{"id":"https://openalex.org/W138554334","doi":"https://doi.org/10.1152/ajpcell.1987.253.2.c230","title":"High NaCl induces stable changes in phenotype and karyotype of renal cells in culture","display_name":"High NaCl induces stable changes in phenotype and karyotype of renal cells in culture","publication_year":1987,"publication_date":"1987-08-01","ids":{"openalex":"https://openalex.org/W138554334","doi":"https://doi.org/10.1152/ajpcell.1987.253.2.c230","mag":"138554334","pmid":"https://pubmed.ncbi.nlm.nih.gov/3303963"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1987.253.2.c230","doi":"https://doi.org/10.1152/ajpcell.1987.253.2.c230","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1987.253.2.c230","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008201708","display_name":"Shunya Uchida","orcid":"https://orcid.org/0000-0002-0480-4212","observed_orcids":["https://orcid.org/0000-0002-0480-4212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Uchida","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080249380","display_name":"N. Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Green","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074330016","display_name":"HAYDEN G. COON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Coon","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074799995","display_name":"T. J. Triche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Triche","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111963261","display_name":"Steven D. Mims","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Mims","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Burg","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5151,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.82042856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"253","issue":"2","first_page":"C230","last_page":"C242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperosmotic-adaptation","display_name":"hyperosmotic adaptation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/osmolality","display_name":"osmolality","score":0.6600000262260437},{"id":"https://openalex.org/keywords/karyotype-changes","display_name":"karyotype changes","score":0.6819999814033508},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/multinucleation","display_name":"multinucleation","score":0.859000027179718},{"id":"https://openalex.org/keywords/cell-phenotype","display_name":"cell phenotype","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cloning-efficiency","display_name":"cloning efficiency","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.8526160717010498},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6143983006477356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.598074734210968},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.5148331522941589},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47615692019462585},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.43707507848739624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4230494797229767},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4147789478302002},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4137156307697296},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36870068311691284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30465710163116455},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.19614669680595398},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17611795663833618},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16168609261512756}],"mesh":[{"descriptor_ui":"D000073718","descriptor_name":"Pancreatitis-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1987.253.2.c230","doi":"https://doi.org/10.1152/ajpcell.1987.253.2.c230","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1987.253.2.c230","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:3303963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3303963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W130130137","https://openalex.org/W1577149434","https://openalex.org/W1967159904","https://openalex.org/W1981305491","https://openalex.org/W2004952617","https://openalex.org/W2010092699","https://openalex.org/W2033935839","https://openalex.org/W2035489393","https://openalex.org/W2056107617","https://openalex.org/W2059080130","https://openalex.org/W2095043535","https://openalex.org/W2170418964"],"related_works":["https://openalex.org/W2414649657","https://openalex.org/W1996648108","https://openalex.org/W2415951527","https://openalex.org/W2127787895","https://openalex.org/W2201211593","https://openalex.org/W2098849975","https://openalex.org/W1978552021","https://openalex.org/W2081557478","https://openalex.org/W2160933716","https://openalex.org/W2050566272"],"abstract_inverted_index":{"Extracellular":[0],"fluid":[1],"in":[2,31,73,81,109,136,169,176,190,201,209],"the":[3,50,95,144,173,182],"renal":[4,21],"medulla":[5],"normally":[6],"is":[7,47],"hyperosmotic.":[8],"To":[9],"test":[10],"adaptation":[11,142],"to":[12,36,56,141,150,181,188],"such":[13],"an":[14],"environment,":[15],"a":[16,37,103,153],"continuous":[17],"line":[18],"of":[19,44,102,143,146,152,155],"rabbit":[20],"inner":[22],"medullary":[23],"epithelial":[24],"cells":[25,46,62,123,128,147,156,213],"(GRB-PAP1),":[26],"which":[27],"had":[28],"been":[29],"established":[30],"isosmotic":[32,82,170],"medium,":[33,171],"was":[34,52,97,163],"switched":[35],"medium":[38,85,111,184],"containing":[39],"high":[40],"NaCl.":[41],"The":[42,91,131],"origin":[43],"these":[45,159,195],"described.":[48],"When":[49],"osmolality":[51],"raised":[53],"from":[54],"300":[55],"600":[57],"mosmol/kg":[58],"by":[59],"adding":[60],"NaCl,":[61],"eventually":[63],"survived":[64],"and":[65,75,115,148],"proliferated,":[66],"but":[67,172],"unexpectedly,":[68],"they":[69,134],"underwent":[70],"major":[71],"changes":[72,96,196],"phenotype":[74],"karyotype":[76],"that":[77,107,194],"persisted":[78],"during":[79],"proliferation":[80],"or":[83],"hyperosmotic":[84,110,177,183,215],"for":[86,94,165],"at":[87],"least":[88],"7":[89],"months.":[90],"threshold":[92],"concentration":[93],"approximately":[98],"500":[99],"mosmol/kg.":[100],"Cells":[101],"typical":[104],"strain":[105],"(PAP-HT25)":[106],"formed":[108],"were":[112,120,124,129,139],"much":[113],"larger":[114],"more":[116],"often":[117],"multinucleated":[118],"than":[119,167],"GRB-PAP1.":[121],"GRB-PAP1":[122,166],"near":[125],"diploid;":[126],"PAP-HT25":[127,168],"polyploid.":[130],"changes,":[132],"since":[133],"occurred":[135,175],"most":[137],"clones,":[138],"due":[140],"majority":[145],"not":[149],"selection":[151],"minority":[154],"already":[157],"having":[158],"characteristics.":[160],"Cloning":[161],"efficiency":[162],"higher":[164],"reverse":[174],"medium.":[178],"Thus":[179],"exposure":[180],"induced":[185],"greater":[186],"ability":[187],"clone":[189],"it.":[191],"We":[192],"suggest":[193],"may":[197],"involve":[198],"persistent":[199],"alterations":[200],"gene":[202],"regulation,":[203],"possibly":[204],"like":[205],"those":[206],"previously":[207],"reported":[208],"chicken":[210],"embryo":[211],"fibroblast":[212],"after":[214],"NaCl":[216],"(Cell":[217],"30:":[218],"131-139,":[219],"1982).":[220]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
