{"id":"https://openalex.org/W135221397","doi":null,"title":"Effects of enzymatic hydrolysis on the allergenicity of whey protein concentrates.","display_name":"Effects of enzymatic hydrolysis on the allergenicity of whey protein concentrates.","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W135221397","mag":"135221397","pmid":"https://pubmed.ncbi.nlm.nih.gov/24659158"},"language":"en","primary_location":{"id":"pmid:24659158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24659158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of allergy, asthma, and immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/e362f23b9e6040538b02bc70ae54e986","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002367845","display_name":"Cuicui Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuicui Duan","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. duancui19841111@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. duancui19841111@163.com","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108349385","display_name":"Lijie Yang","orcid":"https://orcid.org/0000-0003-0958-5183","observed_orcids":["https://orcid.org/0000-0003-0958-5183"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijie Yang","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. ljyang01@eyou.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. ljyang01@eyou.com","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101868164","display_name":"Aili Li","orcid":"https://orcid.org/0000-0002-2558-8475","observed_orcids":["https://orcid.org/0000-0002-2558-8475"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aili Li","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. aili-mail@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. aili-mail@163.com","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101485744","display_name":"Rui Zhao","orcid":"https://orcid.org/0000-0002-2709-6546","observed_orcids":["https://orcid.org/0000-0002-2709-6546"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhao","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. 151290185@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. 151290185@qq.com","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037652791","display_name":"Guicheng Huo","orcid":"https://orcid.org/0000-0003-3744-3529","observed_orcids":["https://orcid.org/0000-0003-3744-3529","https://orcid.org/0000-0002-2617-9737"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guicheng Huo","raw_affiliation_strings":["Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. gchuo58@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. gchuo58@163.com","institution_ids":["https://openalex.org/I169572211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I169572211"],"apc_list":null,"apc_paid":null,"fwci":1.8516,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.8411215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"4","first_page":"231","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.09350000321865082,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whey-protein-concentrate","display_name":"whey protein concentrate","score":0.847000002861023},{"id":"https://openalex.org/keywords/enzymatic-hydrolysis","display_name":"enzymatic hydrolysis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tryptic-hydrolysis","display_name":"trypsin hydrolysis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/food-allergenicity","display_name":"food allergenicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cow-s-milk-allergy","display_name":"cow's milk allergy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.6980000138282776},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.722000002861023},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8989999890327454},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hydrolysate","display_name":"hydrolysate","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.8070714473724365},{"id":"https://openalex.org/C2777897731","wikidata":"https://www.wikidata.org/wiki/Q424430","display_name":"Whey protein","level":2,"score":0.7466129064559937},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6070855259895325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6035763621330261},{"id":"https://openalex.org/C53270655","wikidata":"https://www.wikidata.org/wiki/Q5381536","display_name":"Enzymatic hydrolysis","level":3,"score":0.5554999709129333},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5374338030815125},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.49720004200935364},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41412535309791565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3732560873031616}],"mesh":[{"descriptor_ui":"D000067816","descriptor_name":"Whey Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:24659158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24659158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of allergy, asthma, and immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.957.6442","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.957.6442","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.sid.ir/en/VEWSSID/J_pdf/94320140408.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e362f23b9e6040538b02bc70ae54e986","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e362f23b9e6040538b02bc70ae54e986","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Allergy, Asthma and Immunology, Vol 13, Iss 4 (2014)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:e362f23b9e6040538b02bc70ae54e986","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e362f23b9e6040538b02bc70ae54e986","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Allergy, Asthma and Immunology, Vol 13, Iss 4 (2014)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W123333628","https://openalex.org/W1865750873","https://openalex.org/W1917425276","https://openalex.org/W1968538874","https://openalex.org/W1975277328","https://openalex.org/W1981458826","https://openalex.org/W1983492046","https://openalex.org/W1983749274","https://openalex.org/W1990355893","https://openalex.org/W1992468355","https://openalex.org/W2018242890","https://openalex.org/W2021192261","https://openalex.org/W2021635824","https://openalex.org/W2023327333","https://openalex.org/W2023432258","https://openalex.org/W2038124546","https://openalex.org/W2043207848","https://openalex.org/W2066097229","https://openalex.org/W2067308941","https://openalex.org/W2068111771","https://openalex.org/W2083103458","https://openalex.org/W2103146821","https://openalex.org/W2103165535","https://openalex.org/W2116252899","https://openalex.org/W2119477871","https://openalex.org/W2121793070","https://openalex.org/W2153333287"],"related_works":["https://openalex.org/W2376459627","https://openalex.org/W2365441367","https://openalex.org/W2803436479","https://openalex.org/W1521274240","https://openalex.org/W1977176319","https://openalex.org/W1968500106","https://openalex.org/W4415916372","https://openalex.org/W4312350736","https://openalex.org/W2317022128","https://openalex.org/W4381194327"],"abstract_inverted_index":{"Cow's":[0],"milk":[1],"whey":[2,52],"consists":[3],"of":[4,10,35,51,123,142,158,172,176,182,201],"many":[5],"protein":[6,53],"components":[7],"and":[8,16,64,73,78,118,129,137,149,160],"some":[9],"them":[11],"are":[12],"antigens":[13],"to":[14,18,28,39,133,185,197],"human":[15],"known":[17],"modulate":[19],"immune":[20],"responses.":[21],"Enzymatic":[22],"hydrolysis":[23,46,192],"is":[24],"a":[25,195],"useful":[26],"method":[27],"modify":[29],"proteins":[30],"with":[31,75,154],"allergenicity.":[32],"The":[33,89,156],"objective":[34],"this":[36,57],"study":[37],"was":[38,94],"identify":[40],"whether":[41],"the":[42,49,83,99,151,170,180,199],"in":[43,126,131],"vitro":[44],"enzymatic":[45],"could":[47],"reduce":[48,198],"allergenicity":[50,200],"concentrates":[54],"(WPC).":[55],"In":[56],"study,":[58],"WPC":[59,76,79,115,134,167,177],"were":[60,68,146,162],"hydrolyzed":[61],"by":[62,165],"trypsin":[63],"twenty-four":[65],"BALB/c":[66],"mice":[67,85,106,117,136],"divided":[69],"into":[70],"three":[71],"groups":[72],"fed":[74],"formula":[77],"hydrolysates":[80,175],"formula,":[81],"while":[82,174],"control":[84,138,186],"received":[86],"milk-free":[87],"diet.":[88],"results":[90,189],"revealed":[91],"that":[92,191],"there":[93],"no":[95],"significant":[96],"difference":[97],"between":[98],"body":[100],"weights":[101],"among":[102],"all":[103],"groups.":[104],"WPC-fed":[105],"produced":[107,120],"an":[108],"elevated":[109],"spleen":[110],"lymphocyte":[111],"proliferation":[112],"level":[113],"than":[114],"hydrolysates-fed":[116,135],"also":[119,147],"higher":[121],"levels":[122,145],"WPC-specific":[124],"IgE":[125],"intestinal":[127],"tract":[128],"serum":[130],"comparison":[132],"group.":[139,187],"Significant":[140],"up-regulation":[141],"plasma":[143],"histamine":[144],"observed":[148],"showed":[150],"same":[152],"trend":[153],"IgE.":[155],"secretions":[157],"IL-4":[159],"IL-5":[161],"significantly":[163,168,178],"enhanced":[164],"WPC.":[166,202],"suppressed":[169],"secretion":[171,181],"IFN-\u03b3":[173,183],"increased":[179],"compared":[184],"These":[188],"suggest":[190],"may":[193],"play":[194],"role":[196]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
