{"id":"https://openalex.org/W13632809","doi":null,"title":"Alleles of apolipoprotein E gene (APOE) as genetic determinants of dementia","display_name":"Alleles of apolipoprotein E gene (APOE) as genetic determinants of dementia","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W13632809","mag":"13632809"},"language":"en","primary_location":{"id":"mag:13632809","doi":null,"is_oa":false,"landing_page_url":"http://irep.iium.edu.my/27960/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W13632809"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110261769","display_name":"Seikh Farid Uddin Akter","orcid":"https://orcid.org/0009-0003-4639-1908","observed_orcids":["https://orcid.org/0009-0003-4639-1908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seikh Farid Uddin Akter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108686359","display_name":"Mohammed Fauzi Abdul Rani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Fauzi Abdul Rani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079523682","display_name":"Jamalludin Ab Rahman","orcid":"https://orcid.org/0000-0003-4323-1194","observed_orcids":["https://orcid.org/0000-0003-4323-1194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamalludin Ab Rahman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4323-1194","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049721427","display_name":"Sarina Sulong","orcid":"https://orcid.org/0000-0001-5369-2707","observed_orcids":["https://orcid.org/0000-0001-5369-2707"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarina Sulong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5369-2707","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085372024","display_name":"Mohd Aznan Aris","orcid":"https://orcid.org/0000-0002-9967-1327","observed_orcids":["https://orcid.org/0000-0002-9967-1327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohd Aznan Aris","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9967-1327","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022066689","display_name":"Ing Chia Phang","orcid":"https://orcid.org/0000-0001-8684-1748","observed_orcids":["https://orcid.org/0000-0001-8684-1748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ing Chia Phang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8684-1748","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031064669","display_name":"Muhammad Muzaffar Ali Khan Khattak","orcid":"https://orcid.org/0000-0002-4072-5001","observed_orcids":["https://orcid.org/0000-0002-4072-5001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Muzaffar Ali Khan Khattak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4072-5001","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008553322","display_name":"Muhammad Bakhtiar","orcid":"https://orcid.org/0009-0002-5742-8895","observed_orcids":["https://orcid.org/0009-0002-5742-8895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Taher Bakhtiar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-5742-8895","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00219249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.8190000057220459},{"id":"https://openalex.org/keywords/apolipoprotein-e-gene","display_name":"apolipoprotein E gene","score":0.9070000052452087},{"id":"https://openalex.org/keywords/apoe-alleles","display_name":"APOE alleles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dementia-prevalence","display_name":"dementia prevalence","score":0.8270000219345093},{"id":"https://openalex.org/keywords/malaysia","display_name":"Malaysia","score":0.3440000116825104},{"id":"https://openalex.org/keywords/case-control-study","display_name":"case-control study","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7672144770622253},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7610400915145874},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5193873047828674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4538184702396393},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4377817213535309},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.4201123118400574},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40028589963912964},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3500025272369385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34168288111686707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32593026757240295},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3202030062675476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2893901467323303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24293208122253418},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:13632809","doi":null,"is_oa":false,"landing_page_url":"http://irep.iium.edu.my/27960/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2423886799","https://openalex.org/W2946298116","https://openalex.org/W4417269282","https://openalex.org/W1964401642","https://openalex.org/W2013311962","https://openalex.org/W2014285701","https://openalex.org/W2378027322","https://openalex.org/W2096136866","https://openalex.org/W7098131182","https://openalex.org/W2775585916"],"abstract_inverted_index":{"Dementia":[0],"is":[1],"emerging":[2],"as":[3,114,121],"a":[4,16,68],"silent":[5],"epidemic":[6],"for":[7,52,64,70,104],"rapidly":[8],"developing":[9],"countries":[10],"like":[11],"Malaysia.":[12],"Its":[13],"prevalence":[14],"and":[15,59,73],"generic":[17],"determinant":[18],"assessment":[19],"were":[20,28,45,81,99,125],"the":[21,53,78,85,88,102,130,137,142],"focused":[22],"objectives":[23],"of":[24,87,90,141],"this":[25,32],"study.":[26],"There":[27],"two":[29],"phases":[30],"in":[31],"study":[33,49,133,146],"-":[34],"an":[35,41],"initial":[36],"descriptive":[37],"phase":[38,66],"followed":[39,82],"by":[40],"analytic":[42,65],"phase.":[43],"Data":[44],"collected":[46],"from":[47,129],"197":[48],"subjects":[50],"intially":[51],"secriptive":[54],"phase;":[55],"65":[56],"dementia":[57,135],"cases":[58],"103":[60],"age":[61],"matched":[62],"controls":[63],"using":[67,101],"questionnaire":[69],"personal":[71],"profile":[72],"other":[74],"related":[75],"factors.":[76],"Furthermore,":[77],"standard":[79],"protocols":[80],"to":[83,110],"determine":[84],"frequencies":[86],"alleles":[89],"apolipoprotein":[91],"E":[92],"gene":[93],"(APOE).":[94],"The":[96],"statistical":[97,118],"analyses":[98,119],"performed":[100],"SPSS":[103],"Windows,":[105],"Version":[106],"17.":[107],"In":[108],"addition":[109],"descriotive":[111],"statistics":[112],"such":[113,120],"percentage,":[115],"pertinent":[116],"inferential":[117],"chi":[122],"square":[123],"test":[124],"performed.":[126],"It":[127],"appears":[128],"inital":[131],"descriptvie":[132],"that":[134],"was":[136],"leadinf":[138],"disease":[139],"(72.1%)":[140],"identified":[143],"diseases":[144],"among":[145],"subjects.":[147]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}