{"id":"https://openalex.org/W137754632","doi":null,"title":"Physiology of the medial frontal cortex during decision-making in adult and senescent rats","display_name":"Physiology of the medial frontal cortex during decision-making in adult and senescent rats","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W137754632","mag":"137754632"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/196140","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/196140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062306809","display_name":"Nathan Insel","orcid":"https://orcid.org/0000-0001-5477-9716","observed_orcids":["https://orcid.org/0000-0001-5477-9716"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nathan Insel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5477-9716","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062306809"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.21060000360012054,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dorsomedial-prefrontal-cortex","display_name":"dorsomedial prefrontal cortex","score":0.9610000252723694},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.9860000014305115},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9629999995231628},{"id":"https://openalex.org/keywords/gamma-oscillations","display_name":"gamma oscillations","score":0.9300000071525574},{"id":"https://openalex.org/keywords/theta-oscillations","display_name":"theta oscillations","score":0.9570000171661377},{"id":"https://openalex.org/keywords/local-field-potentials","display_name":"local field potentials","score":0.8019999861717224},{"id":"https://openalex.org/keywords/single-unit-activity","display_name":"single-unit activity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/goal-directed-action","display_name":"goal-directed action","score":0.7459999918937683},{"id":"https://openalex.org/keywords/action-selection","display_name":"action selection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/neural-coding","display_name":"neural coding","score":0.5979999899864197},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.6890000104904175},{"id":"https://openalex.org/keywords/error-trials","display_name":"error trials","score":0.5680000185966492},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2983163835","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal cortex","level":2,"score":0.5804319381713867},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5695092082023621},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4479557275772095},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4367578625679016},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.42180415987968445},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.349963903427124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33775901794433594}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/196140","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/196140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.471.7658","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.471.7658","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://arizona.openrepository.com/arizona/bitstream/10150/196140/1/azu_etd_11394_sip1_m.pdf","raw_type":"text"},{"id":"mag:137754632","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/196140","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969825312","https://openalex.org/W4415216928","https://openalex.org/W4399018289","https://openalex.org/W3092811789","https://openalex.org/W2810783283","https://openalex.org/W2130245896","https://openalex.org/W3027644791","https://openalex.org/W2972560979","https://openalex.org/W2104254530","https://openalex.org/W7097180563"],"abstract_inverted_index":{"Convergent":[0],"evidence":[1],"suggests":[2],"that":[3,29,38,60,91,150,226,284],"the":[4,48,51,92,103,140,145,158,174,187,214,218,224,227,251,288,304,330,337],"dorsal":[5],"medial":[6],"prefrontal":[7],"cortex":[8],"(dmPFC)":[9],"makes":[10],"an":[11],"important":[12,334],"contribution":[13],"to":[14,200,212,257,299,311],"goal-directed":[15,344],"action":[16],"selection.":[17],"The":[18],"dmPFC":[19,49,93,228,289],"is":[20,63,283],"also":[21],"part":[22],"of":[23,26,43,53,102,139,186,280,323,340],"a":[24,78,191,271,274],"network":[25,324],"brain":[27,316],"regions":[28],"becomes":[30],"compromised":[31],"in":[32,47,71,170,181,217,287,302,329],"old":[33],"age.":[34],"It":[35],"was":[36,168,233,244,254],"hypothesized":[37],"during":[39,97,115,250],"decision-making,":[40,201],"some":[41],"process":[42,62],"comparison":[44],"takes":[45],"place":[46,259],"between":[50,164],"representation":[52],"available":[54],"actions":[55,232],"and":[56,59,73,85,99,109,112,118,132,144,152,166,173,183,204,267,307,326,332,343],"associated":[57],"values,":[58],"this":[61],"changed":[64],"with":[65,105,179],"aging.":[66],"These":[67,318],"hypotheses":[68],"were":[69,154,177],"tested":[70],"aged":[72,171,188,203],"young":[74,205],"adult":[75,206],"rats":[76,172,207,269],"performing":[77],"novel":[79],"3-choice,":[80,219],"2-cue":[81,220],"decision":[82,98,141,182,252],"task.":[83,221],"Neuron":[84],"local":[86,107],"field":[87],"potential":[88],"activity":[89,114,122,134,238,249],"revealed":[90,149],"experienced":[94],"different":[95],"states":[96],"outcome":[100],"phases":[101,138],"task,":[104,142],"increased":[106,119],"inhibition":[108,153,167],"oscillatory":[110],"(gamma":[111],"theta)":[113],"cue":[116,216,306],"presentation,":[117],"excitatory":[120,131],"neuron":[121,237],"(among":[123],"regular":[124],"firing":[125],"neurons)":[126],"at":[127],"goal":[128,242,285],"zones.":[129],"Although":[130],"inhibitory":[133],"appeared":[135],"anti-correlated":[136],"over":[137,209],"cross-correlations":[143],"prominent":[146],"gamma":[147],"oscillation":[148],"excitation":[151,165],"highly":[155],"correlated":[156,178],"on":[157,260,264],"millisecond":[159],"scale.":[160],"This":[161],"\"micro-scale\"":[162],"coupling":[163],"altered":[169],"observed":[175],"changes":[176,180],"movement":[184],"speeds":[185],"animals,":[189],"suggesting":[190],"putative":[192],"mechanism":[193],"for":[194,223,240,273,336],"age-related":[195],"behavioral":[196],"slowing.":[197],"With":[198],"respect":[199],"both":[202],"learned":[208,294],"multiple":[210],"days":[211],"follow":[213],"rewarded":[215],"Support":[222],"hypothesis":[225],"simultaneously":[229],"represents":[230],"alternative":[231],"not":[234],"found;":[235],"however,":[236],"selective":[239],"particular":[241,275],"zones":[243],"observed.":[245],"Interestingly,":[246],"goal-selective":[247],"neural":[248,327,338],"period":[253],"more":[255],"likely":[256,298],"take":[258],"error":[261],"trials,":[262],"particularly":[263],"high-performing":[265],"sessions":[266],"when":[268],"exhibited":[270],"preference":[272],"feeder.":[276],"A":[277],"possible":[278],"interpretation":[279],"these":[281],"patterns":[282],"representations":[286],"might":[290],"have":[291,333],"sometimes":[292],"overruled":[293],"habits,":[295],"which":[296,308],"are":[297,309],"be":[300,312],"involved":[301],"following":[303],"correct":[305],"known":[310],"supported":[313],"by":[314],"other":[315],"regions.":[317],"results":[319],"describe":[320],"fundamental":[321],"properties":[322],"dynamics":[325],"coding":[328],"dmPFC,":[331],"implications":[335],"basis":[339],"processing":[341],"speed":[342],"action.":[345]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}