{"id":"https://openalex.org/W135377121","doi":null,"title":"Engineering substrate-mediated gene delivery with self-assembled monolayers","display_name":"Engineering substrate-mediated gene delivery with self-assembled monolayers","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W135377121","mag":"135377121"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unl.edu:biosysengpres-1047","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/biosysengpres/47","pdf_url":"http://digitalcommons.unl.edu/biosysengpres/47","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Biological Systems Engineering: Conference Presentations and White Papers","raw_type":"text"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://digitalcommons.unl.edu/biosysengpres/47","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056977278","display_name":"Angela K. Pannier","orcid":"https://orcid.org/0000-0002-7589-9351","observed_orcids":["https://orcid.org/0000-0002-7589-9351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela K. Pannier","raw_affiliation_strings":["Biological Systems Engineering"],"raw_orcid":"https://orcid.org/0000-0002-7589-9351","affiliations":[{"raw_affiliation_string":"Biological Systems Engineering","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110154474","display_name":"Lonnie D. Shea","orcid":"https://orcid.org/0000-0002-4449-9806","observed_orcids":["https://orcid.org/0000-0002-4449-9806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lonnie D. Shea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00668191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-assembled-monolayers","display_name":"self-assembled monolayers","score":0.9179999828338623},{"id":"https://openalex.org/keywords/alkanethiol-monolayers","display_name":"alkanethiol monolayers","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gold-surfaces","display_name":"gold surfaces","score":0.8109999895095825},{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/polyethylenimine","display_name":"polyethyleneimine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-immobilization","display_name":"DNA immobilization","score":0.718999981880188},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.8679999709129333},{"id":"https://openalex.org/keywords/covalent-tethering","display_name":"covalent tethering","score":0.8579999804496765},{"id":"https://openalex.org/keywords/surface-hydrophilicity","display_name":"surface hydrophilicity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/surface-ionization","display_name":"surface ionization","score":0.8799999952316284},{"id":"https://openalex.org/keywords/serum-exposure","display_name":"serum exposure","score":0.5889999866485596},{"id":"https://openalex.org/keywords/biomaterial-surfaces","display_name":"biomaterial surfaces","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6221134662628174},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.599556565284729},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4932817816734314},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4289765954017639},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3809557259082794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3759521245956421},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3648785650730133},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33517974615097046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28206291794776917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23905155062675476},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.1881067156791687},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08443832397460938}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unl.edu:biosysengpres-1047","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/biosysengpres/47","pdf_url":"http://digitalcommons.unl.edu/biosysengpres/47","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Biological Systems Engineering: Conference Presentations and White Papers","raw_type":"text"},{"id":"mag:135377121","doi":null,"is_oa":false,"landing_page_url":"http://www.nt.ntnu.no/users/skoge/prost/proceedings/aiche-2005/non-topical/Non%20topical/papers/260d.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306497051","display_name":"05AIChE: 2005 AIChE Annual Meeting and Fall Showcase","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"05AIChE: 2005 AIChE Annual Meeting and Fall Showcase","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unl.edu:biosysengpres-1047","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/biosysengpres/47","pdf_url":"http://digitalcommons.unl.edu/biosysengpres/47","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Biological Systems Engineering: Conference Presentations and White Papers","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W135377121.pdf","grobid_xml":"https://content.openalex.org/works/W135377121.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W590073934","https://openalex.org/W2008317773","https://openalex.org/W1963566048","https://openalex.org/W2116150864","https://openalex.org/W2198818722","https://openalex.org/W2137696578","https://openalex.org/W158183843","https://openalex.org/W2153373151","https://openalex.org/W2078741699","https://openalex.org/W3011536866"],"abstract_inverted_index":{"Gene":[0],"transfer":[1,71],"has":[2],"many":[3],"potential":[4,277],"applications":[5,136],"in":[6,124,134,232,286],"basic":[7],"and":[8,16,60,79,82,85,92,96,101,104,184,192,244],"applied":[9],"sciences,":[10],"including":[11],"functional":[12,218,225],"genomics,":[13],"gene":[14,70,180],"therapy,":[15],"tissue":[17,287],"engineering.":[18],"Substrate-":[19],"mediated":[20],"delivery,":[21,26],"also":[22],"termed":[23],"solid":[24],"phase":[25],"describes":[27],"the":[28,53,57,90,127,139,146,160,195,224,229,233,240,255,258,276],"immobilization":[29,116,191],"of":[30,64,75,98,152,162,197,223],"DNA,":[31,206],"complexed":[32,207],"with":[33,208,275],"nonviral":[34],"vectors,":[35],"to":[36,48,68,121,131,158,172,188,201,214,239,253,263,270,278,281],"a":[37,73,221,267],"biomaterial":[38,147,175,282],"or":[39],"substrate":[40],"that":[41,138],"supports":[42],"cell":[43],"adhesion.":[44],"A":[45],"critical":[46],"component":[47],"this":[49,65],"process":[50],"is":[51],"designing":[52],"appropriate":[54,174,217],"interactions":[55,88],"between":[56,89],"DNA":[58],"complexes":[59,91,140,165,200,249,256],"substrate.":[61,93],"The":[62,94],"objective":[63],"study":[66,159],"was":[67,204,211],"investigate":[69],"as":[72],"function":[74],"i)":[76],"complex":[77,99],"formation":[78],"deposition":[80],"conditions":[81],"ii)":[83],"non-specific":[84],"specific":[86,170],"binding":[87],"volume":[95,105],"time":[97,103],"formation,":[100],"incubation":[102],"were":[106,156,186,236],"investigated":[107],"for":[108,133,178,284],"their":[109],"effects":[110],"on":[111,154,168,228],"transfection":[112,123,163,203],"efficiency.":[113],"While":[114],"nonspecific":[115],"strategies":[117,274],"have":[118],"been":[119],"used":[120,157],"enhance":[122],"vitro,":[125],"translating":[126],"substrate-mediated":[128],"delivery":[129],"approach":[130,252,269],"biomaterials":[132],"vivo":[135],"requires":[137],"be":[141,279],"more":[142],"effectively":[143],"retained":[144],"at":[145,257],"surface.":[148],"Self-assembled":[149],"monolayers":[150],"(SAMs)":[151],"alkanethiols":[153],"gold":[155],"mechanisms":[161],"by":[164],"nonspecifically":[166],"immobilized":[167],"chemically":[169],"substrates,":[171],"determine":[173],"surface":[176],"properties":[177],"efficient":[179],"delivery.":[181],"Surface":[182],"hydrophilicity":[183],"ionization":[185],"found":[187],"mediate":[189,202],"both":[190],"transfection.":[193],"Furthermore,":[194],"ability":[196],"specifically":[198],"tethered":[199,248],"investigated.":[205],"polyethylenimine":[209],"(PEI),":[210],"covalently":[212],"linked":[213],"SAMs":[215,241,265],"presenting":[216],"groups":[219,226],"through":[220,242],"fraction":[222],"available":[227],"PEI":[230],"present":[231],"complex.":[234],"Complexes":[235],"directly":[237],"coupled":[238],"degradable":[243],"non-degradable":[245],"tethers.":[246],"Covalently":[247],"provide":[250,266],"an":[251],"retain":[254],"surface,":[259],"particularly":[260],"following":[261],"exposure":[262],"serum.":[264],"versatile":[268],"identify":[271],"covalent":[272],"tethering":[273],"translated":[280],"surfaces":[283],"use":[285],"engineering":[288],"applications.":[289]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}