{"id":"https://openalex.org/W138588639","doi":null,"title":"Proteomics in biomarker research : Insights into the effects of aging and environment on biological systems","display_name":"Proteomics in biomarker research : Insights into the effects of aging and environment on biological systems","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W138588639","mag":"138588639"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-56483","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059753521","display_name":"Hanna Amelina","orcid":"https://orcid.org/0000-0002-9006-9217","observed_orcids":["https://orcid.org/0000-0002-9006-9217"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hanna Amelina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9006-9217","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059753521"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8980000019073486},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9800000190734863},{"id":"https://openalex.org/keywords/environmental-pollution","display_name":"environmental pollution","score":0.9160000085830688},{"id":"https://openalex.org/keywords/marine-pollution","display_name":"marine pollution","score":0.9330000281333923},{"id":"https://openalex.org/keywords/kidney-proteome","display_name":"kidney proteome","score":0.8130000233650208},{"id":"https://openalex.org/keywords/liver-proteome","display_name":"liver proteome","score":0.7749999761581421},{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/itraq","display_name":"iTRAQ","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.8199999928474426},{"id":"https://openalex.org/keywords/protein-delivery","display_name":"protein delivery","score":0.7429999709129333},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.4230000078678131},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.6380000114440918},{"id":"https://openalex.org/keywords/gender-differences","display_name":"gender differences","score":0.5799999833106995},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7937862873077393},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5581503510475159},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5303747653961182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4118023216724396},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3399164080619812},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3369028568267822},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3245399296283722},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10110121965408325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-56483","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:138588639","doi":null,"is_oa":false,"landing_page_url":"https://su.diva-portal.org/smash/record.jsf?pid=diva2:411567","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-56483","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W9262937","https://openalex.org/W44858067","https://openalex.org/W115161277","https://openalex.org/W1496939833","https://openalex.org/W1533171028","https://openalex.org/W1545328514","https://openalex.org/W1550351158","https://openalex.org/W1574601702","https://openalex.org/W1584683177","https://openalex.org/W1591583672","https://openalex.org/W1597678601","https://openalex.org/W1600871831","https://openalex.org/W1606423922","https://openalex.org/W1898218536","https://openalex.org/W1909936605","https://openalex.org/W1914116854","https://openalex.org/W1964831752","https://openalex.org/W1965806060","https://openalex.org/W1966023540","https://openalex.org/W1967609695","https://openalex.org/W1971704699","https://openalex.org/W1972461735","https://openalex.org/W1972791227","https://openalex.org/W1973332943","https://openalex.org/W1974830441","https://openalex.org/W1975558168","https://openalex.org/W1981109259","https://openalex.org/W1982499813","https://openalex.org/W1984228258","https://openalex.org/W1987137829","https://openalex.org/W1988556197","https://openalex.org/W1993715367","https://openalex.org/W1994150194","https://openalex.org/W1995436480","https://openalex.org/W1998116653","https://openalex.org/W1999616914","https://openalex.org/W1999676604","https://