{"id":"https://openalex.org/W136234913","doi":"https://doi.org/10.1007/3-540-29717-0_3","title":"Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response","display_name":"Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response","publication_year":2005,"publication_date":"2005-12-28","ids":{"openalex":"https://openalex.org/W136234913","doi":"https://doi.org/10.1007/3-540-29717-0_3","mag":"136234913","pmid":"https://pubmed.ncbi.nlm.nih.gov/16610355"},"language":"en","primary_location":{"id":"doi:10.1007/3-540-29717-0_3","doi":"https://doi.org/10.1007/3-540-29717-0_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/3-540-29717-0_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W614210878","display_name":"Molecular Chaperones in Health and Disease"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011891226","display_name":"Kezhong Zhang","orcid":"https://orcid.org/0000-0002-6062-235X","observed_orcids":["https://orcid.org/0000-0002-6062-235X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Zhang","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015378855","display_name":"Randal J. Kaufman","orcid":"https://orcid.org/0000-0003-4277-316X","observed_orcids":["https://orcid.org/0000-0003-4277-316X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R.J. Kaufman","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical Center, 1150W. Medical Center Dr., Ann Arbor, MI, 48109, USA","[University of Michigan Medical Center]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical Center, 1150W. Medical Center Dr., Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"]},{"raw_affiliation_string":"[University of Michigan Medical Center]","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015378855"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":22.9243,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.99701493,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":null,"issue":"172","first_page":"69","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8859999775886536},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.9739999771118164},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.7540000081062317},{"id":"https://openalex.org/keywords/er-homeostasis","display_name":"ER homeostasis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/misfolded-proteins","display_name":"misfolded proteins","score":0.7710000276565552},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.902999997138977},{"id":"https://openalex.org/keywords/secretory-protein-synthesis","display_name":"secretory protein synthesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.873842716217041},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8656208515167236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7290564179420471},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.6053906083106995},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6018079519271851},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5880540013313293},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.46335673332214355},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.46087199449539185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44029393792152405},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.4199387729167938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39582550525665283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3164967894554138},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.24381104111671448}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/3-540-29717-0_3","doi":"https://doi.org/10.1007/3-540-29717-0_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/3-540-29717-0_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},{"id":"pmid:16610355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16610355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of experimental pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G533944174","display_name":null,"funder_award_id":"DK42394","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W62793449","https://openalex.org/W315837935","https://openalex.org/W1495548641","https://openalex.org/W1504266925","https://openalex.org/W1505761263","https://openalex.org/W1546139069","https://openalex.org/W1557299747","https://openalex.org/W1559266759","https://openalex.org/W1575978940","https://openalex.org/W1672219033","https://openalex.org/W1877873625","https://openalex.org/W1895982166","https://openalex.org/W1905806846","https://openalex.org/W1906283391","https://openalex.org/W1963909878","https://openalex.org/W1964706050","https://openalex.org/W1965843055","https://openalex.org/W1967883750","https://openalex.org/W1970090817","https://openalex.org/W1977498240","https://openalex.org/W1978999653","https://openalex.org/W1984672567","https://openalex.org/W1985339713","https://openalex.org/W1986737010","https://openalex.org/W1988482079","https://openalex.org/W1990400035","https://openalex.org/W1991958238","https://openalex.org/W1991999080","https://openalex.org/W1996785364","https://openalex.org/W1999719904","https://openalex.org/W2001617515","https://openalex.org/W2002733795","https://openalex.org/W2005129842","https://openalex.org/W2007078899","https://openalex.org/W2009020353","https://openalex.org/W2010494349","https://openalex.org/W2010668098","https://openalex.org/W2014002820","https://openalex.org/W2015288395","https://openalex.org/W2019386694","https://openalex.org/W2019424220","https://openalex.org/W2023680254","https://openalex.org/W2025226894","https://openalex.org/W2025846979","https://openalex.org/W2028279477","https://openalex.org/W2028878583","https://openalex.org/W2033088972","https://openalex.org/W2034213169","https://openalex.org/W2034505413","https://openalex.org/W2034810866","https://openalex.org/W2036677133","https://openalex.org/W2038763220","https://openalex.org/W2039824115","https://openalex.org/W2040993603","https://openalex.org/W2044613643","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2049043048","https://openalex.org/W2049127225","https://openalex.org/W2051793369","https://openalex.org/W2053152816","https://openalex.org/W2053823780","https://openalex.org/W2058723245","https://openalex.org/W2064950130","https://openalex.org/W2071002178","https://openalex.org/W2071273959","https://openalex.org/W2075045129","https://openalex.org/W2080901528","https://openalex.org/W2081294646","https://openalex.org/W2090839709","https://openalex.org/W2093158584","https://openalex.org/W2100347985","https://openalex.org/W2104085655","https://openalex.org/W2106314483","https://openalex.org/W2106983618","https://openalex.org/W2107601804","https://openalex.org/W2110780830","https://openalex.org/W2115205812","https://openalex.org/W2119902047","https://openalex.org/W2120736516","https://openalex.org/W2123142240","https://openalex.org/W2127639686","https://openalex.org/W2127906377","https://openalex.org/W2130764195","https://openalex.org/W2131632095","https://openalex.org/W2133425838","https://openalex.org/W2133771702","https://openalex.org/W2137755719","https://openalex.org/W2139577310","https://openalex.org/W2142638534","https://openalex.org/W2142780460","https://openalex.org/W2143952529","https://openalex.org/W2144065739","https://openalex.org/W2144859756","https://openalex.org/W2145112854","https://openalex.org/W2155884826","https://openalex.org/W2158636606","https://openalex.org/W2162076197","https://openalex.org/W2163285372","https://openalex.org/W2165092054","https://openalex.org/W2170504875","https://openalex.org/W2170939329","https://openalex.org/W2192080449","https://openalex.org/W2232982662","https://openalex.org/W4254493498"],"related_works":["https://openalex.org/W2063193694","https://openalex.org/W2031267215","https://openalex.org/W2081731224","https://openalex.org/W145984196","https://openalex.org/W2033554865","https://openalex.org/W2024475665","https://openalex.org/W2280358180","https://openalex.org/W141717017","https://openalex.org/W1977603207","https://openalex.org/W2162679859"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}