{"id":"https://openalex.org/W13621067","doi":null,"title":"MEDIATION OF CHEMOTHERAPY-INDUCED APOPTOSIS BY THE LYSOSOMAL PROTEASE CATHEPSIN D","display_name":"MEDIATION OF CHEMOTHERAPY-INDUCED APOPTOSIS BY THE LYSOSOMAL PROTEASE CATHEPSIN D","publication_year":2005,"publication_date":"2005-07-25","ids":{"openalex":"https://openalex.org/W13621067","mag":"13621067"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7987","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/7987/1/EmertSedlakLoriETD2005.pdf","pdf_url":"https://d-scholarship.pitt.edu/7987/1/EmertSedlakLoriETD2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009330527","display_name":"Lori A. Emert\u2010Sedlak","orcid":"https://orcid.org/0000-0001-8123-7891","observed_orcids":["https://orcid.org/0000-0001-8123-7891"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lori A. Emert\u2010Sedlak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8123-7891","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009330527"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00093809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemotherapy-induced-apoptosis","display_name":"chemotherapy-induced apoptosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lysosomal-proteases","display_name":"lysosomal proteases","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.48500001430511475},{"id":"https://openalex.org/keywords/death-receptor-signaling","display_name":"death receptor signaling","score":0.5600000023841858},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.8029999732971191},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.7480000257492065},{"id":"https://openalex.org/keywords/caspase-independent-cell-death","display_name":"caspase-independent cell death","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7620000243186951},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5899999737739563},{"id":"https://openalex.org/keywords/protein-kinase-c-inhibition","display_name":"protein kinase C inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.35100001096725464},{"id":"https://openalex.org/keywords/tnfr1","display_name":"TNFR1","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.7265942692756653},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5639845132827759},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.5334855318069458},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.5311089158058167},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5295686721801758},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5111122727394104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4505062401294708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4240695536136627},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42218005657196045},{"id":"https://openalex.org/C2780034444","wikidata":"https://www.wikidata.org/wiki/Q5052485","display_name":"Cathepsin L","level":4,"score":0.41513317823410034},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.41072767972946167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3503836393356323},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3230457007884979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20346012711524963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15661916136741638},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11854591965675354},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05379036068916321},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:7987","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/7987/1/EmertSedlakLoriETD2005.pdf","pdf_url":"https://d-scholarship.pitt.edu/7987/1/EmertSedlakLoriETD2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:13621067","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/7987/1/EmertSedlakLoriETD2005.