.org/W2063254598","https://openalex.org/W2065310958","https://openalex.org/W2066778206","https://openalex.org/W2070094134","https://openalex.org/W2070554638","https://openalex.org/W2070564266","https://openalex.org/W2073444234","https://openalex.org/W2074106269","https://openalex.org/W2075300550","https://openalex.org/W2075775518","https://openalex.org/W2077815376","https://openalex.org/W2077886045","https://openalex.org/W2079335891","https://openalex.org/W2080796053","https://openalex.org/W2081306620","https://openalex.org/W2083249633","https://openalex.org/W2084503634","https://openalex.org/W2084621409","https://openalex.org/W2086069830","https://openalex.org/W2088960285","https://openalex.org/W2089657872","https://openalex.org/W2091070751","https://openalex.org/W2091144383","https://openalex.org/W2092049057","https://openalex.org/W2092327932","https://openalex.org/W2092568903","https://openalex.org/W2093198351","https://openalex.org/W2095151181","https://openalex.org/W2099099776","https://openalex.org/W2102694589","https://openalex.org/W2105668301","https://openalex.org/W2108224709","https://openalex.org/W2110778333","https://openalex.org/W2111689106","https://openalex.org/W2116064503","https://openalex.org/W2116424844","https://openalex.org/W2117991391","https://openalex.org/W2119352721","https://openalex.org/W2121143857","https://openalex.org/W2125449455","https://openalex.org/W2125450037","https://openalex.org/W2125684318","https://openalex.org/W2126020016","https://openalex.org/W2127677388","https://openalex.org/W2128520971","https://openalex.org/W2128882718","https://openalex.org/W2130501958","https://openalex.org/W2131288855","https://openalex.org/W2131944695","https://openalex.org/W2131957545","https://openalex.org/W2134906786","https://openalex.org/W2135732933","https://openalex.org/W2137584261","https://openalex.org/W2137714257","https://openalex.org/W2139640647","https://openalex.org/W2141178875","https://openalex.org/W2141729181","https://openalex.org/W2143139841","https://openalex.org/W2144843461","https://openalex.org/W2149147994","https://openalex.org/W2156955518","https://openalex.org/W2157584018","https://openalex.org/W2159675169","https://openalex.org/W2160863389","https://openalex.org/W2161560970","https://openalex.org/W2162176191","https://openalex.org/W2166915947","https://openalex.org/W2167806590","https://openalex.org/W2169883424","https://openalex.org/W2171342228","https://openalex.org/W2242059436","https://openalex.org/W2335752216","https://openalex.org/W2937600279","https://openalex.org/W2949438911","https://openalex.org/W3148913165"],"related_works":["https://openalex.org/W2090429815","https://openalex.org/W1819932851","https://openalex.org/W1987480666","https://openalex.org/W2369899950","https://openalex.org/W3159733098","https://openalex.org/W1959978768","https://openalex.org/W1490477754","https://openalex.org/W2071557649","https://openalex.org/W2906867340","https://openalex.org/W2735374394"],"abstract_inverted_index":{"Delivery":[0],"of":[1,15,71,98,140,148,157,184,193,202,207,231,253,276,294,307],"proteins":[2,83],"and":[3,22,51,170,173,200,236,266,299],"nucleic":[4],"acids":[5],"into":[6,84,100,297],"cells":[7,101],"is":[8,87,114,291],"a":[9,118,124,175,218,260,273],"major":[10],"challenge":[11],"to":[12,28,34,67,79,104,116,130,144,153,159,171,196,224,282,285],"the":[13,69,72,96,146,149,155,191,198,251,270,286,305],"\\ndevelopment":[14,192],"biological":[16],"therapeutics.":[17],"Cell":[18],"penetrating":[19],"peptides":[20],"(CPPs)":[21],"\\ncationic":[23],"liposomes":[24],"have":[25,211],"been":[26,187,212,264],"shown":[27,78],"internalise":[29],"short":[30],"interfering":[31],"RNA":[32],"(siRNA)":[33],"\\nachieve":[35],"gene":[36],"silencing,":[37],"but":[38],"no":[39],"standard":[40],"reagent":[41],"exists":[42],"which":[43,127,178,221,268,279],"can":[44],"safely":[45],"deliver":[46],"\\nmacromolecules":[47],"both":[48],"in":[49,52,65,102,121,151,272],"vitro":[50],"vivo.":[53],"Small":[54],"Molecule":[55],"Carriers":[56],"(SMoCs)":[57],"are":[58,143,280],"\\namphipathic":[59],"\u03b1-helix":[60],"mimetics":[61],"displaying":[62],"guanidine":[63],"groups":[64],"order":[66,103,152],"mimic":[68],"\\nstructure":[70],"CPP":[73,122],"penetratin.":[74],"Previously,":[75],"SMoCs":[76,90,150,162,185,208,254,278],"were":[77],"effectively":[80],"\\ndeliver":[81],"active":[82],"cells.":[85],"It":[86],"hypothesized":[88],"that":[89,161],"may":[91,132,163,222,300],"also":[92,292,301],"be":[93,117,133,164,302],"applied":[94],"\\nto":[95,216],"delivery":[97,257],"siRNA":[99,167,180,210,256,296],"knockdown":[105],"target":[106],"genes.":[107],"In":[108],"addition,":[109],"\\nsince":[110],"cell":[111,287],"surface":[112],"binding":[113,129,232,284],"thought":[115],"crucial":[119],"step":[120],"internalisation,":[123],"new":[125,176,194,274],"\\nSMoC":[126],"optimises":[128],"proteoglycans":[131],"more":[134],"efficiently":[135],"taken":[136],"up.":[137],"\\nThe":[138],"aims":[139],"this":[141],"thesis":[142],"optimise":[145],"synthesis":[147,183],"\\nincrease":[154],"quantity":[156],"product;":[158],"demonstrate":[160],"used":[165],"as":[166,227,229,255],"\\ndelivery":[168],"agents;":[169],"design":[172],"synthesize":[174],"SMoC":[177,262,290],"maximises":[179],"\\nuptake.":[181],"The":[182,204],"has":[186,263],"significantly":[188],"enhanced,":[189],"with":[190,209],"reagents":[195],"improve":[197],"yields":[199],"cost":[201],"production.":[203],"\\nelectrostatic":[205],"interactions":[206],"characterised,":[213],"using":[214,234,242],"NMR":[215],"examine":[217],"\u03c0-cation":[219],"interaction":[220],"contribute":[223],"anion":[225],"binding,":[226],"well":[228],"\\ndetermination":[230],"affinities":[233],"ITC":[235],"gel":[237],"shift":[238],"assays.":[239],"Initial":[240],"\\nexperiments":[241],"SMoC-siRNA":[243],"complexes":[244],"show":[245],"significant":[246],"mRNA":[247],"knowdown":[248],"\\nwhich":[249],"demonstrates":[250],"potential":[252],"vectors.":[258],"Finally,":[259],"\\nnew":[261],"designed":[265,281],"synthesized":[267],"represents":[269],"first":[271],"\\nclass":[275],"dendritic":[277],"maximise":[283],"surface.":[288],"\\nThis":[289],"capable":[293],"delivering":[295],"cells,":[298],"expanded":[303],"\\nby":[304],"addition":[306],"targeting":[308],"peptides.":[309]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}