openalex.org/W2000652492","https://openalex.org/W2001582257","https://openalex.org/W2002381116","https://openalex.org/W2002899427","https://openalex.org/W2008442219","https://openalex.org/W2008576706","https://openalex.org/W2008588453","https://openalex.org/W2014578307","https://openalex.org/W2015321260","https://openalex.org/W2019584119","https://openalex.org/W2023096047","https://openalex.org/W2026029194","https://openalex.org/W2028931227","https://openalex.org/W2029846915","https://openalex.org/W2030389371","https://openalex.org/W2030694040","https://openalex.org/W2031475765","https://openalex.org/W2034512598","https://openalex.org/W2035826410","https://openalex.org/W2035870580","https://openalex.org/W2037765889","https://openalex.org/W2039213813","https://openalex.org/W2042143995","https://openalex.org/W2044033722","https://openalex.org/W2044287438","https://openalex.org/W2047330128","https://openalex.org/W2048280438","https://openalex.org/W2048760229","https://openalex.org/W2049263920","https://openalex.org/W2050880521","https://openalex.org/W2053196299","https://openalex.org/W2053697292","https://openalex.org/W2054218003","https://openalex.org/W2055063265","https://openalex.org/W2055753513","https://openalex.org/W2060881889","https://openalex.org/W2060909570","https://openalex.org/W2061861550","https://openalex.org/W2063001525","https://openalex.org/W2067025010","https://openalex.org/W2067074165","https://openalex.org/W2067507317","https://openalex.org/W2068317646","https://openalex.org/W2068359657","https://openalex.org/W2068413443","https://openalex.org/W2073292063","https://openalex.org/W2073352191","https://openalex.org/W2076077839","https://openalex.org/W2076875064","https://openalex.org/W2077248448","https://openalex.org/W2077956068","https://openalex.org/W2079720946","https://openalex.org/W2080971086","https://openalex.org/W2082060324","https://openalex.org/W2084813091","https://openalex.org/W2088412300","https://openalex.org/W2089939834","https://openalex.org/W2090230645","https://openalex.org/W2090311725","https://openalex.org/W2092000721","https://openalex.org/W2093828656","https://openalex.org/W2096316787","https://openalex.org/W2098334905","https://openalex.org/W2099516648","https://openalex.org/W2102125805","https://openalex.org/W2107417172","https://openalex.org/W2109156884","https://openalex.org/W2110065044","https://openalex.org/W2111208057","https://openalex.org/W2111882191","https://openalex.org/W2111994795","https://openalex.org/W2113288814","https://openalex.org/W2114108892","https://openalex.org/W2115105586","https://openalex.org/W2116577297","https://openalex.org/W2116951302","https://openalex.org/W2117517043","https://openalex.org/W2118493278","https://openalex.org/W2118577784","https://openalex.org/W2120016245","https://openalex.org/W2121418514","https://openalex.org/W2124523818","https://openalex.org/W2128432283","https://openalex.org/W2128969781","https://openalex.org/W2130381045","https://openalex.org/W2130669719","https://openalex.org/W2131150217","https://openalex.org/W2131865610","https://openalex.org/W2132762612","https://openalex.org/W2134389439","https://openalex.org/W2140946052","https://openalex.org/W2140985419","https://openalex.org/W2143079975","https://openalex.org/W2144109599","https://openalex.org/W2146264968","https://openalex.org/W2146548905","https://openalex.org/W2147507661","https://openalex.org/W2154787199","https://openalex.org/W2155676135","https://openalex.org/W2159803276","https://openalex.org/W2161574105","https://openalex.org/W2164639151","https://openalex.org/W2165469555","https://openalex.org/W2165656077","https://openalex.org/W2166998713","https://openalex.org/W2169251214","https://openalex.org/W2170566884","https://openalex.org/W2170949754","https://openalex.org/W2171160963","https://openalex.org/W2231081458","https://openalex.org/W2410317566","https://openalex.org/W2411969813","https://openalex.org/W2413107236","https://openalex.org/W2912078763","https://openalex.org/W2949661493","https://openalex.org/W2965858921","https://openalex.org/W3148913165","https://openalex.org/W3191603679"],"related_works":["https://openalex.org/W2450072","https://