{"id":"https://openalex.org/W136332850","doi":null,"title":"The effects of germacrone on lipopolysaccharide-induced acute lung injury in neonatal rats.","display_name":"The effects of germacrone on lipopolysaccharide-induced acute lung injury in neonatal rats.","publication_year":2014,"publication_date":"2014-11-16","ids":{"openalex":"https://openalex.org/W136332850","mag":"136332850","pmid":"https://pubmed.ncbi.nlm.nih.gov/25399081"},"language":"en","primary_location":{"id":"pmid:25399081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25399081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091801076","display_name":"J-F An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J-F An","raw_affiliation_strings":["Xi'an Children's Hospital Department of Integrated TCM & Western Medicine Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi'an Children's Hospital Department of Integrated TCM & Western Medicine Xi'an China","institution_ids":["https://openalex.org/I4210142339"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Sun","raw_affiliation_strings":["First Affiliated Hospital of Xi'an Jiaotong University Department of Traditional Chinese Medicine Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Xi'an Jiaotong University Department of Traditional Chinese Medicine Xi'an China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103528944","display_name":"Q-L Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q-L Zhang","raw_affiliation_strings":["Shanghai Jiao Tong University Center for Reproductive Medicine, Renji Hospital, School of Medicine Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University Center for Reproductive Medicine, Renji Hospital, School of Medicine Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F-L Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F-L Zhang","raw_affiliation_strings":["Xi'an Hospital of Traditional Chinese Medicine Department of Respiration Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi'an Hospital of Traditional Chinese Medicine Department of Respiration Xi'an China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112568665","display_name":"JL Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J-L Zhang","raw_affiliation_strings":["Xi'an Children's Hospital Department of Neonatology Xi'an China zjuanlijl@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi'an Children's Hospital Department of Neonatology Xi'an China zjuanlijl@163.com","institution_ids":["https://openalex.org/I4210142339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5339,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.6987788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"60","issue":"4","first_page":"8","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.14640000462532043,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.08259999752044678,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/germacrone","display_name":"germacrone","score":1.0},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.8849999904632568},{"id":"https://openalex.org/keywords/curcumae-rhizoma","display_name":"Curcumae Rhizoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9610000252723694},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9559999704360962},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/claudin-4","display_name":"claudin-4","score":0.9229999780654907},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7292370200157166},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7057142853736877},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5413998365402222},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5302647352218628},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5252611041069031},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5127149820327759},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.47761791944503784},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.45646607875823975},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4532807469367981},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4455488622188568},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.419376939535141},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2586855888366699},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24646639823913574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24294176697731018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1813240945339203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17134332656860352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12447091937065125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D030024","descriptor_name":"Curcuma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045788","descriptor_name":"Sesquiterpenes, Germacrane","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D045788","descriptor_name":"Sesquiterpenes, Germacrane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045788","descriptor_name":"Sesquiterpenes, Germacrane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D062506","descriptor_name":"Claudin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25399081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25399081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:136332850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25399081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2787927655","https://openalex.org/W2373646382","https://openalex.org/W2033205428","https://openalex.org/W2063140554","https://openalex.org/W2748648412","https://openalex.org/W3046461314","https://openalex.org/W2022465723","https://openalex.org/W3044016033","https://openalex.org/W4220720124","https://openalex.org/W7126112730"],"abstract_inverted_index":{"Germacrone":[0],"is":[1],"one":[2],"of":[3,33,53,62,142,174],"the":[4,9,30,51,60,100,116,131,140],"main":[5],"bioactive":[6],"components":[7],"in":[8,41,78,104,123,145,148],"traditional":[10],"Chinese":[11],"medicine":[12],"Rhizoma":[13],"curcuma":[14],"and":[15,57,66,90,111,147,156],"has":[16],"been":[17],"shown":[18,151],"to":[19,28],"possess":[20],"an":[21],"anti-in\ufb02ammatory":[22],"activity.":[23],"Our":[24],"present":[25],"study":[26,161],"aimed":[27],"investigate":[29],"protective":[31],"effects":[32],"germacrone":[34,47,72,85,96,128,137,164],"on":[35],"lipopolysaccharide":[36],"(LPS)-induced":[37],"acute":[38],"lung":[39],"injury":[40],"neonatal":[42,79,166],"rats.":[43],"Results":[44],"showed":[45,114],"that":[46,95,115,136,163],"treatment":[48,138],"significantly":[49,98,121],"decreased":[50],"expression":[52,61,141],"pro-inflammatory":[54],"cytokines":[55],"IL-6":[56],"TNF-\u03b1.":[58],"Meanwhile,":[59],"anti-inflammatory":[63],"mediators":[64],"TGF-\u03b21":[65],"IL-10":[67],"was":[68,120],"obviously":[69],"increased":[70,99],"following":[71],"administration.":[73],"The":[74],"LPS-induced":[75,169],"pathological":[76],"changes":[77],"rats":[80,167],"were":[81],"also":[82],"attenuated":[83],"by":[84,152,172],"treatment.":[86],"In":[87],"vitro,":[88],"MTT":[89],"EdU":[91],"incorporation":[92],"assay":[93],"indicated":[94],"administration":[97],"A549":[101],"cell":[102,117],"viabilities":[103],"a":[105,124],"dose-dependent":[106],"manner.":[107],"Besides,":[108],"flow":[109],"cytometry":[110],"TUNEL":[112],"analysis":[113],"apoptosis":[118],"rate":[119],"reduced":[122],"concentration-dependent":[125],"manner":[126],"after":[127],"injection.":[129],"At":[130],"molecular":[132],"level,":[133],"we":[134],"found":[135],"promoted":[139],"claudin-4":[143],"both":[144],"vivo":[146],"vitro":[149],"as":[150],"real":[153],"time":[154],"PCR":[155],"western":[157],"blot.":[158],"Collectively,":[159],"our":[160],"demonstrated":[162],"protected":[165],"against":[168],"ALI":[170],"partially":[171],"modulation":[173],"claudin-4.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}