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W32652449","https://openalex.org/W44401740","https://openalex.org/W51229851","https://openalex.org/W103566770","https://openalex.org/W152522539","https://openalex.org/W208592351","https://openalex.org/W1481273911","https://openalex.org/W1536239816","https://openalex.org/W1543932951","https://openalex.org/W1560487523","https://openalex.org/W1582816740","https://openalex.org/W1598109746","https://openalex.org/W1603821125","https://openalex.org/W1605749013","https://openalex.org/W1660893922","https://openalex.org/W1828517887","https://openalex.org/W1890027265","https://openalex.org/W1896927510","https://openalex.org/W1898248824","https://openalex.org/W1898898539","https://openalex.org/W1942214720","https://openalex.org/W1942834335","https://openalex.org/W1963971594","https://openalex.org/W1964617786","https://openalex.org/W1968210150","https://openalex.org/W1974341306","https://openalex.org/W1976426225","https://openalex.org/W1978813721","https://openalex.org/W1978841975","https://openalex.org/W1979842763","https://openalex.org/W1980837484","https://openalex.org/W1980880143","https://openalex.org/W1981343458","https://openalex.org/W1984073321","https://openalex.org/W1984145308","https://openalex.org/W1984254677","https://openalex.org/W1984547206","https://openalex.org/W1987876460","https://openalex.org/W1988294401","https://openalex.org/W1988728998","https://openalex.org/W1992900472","https://openalex.org/W1993300108","https://openalex.org/W1995684250","https://openalex.org/W1996681941","https://openalex.org/W1997005484","https://openalex.org/W1999301383","https://openalex.org/W2000623989","https://openalex.org/W2003122962","https://openalex.org/W2008317513","https://openalex.org/W2010083809","https://openalex.org/W2011393926","https://openalex.org/W2013314062","https://openalex.org/W2017102177","https://openalex.org/W2017208305","https://openalex.org/W2018692481","https://openalex.org/W2019083595","https://openalex.org/W2019363409","https://openalex.org/W2019687681","https://openalex.org/W2020169963","https://openalex.org/W2022020054","https://openalex.org/W2022306557","https://openalex.org/W2022520367","https://openalex.org/W2023750468","https://openalex.org/W2024611184","https://openalex.org/W2025093370","https://openalex.org/W2025807026","https://openalex.org/W2025969002","https://openalex.org/W2028520206","https://openalex.org/W2028582699","https://openalex.org/W2029797799","https://openalex.org/W2031727967","https://openalex.org/W2034269086","https://openalex.org/W2034279252","https://openalex.org/W2035055307","https://openalex.org/W2037282170","https://openalex.org/W2037827452","https://openalex.org/W2038118195","https://openalex.org/W2043287922","https://openalex.org/W2044247344","https://openalex.org/W2045935725","https://openalex.org/W2046325449","https://openalex.org/W2046482455","https://openalex.org/W2048116131","https://openalex.org/W2048255626","https://openalex.org/W2048980943","https://openalex.org/W2052488557","https://openalex.org/W2052853635","https://openalex.org/W2053305234","https://openalex.org/W2054728806","https://openalex.org/W2058501774","https://openalex.org/W2058519081","https://openalex.org/W2060056050","https://openalex.org/W2060359113","https://openalex.org/W2062853648","https://openalex.org/W2064127449","https://openalex.org/W2068023718","https://openalex.org/W2068608662","https://openalex.org/W2074511516","https://openalex.org/W2074816789","https://openalex.org/W2076912059","https://openalex.org/W2077965127","https://openalex.org/W2078520504","https://openalex.org/W2078689358","https://openalex.org/W2080424930","https://openalex.org/W2082113351","https://openalex.org/W2083944684","https://openalex.org/W2085634002","https://openalex.org/W2087982141","https://openalex.org/W2088555531","https://openalex.org/W2089540661","https://openalex.org/W2089767192","https://openalex.org/W2091998314","https://openalex.org/W2096745826","https://openalex.org/W2098248666","https://openalex.org/W2105253056","https://openalex.org/W2106966818","https://openalex.org/W2108086395","https://openalex.org/W2110251929","https://openalex.org/W2115970169","https://openalex.org/W2116494516","https://openalex.org/W2116553523","https://openalex.org/W2117390254","https://openalex.org/W2122028337","https://openalex.org/W2123513769","https://openalex.org/W2128212057","https://openalex.org/W2130898002","https://openalex.org/W2134388096","https://openalex.org/W2135233980","https://openalex.org/W2136269288","https://openalex.org/W2140618402","https://openalex.org/W2140955159","https://openalex.org/W2142120946","https://openalex.org/W2142795591","https://openalex.org/W2143652083","https://openalex.org/W2145269229","https://openalex.org/W2145472547","https://openalex.org/W2146159388","https://openalex.org/W2151411140","https://openalex.org/W2151642508","https://openalex.org/W2152826290","https://openalex.org/W2152902624","https://openalex.org/W2153225914","https://openalex.org/W2153747430","https://openalex.org/W2155808288","https://openalex.org/W2156390455","https://openalex.org/W2157962166","https://openalex.org/W2159153404","https://openalex.org/W2159627505","https://openalex.org/W2160912752","https://openalex.org/W2162889783","https://openalex.org/W2167408727","https://openalex.org/W2169232755","https://openalex.org/W2226271841","https://openalex.org/W2258951277","https://openalex.org/W2278332927","https://openalex.org/W2322277401","https://openalex.org/W2325862576","https://openalex.org/W2328267773","https://openalex.org/W2330592356","https://openalex.org/W2338543817","https://openalex.org/W2399547257","https://openalex.org/W2406040674"],"related_works":["https://openalex.org/W2159131006","https://openalex.org/W210274072","https://openalex.org/W2015052614","https://openalex.org/W1560135361","https://openalex.org/W1963971594","https://openalex.org/W7001968192","https://openalex.org/W2077965127","https://openalex.org/W2076912059","https://openalex.org/W2031727967","https://openalex.org/W2018531084"],"abstract_inverted_index":{"One":[0],"of":[1,6,10,17,21,30,37,92,109,118,129,177,195,202,223,294,315,333],"the":[2,18,22,28,35,42,53,61,67,82,90,96,107,110,133,142,161,171,334],"most":[3],"common":[4],"hallmarks":[5],"cancer":[7,47],"is":[8,25,58,329],"dysregulation":[9],"cellular":[11],"apoptotic":[12,23,63,98,335],"processes.":[13],"A":[14],"comprehensive":[15],"knowledge":[16],"underlying":[19],"mechanisms":[20],"machinery":[24],"vital":[26],"for":[27,71,154],"identification":[29],"new":[31],"drug":[32,135,148],"targets":[33],"and":[34,73,81,120,160,165,197,208,233,240,252,337,351],"development":[36],"innovative":[38],"agents":[39],"that":[40,52,126,189,273,280,310,326,338],"stimulate":[41],"cell":[43,217],"death":[44,68,218,226],"process":[45],"in":[46,60,95,115,206,268],"cells.":[48,122],"Studies":[49],"have":[50],"shown":[51],"lysosomal":[54,111,162],"protease":[55,112],"cathepsin":[56,93,113,137,155,158,185,190,198,203,244,277,281,305,316,327],"D":[57,94,114,138,180,186,191,199,204,245,282,328],"important":[59,331],"extrinsic":[62],"pathway":[64,99,336],"stimulated":[65],"by":[66,78,304],"receptor":[69,227],"ligands":[70],"TNFR1":[72],"FAS,":[74],"as":[75,77,157],"well":[76],"oxidative":[79,229],"stress":[80],"protein":[83],"kinase":[84],"C":[85],"inhibitor":[86],"staurosporine.":[87],"To":[88],"date,":[89],"role":[91,108],"chemotherapy-induced":[97,116,355],"has":[100],"not":[101,168,313],"been":[102],"characterized.":[103],"This":[104,150],"project":[105],"examined":[106],"apoptosis":[117],"HeLa":[119,241],"U937":[121,130,207,239,263],"The":[123],"data":[124],"demonstrated":[125],"following":[127,173,255],"stimulation":[128],"cells":[131,210,242,264],"with":[132,276],"chemotherapy":[134,235],"VP-16,":[136],"was":[139,152,213],"released":[140,169,265],"into":[141,170],"cytosol":[143,172],"approximately":[144],"4":[145],"hours":[146],"after":[147],"treatment.":[149,175,257],"release":[151,192,251,302,350],"selective":[153],"D,":[156,278],"B":[159],"markers":[163],"LAMP":[164],"\u00e2-hexosaminidase":[166],"were":[167,274],"VP-16":[174,256],"Inhibitors":[176],"caspases":[178,295,311],"andcathepsin":[179],"had":[181,296],"no":[182,297],"effect":[183],"on":[184,284,299],"release,":[187],"demonstrating":[188,309],"occurred":[193],"independently":[194],"caspase":[196,352],"activities.":[200],"Downregulation":[201],"expression":[205],"Hela":[209],"using":[211],"siRNA":[212,246],"found":[214],"to":[215,270,288,346],"inhibit":[216],"resulting":[219],"from":[220,261],"a":[221,285],"variety":[222],"stimuli,":[224],"including":[225],"ligands,":[228],"stress,":[230],"PKC":[231],"inhibitors,":[232],"importantly,":[234],"drugs.":[236],"In":[237],"addition,":[238],"expressing":[243],"exhibited":[247],"delayed":[248],"cytochrome":[249,266,290,300,318,348],"c":[250,267,291,301,319,349],"caspase-3":[253],"activation":[254,353],"Moreover,":[258],"isolated":[259],"mitochondria":[260],"wild-type":[262],"response":[269],"cytosolic":[271,286,307,344],"extracts":[272],"treated":[275],"suggesting":[279],"acts":[283,340],"factor":[287,345],"induce":[289],"release.":[292,320],"Inhibition":[293],"impact":[298],"provoked":[303],"D-cleaved":[306],"extract,":[308],"are":[312],"mediators":[314],"D-induced":[317],"Taken":[321],"together,":[322],"these":[323],"results":[324],"demonstrate":[325],"an":[330,342],"component":[332],"it":[339],"via":[341],"intermediary":[343],"promote":[347],"during":[354],"apoptosis.":[356]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
