{"id":"https://openalex.org/W135322048","doi":null,"title":"Effectiveness of oral route isosorbide 5-mononitrate on peritoneal solute and fluid transports in CAPD patients.","display_name":"Effectiveness of oral route isosorbide 5-mononitrate on peritoneal solute and fluid transports in CAPD patients.","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W135322048","mag":"135322048","pmid":"https://pubmed.ncbi.nlm.nih.gov/17044464"},"language":"en","primary_location":{"id":"pmid:17044464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17044464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033857644","display_name":"Talerngsak Kanjanabuch","orcid":"https://orcid.org/0000-0002-2996-8934","observed_orcids":["https://orcid.org/0000-0002-2996-8934"]},"institutions":[{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Talerngsak Kanjanabuch","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, King Chulalongkorn Memorial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, King Chulalongkorn Memorial Hospital","institution_ids":["https://openalex.org/I2802209374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011069189","display_name":"Somchai Eiam\u2010Ong","orcid":"https://orcid.org/0000-0002-6214-7855","observed_orcids":["https://orcid.org/0000-0002-6214-7855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Somchai Eiam-Ong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"89 Suppl 2","issue":null,"first_page":"S129","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isosorbide-mononitrate","display_name":"isosorbide mononitrate","score":0.9559999704360962},{"id":"https://openalex.org/keywords/continuous-ambulatory-peritoneal-dialysis","display_name":"continuous ambulatory peritoneal dialysis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/peritoneal-solute-transport","display_name":"peritoneal solute transport","score":0.7739999890327454},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9470000267028809},{"id":"https://openalex.org/keywords/peritoneal-permeability","display_name":"peritoneal permeability","score":0.718999981880188},{"id":"https://openalex.org/keywords/net-ultrafiltration","display_name":"net ultrafiltration","score":0.7080000042915344},{"id":"https://openalex.org/keywords/peritoneal-surface-area","display_name":"peritoneal surface area","score":0.6830000281333923},{"id":"https://openalex.org/keywords/oral-nitrates","display_name":"oral nitrates","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8724749088287354},{"id":"https://openalex.org/C2778492647","wikidata":"https://www.wikidata.org/wiki/Q423401","display_name":"Isosorbide mononitrate","level":2,"score":0.7748894691467285},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.728312611579895},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6580145359039307},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.53532475233078},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5229818820953369},{"id":"https://openalex.org/C2778949068","wikidata":"https://www.wikidata.org/wiki/Q179748","display_name":"Isosorbide dinitrate","level":2,"score":0.5152297616004944},{"id":"https://openalex.org/C2779056158","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Peritoneal dialysis","level":2,"score":0.43418997526168823},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4248751997947693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32081276178359985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.317694753408432},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09224170446395874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06920868158340454},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010531","descriptor_name":"Peritoneal Dialysis, Continuous Ambulatory","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015314","descriptor_name":"Dialysis Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17044464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17044464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.610.2479","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.610.2479","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mat.or.th/journal/files/Vol89_Suppl.2_129_4947.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W187983981","https://openalex.org/W249357037","https://openalex.org/W426394004","https://openalex.org/W597102498","https://openalex.org/W1595252365","https://openalex.org/W1890346756","https://openalex.org/W1968893131","https://openalex.org/W1982749310","https://openalex.org/W1989856113","https://openalex.org/W1991060471","https://openalex.org/W1997975259","https://openalex.org/W1998308288","https://openalex.org/W2013261295","https://openalex.org/W2018824883","https://openalex.org/W2026129947","https://openalex.org/W2026782054","https://openalex.org/W2028008593","https://openalex.org/W2042004183","https://openalex.org/W2043498565","https://openalex.org/W2044262390","https://openalex.org/W2056572422","https://openalex.org/W2059185726","https://openalex.org/W2067564338","https://openalex.org/W