{"id":"https://openalex.org/W136985941","doi":null,"title":"Pro- versus anti-inflammatory cytokines: myth or reality.","display_name":"Pro- versus anti-inflammatory cytokines: myth or reality.","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W136985941","mag":"136985941","pmid":"https://pubmed.ncbi.nlm.nih.gov/11502077"},"language":"en","primary_location":{"id":"pmid:11502077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11502077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063108232","display_name":"Jean\u2010Marc Cavaillon","orcid":"https://orcid.org/0000-0001-7721-2106","observed_orcids":["https://orcid.org/0000-0001-7721-2106"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J M Cavaillon","raw_affiliation_strings":["Department of Physiopathology, Institut Pasteur, Paris, France. jmcavail@pasteur.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiopathology, Institut Pasteur, Paris, France. jmcavail@pasteur.fr","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063108232"],"corresponding_institution_ids":["https://openalex.org/I157536573"],"apc_list":null,"apc_paid":null,"fwci":3.0325,"has_fulltext":false,"cited_by_count":300,"citation_normalized_percentile":{"value":0.91843414,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"47","issue":"4","first_page":"695","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9539999961853027},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.777999997138977},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9139999747276306},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9110000133514404},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9610000252723694},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9739999771118164},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.831276535987854},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6113787889480591},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6072290539741516},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5054073333740234},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4893442988395691},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4426320195198059},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.4225784242153168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37866079807281494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34832295775413513}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11502077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11502077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:136985941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11502077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W95884546","https://openalex.org/W204546040","https://openalex.org/W591888808","https://openalex.org/W1274671738","https://openalex.org/W1419470924","https://openalex.org/W1493233127","https://openalex.org/W1502971607","https://openalex.org/W1510783223","https://openalex.org/W1514001940","https://openalex.org/W1533977973","https://openalex.org/W1550495414","https://openalex.org/W1553216313","https://openalex.org/W1579051972","https://openalex.org/W1799631694","https://openalex.org/W1837576575","https://openalex.org/W1855737037","https://openalex.org/W1891447727","https://openalex.org/W1946793455","https://openalex.org/W1964093850","https://openalex.org/W1964122042","https://openalex.org/W1964323924","https://openalex.org/W1964379882","https://openalex.org/W1968034889","https://openalex.org/W1972133618","https://openalex.org/W1972265041","https://openalex.org/W1979688334","https://openalex.org/W1981562549","https://openalex.org/W1987150557","https://openalex.org/W1992256266","https://openalex.org/W1997597704","https://openalex.org/W1999939412","https://openalex.org/W2003437558","https://openalex.org/W2006619058","https://openalex.org/W2007223625","https://openalex.org/W2007415847","https://openalex.org/W2008121963","https://openalex.org/W2008827762","https://openalex.org/W2009330030","https://openalex.org/W2012595712","https://openalex.org/W2026542245","https://openalex.org/W2033625115","https://openalex.org/W2038748367","https://openalex.org/W2038992843","https://openalex.org/W2046099042","https://openalex.org/W2060757943","https://openalex.org/W2060763719","https://openalex.org/W2063765445","https://openalex.org/W2064779863","https://openalex.org/W2083132915","https://openalex.org/W2083955105","https://openalex.org/W2084990572","https://openalex.org/W2086749916","https://openalex.org/W2091433468","https://openalex.org/W2096353975","https://openalex.org/W2106510927","https://openalex.org/W2120033129","https://openalex.org/W2124566107","https://openalex.org/W2125092518","https://openalex.org/W2132932119","https://openalex.org/W2133487448","https://openalex.org/W2142167349","https://openalex.org/W2145677005","https://openalex.org/W2151476030","https://openalex.org/W2154923159","https://openalex.org/W2155020462","https://openalex.org/W2169056709","https://openalex.org/W2232949844","https://openalex.org/W2259673668","https://openalex.org/W2268870741","https://openalex.org/W2293615862","https://openalex.org/W2409552990","https://openalex.org/W2460292361","https://openalex.org/W4313331894","https://openalex.org/W4313333836","https://openalex.org/W4313335081"],"related_works":["https://openalex.org/W4402151525","https://openalex.org/W2401764055","https://openalex.org/W7097422832","https://openalex.org/W115674540","https://openalex.org/W4388325908","https://openalex.org/W2004188401","https://openalex.org/W1982717500","https://openalex.org/W7166130052","https://openalex.org/W2901402228","https://openalex.org/W7096610241"],"abstract_inverted_index":{"Inflammation":[0],"is":[1,65],"characterized":[2,38],"by":[3],"an":[4,87],"interplay":[5],"between":[6],"pro-":[7,83],"and":[8,31,47,69,118],"anti-inflammatory":[9,54,88],"cytokines.":[10,55],"Cytokines":[11],"are":[12,36,51,123],"commonly":[13],"classified":[14],"in":[15],"one":[16],"or":[17],"the":[18,91,94,97,100,103,106,111,113,120],"other":[19],"category:":[20],"interleukin-1":[21],"(IL-1),":[22],"tumor":[23],"necrosis":[24],"factor":[25,35],"(TNF),":[26],"gamma-interferon":[27],"(IFN-gamma),":[28],"IL-12,":[29],"IL-18":[30],"granulocyte-macrophage":[32],"colony":[33],"stimulating":[34],"well":[37,85],"as":[39,53,81,84,86],"pro-inflammatory":[40],"cytokines":[41],"whereas":[42],"IL4,":[43],"IL-10,":[44],"IL-13,":[45],"IFN-alpha":[46],"transforming":[48],"growth":[49],"factor-beta":[50],"recognized":[52],"In":[56],"this":[57,63],"review,":[58],"we":[59,70],"point":[60],"out":[61],"that":[62,75],"classification":[64],"far":[66],"too":[67],"simplistic":[68],"provide":[71],"numerous":[72],"examples":[73],"illustrating":[74],"a":[76,82],"given":[77],"cytokine":[78,92,116,128],"may":[79],"behave":[80],"cytokine.":[89],"Indeed,":[90],"amount,":[93],"nature":[95,101,107],"of":[96,102,108,115],"target":[98],"cell,":[99],"activating":[104],"signal,":[105],"produced":[109],"cytokines,":[110],"timing,":[112],"sequence":[114],"action":[117],"even":[119],"experimental":[121],"model":[122],"parameters":[124],"which":[125],"greatly":[126],"influence":[127],"properties.":[129]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
