{"id":"https://openalex.org/W136305909","doi":null,"title":"In-vivo evaluation of Lu-177 hydroxyapatite for application in radiation synovectomy of digital joints","display_name":"In-vivo evaluation of Lu-177 hydroxyapatite for application in radiation synovectomy of digital joints","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W136305909","mag":"136305909"},"language":"en","primary_location":{"id":"mag:136305909","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/52/supplement_1/1384","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108105619","display_name":"Muhammad Sohaib","orcid":"https://orcid.org/0009-0009-2685-1309","observed_orcids":["https://orcid.org/0009-0009-2685-1309"]},"institutions":[{"id":"https://openalex.org/I134276161","display_name":"Pakistan Institute of Engineering and Applied Sciences","ror":"https://ror.org/04d4mbk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I134276161"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Sohaib","raw_affiliation_strings":["Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan","institution_ids":["https://openalex.org/I134276161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076074841","display_name":"Imtiaz Ahmed Abbasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76957882","display_name":"Pakistan Institute of Nuclear Science and Technology","ror":"https://ror.org/04bmzpd39","country_code":"PK","type":"facility","lineage":["https://openalex.org/I76957882"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Imtiaz Ahmed Abbasi","raw_affiliation_strings":["Isotopes Production Division, Pakistan Institute of Nuclear Science & Technology, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isotopes Production Division, Pakistan Institute of Nuclear Science & Technology, Islamabad, Pakistan","institution_ids":["https://openalex.org/I76957882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103516897","display_name":"Malik Muhammad Ishfaq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76957882","display_name":"Pakistan Institute of Nuclear Science and Technology","ror":"https://ror.org/04bmzpd39","country_code":"PK","type":"facility","lineage":["https://openalex.org/I76957882"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Malik Ishfaq","raw_affiliation_strings":["Isotopes Production Division, Pakistan Institute of Nuclear Science & Technology, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isotopes Production Division, Pakistan Institute of Nuclear Science & Technology, Islamabad, Pakistan","institution_ids":["https://openalex.org/I76957882"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"52","issue":null,"first_page":"1384","last_page":"1384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lutetium-177","display_name":"lutetium-177","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.8679999709129333},{"id":"https://openalex.org/keywords/radiosynovectomy","display_name":"radiosynovectomy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/knee-joint","display_name":"knee joint","score":0.5059999823570251},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5379999876022339},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7429999709129333},{"id":"https://openalex.org/keywords/effective-half-life","display_name":"effective half-life","score":0.7940000295639038},{"id":"https://openalex.org/keywords/radiochemical-purity","display_name":"radiochemical purity","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2775882047","wikidata":"https://www.wikidata.org/wiki/Q971969","display_name":"Synovectomy","level":3,"score":0.633274495601654},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.591568648815155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4619809091091156},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44246286153793335},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.41177576780319214},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.38952183723449707},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32301652431488037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17002904415130615},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.10501083731651306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:136305909","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/52/supplement_1/1384","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042634642","https://openalex.org/W2462238073","https://openalex.org/W1996473079","https://openalex.org/W2074027145","https://openalex.org/W2186514525","https://openalex.org/W2288177869","https://openalex.org/W2073236242","https://openalex.org/W3212048535","https://openalex.org/W2073647809","https://openalex.org/W2014828564"],"abstract_inverted_index":{"1384":[0],"Objectives":[2],"Coupling":[4],"of":[5,10,26,36,67,91,104,119,155,169,195,221,224,253,268,299,302],"Lutetium-177":[6],"(Lu-177)":[7],"with":[8,148,166,233],"biomolecules":[9],"hydroxyapatite":[11,41,182],"(HA)":[12],"labeled":[13,40],"is":[14],"being":[15],"supported":[16],"by":[17,75,84],"many":[18],"researchers":[19],"for":[20,60,126,240,296],"the":[21,34,131,141,153,160,215,250,263,271,297],"use":[22],"in":[23,43,94,130,209,261,270],"radiation":[24,300],"synovectomy":[25,301],"small":[27,44,303],"synovial":[28,161],"joints.":[29],"The":[30,174,184,218,265],"present":[31],"work":[32],"describes":[33],"bio-evaluation":[35],"locally":[37],"prepared":[38],"Lu-177":[39,92,156,196,254,290],"particles":[42,70,198],"animals.":[45],"Methods":[47],"Natural":[49],"Lu2O3":[50],"target":[51],"was":[52,82,98,181,187,199,207,259,284],"irradiated":[53],"at":[54,110,201],"a":[55,117,146],"thermal":[56],"flux":[57],"~8.0\u00d710^13":[58],"n/cm^2/s":[59],"12":[61],"h":[62],"to":[63,151],"yield":[64,193],"~25.3":[65],"mCi/mg":[66],"Lu-177.":[68,170],"HA":[69,93,157,197,269,291],"were":[71,114,123,143,227],"synthesized":[72],"and":[73,77,163,192,230,238,243,281],"characterized":[74],"FTIR-ATR":[76],"X-ray":[78],"diffractometry.":[79],"Ca/P":[80,185],"ratio":[81,186],"determined":[83],"ICP-OES.":[85],"For":[86,133],"animal":[87],"study":[88],"5-10":[89],"MBq":[90],"0.1":[95],"mL":[96],"solution":[97],"injected":[99,216],"into":[100],"knee":[101,225],"joint":[102],"spaces":[103],"two":[105],"healthy":[106],"rabbits.":[107,264],"Sequential":[108],"images":[109],"11":[111],"time":[112],"points":[113],"acquired":[115],"over":[116,140],"period":[118],"30":[120],"days.":[121,286],"They":[122],"analyzed":[124],"visually":[125],"any":[127,210],"extra-articular":[128,205],"activity":[129,158,206],"torso.":[132],"quantitative":[134],"analysis":[135],"counts":[136,226],"within":[137],"appropriate":[138],"ROIs":[139],"knees":[142,272],"plotted":[144],"on":[145,178],"semi-log":[147],"exponential":[149,222],"line-fit":[150,223],"show":[152],"disappearance":[154],"from":[159,249,274],"cavity":[162],"compared":[164],"it":[165],"physical":[167,282],"decay":[168,252],"Results":[172],"chief":[175],"inorganic":[176],"phase":[177],"XRD":[179],"pattern":[180],"crystal.":[183],"1.68.":[188],"High":[189],"radiochemical":[190],"purity":[191],"(98%)":[194],"achieved":[200],"pH":[202],"7.":[203],"No":[204],"seen":[208,260],"image":[211],"even":[212],"after":[213],"masking":[214],"joint.":[217],"half":[219,267],"lives":[220],"154":[228],"hours":[229,232],"158":[231],"linear":[234],"coefficients":[235],"(r)":[236],"0.998":[237],"0.997":[239],"rabbit":[241],"1":[242],"2":[244],"respectively.":[245],"Minimal":[246],"downward":[247],"divergence":[248],"theoretical":[251],"(T1/2":[255],"=":[256],"161.5":[257],"hours)":[258,280],"both":[262],"biological":[266,294],"calculated":[273],"effective":[275],"half-life":[276,283],"(average":[277],"i.e.,":[278],"156":[279],"190":[285],"Conclusions":[288],"has":[292],"adequate":[293],"characteristics":[295],"application":[298],"joints":[304]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}