openalex.org/W2014001445","https://openalex.org/W1998116653","https://openalex.org/W1482911989","https://openalex.org/W3097973013","https://openalex.org/W2124346263","https://openalex.org/W2126725013","https://openalex.org/W2298326695","https://openalex.org/W2038762626","https://openalex.org/W1594939251"],"abstract_inverted_index":{"Proteomics":[0],"is":[1,54,279],"the":[2,17,25,42,46,99,114,145,163,200,208,270,287,293,302,331,345],"global":[3],"analysis":[4],"of":[5,12,21,45,81,101,135,147,165,170,180,191,203,210,289,295,304,333,348],"proteins":[6,22,252],"that":[7,73,266,276,325],"covers":[8],"a":[9,117,151,174,176,216,319,342],"broad":[10],"range":[11,202],"technologies":[13],"aimed":[14],"at":[15],"determining":[16],"identity":[18],"and":[19,30,66,90,93,106,206,227,235,292,337],"quantity":[20],"expressed":[23],"in":[24,150,167,188,244,257,269,286,297,338],"cell,":[26,47],"their":[27],"three-dimensional":[28],"structure":[29],"interaction":[31],"partners.":[32],"In":[33,84,113,195],"contrast":[34],"to":[35,58,97,126,144,161,197,232,240,335],"genome,":[36],"proteome":[37,189,272,278],"reflects":[38],"more":[39],"accurately":[40],"on":[41,122],"dynamic":[43,201],"state":[44],"tissue,":[48],"or":[49,78],"an":[50],"organism.":[51],"Therefore":[52],"much":[53],"expected":[55],"from":[56,247],"proteomics":[57],"yield":[59],"better":[60],"disease":[61],"markers":[62],"for":[63,225,310,330,344],"early":[64],"diagnosis":[65],"therapy":[67,347],"monitoring,":[68],"as":[69,71,103,105,308,318],"well":[70,104],"biomarkers":[72],"would":[74],"indicate":[75],"environmental":[76,107],"exposure":[77],"provide":[79,341],"prediction":[80],"biological":[82],"age.":[83,284],"this":[85,136,158],"thesis,":[86],"I":[87,155,213,299],"have":[88,156,214,300],"developed":[89],"applied":[91,215],"robust":[92],"sensitive":[94],"subproteomic":[95,159],"approaches":[96],"study":[98,162,241,264],"effect":[100,164],"aging":[102,166,181,192,290],"pollution":[108,149],"using":[109,222,316],"different":[110],"animal":[111],"models.":[112],"first":[115],"part,":[116],"high-throughput":[118],"proteomic":[119,211,220],"method":[120,137],"based":[121],"liquid":[123,233],"chromatography":[124,234],"coupled":[125,231],"2-dimensional":[127],"gel":[128],"electrophoresis":[129],"(LC/2-DE)":[130],"was":[131,183],"developed.":[132],"The":[133,321],"usefulness":[134],"has":[138],"been":[139],"demonstrated":[140],"by":[141],"applying":[142],"it":[143],"assessment":[146],"marine":[148],"field":[152],"experiment.":[153],"Next,":[154],"utilized":[157],"approach":[160,221],"mouse":[168,193,248],"kidney":[169,182],"both":[171],"genders.":[172],"As":[173],"result,":[175],"protein":[177,204,311,346],"expression":[178,205,258],"signature":[179],"obtained,":[184],"revealing":[185],"gender-dependent":[186],"alterations":[187],"profiles":[190],"kidney.":[194],"order":[196],"further":[198],"reduce":[199],"increase":[207],"sensitivity":[209],"analysis,":[212],"shotgun":[217],"mass":[218,237],"spectrometry-based":[219],"isobaric":[223],"tags":[224],"relative":[226],"absolute":[228],"quantification":[229],"(iTRAQ)":[230],"tandem":[236],"spectrometry":[238],"(LC-MS/MS)":[239],"age-related":[242,349],"differences":[243],"peroxisome-enriched":[245],"fractions":[246],"liver.":[249],"Only":[250],"eight":[251],"showed":[253],"statistically":[254],"significant":[255],"difference":[256],"(p<0.05)":[259],"with":[260],"moderate":[261],"folds.":[262],"This":[263],"indicates":[265],"age-depended":[267],"changes":[268],"liver":[271],"are":[273],"minimal,":[274],"suggesting":[275],"its":[277],"efficiently":[280],"maintained":[281],"until":[282],"certain":[283],"Finally,":[285],"context":[288],"studies":[291],"role":[294],"peroxisomes":[296,315,336],"aging,":[298],"tested":[301],"utility":[303],"cell-penetrating":[305],"peptides":[306],"(CPPs)":[307],"agents":[309],"delivery":[312,332],"into":[313],"acatalasemic":[314],"yeast":[317],"model.":[320],"results":[322],"obtained":[323],"suggest":[324],"CPPs":[326],"may":[327],"be":[328],"suitable":[329],"antioxidants":[334],"future":[339],"could":[340],"tool":[343],"diseases.":[350]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
