{"id":"https://openalex.org/W1357140","doi":null,"title":"Synergistic Combination of an In-office Procedure and Home Regimen for the Treatment of Facial Hyperpigmentation.","display_name":"Synergistic Combination of an In-office Procedure and Home Regimen for the Treatment of Facial Hyperpigmentation.","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W1357140","mag":"1357140","pmid":"https://pubmed.ncbi.nlm.nih.gov/22708006","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366447"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2381626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366447","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019581272","display_name":"Joel L. Cohen","orcid":"https://orcid.org/0000-0001-6513-7129","observed_orcids":["https://orcid.org/0000-0001-6513-7129","https://orcid.org/0000-0001-8838-2776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel L Cohen","raw_affiliation_strings":["AboutSkin Dermatology and DermSurgery, Englewood, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AboutSkin Dermatology and DermSurgery, Englewood, Colorado","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021097347","display_name":"Elizabeth T Makino","orcid":"https://orcid.org/0000-0002-6243-861X","observed_orcids":["https://orcid.org/0000-0002-6243-861X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Makino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113481135","display_name":"Sujatha Sonti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sujatha Sonti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051112784","display_name":"Rahul Mehta","orcid":"https://orcid.org/0000-0002-7613-5847","observed_orcids":["https://orcid.org/0000-0002-7613-5847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahul Mehta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3625,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61379535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"4","first_page":"33","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/facial-hyperpigmentation","display_name":"facial hyperpigmentation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melasma","display_name":"melasma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/solar-lentigines","display_name":"liver spots","score":1.0},{"id":"https://openalex.org/keywords/hydroquinone","display_name":"hydroquinone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sunscreen","display_name":"sunscreen","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sun-protection-factor","display_name":"sun protection factor","score":0.5830000042915344},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cost-effective-treatment","display_name":"cost-effective treatment","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9080044031143188},{"id":"https://openalex.org/C2776728111","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Hyperpigmentation","level":2,"score":0.819922924041748},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.8181090950965881},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7600914239883423},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.543091893196106},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35821670293807983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2078602910041809},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.08629041910171509}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2381626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2400913","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3396456","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3366447","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366447","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},{"id":"pmid:22708006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22708006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical and aesthetic dermatology","raw_type":"Journal Article"},{"id":"mag:1357140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22708006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2381626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W154085219","https://openalex.org/W207336132","https://openalex.org/W956804112","https://openalex.org/W1965624625","https://openalex.org/W1998825789","https://openalex.org/W2041939215","https://openalex.org/W2064177412","https://openalex.org/W2085684974","https://openalex.org/W2109189800","https://openalex.org/W2118754948","https://openalex.org/W2155142927","https://openalex.org/W2301978850","https://openalex.org/W2406661861","https://openalex.org/W2417548397"],"related_works":["https://openalex.org/W2439944820","https://openalex.org/W79870540","https://openalex.org/W2989894838","https://openalex.org/W157351941","https://openalex.org/W2575981937","https://openalex.org/W4254176786","https://openalex.org/W4391353848","https://openalex.org/W1415721447","https://openalex.org/W3118468782","https://openalex.org/W4238584613"],"abstract_inverted_index":{"Hyperpigmentation":[0],"disorders,":[1],"such":[2,22],"as":[3,23,183],"melasma":[4,117],"and":[5,26,28,68,95,110,112,129,138,197,228],"solar":[6,114],"lentigines,":[7],"pose":[8],"a":[9,17,71,84,163],"significant":[10],"treatment":[11,43,73,181,209],"challenge":[12],"for":[13,54,231],"most":[14],"patients.":[15,55],"Combining":[16],"series":[18,57],"of":[19,58,70,90,148,159,172,219],"in-office":[20,48,77,213],"procedures,":[21],"chemical":[24,79],"peels":[25],"light-":[27],"laser-based":[29],"treatments,":[30],"with":[31,97,105,157,178,233],"maintenance":[32,87,221],"therapies":[33],"have":[34],"been":[35],"shown":[36],"to":[37,64],"provide":[38,224],"greater":[39],"efficacy":[40,67],"than":[41],"one":[42,76,212],"alone.":[44],"However,":[45],"receiving":[46],"multiple":[47],"procedures":[49],"may":[50,223],"be":[51],"cost":[52],"prohibitive":[53],"A":[56],"eight":[59,144],"case":[60,203],"studies":[61,204],"were":[62,132],"conducted":[63],"evaluate":[65],"the":[66,160,173,179,195],"tolerability":[69],"novel":[72,180],"regimen":[74,182,210],"combining":[75,211],"superficial":[78],"peel":[80],"procedure":[81,214],"followed":[82,215],"by":[83,216],"12-week":[85],"topical":[86,220],"program":[88],"consisting":[89],"micro-entrapped":[91],"4%":[92],"hydroquinone,":[93],"tri-retinol,":[94],"sunscreen":[96],"sun":[98],"protection":[99],"factor":[100],"(SPF)":[101],"30+.":[102],"Patients":[103],"presented":[104],"Fitzpatrick":[106],"skin":[107],"types":[108],"II":[109],"III":[111],"mild-to-moderate":[113],"lentigines":[115],"and/or":[116],"on":[118],"their":[119,176],"facial":[120,155,234],"skin.":[121],"Physician-graded":[122],"overall":[123,154,167],"improvement":[124],"in":[125,153],"hyperpigmentation,":[126,156],"standardized":[127],"photography,":[128],"patient":[130,189,198],"satisfaction":[131],"evaluated":[133],"at":[134,149],"Weeks":[135],"4,":[136],"8,":[137],"12.":[139],"At":[140],"Week":[141],"12,":[142],"all":[143],"patients":[145,161,174,232],"demonstrated":[146],"improvements":[147],"least":[150],"25":[151],"percent":[152,171],"six":[158],"demonstrating":[162],"50-":[164],"or":[165,185],"75-percent":[166],"improvement.":[168],"One":[169],"hundred":[170],"rated":[175],"experience":[177],"\"excellent\"":[184],"\"good\"":[186],"reflecting":[187],"high":[188],"satisfaction.":[190],"Standardized":[191],"photographs":[192],"also":[193],"support":[194],"physician":[196],"findings.":[199],"Results":[200],"from":[201],"these":[202],"demonstrate":[205],"that":[206],"this":[207],"unique":[208],"12":[217],"weeks":[218],"therapy,":[222],"an":[225],"effective,":[226],"simple,":[227],"cost-effective":[229],"option":[230],"hyperpigmentation.":[235]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}