{"id":"https://openalex.org/W135448166","doi":null,"title":"Resistant arterial hypertension and hyperlipidemia: atorvastatin, not vitamin C, for blood pressure control.","display_name":"Resistant arterial hypertension and hyperlipidemia: atorvastatin, not vitamin C, for blood pressure control.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W135448166","mag":"135448166","pmid":"https://pubmed.ncbi.nlm.nih.gov/15609886"},"language":"en","primary_location":{"id":"pmid:15609886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15609886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Israel Medical Association journal : IMAJ","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008998857","display_name":"Eli Magen","orcid":"https://orcid.org/0000-0002-7713-423X","observed_orcids":["https://orcid.org/0000-0002-7713-423X"]},"institutions":[{"id":"https://openalex.org/I2802646120","display_name":"Barzilai Medical Center","ror":"https://ror.org/00hmeez77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802646120"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eli Magen","raw_affiliation_strings":["WHO Collaborative Center for Prevention of Cardiovascular Disease, Barzilai Medical Center, Ashkelon, Israel. elimgen2@netvision.net.il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO Collaborative Center for Prevention of Cardiovascular Disease, Barzilai Medical Center, Ashkelon, Israel. elimgen2@netvision.net.il","institution_ids":["https://openalex.org/I2802646120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112476490","display_name":"Reuven J. Viskoper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reuven Viskoper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108195883","display_name":"Joseph Mishal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Mishal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064816073","display_name":"Rita Priluk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rita Priluk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009507632","display_name":"Arkadi Berezovsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arkadi Berezovsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112252446","display_name":"A. Laszt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anni Laszt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel London","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel London","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084929520","display_name":"Chaim Yosefy","orcid":"https://orcid.org/0000-0001-5867-6263","observed_orcids":["https://orcid.org/0000-0001-5867-6263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaim Yosefy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0718,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.87352514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"12","first_page":"742","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resistant-hypertension","display_name":"resistant hypertension","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9919999837875366},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.8740000128746033},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.984000027179718},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6700000166893005},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure","display_name":"ambulatory blood pressure","score":0.8230000138282776},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.5090000033378601},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.609000027179718},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9626529216766357},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.8902692794799805},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6845031976699829},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.6669699549674988},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.6549199223518372},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.6014038324356079},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5558539032936096},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.5441551804542542},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.42524319887161255},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33530110120773315},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10275572538375854},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15609886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15609886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Israel Medical Association journal : IMAJ","raw_type":"Clinical Trial"},{"id":"mag:135448166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15609886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043146306","https://openalex.org/W2385535924","https://openalex.org/W2392657712","https://openalex.org/W2159912950","https://openalex.org/W1985574798","https://openalex.org/W2365782243","https://openalex.org/W4366330977","https://openalex.org/W2131614310","https://openalex.org/W2362080127","https://openalex.org/W2368612854"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypertension":[1],"is":[2,310],"considered":[3],"resistant":[4,67],"if":[5],"blood":[6,61],"pressure":[7,62],"cannot":[8],"be":[9],"reduced":[10],"to":[11,45,103,195,287,294,312],"<140/90":[12],"mmHg":[13,82,88],"with":[14,23,34,66,76,92,279],"an":[15,20],"appropriate":[16],"triple-drug":[17],"regimen,":[18],"including":[19],"oral":[21],"diuretic,":[22],"all":[24],"agents":[25],"administered":[26],"at":[27,209],"maximal":[28,96],"dosages.":[29],"This":[30],"definition":[31],"has":[32],"evolved":[33],"the":[35,218,272,314],"development":[36],"of":[37,225,253],"new":[38],"therapies":[39],"and":[40,55,60,70,165,201,212,251,267,281,299],"evidence-based":[41],"data":[42],"supporting":[43],"treatment":[44,91],"lower":[46],"BP":[47,80,86,205,297],"goals.":[48],"OBJECTIVE:":[49],"To":[50],"assess":[51,313],"whether":[52],"vitamin":[53,134,288],"C":[54,135,289],"atorvastatin":[56,162,283],"improve":[57,300],"endothelial":[58,301],"function":[59,302],"control":[63,298],"in":[64,95,264,271,303,317],"subjects":[65,75,278],"arterial":[68],"hypertension":[69],"dyslipidemia.":[71],"METHODS:":[72],"Forty-eight":[73],"hyperlipidemic":[74],"RH":[77,280],"(office":[78],"systolic":[79],">140":[81],"and/or":[83],"office":[84],"diastolic":[85],">90":[87],"notwithstanding":[89],"antihypertensive":[90],"three":[93,101],"medications":[94],"doses)":[97],"were":[98,222,269],"randomized":[99],"into":[100],"groups":[102],"receive":[104],"additional":[105],"medication":[106],"for":[107,320],"8":[108,214],"weeks.":[109,215],"Group":[110,140,166],"VTC":[111],"(n":[112,142,168],"=":[113,143,169],"17)--mean":[114],"24":[115,145,171,202],"hour":[116,146,172,203],"SBP":[117,147,173,226],"150.6":[118],"+/-":[119,124,131,149,154,159,175,180,185,229,237,245,259],"5.2":[120],"mmHg,":[121,126,151,156,177,182,231,239],"DBP":[122,152,178,234],"86.1":[123],"3.3":[125],"low":[127],"density":[128],"lipoprotein":[129],"158.1":[130],"24.5":[132],"mg/dl--received":[133,161,187],"500":[136,290],"mg":[137],"per":[138],"day;":[139],"ATR":[141,219],"15)--mean":[144],"153.1":[148],"4.8":[150],"87.1":[153],"6.7":[155],"LDL":[157,183,242,266],"162.6":[158],"13.6":[160],"20":[163,284],"mg/day;":[164],"PLA":[167],"16)--mean":[170],"151.1":[174],"7.4":[176],"84.8":[179],"5.9":[181],"156.7":[184],"26.1":[186],"a":[188,304],"placebo.":[189],"High":[190],"resolution":[191],"ultrasound":[192],"was":[193,207],"used":[194],"calculate":[196],"brachial":[197,254],"artery":[198,255],"flow-mediated":[199],"dilation,":[200],"ambulatory":[204],"monitoring":[206],"performed":[208],"study":[210],"entry":[211],"after":[213],"RESULTS:":[216],"In":[217,277],"group":[220],"there":[221],"significant":[223,262],"reductions":[224],"(deltaSBP1-2:":[227],"13.7":[228],"5.6":[230],"P":[232,240,248],"0.001),":[233],"(deltaDBP1-2:":[235],"7.8":[236],"5.7":[238],"0.01),":[241],"(deltaLDL1-2:":[243],"67.7":[244],"28.3":[246],"mg/dl,":[247],"<":[249],"0.001)":[250],"improvement":[252],"FMD":[256,268],"(deltaFMD2-1:":[257],"4.2":[258],"2.6%).":[260],"No":[261],"changes":[263],"BP,":[265],"observed":[270],"other":[273],"two":[274],"groups.":[275],"CONCLUSIONS:":[276],"dyslipidemia,":[282],"mg/day":[285,291],"compared":[286],"may":[292],"help":[293],"achieve":[295],"better":[296],"finite":[305],"period.":[306],"A":[307],"larger":[308],"trial":[309],"needed":[311],"drug's":[315],"efficacy":[316],"this":[318],"population":[319],"longer":[321],"periods.":[322]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}