{"id":"https://openalex.org/W136134437","doi":"https://doi.org/10.1007/978-3-642-56833-6_8","title":"Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABAA Receptors","display_name":"Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABAA Receptors","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W136134437","doi":"https://doi.org/10.1007/978-3-642-56833-6_8","mag":"136134437"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-56833-6_8","doi":"https://doi.org/10.1007/978-3-642-56833-6_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-56833-6_8","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W620094902","display_name":"Pharmacology of GABA and Glycine Neurotransmission"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051515082","display_name":"E. Costa","orcid":"https://orcid.org/0000-0003-0792-5439","observed_orcids":["https://orcid.org/0000-0003-0792-5439"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"E. Costa","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, ETH and University of Z\u00fcrich, Winterthurerstr. 190, CH-8057, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, ETH and University of Z\u00fcrich, Winterthurerstr. 190, CH-8057, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090826335","display_name":"James Auta","orcid":"https://orcid.org/0000-0002-5468-7704","observed_orcids":["https://orcid.org/0000-0002-5468-7704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Auta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Guidotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051515082"],"corresponding_institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"],"apc_list":null,"apc_paid":null,"fwci":2.1475,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.86806883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"227","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/benzodiazepine-binding-site","display_name":"benzodiazepine binding site","score":0.9610000252723694},{"id":"https://openalex.org/keywords/benzodiazepine-dependence","display_name":"benzodiazepine dependence","score":0.828000009059906},{"id":"https://openalex.org/keywords/endozepines","display_name":"endozepines","score":0.7900000214576721},{"id":"https://openalex.org/keywords/neurosteroids","display_name":"neurosteroids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gaba-gated-chloride-channels","display_name":"GABA-gated chloride channels","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.9359999895095825},{"id":"https://openalex.org/keywords/synaptic-inhibition","display_name":"synaptic inhibition","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.9147399067878723},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7322787642478943},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.6888072490692139},{"id":"https://openalex.org/C9224880","wikidata":"https://www.wikidata.org/wiki/Q798179","display_name":"GABAA-rho receptor","level":4,"score":0.6725289225578308},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5521116852760315},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5343356132507324},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.4908193051815033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.414247065782547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3621136248111725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1541241705417633}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-56833-6_8","doi":"https://doi.org/10.1007/978-3-642-56833-6_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-56833-6_8","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W25113821","https://openalex.org/W613940653","https://openalex.org/W1508825618","https://openalex.org/W1575058407","https://openalex.org/W1684501056","https://openalex.org/W1883602621","https://openalex.org/W1915339567","https://openalex.org/W1919267946","https://openalex.org/W1929455229","https://openalex.org/W1946527501","https://openalex.org/W1962066307","https://openalex.org/W1964181148","https://openalex.org/W1968898388","https://openalex.org/W1970739803","https://openalex.org/W1971336985","https://openalex.org/W1972023310","https://openalex.org/W1972283382","https://openalex.org/W1972994417","https://openalex.org/W1976487964","https://openalex.org/W1981592369","https://openalex.org/W1982685000","https://openalex.org/W1988045452","https://openalex.org/W1990356194","https://openalex.org/W1990584558","https://openalex.org/W1992157772","https://openalex.org/W1992786849","https://openalex.org/W1996033662","https://openalex.org/W1996085257","https://openalex.org/W2000713005","https://openalex.org/W2004557551","https://openalex.org/W2005533504","https://openalex.org/W2006000052","https://openalex.org/W2006550065","https://openalex.org/W2008627941","https://openalex.org/W2010368932","https://openalex.org/W2013683917","https://openalex.org/W2017206888","https://openalex.org/W2017337653","https://openalex.org/W2018484090","https://openalex.org/W2032218383","https://openalex.org/W2037973675","https://openalex.org/W2039738625","https://openalex.org/W2040579648","https://openalex.org/W2044553756","https://openalex.org/W2050349038","https://openalex.org/W2052184294","https://openalex.org/W2058308027","https://openalex.org/W2065342106","https://openalex.org/W2069279318","https://openalex.org/W2076076801","https://openalex.org/W2077813306","https://openalex.org/W2081317561","https://openalex.org/W2089700993","https://openalex.org/W2094151893","https://openalex.org/W2095712681","https://openalex.org/W2111775018","https://openalex.org/W2130856363","https://openalex.org/W2145294340","https://openalex.org/W2149348217","https://openalex.org/W2169533599","https://openalex.org/W2171129696","https://openalex.org/W2186363591","https://openalex.org/W2243793709","https://openalex.org/W2268187232","https://openalex.org/W2279855182","https://openalex.org/W2283212374","https://openalex.org/W2330700346","https://openalex.org/W2337057859","https://openalex.org/W2407208693","https://openalex.org/W2418677768","https://openalex.org/W2433839752","https://openalex.org/W2472264772","https://openalex.org/W2477230890","https://openalex.org/W2535968102","https://openalex.org/W3151144641","https://openalex.org/W4406059090","https://openalex.org/W4406065735"],"related_works":["https://openalex.org/W1972823445","https://openalex.org/W1616776977","https://openalex.org/W2023132644","https://openalex.org/W107261294","https://openalex.org/W226400571","https://openalex.org/W1990610135","https://openalex.org/W2623302288","https://openalex.org/W2049983745","https://openalex.org/W2013903929","https://openalex.org/W215973046"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
