{"id":"https://openalex.org/W137610686","doi":null,"title":"Influence of experimental chronic high-pressure glaucoma on age-related macular degeneration in rhesus monkeys.","display_name":"Influence of experimental chronic high-pressure glaucoma on age-related macular degeneration in rhesus monkeys.","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W137610686","mag":"137610686","pmid":"https://pubmed.ncbi.nlm.nih.gov/10967053"},"language":"en","primary_location":{"id":"pmid:10967053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10967053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109152841","display_name":"Jost B. Jonas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J B Jonas","raw_affiliation_strings":["Department of Ophthalmology and Eye Hospital, Friedrich-Alexander University of Erlangen-N\u00fcrnberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Eye Hospital, Friedrich-Alexander University of Erlangen-N\u00fcrnberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048270366","display_name":"Sohan Singh Hayreh","orcid":"https://orcid.org/0000-0002-0709-886X","observed_orcids":["https://orcid.org/0000-0002-0709-886X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Hayreh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6117,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.66777678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"10","first_page":"2972","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9869999885559082},{"id":"https://openalex.org/keywords/experimental-glaucoma","display_name":"experimental glaucoma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9559999704360962},{"id":"https://openalex.org/keywords/parapapillary-atrophy","display_name":"parapapillary atrophy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/drusen","display_name":"drusen","score":0.7820000052452087},{"id":"https://openalex.org/keywords/optic-disc","display_name":"optic nerve head","score":0.6850000023841858},{"id":"https://openalex.org/keywords/retinal-nerve-fiber-layer","display_name":"retinal nerve fiber layer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7960000038146973},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/macular-degeneration","display_name":"macular degeneration","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7836554050445557},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7686853408813477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7662152051925659},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7456509470939636},{"id":"https://openalex.org/C2779093074","wikidata":"https://www.wikidata.org/wiki/Q1140528","display_name":"Drusen","level":3,"score":0.6373497843742371},{"id":"https://openalex.org/C2776391266","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Fundus (uterus)","level":2,"score":0.6277040839195251},{"id":"https://openalex.org/C2780592520","wikidata":"https://www.wikidata.org/wiki/Q4423908","display_name":"Nerve fiber layer","level":3,"score":0.6145878434181213},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5946170091629028},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.5537166595458984},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4632718563079834},{"id":"https://openalex.org/C96021297","wikidata":"https://www.wikidata.org/wiki/Q7098791","display_name":"Optic cup (embryology)","level":5,"score":0.4548443555831909},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43860530853271484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14703187346458435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06351584196090698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C114696181","wikidata":"https://www.wikidata.org/wiki/Q5422650","display_name":"Eye development","level":4,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009896","descriptor_name":"Optic Atrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009898","descriptor_name":"Optic Disk","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10967053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10967053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:137610686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10967053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8026289709","display_name":"EXPERIMENTAL OCULAR VASCULAR OCCLUSIVE STUDIES","funder_award_id":"R01EY001576","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W25711235","https://openalex.org/W1491820399","https://openalex.org/W1521434476","https://openalex.org/W1780202576","https://openalex.org/W1882214116","https://openalex.org/W1968597772","https://openalex.org/W1970357151","https://openalex.org/W1972443523","https://openalex.org/W1989256058","https://openalex.org/W1992429621","https://openalex.org/W1994140172","https://openalex.org/W1994204839","https://openalex.org/W1995575842","https://openalex.org/W2000721846","https://openalex.org/W2033902287","https://openalex.org/W2044649637","https://openalex.org/W2045684086","https://openalex.org/W2055725912","https://openalex.org/W2060346414","https://openalex.org/W2082283271","https://openalex.org/W2083586894","https://openalex.org/W2089945679","https://openalex.org/W2151104719","https://openalex.org/W2165062842","https://openalex.org/W2171643397","https://openalex.org/W4238871513"],"related_works":["https://openalex.org/W2089425725","https://openalex.org/W25711235","https://openalex.org/W2003335364","https://openalex.org/W1972870006","https://openalex.org/W2095582287","https://openalex.org/W3182537613","https://openalex.org/W4411089473","https://openalex.org/W6908691187","https://openalex.org/W2153440518","https://openalex.org/W2060542745"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"assess":[2],"prospectively":[3],"whether":[4,19],"development":[5,189,226,249],"of":[6,26,47,96,104,140,146,155,163,181,187,190,194,202,210,219,227,242,250],"age-related":[7,20,147,211,233],"macular":[8,21,116,148,182,212,234],"degeneration":[9,22,183,213,235],"is":[10,217],"influenced":[11],"by":[12,128],"experimentally":[13,61,86],"induced":[14,62,87],"chronic":[15,33,64,221,244],"high-pressure":[16,34,65,222,245],"glaucoma,":[17,223],"and":[18,71,83,120,136,153,160,197],"influences":[23],"the":[24,27,102,105,138,141,158,164,171,176,179,188,200,203,225,240,248],"appearance":[25],"optic":[28,118],"nerve":[29,122,205],"head":[30],"in":[31,36,88,92,157,199,214,253],"experimental":[32,243],"glaucoma":[35,66,246],"older":[37],"rhesus":[38,49,215],"monkeys.":[39,50,97,254],"METHODS:":[40],"The":[41,51,115,144],"longitudinal":[42],"study":[43,53,90,106,173],"included":[44],"102":[45],"eyes":[46],"52":[48],"total":[52],"group":[54,59,75],"was":[55,107,184],"divided":[56],"into":[57],"a":[58,72,93],"with":[60],"unilateral":[63],"(n":[67,76],"=":[68,77],"40":[69],"eyes)":[70],"normal":[73],"control":[74],"62":[78],"eyes).":[79],"Additionally,":[80],"arterial":[81],"hypertension":[82],"atherosclerosis":[84],"were":[85,125],"both":[89],"groups":[91],"similar":[94],"percentage":[95],"Mean":[98],"monkey":[99],"age":[100],"at":[101,134,137],"end":[103,139],"19.6":[108],"+/-":[109],"3.1":[110],"years":[111],"(range,":[112],"13-24":[113],"years).":[114],"region,":[117],"disc,":[119],"retinal":[121,204],"fiber":[123,206],"layer":[124],"morphometrically":[126],"evaluated":[127],"color":[129],"wide-angle":[130],"fundus":[131],"photographs":[132],"taken":[133],"baseline":[135],"study.":[142],"RESULTS:":[143],"degree":[145,180],"degeneration,":[149],"measured":[150],"as":[151],"number":[152],"area":[154],"drusen":[156],"foveal":[159],"extrafoveal":[161],"region":[162],"macula,":[165],"did":[166],"not":[167,237],"differ":[168],"significantly":[169],"between":[170],"two":[172],"groups.":[174],"In":[175],"glaucomatous":[177,228],"group,":[178],"statistically":[185],"independent":[186,218],"parapapillary":[191,229,251],"atrophy,":[192],"loss":[193],"neuroretinal":[195],"rim,":[196],"decrease":[198],"visibility":[201],"layer.":[207],"CONCLUSIONS:":[208],"Development":[209],"monkeys":[216],"concomitant":[220],"including":[224],"chorioretinal":[230],"atrophy.":[231],"Conversely,":[232],"does":[236],"markedly":[238],"influence":[239],"course":[241],"or":[247],"atrophy":[252]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}