{"id":"https://openalex.org/W139342771","doi":null,"title":"Undifferentiated connective tissue diseases in 2004.","display_name":"Undifferentiated connective tissue diseases in 2004.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W139342771","mag":"139342771","pmid":"https://pubmed.ncbi.nlm.nih.gov/15344591"},"language":"en","primary_location":{"id":"pmid:15344591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15344591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057848064","display_name":"Marta Mosca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Mosca","raw_affiliation_strings":["Department of Internal Medicine, University of Pisa, Italy. marta.mosca@int.med.unipi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pisa, Italy. marta.mosca@int.med.unipi.it","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060947425","display_name":"Chiara Baldini","orcid":"https://orcid.org/0000-0002-4454-1824","observed_orcids":["https://orcid.org/0000-0002-4454-1824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Baldini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101579609","display_name":"Stefano Bombardieri","orcid":"https://orcid.org/0000-0002-3878-5216","observed_orcids":["https://orcid.org/0000-0002-3878-5216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Bombardieri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8403,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.71693069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"3 Suppl 33","first_page":"S14","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.38260000944137573,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/undifferentiated-connective-tissue-disease","display_name":"undifferentiated connective tissue disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.9079999923706055},{"id":"https://openalex.org/keywords/classification-criteria","display_name":"classification criteria","score":0.7329999804496765},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8009999990463257},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.527999997138977},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/autoimmune-disease-pathogenesis","display_name":"autoimmune disease pathogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2778962941","wikidata":"https://www.wikidata.org/wiki/Q16543725","display_name":"Undifferentiated connective tissue disease","level":5,"score":0.9233075380325317},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8289281129837036},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.666248083114624},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.6422902941703796},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.6309117078781128},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6088187098503113},{"id":"https://openalex.org/C125533998","wikidata":"https://www.wikidata.org/wiki/Q1024499","display_name":"CTD","level":2,"score":0.506466269493103},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38648369908332825},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.36283165216445923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3582736849784851},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1195211112499237},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003240","descriptor_name":"Connective Tissue Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003240","descriptor_name":"Connective Tissue Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15344591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15344591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/202180","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/202180","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:139342771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15344591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W60626254","https://openalex.org/W128163258","https://openalex.org/W181297611","https://openalex.org/W184510336","https://openalex.org/W1776904414","https://openalex.org/W2048002756","https://openalex.org/W2052513122","https://openalex.org/W2063072887","https://openalex.org/W2070448964","https://openalex.org/W2070527591","https://openalex.org/W2095732560","https://openalex.org/W2105834963","https://openalex.org/W2112888006","https://openalex.org/W2120773157","https://openalex.org/W2137523132","https://openalex.org/W2146203649","https://openalex.org/W2152348310","https://openalex.org/W2314311014","https://openalex.org/W2394595131","https://openalex.org/W2399667138","https://openalex.org/W2405779569","https://openalex.org/W2414528274","https://openalex.org/W2414614894","https://openalex.org/W2417377791"],"related_works":["https://openalex.org/W7097725779","https://openalex.org/W2085191520","https://openalex.org/W2146024190","https://openalex.org/W2124153781","https://openalex.org/W1776904414","https://openalex.org/W3135669504","https://openalex.org/W2010131505","https://openalex.org/W2032077020","https://openalex.org/W73935090","https://openalex.org/W6987741408"],"abstract_inverted_index":{"The":[0,30],"existence":[1],"of":[2,9,33,55,90,107,133,190,196,210,239],"patients":[3,91,134],"with":[4,92],"signs":[5],"and":[6,141,148,151,156,168,206,226,228,237],"symptoms":[7],"suggestive":[8],"a":[10,24,88,105,115,138,152],"systemic":[11],"autoimmune":[12,211],"disease":[13,75,119,204],"but":[14],"not":[15,136],"fulfilling":[16],"the":[17,43,52,74,82,174,188,194,203,207,235,240],"classification":[18,243],"criteria":[19],"for":[20,187],"defined":[21,139,159],"diseases":[22,35,58,126],"is":[23,170],"common":[25],"experience":[26,104],"in":[27,72],"clinical":[28,147,178,185],"practice.":[29],"first":[31],"description":[32],"these":[34,143,160],"dates":[36],"back":[37],"to":[38,50,67,86,114,131,233],"1980,":[39],"when":[40],"LeRoy":[41,79],"proposed":[42],"term":[44],"\"Undifferentiated":[45],"Connective":[46,164],"Tissue":[47,165],"Syndromes\"":[48],"(UCTS)":[49],"define":[51],"early":[53],"phases":[54],"connective":[56,117],"tissue":[57,118],"that":[59,129,142,173],"at":[60],"their":[61,98,224],"onset":[62],"are":[63],"undefined,":[64],"as":[65,85,162,200],"opposed":[66],"mixed":[68],"or":[69,102],"overlapping":[70],"syndromes":[71],"which":[73],"appears":[76],"well":[77],"defined.":[78],"also":[80],"raised":[81],"fundamental":[83],"question":[84],"whether":[87],"proportion":[89],"an":[93,183],"undifferentiated":[94,101,125],"profile":[95],"may":[96],"see":[97],"condition":[99],"remain":[100],"even":[103],"remission":[106],"all":[108],"pathologic":[109],"features,":[110],"rather":[111],"than":[112],"evolving":[113],"definite":[116],"(CTD).":[120],"Many":[121],"studies":[122,229],"conducted":[123],"on":[124,202],"have":[127,158],"shown":[128],"up":[130],"75%":[132],"will":[135,230],"develop":[137],"CTD":[140],"conditions":[144,161],"exhibit":[145],"typical":[146],"serological":[149],"manifestations":[150],"good":[153],"prognosis.":[154],"We":[155],"others":[157],"Undifferentiated":[163],"Diseases":[166],"(UCTD)":[167],"it":[169],"our":[171],"opinion":[172],"UCTD":[175,180],"represent":[176],"distinct":[177],"entites.":[179],"could":[181],"offer":[182],"ideal":[184],"model":[186],"study":[189],"single":[191],"autoantibody":[192],"specificities,":[193],"effects":[195],"various":[197],"factors":[198],"(such":[199],"pregnancy)":[201],"course,":[205],"general":[208],"pathogenesis":[209],"conditions.":[212],"Before":[213],"they":[214],"can":[215],"be":[216,221,231],"so":[217],"used,":[218],"more":[219],"must":[220],"discovered":[222],"about":[223],"nature":[225],"characteristics,":[227],"necessary":[232],"improve":[234],"sensitivity":[236],"specificity":[238],"existing":[241],"preliminary":[242],"criteria.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}