{"id":"https://openalex.org/W136010493","doi":null,"title":"CAST-ELISA test--a new diagnostic tool in pollen allergy.","display_name":"CAST-ELISA test--a new diagnostic tool in pollen allergy.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W136010493","mag":"136010493","pmid":"https://pubmed.ncbi.nlm.nih.gov/9093931"},"language":"en","primary_location":{"id":"pmid:9093931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016356292","display_name":"Wojciech M\u0119drala","orcid":"https://orcid.org/0000-0001-8116-4725","observed_orcids":["https://orcid.org/0000-0001-8116-4725"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]},{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"W Medrala","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroc\u0142aw University of Medicine, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroc\u0142aw University of Medicine, Poland","institution_ids":["https://openalex.org/I219388962","https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110425756","display_name":"J Ma\u0142olepszy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ma\u0142olepszy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016356292","display_name":"Wojciech M\u0119drala","orcid":"https://orcid.org/0000-0001-8116-4725","observed_orcids":["https://orcid.org/0000-0001-8116-4725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Medrala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075837682","display_name":"Jerzy Liebhart","orcid":"https://orcid.org/0000-0003-2414-9275","observed_orcids":["https://orcid.org/0000-0003-2414-9275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Liebhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108187344","display_name":"Marita Marszalska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Marszalska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048635311","display_name":"Rafa\u0142 Dobek","orcid":"https://orcid.org/0000-0003-1386-7562","observed_orcids":["https://orcid.org/0000-0003-1386-7562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Dobek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082329720","display_name":"Krystyna Gietkiewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Gietkiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058922978","display_name":"Marta Litwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Litwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019467156","display_name":"E Pietrzak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Pietrzak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"32","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pollinosis","display_name":"pollinosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/leukocyte-activation","display_name":"leukocyte activation","score":0.871999979019165},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.7590000033378601},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.8330820798873901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7846304178237915},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.6291800737380981},{"id":"https://openalex.org/C7623868","wikidata":"https://www.wikidata.org/wiki/Q1967135","display_name":"Centrifugation","level":2,"score":0.6239668726921082},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.616761326789856},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6114683151245117},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.47728291153907776},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.44095703959465027},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35127586126327515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2420881986618042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12274852395057678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10421723127365112}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007159","descriptor_name":"Immunologic Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015166","descriptor_name":"Monitoring, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9093931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Journal Article"},{"id":"mag:136010493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2465318384","https://openalex.org/W156607507","https://openalex.org/W2786946250","https://openalex.org/W176970130","https://openalex.org/W2418000230","https://openalex.org/W2056856357","https://openalex.org/W7016032558","https://openalex.org/W7099545448","https://openalex.org/W2000115608","https://openalex.org/W2185749005"],"abstract_inverted_index":{"We":[0,158,223],"have":[1,159],"applied":[2],"a":[3,155,161,228],"recently":[4],"developed":[5],"method":[6,20,230],"called":[7],"CAST-ELISA":[8,226],"to":[9,193,231],"evaluate":[10],"the":[11,24,42,51,63,81,106,108,113,130,165,172,180,201,216,233],"degree":[12],"of":[13,26,44,54,77,115,129,132,147,164,175,186,218],"leukocyte":[14,166],"stimulation":[15,86,220],"by":[16,38,68,72],"specific":[17,39,96],"allergen.":[18,140],"This":[19],"is":[21,227],"based":[22],"on":[23],"measurement":[25],"sulfidoleukotriene":[27,134,198],"levels":[28],"in":[29,41,85,117,125,136,188,200,210,236],"supernatants":[30,189],"taken":[31],"from":[32,191],"previously":[33],"stimulated":[34],"peripheral":[35],"blood":[36],"leukocytes":[37],"allergen":[40,97,169,182,219],"presence":[43],"interleukin":[45],"3.23":[46],"patients":[47],"with":[48,93,238],"pollinosis":[49],"entered":[50],"study.":[52],"All":[53],"them":[55],"received":[56],"no":[57],"medication":[58],"during":[59],"2":[60],"weeks":[61],"before":[62],"test.":[64],"Leukocytes":[65],"were":[66,83,110,123,208,221],"isolated":[67],"dextran":[69],"sedimentation":[70],"followed":[71],"single":[73],"centrifugation.":[74],"After":[75,105],"removal":[76],"platelet":[78],"rich":[79],"plasma":[80],"cells":[82,109],"suspended":[84],"buffer":[87],"and":[88,112],"divided":[89],"into":[90],"portions":[91,137],"incubated":[92,138],"or":[94],"without":[95,139],"for":[98],"40":[99],"minutes":[100],"at":[101],"37":[102],"degrees":[103],"C.":[104],"incubation,":[107],"centrifuged":[111],"evaluation":[114],"sulfidoleukotrienes":[116,148,187],"supernatant":[118],"was":[119,152,204],"performed.":[120],"The":[121,141,184,196],"results":[122,207,217],"expressed":[124],"pg/ml":[126,146],"after":[127],"subtraction":[128],"value":[131],"spontaneous":[133,150],"production":[135,151],"concentration":[142,185,199],"higher":[143],"than":[144],"200":[145],"above":[149],"regarded":[153],"as":[154],"positive":[156],"result.":[157],"observed":[160,209],"large":[162],"spectrum":[163],"response":[167],"upon":[168],"stimulation.":[170],"In":[171,213],"initial":[173],"part":[174],"our":[176],"study":[177],"we":[178],"established":[179],"optimal":[181],"concentration.":[183],"ranged":[190],"10":[192],"5130":[194],"pg/ml.":[195],"mean":[197],"whole":[202],"group":[203],"1671.69.":[205],"Positive":[206],"20":[211],"persons.":[212],"3":[214],"persons":[215,237],"negative.":[222],"conclude":[224],"that":[225],"reliable":[229],"determine":[232],"allergic":[234],"status":[235],"pollinosis.":[239]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}