{"id":"https://openalex.org/W13538121","doi":"https://doi.org/10.1007/978-1-4757-2778-4_22","title":"How Essential is the Pre-T-Cell Receptor?","display_name":"How Essential is the Pre-T-Cell Receptor?","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W13538121","doi":"https://doi.org/10.1007/978-1-4757-2778-4_22","mag":"13538121"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4757-2778-4_22","doi":"https://doi.org/10.1007/978-1-4757-2778-4_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-2778-4_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of B-Cell and T-Cell Development","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W596311093","display_name":"Molecular Biology of B-Cell and T-Cell Development"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060304095","display_name":"Jan Buer","orcid":"https://orcid.org/0000-0002-7602-1698","observed_orcids":["https://orcid.org/0000-0002-7602-1698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Buer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012087369","display_name":"Harald von Boehmer","orcid":"https://orcid.org/0000-0002-9714-1613","observed_orcids":["https://orcid.org/0000-0002-9714-1613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harald von Boehmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4356,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62919708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"449","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pre-t-cell-receptor","display_name":"pre-T cell receptor","score":0.7409999966621399},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.6510000228881836},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.8610000014305115},{"id":"https://openalex.org/keywords/allelic-exclusion","display_name":"allelic exclusion","score":0.7620000243186951},{"id":"https://openalex.org/keywords/recombination-activating-genes","display_name":"recombination-activating genes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/tcr-alpha-chain","display_name":"TCR alpha chain","score":0.492000013589859},{"id":"https://openalex.org/keywords/tcr-beta-chain","display_name":"T cell receptor beta chain","score":0.8619999885559082},{"id":"https://openalex.org/keywords/antigen-receptor-diversity","display_name":"antigen receptor diversity","score":0.5440000295639038},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.7260000109672546},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7459853887557983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6971810460090637},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5748511552810669},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5529343485832214},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48129501938819885},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44468748569488525},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44261014461517334},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.434079647064209},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.434050589799881},{"id":"https://openalex.org/C103474210","wikidata":"https://www.wikidata.org/wiki/Q142851","display_name":"Immune receptor","level":3,"score":0.43036991357803345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42690131068229675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19556587934494019}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4757-2778-4_22","doi":"https://doi.org/10.1007/978-1-4757-2778-4_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-2778-4_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of B-Cell and T-Cell Development","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W15081168","https://openalex.org/W18653780","https://openalex.org/W169978917","https://openalex.org/W208730735","https://openalex.org/W258316223","https://openalex.org/W1479717491","https://openalex.org/W1527612372","https://openalex.org/W1581464052","https://openalex.org/W1652976025","https://openalex.org/W1775427038","https://openalex.org/W1964432880","https://openalex.org/W1964840267","https://openalex.org/W1966374669","https://openalex.org/W1966889718","https://openalex.org/W1969499881","https://openalex.org/W1969542161","https://openalex.org/W1972331668","https://openalex.org/W1973992050","https://openalex.org/W1974596630","https://openalex.org/W1977546470","https://openalex.org/W1990159938","https://openalex.org/W1990651437","https://openalex.org/W1991102055","https://openalex.org/W1992214487","https://openalex.org/W1994183260","https://openalex.org/W1995179449","https://openalex.org/W1996247810","https://openalex.org/W1996441373","https://openalex.org/W1996822762","https://openalex.org/W2002950843","https://openalex.org/W2008892020","https://openalex.org/W2011389309","https://openalex.org/W2011717162","https://openalex.org/W2014548832","https://openalex.org/W2015468304","https://openalex.org/W2019638830","https://openalex.org/W2021680927","https://openalex.org/W2023667719","https://openalex.org/W2025336339","https://openalex.org/W2028669354","https://openalex.org/W2029350186","https://openalex.org/W2031011895","https://openalex.org/W2031263707","https://openalex.org/W2035820068","https://openalex.org/W2037367542","https://openalex.org/W2039672885","https://openalex.org/W2042173550","https://openalex.org/W2046928493","https://openalex.org/W2055446110","https://openalex.org/W2067707046","https://openalex.org/W2070394329","https://openalex.org/W2070450693","https://openalex.org/W2071632799","https://openalex.org/W2079725260","https://openalex.org/W2080809922","https://openalex.org/W2083847717","https://openalex.org/W2086940038","https://openalex.org/W2092680301","https://openalex.org/W2095016279","https://openalex.org/W2099127242","https://openalex.org/W2103788710","https://openalex.org/W2111078616","https://openalex.org/W2113334969","https://openalex.org/W2115167923","https://openalex.org/W2126464081","https://openalex.org/W2134973492","https://openalex.org/W2140489687","https://openalex.org/W2144935474","https://openalex.org/W2156423848","https://openalex.org/W2164488073","https://openalex.org/W2165352885","https://openalex.org/W2168728330","https://openalex.org/W2171240903","https://openalex.org/W2578150941"],"related_works":["https://openalex.org/W1980352","https://openalex.org/W7096287987","https://openalex.org/W2438727041","https://openalex.org/W1794076386","https://openalex.org/W124330282","https://openalex.org/W4388177075","https://openalex.org/W2169450163","https://openalex.org/W2414207997","https://openalex.org/W7066585833","https://openalex.org/W4236031456"],"abstract_inverted_index":{"The":[0,171],"immune":[1,117,133],"system":[2],"has":[3,282],"the":[4,23,31,37,56,75,127,149,160,231,246,299,302,312,332,346,353,359],"capacity":[5],"to":[6,11,68,91,202,268,291],"distinguish":[7],"and":[8,33,48,121,126,129,153,159,162,166,176,187,242,254,343,352],"respond":[9],"specifically":[10],"a":[12,69,85,214,262,288,321,329],"large":[13,70],"variety":[14,71],"of":[15,36,53,72,106,131,144,184,205,239,248,272,311],"antigens.":[16,54],"This":[17,348],"function":[18],"is":[19,81,304,350],"performed":[20],"mostly":[21],"by":[22,341,345],"lymphocytes":[24,64,310],"that":[25,87,98,224],"form":[26],"two":[27,38,145,327],"major":[28,92],"cell":[29,108,111,333],"lineages:":[30],"B-cells":[32,158],"T-cells.":[34,170],"Cells":[35],"lymphoid":[39],"lineages":[40],"express":[41,266,315,326],"distinct,":[42],"but":[43],"related":[44],"cell-surface":[45],"antigen":[46,80,140,273],"receptors,":[47],"thereby":[49],"recognize":[50],"different":[51,62,73,328],"types":[52],"Although":[55],"diverse":[57],"immunoglobulin":[58],"(Ig)":[59],"receptors":[60,141],"on":[61,157,169,276],"B":[63],"generally":[65,200],"can":[66,325],"bind":[67],"substances,":[74],"T-cell":[76],"receptor":[77,274,286],"(TCR)":[78],"for":[79,174],"built":[82],"in":[83,221,234],"such":[84,135],"way":[86],"it":[88],"binds":[89],"preferentially":[90],"histocompatibility":[93],"complex":[94],"(MHC)":[95],"encoded":[96],"molecules":[97],"present":[99],"various":[100],"peptides,":[101],"which":[102],"are":[103,142,179,199],"degradation":[104],"products":[105],"either":[107,220],"exogenous":[109],"or":[110,164,209,233],"endogenous":[112],"proteins.":[113],"TCR-peptide\u2014MHC":[114],"recognition":[115],"regulates":[116],"responses":[118],"including":[119],"graft":[120],"tumor":[122],"rejection,":[123],"antiviral":[124],"cytolysis,":[125],"recruitment":[128],"control":[130],"other":[132],"cells":[134],"as":[136,292,358],"antibody-producing":[137],"B-cells.":[138],"Lymphocyte":[139],"composed":[143],"variable":[146],"glycoprotein":[147],"subunits:":[148],"Ig":[150,175,243],"heavy":[151],"(IgH)":[152],"light":[154],"chains":[155,168,178,275,330],"(IgL)":[156],"TCR\u03b1":[161],"\u03b2,":[163],"\u03b3":[165],"\u03b4":[167],"genes":[172,244,251],"coding":[173,196],"TCR":[177,241],"formed":[180],"through":[181],"somatic":[182],"rearrangement":[183],"V,":[185],"D,":[186],"J":[188],"gene":[189,197,232],"segments":[190,198],"(1,2)":[191],".":[192,212,257,336],"During":[193],"V-D-J":[194,216],"recombination,":[195],"subjected":[201],"varying":[203],"degrees":[204],"base":[206],"deletion,":[207],"addition,":[208],"both":[210,240],"(3)":[211],"As":[213],"consequence,":[215],"joining":[217],"could":[218,264],"result":[219],"productive":[222],"rearrangements":[223],"maintain":[225],"an":[226],"\u201copen":[227],"reading":[228],"frame\u201d":[229],"throughout":[230],"\u201cout-of-frame,\u201d":[235],"nonproductive":[236],"rearrangements.":[237],"Rearrangement":[238],"requires":[245],"expression":[247],"recombination":[249],"activating":[250],"(RAG":[252],"1":[253],"RAG2)":[255],"(4,5)":[256],"Given":[258],"its":[259,277],"diploid":[260],"nature,":[261],"lymphocyte":[263],"theoretically":[265],"up":[267],"four":[269],"distinct":[270],"combinations":[271],"surface.":[278],"However,":[279],"each":[280],"B-cell":[281],"only":[283,316],"one":[284,317],"antibody":[285],"specificity,":[287],"phenomenon":[289],"referred":[290],"allelic":[293],"exclusion.":[294],"In":[295],"thymocytes":[296],"developing":[297],"along":[298],"TCR\u03b1\u03b2":[300],"lineage,":[301],"situation":[303],"different;":[305],"although":[306],"virtually":[307],"all":[308],"T":[309],"\u03b1\u03b2":[313],"lineage":[314],"particular":[318],"TCR\u03b2":[319],"chain,":[320],"significant":[322],"proportion":[323],"ofT-cells":[324],"at":[331],"surface":[334],"(6,7)":[335],"These":[337],"keywords":[338,354],"were":[339],"added":[340],"machine":[342],"not":[344],"authors.":[347],"process":[349],"experimental":[351],"may":[355],"be":[356],"updated":[357],"learning":[360],"algorithm":[361],"improves.":[362]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
