{"id":"https://openalex.org/W136274242","doi":null,"title":"Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage.","display_name":"Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage.","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W136274242","mag":"136274242","pmid":"https://pubmed.ncbi.nlm.nih.gov/22294531"},"language":"en","primary_location":{"id":"pmid:22294531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22294531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of invasive cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081408557","display_name":"Mariano E. Brizzio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariano E Brizzio","raw_affiliation_strings":["The Valley Heart and Vascular Institute, 223 North van Dien Avenue, Ridgewood, NJ 07450, USA. mbrizzio@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Valley Heart and Vascular Institute, 223 North van Dien Avenue, Ridgewood, NJ 07450, USA. mbrizzio@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101513512","display_name":"Richard E. Shaw","orcid":"https://orcid.org/0000-0003-2947-8502","observed_orcids":["https://orcid.org/0000-0003-2947-8502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard E Shaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077307986","display_name":"Beth Bosticco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beth Bosticco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033629344","display_name":"Mary Beth Collins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Collins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103239369","display_name":"Juan B. Grau","orcid":"https://orcid.org/0000-0002-6160-3310","observed_orcids":["https://orcid.org/0000-0002-6160-3310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan B Grau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042341476","display_name":"Andrew W. C. Mak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew W C Mak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009548028","display_name":"Alex Zapolanski","orcid":"https://orcid.org/0000-0003-3992-8300","observed_orcids":["https://orcid.org/0000-0003-3992-8300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Zapolanski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4446,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.83256451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"2","first_page":"49","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-inhibition","display_name":"platelet aggregation inhibition","score":0.8619999885559082},{"id":"https://openalex.org/keywords/verifynow-assay","display_name":"VerifyNow assay","score":0.925000011920929},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.8799999952316284},{"id":"https://openalex.org/keywords/off-pump-coronary-artery-bypass-grafting","display_name":"off-pump coronary artery bypass","score":0.9940000176429749},{"id":"https://openalex.org/keywords/preoperative-assessment","display_name":"preoperative assessment","score":0.6060000061988831},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.5789999961853027},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.6840000152587891},{"id":"https://openalex.org/keywords/reoperation","display_name":"reoperation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/timing-of-surgery","display_name":"timing of surgery","score":0.7379999756813049},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.982154130935669},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.9286094903945923},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4600084125995636},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4421478807926178},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43441349267959595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4050697088241577},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40035688877105713},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.17773422598838806}],"mesh":[{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D047549","descriptor_name":"Coronary Artery Bypass, Off-Pump","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22294531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22294531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of invasive cardiology","raw_type":"Journal Article"},{"id":"mag:136274242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22294531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1130020850","https://openalex.org/W2068635657","https://openalex.org/W2119897760","https://openalex.org/W2013093342","https://openalex.org/W1998899422","https://openalex.org/W1980549287","https://openalex.org/W2283985025","https://openalex.org/W1543191655","https://openalex.org/W4214621582","https://openalex.org/W2964508380"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,168],"current":[2],"standard":[3],"of":[4,26,64,86,145,178,234,243,251,265],"care":[5],"is":[6],"to":[7,16,22,34,45,83,93,255,261,271],"delay":[8],"coronary":[9,47,266],"surgery":[10,51,173,267],"5-7":[11],"days":[12,182,189],"after":[13],"clopidogrel":[14,43,138,179,256],"exposure":[15],"prevent":[17],"bleeding":[18,201,277],"complications.":[19],"We":[20,98],"sought":[21],"determine":[23,84],"the":[24,31,77,87,94,100,125,175,184,191,194,248,263],"utility":[25],"an":[27],"objective":[28],"tool":[29,246],"(ie,":[30],"VerifyNow":[32,78],"assay)":[33],"measure":[35],"platelet":[36],"inhibition":[37],"(PI)":[38],"in":[39,165,205,214,219,238,247,274],"patients":[40,90,107,117,132,150,253],"receiving":[41],"preoperative":[42,142,156,249],"prior":[44],"off-pump":[46],"artery":[48],"bypass":[49],"grafting":[50],"(OPCABG).":[52],"PATIENTS":[53],"AND":[54],"METHODS:":[55],"Between":[56],"June":[57],"2007":[58],"and":[59,139,147,160,187,231,268,278],"July":[60],"2009,":[61],"a":[62,141,244,272],"total":[63],"482":[65],"isolated":[66],"OPCABG":[67,252],"procedures":[68],"were":[69,81,91,111,121,136,163,236],"performed":[70,197],"at":[71],"our":[72],"institution.":[73],"In":[74],"160":[75],"patients,":[76],"assay":[79],"results":[80],"used":[82],"timing":[85,264],"OPCABG.":[88],"These":[89],"compared":[92,164],"remaining":[95],"322":[96],"patients.":[97],"divided":[99],"cohort":[101],"into":[102],"4":[103,149,207,226],"subgroups:":[104],"Group":[105,115,130,148,206,215],"1":[106,216],"(n":[108,118,133,151],"=":[109,119,134,152],"205)":[110],"not":[112,128],"taking":[113,122,137],"clopidogrel;":[114],"2":[116,221],"117)":[120],"clopidogrel,":[123],"but":[124],"test":[126,195],"was":[127,180,196,212],"performed;":[129],"3":[131,188,223],"122)":[135],"had":[140,154],"PI":[143,245],"result":[144],"\u226420%;":[146],"38)":[153],"\u226521%":[155],"PI.":[157],"RESULTS:":[158],"Demographic":[159],"clinical":[161],"factors":[162],"all":[166,239],"groups.":[167,240],"median":[169],"waiting":[170],"time":[171],"for":[172,183,190,200,276],"from":[174],"last":[176],"dose":[177],"6":[181],"control":[185],"groups":[186,192],"where":[193],"(P<.001).":[198,228],"Reoperation":[199],"occurred":[202],"most":[203],"often":[204],"(7.9%;":[208],"P=.003).":[209],"Blood":[210],"utilization":[211],"lower":[213],"(24.4%)":[217],"than":[218],"Groups":[220],"(34.2%),":[222],"(40.2%),":[224],"or":[225],"(55.3%)":[227],"Major":[229],"complications":[230],"postoperative":[232],"length":[233],"stay":[235],"similar":[237],"CONCLUSIONS:":[241],"Utilization":[242],"assessment":[250],"exposed":[254],"can":[257],"provide":[258],"valuable":[259],"information":[260],"guide":[262],"may":[269],"lead":[270],"decrease":[273],"reoperation":[275],"blood":[279],"usage.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
