{"id":"https://openalex.org/W136653594","doi":null,"title":"Genomic analysis of the fresh water mollusc Biomphalaria glabrata to understand host : parasite interactions","display_name":"Genomic analysis of the fresh water mollusc Biomphalaria glabrata to understand host : parasite interactions","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W136653594","mag":"136653594"},"language":"en","primary_location":{"id":"pmh:oai:bura.brunel.ac.uk:2438/4431","doi":null,"is_oa":true,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/4431","pdf_url":"http://bura.brunel.ac.uk/handle/2438/4431","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://bura.brunel.ac.uk/handle/2438/4431","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039893182","display_name":"Edwin C. Odoemelam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Edwin C. Odoemelam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039893182"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomphalaria-glabrata","display_name":"Biomphalaria glabrata","score":1.0},{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9980000257492065},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.890999972820282},{"id":"https://openalex.org/keywords/chromosome-mapping","display_name":"chromosome mapping","score":0.5509999990463257},{"id":"https://openalex.org/keywords/embryonic-cell-line","display_name":"embryonic cell line","score":0.7459999918937683},{"id":"https://openalex.org/keywords/interphase-nucleus","display_name":"interphase nuclei","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chromosome-territories","display_name":"chromosome territories","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gene-relocation","display_name":"gene relocation","score":0.699999988079071},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2776453879","wikidata":"https://www.wikidata.org/wiki/Q1835536","display_name":"Biomphalaria glabrata","level":5,"score":0.9463716745376587},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.6996908187866211},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6563377976417542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6458911299705505},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33207112550735474},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3174508810043335},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.31666451692581177},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.18513813614845276},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.12513470649719238},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.0951228141784668},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.07513001561164856},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0636763870716095}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bura.brunel.ac.uk:2438/4431","doi":null,"is_oa":true,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/4431","pdf_url":"http://bura.brunel.ac.uk/handle/2438/4431","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:136653594","doi":null,"is_oa":false,"landing_page_url":"https://bura.brunel.ac.uk/bitstream/2438/4431/1/FulltextThesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bura.brunel.ac.uk:2438/4431","doi":null,"is_oa":true,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/4431","pdf_url":"http://bura.brunel.ac.uk/handle/2438/4431","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W136653594.pdf","grobid_xml":"https://content.openalex.org/works/W136653594.grobid-xml"},"referenced_works_count":208,"referenced_works":["https://openalex.org/W3357219","https://openalex.org/W20935937","https://openalex.org/W45396841","https://openalex.org/W88046892","https://openalex.org/W116760487","https://openalex.org/W1483692899","https://openalex.org/W1485491269","https://openalex.org/W1492384170","https://openalex.org/W1495715524","https://openalex.org/W1506364108","https://openalex.org/W1508475203","https://openalex.org/W1528082486","https://openalex.org/W1531776222","https://openalex.org/W1567582741","https://openalex.org/W1600319253","https://openalex.org/W1618116785","https://openalex.org/W1688631023","https://openalex.org/W1909259001","https://openalex.org/W1965813621","https://openalex.org/W1968887640","https://openalex.org/W1969388639","https://openalex.org/W1972023943","https://openalex.org/W1972285677","https://openalex.org/W1973641526","https://openalex.org/W1976627608","https://openalex.org/W1978493564","https://openalex.org/W1978799378","https://openalex.org/W1980711204","https://openalex.org/W1982854599","https://openalex.org/W1982964856","https://openalex.org/W1983170790","https://openalex.org/W1983348782","https://openalex.org/W1984731778","https://openalex.org/W1985254947","https://openalex.org/W1988834288","https://openalex.org/W1989612038","https://openalex.org/W1990374273","https://openalex.org/W1993558252","https://openalex.org/W1995804693","https://openalex.org/W1996749102","https://openalex.org/W1997