{"id":"https://openalex.org/W138387108","doi":"https://doi.org/10.1182/blood.v29.2.214.214","title":"Chromosomal Aberrations Common to Three Types of Monoclonal Gammopathies","display_name":"Chromosomal Aberrations Common to Three Types of Monoclonal Gammopathies","publication_year":1967,"publication_date":"1967-02-01","ids":{"openalex":"https://openalex.org/W138387108","doi":"https://doi.org/10.1182/blood.v29.2.214.214","mag":"138387108","pmid":"https://pubmed.ncbi.nlm.nih.gov/4164446"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v29.2.214.214","doi":"https://doi.org/10.1182/blood.v29.2.214.214","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v29.2.214.214","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020057141","display_name":"Elsie W. Houston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELSIE W. HOUSTON","raw_affiliation_strings":["Department of Medicine, the Hematology Research Laboratory, and the Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","Hematology Research Laboratory, Department of Medicine, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, the Hematology Research Laboratory, and the Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Hematology Research Laboratory, Department of Medicine, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111491448","display_name":"Stephan E. Ritzmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHAN E. RITZMANN","raw_affiliation_strings":["Department of Medicine, the Hematology Research Laboratory, and the Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","Research Associate Professor of Medicine and Director, Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, the Hematology Research Laboratory, and the Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Research Associate Professor of Medicine and Director, Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":null,"display_name":"WILLIAM C. LEVIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800697196","display_name":"John Sealy Hospital","ror":"https://ror.org/02fxjt553","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800697196"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM C. LEVIN","raw_affiliation_strings":["Department of Medicine, the Hematology Research Laboratory, and the Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","John Sealy Hospital Blood Bank and Hematology Research Laboratory, Department of Medicine, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, the Hematology Research Laboratory, and the Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"John Sealy Hospital Blood Bank and Hematology Research Laboratory, Department of Medicine, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I2800697196","https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":7.0537,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.96599154,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"2","first_page":"214","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immunoglobulin-m","display_name":"immunoglobulin M","score":0.5260000228881836},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immunoglobulin-a","display_name":"immunoglobulin A","score":0.9760000109672546},{"id":"https://openalex.org/keywords/primary-macroglobulinemia","display_name":"primary macroglobulinemia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.7694176435470581},{"id":"https://openalex.org/C2776407475","wikidata":"https://www.wikidata.org/wiki/Q1981783","display_name":"Pathognomonic","level":3,"score":0.7485722303390503},{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.5527832508087158},{"id":"https://openalex.org/C2909682104","wikidata":"https://www.wikidata.org/wiki/Q4301818","display_name":"Paraproteinemias","level":5,"score":0.5451655983924866},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.5161556005477905},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.48694145679473877},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.46589434146881104},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4460318684577942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42557424306869507},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3866967558860779},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3614668846130371},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35677510499954224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34029656648635864},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.31866317987442017},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2604714035987854},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.16505646705627441},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12699079513549805},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11281925439834595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001796","descriptor_name":"Blood Protein Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v29.2.214.214","doi":"https://doi.org/10.1182/blood.v29.2.214.214","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v29.2.214.214","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:4164446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4164446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.981.36","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.981.36","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bloodjournal.org/content/bloodjournal/29/2/214.full.pdf?sso-checked%3Dtrue","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W106229540","https://openalex.org/W1623977612","https://openalex.org/W1925935711","https://openalex.org/W1965249340","https://openalex.org/W2005734626","https://openalex.org/W2013199096","https://openalex.org/W2015355733","https://openalex.org/W2019644269","https://openalex.org/W2027574956","https://openalex.org/W2030311518","https://openalex.org/W2031494231","https://openalex.org/W2033867025","https://openalex.org/W2040008335","https://openalex.org/W2041787837","https://openalex.org/W2042044480","https://openalex.org/W2049638178","https://openalex.org/W2050361501","https://openalex.org/W2054081139","https://openalex.org/W2060394965","https://openalex.org/W2067689361","https://openalex.org/W2067986706","https://openalex.org/W2078789433","https://openalex.org/W2091190628","https://openalex.org/W2106241583","https://openalex.org/W2110185800","https://openalex.org/W2218853694","https://openalex.org/W2230865558","https://openalex.org/W2293002065","https://openalex.org/W2395052250","https://openalex.org/W2412584211","https://openalex.org/W2415852041","https://openalex.org/W2417831152","https://openalex.org/W2418072744","https://openalex.org/W2428218157","https://openalex.org/W2440167755"],"related_works":["https://openalex.org/W7097076548","https://openalex.org/W2411064479","https://openalex.org/W2388193850","https://openalex.org/W2060394965","https://openalex.org/W4410240496","https://openalex.org/W138362336","https://openalex.org/W2205683412","https://openalex.org/W972416640","https://openalex.org/W7096587140","https://openalex.org/W2520968559"],"abstract_inverted_index":{"Abstract":[0],"1.":[1],"Chromosomal":[2],"patterns":[3],"in":[4,23,32,42,49,57,65,84,88,93,104],"24":[5],"patients":[6,46,53,61],"with":[7,47,54,62,90,95,101],"\u03b3G-,":[8],"\u03b3A-":[9],"and":[10,56,92,108,113],"\u03b3M-type":[11],"monoclonal":[12,28,133],"gammopathies":[13],"(MG)":[14],"are":[15],"described.":[16],"2.":[17],"Significant":[18],"chromosomal":[19,102,122],"abnormalities":[20,116,123],"were":[21,40,82],"observed":[22],"all":[24,85],"three":[25,50,52,130],"types":[26,131],"of":[27,44,51,59,74,132],"gammopathies.":[29],"Abnormal":[30],"chromosomes":[31,70],"the":[33,66,114,129],"AB":[34],"size":[35],"range,":[36],"or":[37,79,139],"larger":[38],"(MG-chromosomes),":[39],"present":[41],"five":[43],"seven":[45,58],"\u03b3M-MG,":[48],"\u03b3A-MG":[55,91],"14":[60],"\u03b3G-MG.":[63,96],"Abnormalities":[64],"smallest":[67],"group":[68],"C":[69],"(pair":[71],"12),":[72],"consisting":[73],"missing":[75],"chromosomes,":[76,78],"extra":[77],"structural":[80],"anomalies,":[81],"noted":[83],"\u03b3M-MG":[86],"patients,":[87],"two":[89],"eight":[94],"3.":[97],"The":[98],"literature":[99],"dealing":[100],"aberrations":[103],"primary":[105],"macroglobulinemia":[106],"(Waldenstro\u0308m)":[107],"myeloma":[109],"has":[110],"been":[111,118],"reviewed,":[112],"various":[115],"have":[117],"discussed.":[119],"4.":[120],"These":[121],"suggest":[124],"a":[125],"common":[126],"denominator":[127],"for":[128],"gammopathies,":[134],"without":[135],"implying":[136],"either":[137],"etiologic":[138],"pathognomonic":[140],"specificity.":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}