2093880182","https://openalex.org/W2097335942","https://openalex.org/W2120372571","https://openalex.org/W2127298405","https://openalex.org/W2163626977","https://openalex.org/W2228319508","https://openalex.org/W2256923819","https://openalex.org/W2280815663","https://openalex.org/W2339694478","https://openalex.org/W2412241091","https://openalex.org/W2412283866","https://openalex.org/W2414593893","https://openalex.org/W2416585670","https://openalex.org/W2417391291","https://openalex.org/W2417556315","https://openalex.org/W2419488192","https://openalex.org/W2470050709","https://openalex.org/W4302402784"],"related_works":["https://openalex.org/W2026129947","https://openalex.org/W2093880182","https://openalex.org/W1989445453","https://openalex.org/W2394664896","https://openalex.org/W2417391291","https://openalex.org/W2018494349","https://openalex.org/W2471510225","https://openalex.org/W2412283866","https://openalex.org/W2184140099","https://openalex.org/W7098825245"],"abstract_inverted_index":{"BACKGROUND:":[0],"Addition":[1],"of":[2,33,39,60,92,141,180,221,224,231,240,263,266,273,330,338,346,359,374],"sodium":[3],"nitroprusside":[4],"(NaNTP),":[5],"a":[6,51,57,68,116,238,321],"nitric":[7],"oxide":[8],"(NO)":[9],"donor":[10],"to":[11,30,86,288,362],"peritoneal":[12,18,23,292,298,328,347],"solution":[13],"could":[14,72,226],"enlarge":[15],"the":[16,22,88,132,139,167,187,193,229,261,281,291,296,372],"effective":[17],"surface":[19,348],"area":[20,349],"and":[21,55,71,90,155,174,208,250,333],"pore":[24,354],"size.":[25,355],"This":[26],"would":[27,366],"be":[28,73,367],"leading":[29],"increased":[31,282,297],"clearance":[32],"all":[34,218],"solutes.":[35,335],"Generalized":[36],"clinical":[37],"usage":[38],"NaNTP":[40,325],"in":[41,103,121,186,290,326,353,370],"CAPD":[42,105,124,364],"patients":[43,365],"however":[44],"is":[45,341],"not":[46,277,286],"practical":[47],"because":[48],"it":[49],"has":[50,67,320],"very":[52],"short":[53],"half-life":[54,70],"needs":[56],"specific":[58],"route":[59],"administration.":[61],"Organic":[62],"nitrate,":[63],"another":[64],"NO":[65],"donor,":[66],"longer":[69],"more":[74],"easily":[75],"absorbed":[76],"via":[77,344],"many":[78],"routes.":[79],"OBJECTIVE:":[80],"The":[81,178,336],"present":[82],"study":[83,118],"was":[84,119,304],"conducted":[85],"determine":[87],"effect":[89,323,337],"mechanism":[91],"oral":[93,136,360],"active":[94],"nitrate":[95],"(isosorbide":[96],"5-mononitrate:":[97],"ISMN)":[98],"on":[99],"solute":[100,236,283,299,376],"andfluid":[101],"transports":[102,284],"stable":[104,123,363],"patients.":[106,125],"MATERIAL":[107],"AND":[108],"METHOD:":[109],"A":[110],"prospective":[111],"randomized":[112],"placebo":[113,157,194],"control":[114],"with":[115,237],"crossover":[117],"performed":[120],"nine":[122],"In":[126,161],"group":[127,162],"I":[128],"(n":[129,164],"=":[130,165],"4),":[131],"treatment":[133,168],"included":[134],"1)":[135],"ISMN":[137,175,188,225,319,361],"at":[138],"dose":[140],"20":[142],"mg":[143],"bid":[144],"for":[145,152,158,217,245,248,252,258],"5":[146,159],"days":[147],"2)":[148],"wash":[149,172],"out":[150],"period":[151,189],"7":[153],"days,":[154],"3)":[156],"days.":[160],"2":[163],"5),":[166],"regimens":[169],"were":[170,190,276],"placebo,":[171],"out,":[173],"periods.":[176],"RESULTS:":[177],"MTACs":[179],"low":[181],"molecular":[182,233],"weight":[183,234],"(LMW)":[184],"solutes":[185,272],"greater":[191],"than":[192],"period:":[195],"median":[196],"urea,":[197],"16.7":[198],"vs":[199,205,211,312],"13.8":[200],"ml/min;":[201,207],"creatinine":[202],"(Cr),":[203],"7.9":[204],"6.9":[206],"urate,":[209],"6.1":[210],"5.5":[212],"ml/min":[213],"(p":[214,255],"<":[215,256],"0.05":[216,257],"except":[219],"MTAC":[220],"urea).":[222],"Administration":[223],"also":[227],"enhance":[228],"clearances":[230,329,377],"high":[232],"(HMW)":[235],"magnitude":[239],"increase":[241],"as":[242,268,270,324],"follows:":[243],"10%":[244],"beta2-microglobulin,":[246],"50%":[247],"albumin,":[249],"15%":[251],"immunoglobulin":[253],"G":[254],"all).":[259],"However,":[260],"values":[262],"restrictive":[264],"coefficient":[265],"LMW":[267,332],"well":[269],"HMW":[271,334],"both":[274,331],"groups":[275],"different,":[278],"indicating":[279],"that":[280],"are":[285],"due":[287],"alteration":[289],"membrane":[293],"permeability.":[294],"Despite":[295],"clearance,":[300],"net":[301],"ultrafiltration":[302],"(UF)":[303],"unchanged":[305],"after":[306],"drug":[307],"administration,":[308],"110":[309],"(ISMN":[310],"group)":[311],"120":[313],"ml":[314],"(placebo":[315],"group),":[316],"(NS).":[317],"CONCLUSION:":[318],"similar":[322],"enhancing":[327,371],"ISMN,":[339],"however,":[340],"mediated":[342],"only":[343],"expansion":[345],"without":[350],"significant":[351],"change":[352],"As":[356],"such,":[357],"administration":[358],"practically":[368],"beneficial":[369],"achievement":[373],"target":[375],"suggested":[378],"by":[379],"NKF-":[380],"DOQI":[381],"Guidelines.":[382]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}