{"id":"https://openalex.org/W135935779","doi":null,"title":"Response of Metastatic Cancer Cells to Thermal Changes in vitro","display_name":"Response of Metastatic Cancer Cells to Thermal Changes in vitro","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W135935779","mag":"135935779"},"language":"en","primary_location":{"id":"mag:135935779","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JJHMBC_2007_v37n4_239","pdf_url":null,"source":{"id":"https://openalex.org/S2764999901","display_name":"Han-guk hyeonmigyeong hakoeji/Applied microscopy","issn_l":"1225-6773","issn":["1225-6773","2234-6198","2287-4445","2287-5123"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Han-guk hyeonmigyeong hakoeji/Applied microscopy","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102425769","display_name":"Sang\u2010Il Ahn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang\u2010Il Ahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050080113","display_name":"Young-Ee Kwon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young-Ee Kwon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075017758","display_name":"Ho Soon Choi","orcid":"https://orcid.org/0000-0003-3746-8742","observed_orcids":["https://orcid.org/0000-0003-3746-8742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ho Soon Choi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3746-8742","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036260888","display_name":"Jung Kyun Kwon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung Kyun Kwon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091713984","display_name":"Jin Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021521738","display_name":"Jong Ryong Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Ryong Kim","raw_affiliation_strings":["Hanyang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hanyang University","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061861055","display_name":"Won Kyu Kim","orcid":"https://orcid.org/0000-0002-6286-0925","observed_orcids":["https://orcid.org/0000-0002-6286-0925","https://orcid.org/0000-0002-9796-8266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Won Kyu Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6286-0925","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4","first_page":"239","last_page":"248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thermal-stress-biology","display_name":"thermal stress (biology)","score":0.8410000205039978},{"id":"https://openalex.org/keywords/metastatic-tumor-cells","display_name":"metastatic cancer cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gallbladder-cancer","display_name":"gallbladder cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metastatic-lymph-nodes","display_name":"metastatic lymph nodes","score":0.7300000190734863},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8349999785423279},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.968999981880188},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7696124315261841},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7632720470428467},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.589425802230835},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5457072854042053},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5446951985359192},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5005381107330322},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.47480833530426025},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45607665181159973},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.4457387626171112},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4402523338794708},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42786288261413574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4246435761451721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39387398958206177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33699917793273926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16498667001724243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08008095622062683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:135935779","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JJHMBC_2007_v37n4_239","pdf_url":null,"source":{"id":"https://openalex.org/S2764999901","display_name":"Han-guk hyeonmigyeong hakoeji/Applied microscopy","issn_l":"1225-6773","issn":["1225-6773","2234-6198","2287-4445","2287-5123"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Han-guk hyeonmigyeong hakoeji/Applied microscopy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W142053782","https://openalex.org/W1582005136","https://openalex.org/W1585007382","https://openalex.org/W1843503887","https://openalex.org/W1964140720","https://openalex.org/W1971967721","https://openalex.org/W1973570584","https://openalex.org/W1980365520","https://openalex.org/W1983338662","https://openalex.org/W1991605763","https://openalex.org/W1993614010","https://openalex.org/W1994388737","https://openalex.org/W1998914673","https://openalex.org/W2005040182","https://openalex.org/W2018245692","https://openalex.org/W2020169963","https://openalex.org/W2022537145","https://openalex.org/W2034915619","https://openalex.org/W2035992337","https://openalex.org/W2038379840","https://openalex.org/W2054947514","https://openalex.org/W2061154169","https://openalex.org/W2063956958","https://openalex.org/W2069163264","https://openalex.org/W2072310161","https://openalex.org/W2073631243","https://openalex.org/W2080462115","https://openalex.org/W2081211388","https://openalex.org/W2083155294","https://openalex.org/W2095973419","https://openalex.org/W2104660225","https://openalex.org/W2113614699","https://openalex.org/W2122413503","https://openalex.org/W2125007784","https://openalex.org/W2128571608","https://openalex.org/W2137417707","https://openalex.org/W2144143622","https://openalex.org/W2152316546","https://openalex.org/W2163443542","https://openalex.org/W2166365175","https://openalex.org/W2170558349","https://openalex.org/W2323995323","https://openalex.org/W2328267773"],"related_works":["https://openalex.org/W4404252511","https://openalex.org/W2120245950","https://openalex.org/W3209218578","https://openalex.org/W3208381586","https://openalex.org/W2001774972","https://openalex.org/W2134783928","https://openalex.org/W2591229176","https://openalex.org/W2055397235","https://openalex.org/W1265068280","https://openalex.org/W2038921253"],"abstract_inverted_index":{"Alteration":[0],"of":[1,5,59,92,150],"temperature":[2,132],"is":[3,29],"one":[4,149],"cancer":[6,61,142],"therapies.":[7],"In":[8,115],"general,":[9],"severe":[10],"hyperthermia":[11,67,106],"(around":[12,18],"43":[13],"\ufffd":[14],"C)":[15,20,71,77],"and":[16,33,44,72,99,107,145],"hypothermia":[17,73,108],"18\ufffd":[19],"trigger":[21],"apoptosis":[22,85],"through":[23,137],"mitochondria,":[24],"though":[25],"the":[26,57,116],"specific":[27],"mechanism":[28,58],"still":[30],"unknown.":[31],"CC-t6":[32],"GB-d1":[34],"cell":[35,62,88,135],"lines,":[36],"which":[37],"were":[38,48,78,101,126],"originally":[39],"derived":[40],"from":[41,50],"human":[42],"cholangiocarcinoma":[43],"gall":[45],"bladder":[46],"cancer,":[47],"established":[49],"a":[51],"metastatic":[52,60,141],"lymph":[53],"node.":[54],"To":[55],"investigate":[56],"response":[63],"to":[64],"thermal":[65],"stresses,":[66],"(37\ufffd":[68,74],"C\u2192":[69,75],"43\ufffd":[70],"17.4\ufffd":[76],"designed.":[79],"Thermal":[80],"stresses":[81],"did":[82],"not":[83,102,123],"induce":[84,134],"but":[86,122],"necrotic":[87,138],"death.":[89],"Any":[90],"alterations":[91],"caspase":[93],"-3,":[94],"-9,":[95],"cytochrome":[96],"c,":[97],"Bax,":[98],"Bcl-2":[100],"found":[103],"in":[104,140,143],"both":[105],"exposed":[109],"cells":[110],"using":[111],"western":[112],"blot":[113],"analysis.":[114],"transmission":[117],"electron":[118],"microscopy,":[119],"typical":[120],"necrotic,":[121],"apoptotic,":[124],"changes":[125,133],"observed.":[127],"These":[128],"results":[129],"suggest":[130],"that":[131],"death":[136],"pathway":[139],"vitro,":[144],"it":[146],"can":[147],"be":[148],"effective":[151],"anticancer":[152],"methods.":[153]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-06-24T00:00:00"}
