{"id":"https://openalex.org/W136073532","doi":null,"title":"Experimental models and behavioural tests used in the study of Parkinson's disease.","display_name":"Experimental models and behavioural tests used in the study of Parkinson's disease.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W136073532","mag":"136073532","pmid":"https://pubmed.ncbi.nlm.nih.gov/8869270"},"language":"en","primary_location":{"id":"pmid:8869270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8869270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060163981","display_name":"Jaroslav Mokr\u00fd","orcid":"https://orcid.org/0000-0001-5769-9973","observed_orcids":["https://orcid.org/0000-0001-5769-9973"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"J Mokr\u00fd","raw_affiliation_strings":["Department of Histology and Embryology, Charles University Medical School, Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Charles University Medical School, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060163981"],"corresponding_institution_ids":["https://openalex.org/I21250087"],"apc_list":null,"apc_paid":null,"fwci":0.5941,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.65139854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"44","issue":"3","first_page":"143","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.9520000219345093},{"id":"https://openalex.org/keywords/behavioural-tests","display_name":"behavioural tests","score":0.921999990940094},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.8569999933242798},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rotation-test","display_name":"rotation test","score":0.6669999957084656},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.6480000019073486},{"id":"https://openalex.org/keywords/graft-incorporation","display_name":"graft integration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/substantia-nigra-lesions","display_name":"substantia nigra lesions","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.8089550733566284},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.741997480392456},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.7202185392379761},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.7085344791412354},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6634474992752075},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6404011249542236},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6143311858177185},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.569314181804657},{"id":"https://openalex.org/C2777288102","wikidata":"https://www.wikidata.org/wiki/Q780181","display_name":"Oxidopamine","level":5,"score":0.5495785474777222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4010693430900574},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3888952136039734},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29709523916244507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23038414120674133}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D010302","descriptor_name":"Parkinson Disease, Secondary","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010302","descriptor_name":"Parkinson Disease, Secondary","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D010302","descriptor_name":"Parkinson Disease, Secondary","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8869270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8869270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological research","raw_type":"Journal Article"},{"id":"mag:136073532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8869270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W162351102","https://openalex.org/W2530418047","https://openalex.org/W597584068","https://openalex.org/W2052446676","https://openalex.org/W1937034110","https://openalex.org/W3066915027","https://openalex.org/W2911992820","https://openalex.org/W2504392599","https://openalex.org/W1531991623","https://openalex.org/W2046632451"],"abstract_inverted_index":{"The":[0,47,64,132,157],"present":[1],"review":[2],"brings":[3],"the":[4,7,41,53,80,103,123,141,173,198,212,219,232,246,252,258],"survey":[5],"of":[6,16,26,34,82,112,125,138,167,172,191,200,208,221,234,237,248,254],"most":[8,65,133],"frequently":[9,66,134],"used":[10,67,100,135,185,229],"behavioural":[11,155,226],"tests":[12,111,183,227,250],"in":[13,28,45,51,84,106,144,169],"experimental":[14,31,136],"models":[15,33,224],"Parkinson's":[17],"disease":[18],"(PD).":[19],"Although":[20],"there":[21],"is":[22,99,140,160],"no":[23],"spontaneous":[24,188],"occurrence":[25],"parkinsonism":[27],"animals,":[29],"several":[30],"animal":[32],"PD":[35,83,139],"have":[36,58],"been":[37],"developed":[38],"to":[39,90,93,101,186,218,230],"achieve":[40],"same":[42],"clinical":[43],"features":[44],"animals.":[46,193,241],"techniques":[48],"employing":[49],"neurotoxins":[50,68],"lesioning":[52],"nigrostriatal":[54,115],"dopaminergic":[55],"(DA)":[56],"system":[57,128],"a":[59,107,161,215],"large":[60],"selectivity":[61],"and":[62,73,153,225],"reproducibility.":[63],"are":[69,184,228],"1-methyl-4-phenyl-":[70],"1,2,3,6-tetrahydropyridine":[71],"(MPTP)":[72],"6-hydroxydopamine":[74],"(6-OHDA).":[75],"MPTP-lesioned":[76],"monkeys":[77],"mimic":[78],"best":[79],"symptomatology":[81],"human":[85],"patients":[86],"while":[87],"rats":[88],"appear":[89],"be":[91],"refractory":[92],"MPTP.":[94],"For":[95],"that":[96],"reason,":[97],"6-OHDA":[98,145],"damage":[102],"substantia":[104],"nigra":[105],"rodent":[108],"model.":[109,176],"Behavioural":[110],"animals":[113],"with":[114],"lesion":[116],"represent":[117],"valuable":[118],"non-invasive":[119],"methods":[120],"for":[121,164],"assessing":[122],"influence":[124,199],"damaged":[126],"DA":[127,209],"on":[129,203],"locomotor":[130,189],"activity.":[131],"model":[137,150],"drug-evoked":[142],"rotation":[143,158],"unilaterally":[146],"lesioned":[147,192],"rats.":[148],"This":[149],"produces":[151],"well-defined":[152],"stable":[154],"deficits.":[156],"test":[159,180],"useful":[162],"parameter":[163],"evaluating":[165],"imbalances":[166],"dopamine":[168],"both":[170],"striata":[171],"hemi-parkinsonian":[174],"rat":[175],"T-maze,":[177],"treadmill":[178],"running":[179],"or":[181,239],"sensorimotor":[182],"evaluate":[187,231],"activity":[190],"Skilled":[194],"motor":[195,205],"tasks":[196],"measure":[197],"dopamine-depleting":[201],"lesions":[202],"complex":[204],"acts.":[206],"Transplantation":[207],"tissue":[210],"into":[211,257],"striatum":[213],"offers":[214],"new":[216],"approach":[217],"treatment":[220],"PD.":[222],"Experimental":[223],"extent":[233],"graft-induced":[235],"recovery":[236],"MPTP-":[238],"6-OHDA-lesioned":[240],"Different":[242],"results":[243],"obtained":[244],"after":[245],"use":[247],"different":[249],"reflect":[251],"level":[253],"graft":[255],"integration":[256],"host":[259],"circuitry.":[260]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