256143","https://openalex.org/W1999155341","https://openalex.org/W1999635972","https://openalex.org/W2000897918","https://openalex.org/W2002202665","https://openalex.org/W2002698073","https://openalex.org/W2004611593","https://openalex.org/W2005046853","https://openalex.org/W2005980437","https://openalex.org/W2012614480","https://openalex.org/W2013523408","https://openalex.org/W2014286894","https://openalex.org/W2014540648","https://openalex.org/W2014788904","https://openalex.org/W2015355733","https://openalex.org/W2018051857","https://openalex.org/W2020497521","https://openalex.org/W2022936129","https://openalex.org/W2028581970","https://openalex.org/W2028702644","https://openalex.org/W2029643771","https://openalex.org/W2030062073","https://openalex.org/W2030104344","https://openalex.org/W2031310237","https://openalex.org/W2032840484","https://openalex.org/W2034247066","https://openalex.org/W2034984150","https://openalex.org/W2036265947","https://openalex.org/W2037688404","https://openalex.org/W2037791207","https://openalex.org/W2040490032","https://openalex.org/W2041932062","https://openalex.org/W2042247342","https://openalex.org/W2045802318","https://openalex.org/W2047295844","https://openalex.org/W2048432638","https://openalex.org/W2048482904","https://openalex.org/W2048761344","https://openalex.org/W2049017075","https://openalex.org/W2053169582","https://openalex.org/W2053950888","https://openalex.org/W2054028958","https://openalex.org/W2055793157","https://openalex.org/W2055977185","https://openalex.org/W2057092823","https://openalex.org/W2057278725","https://openalex.org/W2058348232","https://openalex.org/W2059255388","https://openalex.org/W2060706136","https://openalex.org/W2060863780","https://openalex.org/W2061015334","https://openalex.org/W2061475806","https://openalex.org/W2061848287","https://openalex.org/W2062843323","https://openalex.org/W2062997740","https://openalex.org/W2063604510","https://openalex.org/W2063936987","https://openalex.org/W2064038671","https://openalex.org/W2068365329","https://openalex.org/W2068867344","https://openalex.org/W2069299780","https://openalex.org/W2071949364","https://openalex.org/W2075060465","https://openalex.org/W2075314471","https://openalex.org/W2076142853","https://openalex.org/W2077154575","https://openalex.org/W2077721879","https://openalex.org/W2079779971","https://openalex.org/W2084164320","https://openalex.org/W2085110456","https://openalex.org/W2086410664","https://openalex.org/W2086546613","https://openalex.org/W2087481557","https://openalex.org/W2087973273","https://openalex.org/W2091187928","https://openalex.org/W2091393178","https://openalex.org/W2091660523","https://openalex.org/W2091884937","https://openalex.org/W2092499706","https://openalex.org/W2093189184","https://openalex.org/W2093692312","https://openalex.org/W2094169801","https://openalex.org/W2095652602","https://openalex.org/W2096203972","https://openalex.org/W2098101940","https://openalex.org/W2100805144","https://openalex.org/W2101917229","https://openalex.org/W2104973219","https://openalex.org/W2105392423","https://openalex.org/W2107065535","https://openalex.org/W2107855916","https://openalex.org/W2109802732","https://openalex.org/W2110423812","https://openalex.org/W2112124900","https://openalex.org/W2112913464","https://openalex.org/W2113643663","https://openalex.org/W2114045929","https://openalex.org/W2115209309","https://openalex.org/W2115210567","https://openalex.org/W2116302199","https://openalex.org/W2117717914","https://openalex.org/W2118474157","https://openalex.org/W2119029814","https://openalex.org/W2119143930","https://openalex.org/W2121661168","https://openalex.org/W2124607109","https://openalex.org/W2125310129","https://openalex.org/W2126491567","https://openalex.org/W2127230663","https://openalex.org/W2127517570","https://openalex.org/W2130185662","https://openalex.org/W2132753699","https://openalex.org/W2133803247","https://openalex.org/W2134184546","https://openalex.org/W2134435289","https://openalex.org/W2135271276","https://openalex.org/W2135695460","https://openalex.org/W2135784861","https://openalex.org/W2137470874","https://openalex.org/W2138657939","https://openalex.org/W2139594740","https://openalex.org/W2140125310","https://openalex.org/W2142184221","https://openalex.org/W2143165983","https://openalex.org/W2143658931","https://openalex.org/W2144704949","https://openalex.org/W2144710552","https://openalex.org/W2145512379","https://openalex.org/W2145859809","https://openalex.org/W2146091491","https://openalex.org/W2146427646","https://openalex.org/W2146875241","https://openalex.org/W2147247974","https://openalex.org/W2151991836","https://openalex.org/W2152497365","https://openalex.org/W2155546699","https://openalex.org/W2155725346","https://openalex.org/W2155932202","https://openalex.org/W2158610379","https://openalex.org/W2158805631","https://openalex.org/W2160084724","https://openalex.org/W2160908077","https://openalex.org/W2162219284","https