{"id":"https://openalex.org/W1375663","doi":"https://doi.org/10.1002/gepi.2001.21.s1.s794","title":"Comparison of Variance Components, ANOVA and Regression of Offspring on Midparent (ROMP) Methods for SNP Markers","display_name":"Comparison of Variance Components, ANOVA and Regression of Offspring on Midparent (ROMP) Methods for SNP Markers","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1375663","doi":"https://doi.org/10.1002/gepi.2001.21.s1.s794","mag":"1375663","pmid":"https://pubmed.ncbi.nlm.nih.gov/11793780"},"language":"en","primary_location":{"id":"doi:10.1002/gepi.2001.21.s1.s794","doi":"https://doi.org/10.1002/gepi.2001.21.s1.s794","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gepi.2001.21.s1.s794","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112419294","display_name":"Elizabeth Pugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth W. Pugh","raw_affiliation_strings":["Center for Inherited Disease Research Johns Hopkins University Baltimore, Maryland","Center for Inherited Disease Research, Johns Hopkins University, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inherited Disease Research Johns Hopkins University Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Center for Inherited Disease Research, Johns Hopkins University, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041895974","display_name":"George Papanicolaou","orcid":"https://orcid.org/0000-0003-1036-4329","observed_orcids":["https://orcid.org/0000-0003-1036-4329"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George J. Papanicolaou","raw_affiliation_strings":["Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086203901","display_name":"Cristina M. Justice","orcid":"https://orcid.org/0000-0002-6190-6821","observed_orcids":["https://orcid.org/0000-0002-6190-6821"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina M. Justice","raw_affiliation_strings":["Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070692469","display_name":"Marie\u2010H\u00e9l\u00e8ne Roy\u2010Gagnon","orcid":"https://orcid.org/0000-0001-8747-0846","observed_orcids":["https://orcid.org/0000-0001-8747-0846","https://orcid.org/0000-0003-1381-5180"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-H\u00e9l\u00e8ne Roy-Gagnon","raw_affiliation_strings":["Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043718031","display_name":"Alexa J.M. Sorant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa J.M. Sorant","raw_affiliation_strings":["Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108655919","display_name":"Albert Kingman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Kingman","raw_affiliation_strings":["National Institute of Dental and Craniofacial Research; National Institutes of Health; Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Dental and Craniofacial Research; National Institutes of Health; Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091519811","display_name":"Alexander F. Wilson","orcid":"https://orcid.org/0000-0002-6682-8156","observed_orcids":["https://orcid.org/0000-0002-6682-8156"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander F. Wilson","raw_affiliation_strings":["Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section; National Human Genome Research Institute, National Institutes of Health; Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.182,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.51330315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"S1","first_page":"S794","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solar","display_name":"solar","score":0.843999981880188},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8360000252723694},{"id":"https://openalex.org/keywords/heritability-estimation","display_name":"heritability estimation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/type-i-error-rate","display_name":"type I error rate","score":0.675000011920929},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.7799571752548218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6161820888519287},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5307462215423584},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.47454413771629333},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.4625207185745239},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.439948707818985},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41152238845825195},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23646149039268494},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07140523195266724},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/gepi.2001.21.s1.s794","doi":"https://doi.org/10.1002/gepi.2001.21.s1.s794","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gepi.2001.21.s1.s794","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"pmid:11793780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11793780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic epidemiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1502908645","https://openalex.org/W2115335486","https://openalex.org/W2324458618","https://openalex.org/W2987011813","https://openalex.org/W2991953234"],"related_works":["https://openalex.org/W1998461322","https://openalex.org/W7096923934","https://openalex.org/W4401237031","https://openalex.org/W2101747938","https://openalex.org/W2335376167","https://openalex.org/W6963829509","https://openalex.org/W2202424189","https://openalex.org/W2130488467","https://openalex.org/W7020793221","https://openalex.org/W7098838926"],"abstract_inverted_index":{"An":[0],"extension":[1],"of":[2,6,18,37,75,83,98,137,140,143,162],"the":[3,16,19,27,38,52,56,84,96,99,104,119,138,141,144,154,163,174,178],"traditional":[4],"regression":[5],"offspring":[7],"on":[8,157,170],"midparent":[9],"(ROMP)":[10],"method":[11,54,59],"was":[12,116],"used":[13,49],"to":[14,30,50,71,106,126,160,177],"estimate":[15,26],"heritability":[17,28,142,175],"trait,":[20],"test":[21,66],"for":[22,67,130,148,166],"marker":[23,32,68,115,181],"association,":[24,69],"and":[25,70,86,118,151],"attributable":[29,176],"a":[31,65,72,108],"locus.":[33],"The":[34,134],"fifty":[35],"replicates":[36,93],"Genetic":[39],"Analysis":[40],"Workshop":[41],"(GAW)":[42],"12":[43],"simulated":[44],"general":[45],"population":[46],"data":[47],"were":[48,89,124,146],"compare":[51],"ROMP":[53,85,185],"with":[55],"variance":[57,76],"components":[58],"as":[60,64],"implemented":[61],"in":[62],"SOLAR":[63,150,172],"standard":[73,135],"analysis":[74],"(ANOVA)":[77],"method.":[78],"Large":[79],"sample":[80],"statistical":[81],"properties":[82],"ANOVA":[87],"methods":[88],"compared":[90],"using":[91],"2,000":[92],"resampled":[94],"from":[95],"families":[97],"original":[100],"50":[101],"replicates.":[102],"Overall,":[103],"power":[105],"detect":[107],"completely":[109],"associated":[110,179],"single":[111],"nucleotide":[112],"polymorphism":[113],"(SNP)":[114],"high,":[117],"type":[120],"I":[121],"error":[122],"rates":[123],"similar":[125],"nominal":[127],"significance":[128],"levels":[129],"all":[131],"three":[132],"methods.":[133,168],"deviations":[136],"estimates":[139,155],"trait":[145],"large":[147],"both":[149,167],"ROMP,":[152],"but":[153],"were,":[156],"average,":[158,171],"close":[159],"those":[161],"generating":[164],"model":[165],"However,":[169],"overestimated":[173],"SNP":[180],"(by":[182,188],"256%)":[183],"while":[184],"underestimated":[186],"it":[187],"26%).":[189]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
