{"id":"https://openalex.org/W136252373","doi":null,"title":"Carvedilol in the treatment of mild to moderate hypertension: experience with ambulatory blood pressure monitoring.","display_name":"Carvedilol in the treatment of mild to moderate hypertension: experience with ambulatory blood pressure monitoring.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W136252373","mag":"136252373","pmid":"https://pubmed.ncbi.nlm.nih.gov/8053282"},"language":"en","primary_location":{"id":"pmid:8053282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8053282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta cardiologica","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006966318","display_name":"Patrick Biston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P Biston","raw_affiliation_strings":["Hypertension Clinic, Erasme Hospital, Universit\u00e9 Libre de Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Clinic, Erasme Hospital, Universit\u00e9 Libre de Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113464640","display_name":"P van de Borne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Van de Borne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035964974","display_name":"Christian M\u00e9lot","orcid":"https://orcid.org/0000-0002-6172-0330","observed_orcids":["https://orcid.org/0000-0002-6172-0330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M\u00e9lot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007010271","display_name":"Pascale Smekens","orcid":"https://orcid.org/0009-0008-5207-7006","observed_orcids":["https://orcid.org/0009-0008-5207-7006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Smekens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007470620","display_name":"W Marinus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Marinus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112090214","display_name":"J. P. Degaute","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Degaute","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.01201489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"2","first_page":"145","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":1.0},{"id":"https://openalex.org/keywords/mild-to-moderate-hypertension","display_name":"mild to moderate hypertension","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure-monitoring","display_name":"ambulatory blood pressure monitoring","score":0.9589999914169312},{"id":"https://openalex.org/keywords/office-blood-pressure","display_name":"office blood pressure","score":0.7129999995231628},{"id":"https://openalex.org/keywords/combination-diuretic-therapy","display_name":"diuretic combination therapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.5920000076293945},{"id":"https://openalex.org/keywords/circadian-rhythm-of-blood-pressure","display_name":"circadian blood pressure rhythm","score":0.7369999885559082},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.8009999990463257},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antihypertensive-efficacy","display_name":"antihypertensive efficacy","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.9672027826309204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9378654956817627},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.8633370399475098},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8413976430892944},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.7468756437301636},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6502000689506531},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.5960279107093811},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4472784996032715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4297965168952942},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.4295705258846283},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.42150020599365234},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.41943103075027466},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3309520483016968}],"mesh":[{"descriptor_ui":"D000077261","descriptor_name":"Carvedilol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:8053282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8053282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta cardiologica","raw_type":"Clinical Trial"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/86979","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/86979","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta cardiologica, 49 (2","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:136252373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8053282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051723911","https://openalex.org/W2380499185","https://openalex.org/W2043052407","https://openalex.org/W2370182320","https://openalex.org/W2385694821","https://openalex.org/W2369852098","https://openalex.org/W2663125434","https://openalex.org/W2372731679","https://openalex.org/W2077343361","https://openalex.org/W2076245717"],"abstract_inverted_index":{"An":[0],"open":[1],"randomized":[2],"study":[3,67,232],"was":[4,72],"conducted":[5],"in":[6,32,98,123,132,240,263],"mild":[7,167,244,268],"to":[8,12,30,69,76,103,141,168,172,218,245,269],"moderate":[9,169,246,270],"hypertensive":[10],"patients":[11,63,164,199],"evaluate,":[13],"over":[14],"a":[15,120,252,264],"3":[16,129],"months":[17,130],"treatment":[18,84,131,177,242],"period,":[19],"the":[20,40,61,66,70,133,142,163,198,207,241],"efficacy":[21,41],"and":[22,29,42,48,126,148,155,186,229,238,248],"tolerability":[23],"of":[24,34,44,60,83,90,109,145,162,197,209,214,243,257],"carvedilol":[25,45,49,85,91,102,235],"25":[26,38,50,86,92],"mg":[27,47,51,87,93,105],"OD":[28,106],"compare,":[31],"case":[33],"insufficient":[35],"results":[36],"with":[37,53,139],"mg,":[39],"tolerance":[43],"50":[46,104],"coadministered":[52],"diuretics.":[54],"Mean":[55],"office":[56,156,173],"blood":[57,99,113,116,146,157,174,260],"pressure":[58,117,147,158,175,261],"(sitting)":[59],"91":[62],"who":[64],"completed":[65],"according":[68,171],"protocol":[71],"reduced":[73,112],"from":[74],"161/100":[75],"147/91":[77],"mm":[78,184,193],"Hg":[79,185],"after":[80,128],"4":[81],"weeks":[82],"OD.":[88],"Continuation":[89],"produced":[94],"no":[95],"further":[96,111],"reduction":[97,122],"pressure.":[100,114],"Increasing":[101],"or":[107],"addition":[108],"diuretics":[110],"Ambulatory":[115],"measurements":[118],"showed":[119,233],"significant":[121],"both":[124],"SBP":[125,190],"DBP":[127,181],"three":[134],"groups,":[135],"as":[136,138,166,267],"well":[137],"respect":[140],"circadian":[143],"profile":[144],"heart":[149],"rate.":[150],"Large":[151],"differences":[152],"between":[153],"ambulatory":[154,259],"were":[159,226],"observed:":[160],"37%":[161],"diagnosed":[165],"hypertensives":[170],"before":[176],"had":[178],"mean":[179,188],"daytime":[180,189],"<":[182,191],"90":[183],"39%":[187],"140":[192],"Hg.":[194],"Twenty-eight":[195],"percent":[196],"experienced":[200],"adverse":[201,219,224],"events;":[202],"they":[203],"occurred":[204],"mainly":[205],"at":[206],"beginning":[208],"treatment;":[210],"less":[211],"than":[212],"5%":[213],"participants":[215],"withdrew":[216],"due":[217],"events.":[220],"The":[221],"most":[222],"frequent":[223],"events":[225],"fatigue,":[227],"vertigo":[228],"asthenia.":[230],"This":[231],"that":[234,249],"is":[236,251],"safe":[237],"effective":[239],"hypertension":[247],"there":[250],"high":[253],"prevalence":[254],"(nearly":[255],"40%)":[256],"low":[258],"means":[262],"population":[265],"labelled":[266],"hypertensive.":[271]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