://openalex.org/W2162967758","https://openalex.org/W2163904524","https://openalex.org/W2165673249","https://openalex.org/W2167039756","https://openalex.org/W2167497811","https://openalex.org/W2167660808","https://openalex.org/W2168991217","https://openalex.org/W2169542946","https://openalex.org/W2171611104","https://openalex.org/W2180585235","https://openalex.org/W2188480055","https://openalex.org/W2190667530","https://openalex.org/W2265810346","https://openalex.org/W2319944374","https://openalex.org/W2331671670","https://openalex.org/W2400060553","https://openalex.org/W2410268522","https://openalex.org/W2415242376","https://openalex.org/W2461161208","https://openalex.org/W2472098186","https://openalex.org/W2472153579","https://openalex.org/W2494334534","https://openalex.org/W2504816579","https://openalex.org/W2513499078","https://openalex.org/W2802336040"],"related_works":["https://openalex.org/W2014788904","https://openalex.org/W1499016293","https://openalex.org/W2069893981","https://openalex.org/W2889780538","https://openalex.org/W4392284014","https://openalex.org/W82848210","https://openalex.org/W7125111894","https://openalex.org/W4295066875","https://openalex.org/W2461161208","https://openalex.org/W1976627608"],"abstract_inverted_index":{"The":[0],"fresh":[1],"water":[2],"mollusc":[3],"Biomphalaria":[4,45],"glabrata":[5,28,46,124,271],"is":[6,18,34,50,164,183,192,201,224,301],"the":[7,11,21,30,57,60,66,72,97,111,127,130,138,143,158,186,189,195,198,206,209,219,227,241,244,261,277,281,289,297,312,322,336,345],"intermediate":[8],"host":[9,313],"for":[10,20,41,54,119,157,226,232],"trematode":[12],"parasite":[13,17,330],"Schistosoma":[14],"mansoni,":[15],"this":[16,223],"responsible":[19],"human":[22],"disease":[23],"Schistosomiasis.The":[24],"significance":[25],"of":[26,32,65,87,96,188,197,208,243,280,288,292,304,335,339,348,355],"B.":[27,102,123,270,349],"in":[29,93,107,135,213,218,240,276,311,344],"transmission":[31],"schistosomiasis":[33],"such":[35],"that":[36,185,326],"it":[37,182,215],"has":[38],"been":[39,174],"selected":[40],"complete":[42],"genome":[43,64,159,211],"sequencing.The":[44],"embryonic":[47],"cell":[48,113],"line":[49],"an":[51,154,165],"important":[52,155,225],"resource":[53,156],"researchers":[55],"investigating":[56],"interaction":[58],"between":[59],"snail":[61,210],"and":[62,89,170,180,263],"parasite.The":[63],"Bge":[67,98,112,131,139,220,245,282,298],"cells":[68,132,221,299],"was":[69,91,117,216,249],"analysed":[70],"at":[71],"chromosomal":[73],"level,":[74],"using":[75,133],"DAPI":[76],"karyotyping.The":[77],"karyotype":[78],"revealed":[79,351],"extensive":[80],"aneuploidy,":[81,142],"whereby":[82,168],"a":[83,115],"modal":[84],"chromosome":[85,105,236,257],"complement":[86],"63":[88],"67":[90],"observed":[92,239],"two":[94],"isolates":[95],"cells,":[99,283],"which":[100],"exceeds":[101],"glabrata's":[103],"2n=36":[104],"number.Indeed,":[106],"addition":[108],"to":[109,176,194,252,308,315],"characterising":[110],"chromosomes,":[114],"method":[116],"established":[118],"mapping":[120],"single":[121],"copy":[122],"genes":[125,145,207,272,306,317],"onto":[126,147],"chromosomes":[128,169],"from":[129],"fluorescence":[134],"situ":[136],"hybridisation.Despite":[137],"cell's":[140],"inherent":[141],"four":[144,269],"mapped":[146],"diploid":[148],"homologous":[149],"chromosomes.This":[150],"methodology":[151],"will":[152],"be":[153,177,309],"sequencing":[160,228],"consortium.The":[161],"interphase":[162,190,278,323,346],"nucleus":[163,191],"organised":[166,250,286],"organelle,":[167],"gene":[171],"loci":[172],"have":[173],"shown":[175],"located":[178],"non-randomly":[179,275],"hence":[181],"hypothesised":[184],"organisation":[187],"pertinent":[193],"function":[196],"genome.Since":[199],"there":[200,300],"no":[202],"data":[203],"on":[204],"how":[205],"behaves":[212],"interphase,":[214],"assessed":[217],"line.Again,":[222],"initiative,":[229],"but":[230],"also":[231],"evolutionary":[233],"biology.Radially":[234],"distributed":[235],"territories":[237,258,265],"were":[238,273],"nuclei":[242,279,347],"cells.The":[246],"territory":[247,253],"position":[248],"according":[251],"size,":[254],"with":[255,296],"small":[256],"positioned":[259,274],"towards":[260],"interior":[262],"large":[264],"intermediately":[266],"located.In":[267],"addition,":[268],"again":[284],"emphasising":[285],"positioning":[287],"genome.With":[290],"co-culture":[291],"S.":[293],"mansoni":[294],"miracidia":[295],"up":[302],"regulation":[303],"specific":[305,329,340],"known":[307],"involved":[310],"response":[314],"parasite.These":[316],"are":[318,328],"dramatically":[319],"relocated":[320],"within":[321],"nuclei,":[324],"implying":[325],"these":[327],"induced":[331],"nuclear":[332,353],"events.An":[333],"analysis":[334],"genomic":[337],"distribution":[338,354],"histone":[341],"modified":[342,356],"chromatin":[343],"glabrata,":[350],"different":[352]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}