{"id":"https://openalex.org/W135899488","doi":null,"title":"Hyperglycemic Effect on Brain Cholinergic Functions, Oxidative Stress and Protein Expression of Brain Derived Neurotropic Factor (Bdnf) on Cognitive Functions in Streptozotocin Induced-Diabetic Rats","display_name":"Hyperglycemic Effect on Brain Cholinergic Functions, Oxidative Stress and Protein Expression of Brain Derived Neurotropic Factor (Bdnf) on Cognitive Functions in Streptozotocin Induced-Diabetic Rats","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W135899488","mag":"135899488"},"language":"en","primary_location":{"id":"mag:135899488","doi":null,"is_oa":true,"landing_page_url":"http://article.sapub.org/10.5923.j.neuroscience.20150401.01.html","pdf_url":null,"source":{"id":"https://openalex.org/S4210208814","display_name":"Research in neuroscience","issn_l":"2326-1226","issn":["2326-1226","2326-1234"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Research in neuroscience","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://article.sapub.org/10.5923.j.neuroscience.20150401.01.html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079502334","display_name":"Osaretin Albert Taiwo Ebuehi","orcid":"https://orcid.org/0000-0001-9001-6521","observed_orcids":["https://orcid.org/0000-0001-9001-6521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osaretin Albert Taiwo Ebuehi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9001-6521","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076289031","display_name":"D C Dibie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Dibie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1602,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51189898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"1","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cholinergic-dysfunction","display_name":"cholinergic dysfunction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9470000267028809},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7900000214576721},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.8320000171661377},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8499506711959839},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8291459083557129},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8018782734870911},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.699028730392456},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.64081871509552},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5062243342399597},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.4780307710170746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46188846230506897},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4423134922981262},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.424820214509964},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.38685235381126404},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07785451412200928}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:135899488","doi":null,"is_oa":true,"landing_page_url":"http://article.sapub.org/10.5923.j.neuroscience.20150401.01.html","pdf_url":null,"source":{"id":"https://openalex.org/S4210208814","display_name":"Research in neuroscience","issn_l":"2326-1226","issn":["2326-1226","2326-1234"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Research in neuroscience","raw_type":null}],"best_oa_location":{"id":"mag:135899488","doi":null,"is_oa":true,"landing_page_url":"http://article.sapub.org/10.5923.j.neuroscience.20150401.01.html","pdf_url":null,"source":{"id":"https://openalex.org/S4210208814","display_name":"Research in neuroscience","issn_l":"2326-1226","issn":["2326-1226","2326-1234"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Research in neuroscience","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1509395915","https://openalex.org/W1541032653","https://openalex.org/W1750690213","https://openalex.org/W1775749144","https://openalex.org/W1902784566","https://openalex.org/W1969093481","https://openalex.org/W1971048984","https://openalex.org/W1981225734","https://openalex.org/W1983581469","https://openalex.org/W1987739207","https://openalex.org/W2016943722","https://openalex.org/W2034921827","https://openalex.org/W2040290015","https://openalex.org/W2046949772","https://openalex.org/W2047236160","https://openalex.org/W2051049982","https://openalex.org/W2053696585","https://openalex.org/W2054543840","https://openalex.org/W2063576996","https://openalex.org/W2066080796","https://openalex.org/W2071392805","https://openalex.org/W2073092594","https://openalex.org/W2087454739","https://openalex.org/W2087995208","https://openalex.org/W2091363346","https://openalex.org/W2094958540","https://openalex.org/W2096795975","https://openalex.org/W2103091489","https://openalex.org/W2111817213","https://openalex.org/W2121895272","https://openalex.org/W2144915110","https://openalex.org/W2190724508"],"related_works":["https://openalex.org/W7162475926","https://openalex.org/W2595124237","https://openalex.org/W2048184422","https://openalex.org/W2059760717","https://openalex.org/W2051884548","https://openalex.org/W2050215927","https://openalex.org/W2566243927","https://openalex.org/W2043707180","https://openalex.org/W2962405034","https://openalex.org/W2011668670"],"abstract_inverted_index":{"Background:":[0],"Diabetes":[1],"mellitus":[2],"(DM)":[3],"is":[4],"one":[5],"of":[6,25,30,57,66,76,176,180,209,229],"the":[7,28,58,64,96,177,186,210,214],"most":[8],"severe":[9],"metabolic":[10],"disorders":[11],"in":[12,44,82,112,153],"humans":[13],"characterized":[14],"by":[15],"hyperglycemia":[16,67],"due":[17],"to":[18,62],"a":[19],"relative":[20],"or":[21,27,36],"an":[22,172],"absolute":[23],"lack":[24],"insulin":[26,31],"action":[29],"on":[32,68],"its":[33],"target":[34],"tissue":[35],"both.":[37],"Many":[38],"neurodegenerative":[39],"disorders,":[40],"such":[41,125],"as":[42,126,201,203],"deficits":[43],"learning":[45],"memory":[46,149],"and":[47,73,116,122,138,147,150,170,197,226,237],"cognition,":[48],"are":[49],"associated":[50],"with":[51,109,185],"diabetes":[52],"mellitus.":[53],"Objective:":[54],"The":[55,118,143,159,188],"objective":[56],"present":[59],"study":[60,211],"was":[61],"decipher":[63],"effect":[65],"cholinergic":[69],"functions,":[70],"oxidative":[71,205,221],"stress":[72],"protein":[74,145,199,231],"expression":[75,146],"brain":[77],"derived":[78],"neurotrophic":[79],"factor":[80],"(BDNF)":[81],"streptozotocin":[83,215],"induced-":[84],"diabetic":[85,91,164,182,189,217],"rats.":[86],"Methods:":[88],"Streptozotocin":[89],"(STZ)-induced":[90],"rats":[92,101,111,119,154,165,183,190,218],"were":[93,104,120,141,155],"used":[94],"for":[95],"study.":[97],"Twelve":[98],"male":[99],"Sprague-Dawley":[100],"(130-150g)":[102],"each":[103,113],"divided":[105],"into":[106],"2equal":[107],"groups":[108],"six":[110],"group":[114],"(diabetic":[115],"control).":[117],"sacrificed":[121],"biochemical":[123],"parameters,":[124],"blood":[127],"glucose,":[128],"C-peptide,":[129],"total":[130,198],"protein,":[131],"acetyl":[132,135],"choline":[133],"levels,":[134,200],"cholinesterase":[136],"activity":[137],"antioxidant":[139],"status":[140],"determined.":[142,157],"BDNF":[144,179,230],"learning,":[148,236],"cognitive":[151,238],"functions":[152],"also":[156,171,191],"Results:":[158],"results":[160],"obtained":[161],"showed":[162],"that":[163,213],"exhibited":[166,192],"decreased":[167,194,223],"acetylcholine":[168,224],"level":[169],"alteration":[173],"(down":[174],"regulation)":[175],"expressed":[178],"STZ-induced":[181],"compared":[184],"control.":[187],"significantly":[193],"plasma":[195],"C-peptide":[196],"well":[202],"increased":[204,220],"stress.":[206],"Conclusions:":[207],"Data":[208],"indicate":[212],"induced":[216],"had":[219],"stress,":[222],"levels":[225],"down":[227],"regulation":[228],"expression,":[232],"thereby":[233],"impairing":[234],"memory,":[235],"functions.":[239]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
