{"id":"https://openalex.org/W136042355","doi":null,"title":"Cytochalasin D disrupts outer segment disc morphogenesis in situ in rabbit retina.","display_name":"Cytochalasin D disrupts outer segment disc morphogenesis in situ in rabbit retina.","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W136042355","mag":"136042355","pmid":"https://pubmed.ncbi.nlm.nih.gov/2914762"},"language":"en","primary_location":{"id":"pmid:2914762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2914762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111797208","display_name":"Dana K. Vaughan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D K Vaughan","raw_affiliation_strings":["IES-Neuroscience Research Program, University of California, Santa Barbara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IES-Neuroscience Research Program, University of California, Santa Barbara","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108585423","display_name":"Steven K. Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S K Fisher","raw_affiliation_strings":["IES-Neuroscience Research Program, University of California, Santa Barbara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IES-Neuroscience Research Program, University of California, Santa Barbara","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":null,"apc_paid":null,"fwci":4.0591,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.93046232,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"30","issue":"2","first_page":"339","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochalasin-d","display_name":"cytochalasin D","score":1.0},{"id":"https://openalex.org/keywords/rod-outer-segments","display_name":"rod outer segments","score":0.843999981880188},{"id":"https://openalex.org/keywords/cone-outer-segments","display_name":"cone outer segments","score":0.9980000257492065},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.5130000114440918},{"id":"https://openalex.org/keywords/retinal-photoreceptors","display_name":"retinal photoreceptors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/intraocular-injection","display_name":"intraocular injection","score":0.5830000042915344},{"id":"https://openalex.org/keywords/drug-reversibility","display_name":"drug reversibility","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6991115808486938},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.6732648611068726},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6687279939651489},{"id":"https://openalex.org/C2776041460","wikidata":"https://www.wikidata.org/wiki/Q5201339","display_name":"Cytochalasin D","level":4,"score":0.59349125623703},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.569379448890686},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.5672290325164795},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5201266407966614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5172017812728882},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5062562823295593},{"id":"https://openalex.org/C2775995422","wikidata":"https://www.wikidata.org/wiki/Q5201335","display_name":"Cytochalasin","level":4,"score":0.49956846237182617},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.446181982755661},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4286425709724426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4202691614627838},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4176618158817291},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3709476888179779},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2810364365577698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10042089223861694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08020153641700745},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.04642742872238159},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003572","descriptor_name":"Cytochalasins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015638","descriptor_name":"Cytochalasin D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2914762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2914762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:136042355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2914762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G281537384","display_name":"Experimental Retinal Detachment and Reattachment","funder_award_id":"R01EY000888","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W43721233","https://openalex.org/W1988807285","https://openalex.org/W2021796370","https://openalex.org/W2029779968","https://openalex.org/W2039723960","https://openalex.org/W2047158283","https://openalex.org/W2066510087","https://openalex.org/W2066780072","https://openalex.org/W2086441678","https://openalex.org/W2103446130","https://openalex.org/W2119632652","https://openalex.org/W2162847025","https://openalex.org/W2166241889"],"related_works":["https://openalex.org/W2021796370","https://openalex.org/W2103957162","https://openalex.org/W2076435936","https://openalex.org/W4407388406","https://openalex.org/W1993805514","https://openalex.org/W2116298783","https://openalex.org/W174267592","https://openalex.org/W7145398084","https://openalex.org/W2077817577","https://openalex.org/W2091382438"],"abstract_inverted_index":{"Exposure":[0],"of":[1,62,91],"rabbit":[2],"retina":[3],"to":[4,53,87],"cytochalasin":[5],"D":[6],"(CD)":[7],"via":[8],"a":[9],"single":[10],"intraocular":[11],"injection":[12],"results":[13],"in":[14],"basal":[15,47],"rod":[16],"outer":[17,38],"segment":[18],"(ROS)":[19],"and":[20,49,76,94],"cone":[21],"OS":[22,31],"(COS)":[23],"discs":[24,51],"with":[25],"abnormally":[26],"large":[27],"diameters;":[28],"the":[29,36,45,60,70,77,83,89],"overgrown":[30],"membranes":[32],"extend":[33],"along":[34],"either":[35],"cell":[37],"or":[39],"inner":[40],"segment.":[41],"Twenty-four":[42],"hours":[43],"after":[44],"injection,":[46],"ROS":[48,84],"COS":[50],"appear":[52],"have":[54],"recovered":[55],"their":[56],"normal":[57],"diameter,":[58],"indicating":[59],"reversibility":[61],"this":[63],"drug's":[64],"effect.":[65],"These":[66],"data":[67],"support":[68],"both":[69],"evagination":[71,93],"hypothesis":[72,78],"for":[73],"disc":[74,95],"morphogenesis":[75],"that":[79],"f-actin's":[80],"role":[81],"at":[82],"base":[85],"is":[86],"regulate":[88],"initiation":[90],"membrane":[92],"diameter.":[96]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
